Abstract: A method and apparatus of a network device that allocates a shared memory buffer for an object is described. In an exemplary embodiment, the network device receives an allocation request for the shared memory buffer for the object. In addition, the network device allocates the shared memory buffer from shared memory of a network device, where the shared memory buffer is accessible by a writer and a plurality of readers. The network device further returns a writer pointer to the writer, where the writer pointer references a base address of the shared memory buffer. Furthermore, the network device stores the object in the shared memory buffer, wherein the writer accesses the shared memory using the writer pointer. The network device further shares the writer pointer with at least a first reader of the plurality of readers. The network device additionally translates the base address of the shared memory buffer to a reader pointer, where the reader pointer is expressed in a memory space of the first reader.

Abstract: A system for associating perceived and mapped lane edges can include a processor and a memory. The memory includes instructions such that the processor is configured to receive a sensor data representing a perceived object; receive map data representing a map object; determine a cost matrix a cost matrix indicative of an association cost for associating the map object to the perceived object; compare the association cost with an association cost threshold; and associate the perceived object with the map object based on the association cost.

Abstract: Disclosed techniques relate to fragment launching. In an example, a fragment launcher has a casing, a launch aperture and a detonation position. An inner profile of the casing tapers from the main body towards the fragment launch aperture and from the main body to the detonation position. A fragment is held within the launch aperture such that when in use an explosive charge can be initiated to launch the fragment from the launcher. The launcher is particularly suited to uses where there is a requirement to launch a fragment in a consistent and repeatable manner.

Abstract: The present disclosure features useful compositions and methods to treat repeat expansion disorders (e.g., trinucleotide repeat expansion disorders), in a subject in need thereof. In some aspects, the compositions and methods described herein are useful in the treatment of disorders associated with MSH3 activity.

Abstract: A method and apparatus of a network device that allocates a shared memory buffer for an object is described. In an exemplary embodiment, the network device receives an allocation request for the shared memory buffer for the object. In addition, the network device allocates the shared memory buffer from shared memory of a network device, where the shared memory buffer is accessible by a writer and a plurality of readers. The network device further returns a writer pointer to the writer, where the writer pointer references a base address of the shared memory buffer. Furthermore, the network device stores the object in the shared memory buffer, wherein the writer accesses the shared memory using the writer pointer. The network device further shares the writer pointer with at least a first reader of the plurality of readers. The network device additionally translates the base address of the shared memory buffer to a reader pointer, where the reader pointer is expressed in a memory space of the first reader.

Abstract: Providing policy check functionality to file uploads is disclosed. An attempted file upload is detected at a browser isolation system. A user of a client is prompted to provide a credential associated with the file and usable to access contents of the file. A policy is applied to the file upload.

Abstract: A respiratory flow limitation detection device, which can include an airway pressure treatment generator, determines a flow limitation measure 506 based one or more shape indices for detecting partial obstruction and a measure of a patient's ventilation or respiratory duty cycle. The shape indices may be based on function(s) that ascertain the likelihood of the presence of M-shaped breathing patterns and/or chair-shaped breathing patterns. The measure of ventilation may be based on analysis of current and prior tidal volumes to detect a less than normal patient ventilation. The duty cycle measure may be a ratio of current and prior measures of inspiratory time to respiratory cycle time to detect an increase in the patient's inspiratory cycle time relative to the respiratory cycle time. A pressure setting based on the flow limitation may then be used to adjust the treatment pressure to ameliorate the patient's detected flow limitation condition.

Abstract: Disclosed herein are systems and methods for inducing a substantially non-hazardous atmosphere encompassing a beverage container during filling, such as filling a small volume container with an alcohol product. A multi-tiered approach can be used to reduce the combustibility of the atmosphere encompassing the beverage container. For example, a ventilation module can be provided and configured to dilute vapors of the beverage liquid. Further, a chilling module can be provided and configured to reduce or maintain a reduced temperature of the beverage liquid. Further, a capture module can be provided and configured to dilute stray beverage liquid. The ventilation module, the chilling module, and the capture module can cooperate to define a non-hazardous zone encompassing the beverage container. This can allow non-hazardous rated electrical components to operate proximate and within the atmosphere associating the alcohol product during filling.

Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compound of formula (I) to treat necroptosis and/or inhibit RIP1 and/or MLKL.

Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compounds of formula (I) to treat necroptosis and/or inhibit MLKL.

Abstract: A wearable air purifier including a headgear; an air purifier assembly, the air purifier assembly configured to generate a filtered airflow from an outlet aperture thereof; and a nozzle assembly connected to the headgear by a hinge assembly. The nozzle assembly includes an inlet aperture for receiving the filtered airflow from the outlet aperture of the air purifier assembly and an air outlet for emitting the filtered airflow from the nozzle assembly. The hinge assembly is configured such that the nozzle assembly is movable relative to the headgear between first and second configurations, filtered airflow is emitted from the air outlet in the first configuration and filtered airflow is not emitted from the air outlet in the second configuration.

Abstract: A patient interface includes a shell with a central opening configured to receive the pressurized flow of air, a foam cushion, and an elastomeric support portion that is attached to the shell, supports the foam cushion, and forms at least part of a chamber together with the shell and the foam cushion. The elastomeric support portion includes a side wall that forms a continuous perimeter around the chamber and a resiliently flexible lip that supports the foam cushion and extends from the side wall toward an interior of the chamber. The resiliently flexible lip has an outer perimeter that is anchored to the side wall and an unsupported inner perimeter. The foam cushion overhangs the inner perimeter of the resiliently flexible lip, and the shell is more rigid than the elastomeric support portion. In addition, the foam cushion is configured to directly contact and engage a portion of the patient's skin in use.

Abstract: Embodiments of the present disclosure provide a nanoparticle based platform, and nanoallergens for identifying, evaluating and studying allergen mimotopes as multiple copies of a single mimotope or various combinations on the same particle. The nanoparticle is extremely versatile and allows multivalent binding to IgEs specific to a variety of mimotopes, simulating allergen proteins. Nanoparticles can include various molecular ratios of components. For example, the nanoallergens can include about 0.1-40% mimotope-lipid conjugate and about 60-99.9% lipid. The mimotope-lipid conjugate includes a mimotope, a first linker, and lipid molecule. Nanoallergens can be used in in vitro and in vivo applications to identify a specific patient's sensitivity to a set of epitopes and predict a symptomatic clinical response, identify allergen epitopes through blind screening peptide sequences from allergen protein, and in a clinical application similar to a scratch test.

Abstract: A process for producing a gaseous product comprising hydrogen, said process comprising exposing a gaseous hydrocarbon to microwave radiation in the presence of a solid catalyst, wherein the catalyst comprises at least one metal species on a support, wherein the metal species is at least one a nickel species or a cobalt species; and a solid catalyst suitable for use in said process, and wherein the support comprises at least one of a carbonate or an alkaline earth metal oxide.

Abstract: A system for associating perceived and mapped lane edges can include a processor and a memory. The memory includes instructions such that the processor is configured to receive a sensor data representing a perceived object; receive map data representing a map object; determine a cost matrix a cost matrix indicative of an association cost for associating the map object to the perceived object; compare the association cost with an association cost threshold; and associate the perceived object with the map object based on the association cost.

Abstract: The present disclosure features useful compositions and methods to treat trinucleotide repeat expansion disorders, e.g., in a subject in need thereof. In some aspects, the compositions and methods described herein are useful in the treatment of disorders associated with OGG1 activity.

Abstract: The present disclosure features useful compositions and methods to treat repeat expansion disorders, e.g., in a subject in need thereof. In some aspects, the compositions and methods described herein are useful in the treatment of disorders associated with MLH3 activity.

Abstract: A method for providing container flooring for a container, including: providing a plurality of container flooring boards, each including a plurality of strand layers including strands of wood bonded together, at least a top strand layer and a bottom strand layer of the container flooring board having its strands substantially aligned in a first direction, and a dimension of the container flooring board in a second direction that is perpendicular to the first direction being selected to extend laterally between sides of the container in use; and arranging the container flooring boards inside the container, each container flooring board being positioned so that the strands of the top strand layer and the bottom strand layer are substantially aligned longitudinally relative to the container and the container flooring board extends laterally between the sides of the container, and respective edges of adjacent container flooring boards abut one another.

Abstract: A patient interface includes a shell with a central opening configured to receive the pressurized flow of air, a foam cushion, and an elastomeric support portion that is attached to the shell, supports the foam cushion, and forms at least part of a chamber together with the shell and the foam cushion. The elastomeric support portion includes a side wall that forms a continuous perimeter around the chamber and a resiliently flexible lip that supports the foam cushion and extends from the side wall toward an interior of the chamber. The resiliently flexible lip has an outer perimeter that is anchored to the side wall and an unsupported inner perimeter. The foam cushion overhangs the inner perimeter of the resiliently flexible lip, and the shell is more rigid than the elastomeric support portion. In addition, the foam cushion is configured to directly contact and engage a portion of the patient's skin in use.