Abstract: A respiratory flow limitation detection device, which can include an airway pressure treatment generator, determines a flow limitation measure 506 based one or more shape indices for detecting partial obstruction and a measure of a patient's ventilation or respiratory duty cycle. The shape indices may be based on function(s) that ascertain the likelihood of the presence of M-shaped breathing patterns and/or chair-shaped breathing patterns. The measure of ventilation may be based on analysis of current and prior tidal volumes to detect a less than normal patient ventilation. The duty cycle measure may be a ratio of current and prior measures of inspiratory time to respiratory cycle time to detect an increase in the patient's inspiratory cycle time relative to the respiratory cycle time. A pressure setting based on the flow limitation may then be used to adjust the treatment pressure to ameliorate the patient's detected flow limitation condition.

Abstract: A respiratory flow limitation detection device, which can include an airway pressure treatment generator, determines a flow limitation measure based one or more shape indices for detecting partial obstruction and a measure of a patient's ventilation or respiratory duty cycle. The shape indices may be based on function(s) that ascertain the likelihood of the presence of M-shaped breathing patterns and/or chair-shaped breathing patterns. The measure of ventilation may be based on analysis of current and prior tidal volumes to detect a less than normal patient ventilation. The duty cycle measure may be a ratio of current and prior measures of inspiratory time to respiratory cycle time to detect an increase in the patient's inspiratory cycle time relative to the respiratory cycle time. A pressure setting based on the flow limitation may then be used to adjust the treatment pressure to ameliorate the patient's detected flow limitation condition.

Abstract: The invention relates to a system 10 for conducting a sales mechanism over the internet in accordance with an embodiment of the invention. The system 10 comprises a sales platform 18 for vendors of items such as a real estate property, sales facilitators 16 to administer the sales mechanism, and buyers (also referred to as bidders 14) to interact for selling and buying the items offered for sale. The description to follow will refer to a particular application of the sales mechanism for offering for sale a real estate property; however, the sales mechanism may be utilised for offering for sale any tangible or intangible items that is able to be sold.

Abstract: A new and distinct Mediterranean short-day cultivar of strawberry plant named ‘SRF36’ that is characterized by its uniformly medium to large and conical shaped berries, 300 its berries that are consistently glossy and orange-red in color, its sweet tasting berries that are high in sugar and low in acid, its vigorous and compact growth habit with dark green leaves, and its substantial fruit yields of marketable quality that is medium-late in season.

Abstract: Disclosed herein are techniques for protecting web applications from untrusted endpoints using remote browser isolation. In an example scenario, a browser isolation system receives a request from a client browser executing on a client device to connect with a remote application accessible via a private network. A surrogate browser is provided to facilitate communications between the client browser and the remote application. A security policy is enforced against the communications.

Abstract: The present disclosure features useful compositions and methods to treat repeat expansion disorders, e.g., in a subject in need thereof. In some aspects, the compositions and methods described herein are useful in the treatment of disorders associated with MLH1 activity.

Abstract: Disclosed herein are compounds of Formula I, wherein A, R1 to R6, and x to z have the meanings given in the description.

Abstract: A method and apparatus of a network device that allocates a shared memory buffer for an object is described. In an exemplary embodiment, the network device receives an allocation request for the shared memory buffer for the object. In addition, the network device allocates the shared memory buffer from shared memory of a network device, where the shared memory buffer is accessible by a writer and a plurality of readers. The network device further returns a writer pointer to the writer, where the writer pointer references a base address of the shared memory buffer. Furthermore, the network device stores the object in the shared memory buffer, wherein the writer accesses the shared memory using the writer pointer. The network device further shares the writer pointer with at least a first reader of the plurality of readers. The network device additionally translates the base address of the shared memory buffer to a reader pointer, where the reader pointer is expressed in a memory space of the first reader.

Abstract: The Circle Light is a circular plastic tag filled with electro photo cell material that glows in total darkness. The outside circumference is a reflective tape that glows as soon as light touches the surface. It also contains a GPS electronic chip for tracking. This device can be used on any object, animal or person. To see it clearly day or night as well as determine its location.

Abstract: Described herein are methods of selecting and treating patients likely to respond to treatment with an anti-LIF antibody.

Abstract: An embodiment of a method of automatically generating a background measurement in a spectrometer is described that comprises the steps of: collecting a plurality of candidate scans in the spectrometer; determining for each of the plurality of candidate scans if the candidate scan correlates to an orthonormal basis set that is associated with a recent background description; saving each candidate scan that correlates to the orthonormal basis set as a background scan in a scan cache; and generating a new background measurement from a plurality of the background scans stored in the scan cache if a current background measurement is older than a preselected time interval.

Abstract: Described herein are assays useful for the quantitation of total LIF from biological samples.

Abstract: A method and apparatus of a network device that allocates a shared memory buffer for an object is described. In an exemplary embodiment, the network device receives an allocation request for the shared memory buffer for the object. In addition, the network device allocates the shared memory buffer from shared memory of a network device, where the shared memory buffer is accessible by a writer and a plurality of readers. The network device further returns a writer pointer to the writer, where the writer pointer references a base address of the shared memory buffer. Furthermore, the network device stores the object in the shared memory buffer, wherein the writer accesses the shared memory using the writer pointer. The network device further shares the writer pointer with at least a first reader of the plurality of readers. The network device additionally translates the base address of the shared memory buffer to a reader pointer, where the reader pointer is expressed in a memory space of the first reader.

Abstract: Embodiments of the present disclosure provide a nanoparticle based platform, and nanoallergens for identifying, evaluating and studying allergen mimotopes as multiple copies of a single mimotope or various combinations on the same particle. The nanoparticle is extremely versatile and allows multivalent binding to IgEs specific to a variety of mimotopes, simulating allergen proteins. Nanoparticles can include various molecular ratios of components. For example, the nanoallergens can include about 0.1-40% mimotope-lipid conjugate and about 60-99.9% lipid. The mimotope-lipid conjugate includes a mimotope, a first linker, and lipid molecule. Nanoallergens can be used in in vitro and in vivo applications to identify a specific patient's sensitivity to a set of epitopes and predict a symptomatic clinical response, identify allergen epitopes through blind screening peptide sequences from allergen protein, and in a clinical application similar to a scratch test.

Abstract: The invention provides a strategy for site specific covalent modification of antibodies using a specialized targeting covalent heterobivalent ligand (cHBL), and corresponding design for a covalent heterobivalent inhibitor (cHBI) that can be used to prevent Immunoglobulin E (IgE) mediated allergic reactions triggered by drug molecules, according to one embodiment. These molecules contain four important components: (1) an IgE antigen binding site (ABS) ligand that can be a mimotope for the allergen protein, a small molecule, or a peptidomimetic, (2) an appropriate linker, which can be any flexible or rigid chemical linker, providing spacing between the ABS binder and the other moieties, (3) a nucleotide binding site (NBS) ligand, and (4) a reactive moiety to form a covalent link with an amino acid side chain of target IgE antibodies.

Abstract: A patient interface assembly includes a cushion and frame assembly with a cushion portion and a frame portion that together form a breathing chamber. The frame portion includes an anterior aperture configured to receive the flow of breathable gas. Headgear includes a back portion, a pair of upper headgear straps extending from the back portion, and a pair of lower headgear straps. The patient interface assembly also includes a shroud in the form of a contoured plate. The shroud is removably mounted on the frame portion by way of a snap-fit connection and includes a pair of lower headgear connectors. The patient interface assembly also includes a forehead support extending from the shroud and having a free end with an upper headgear connector. The forehead support has a first curvature that curves in a first direction around an axis that is offset from the patient interface assembly and extends along a length of the forehead support.

Abstract: In providing product reviews relevant to a specific user, a server determines that a user is viewing a current product on a website. The website includes a plurality of product reviews for the current product. In response, the server automatically collects criteria specifically for the user, where the criteria describe the current and past website browsing behavior of the user. The server applies weights to one or more of the criteria, where the weights are specific to the user. The server ranks the plurality of product reviews based on the weighted criteria and sends the rankings of the plurality of product reviews to a web server hosting the website. The plurality of product reviews is displayed on the website according to the rankings. The relevancy rankings can vary between users and thus the display of the most relevant product reviews can vary between users.

Abstract: Provided is a method for dynamically displaying product features related to cognitive customer relevant preferences. The method comprises obtaining user data relevant to user preferences regarding product features. The method further comprises generating a ranking of the product features using the obtained user data. The method further comprises generating a user preference profile based on the ranking of the product features. The method further comprises obtaining product data and applying the user preference profile to the obtained product data to generate relevant product content. The method further comprises displaying the relevant product content.

Abstract: A coating composition containing added diol functionality to a urethane, a urea, or polyurethane urea functional resin where an adipic acid dihydrazide chain extender, or free adipic acid dihydrazide active hydrogens react with the oxirane group found in glycidol is described. The combination of diisocyanate, a polyether segment, optionally at least one polyester diol segment, optionally at least one poly(tetrahydrofuran) diol segment, optionally and at least one dimethylol propionic acid diol segment, at least one dihydrazide segment and glycidol compound introduces an increased hydrophilic structure, by diol addition, in compositions that are usable as coatings, on for example, medical devices.

Abstract: The invention provides a strategy for site specific covalent modification of antibodies using a specialized targeting covalent heterobivalent ligand (cHBL), and corresponding design for a covalent heterobivalent inhibitor (cHBI) that can be used to prevent Immunoglobulin E (IgE) mediated allergic reactions triggered by drug molecules, according to one embodiment. These molecules contain four important components: (1) an IgE antigen binding site (ABS) ligand that can be a mimotope for the allergen protein, a small molecule, or a peptidomimetic, (2) an appropriate linker, which can be any flexible or rigid chemical linker, providing spacing between the ABS binder and the other moieties, (3) a nucleotide binding site (NBS) ligand, and (4) a reactive moiety to form a covalent link with an amino acid side chain of target IgE antibodies.