Abstract: The present disclosure describes apparatuses and methods for manufacturing programmable memory devices with optimized gate oxide thickness. In some aspects, lithography masks are used to fabricate oxide gates for programmable memory devices of an integrated-circuit (IC) die that are thinner than oxide gates fabricated for processor core devices of the IC die. In other aspects, lithography masks are used to fabricate oxide gates for the programmable memory devices of the IC die such that they are thicker than the oxide gates fabricated for the processor core devices of the IC die. By so doing, the programmable memory devices can be manufactured with optimized gate oxide thickness that may reduce programming voltage or increase device reliability of the programmable memory devices.

Abstract: A method of assembling an adjustable fluid-filled lens assembly comprising biaxially tensioning an elastomeric membrane to a surface tension of greater than 180 N/m, typically greater than 1000 N/m; thermally conditioning the tensioned membrane, e.g., for one hour at a temperature of about 80° C., to accelerate relaxation of the membrane; mounting the membrane to a peripheral support structure whilst maintaining the tension in the membrane; assembling the mounted membrane with one or more other components to form an enclosure with the membrane forming one wall of the enclosure; and thereafter filling the enclosure with a fluid. The membrane may be formed from an aromatic polyurethane, and the fluid may be a phenylated siloxane. In some embodiments, the membrane is able to hold a substantially constant surface tension of at least 180 N/m for a period of at least 12 months.

Abstract: Portable convertible rechargeable battery power supplies are described. The battery power supplies generally comprise a casing enclosing one or more battery power cells and associated electronics and electrical interconnections. The power cells are interconnected with a plurality of external ports allowing for at least one recharge input and at least two outputs: one configured for use with an electronic apparatus, such as a vehicle, and at least one configured for use with one or more personal electronic devices. The apparatus may be an electric vehicle, and the battery power supply may be configured to be secured within the electric vehicle. The outputs for the personal electronic devices may include any suitable port, such as, for example, USB, mini-USB, USB-c, lightning, etc.

Abstract: The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.

Abstract: Foldable electrical vehicles and related charging infrastructure are described. The foldable electrical vehicle generally includes three structural members (front and rear wheel-bearing structural members and a seat-bearing structural member) that are pivotally interconnected along their lengths such that they may be pivoted between a closed position wherein the three structural members are disposed roughly parallel to each other in a compact folded configuration, and an open riding configuration wherein an angular relation is formed between the structural members.

Abstract: Provided herein are methods for determining the presence or absence of an enteroviruses and parechoviruses in a biological sample. The methods involve identifying the presence or absence of a target nucleic acids from the viruses using direct amplification from a biological sample without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids. Also provided are methods of diagnosis using the methods provided and compositions and kits for the practice of the methods.

Abstract: The present disclosure describes apparatuses and methods for manufacturing programmable memory devices with optimized gate oxide thickness. In some aspects, lithography masks are used to fabricate oxide gates for programmable memory devices of an integrated-circuit (IC) die that are thinner than oxide gates fabricated for processor core devices of the IC die. In other aspects, lithography masks are used to fabricate oxide gates for the programmable memory devices of the IC die such that they are thicker than the oxide gates fabricated for the processor core devices of the IC die. By so doing, the programmable memory devices can be manufactured with optimized gate oxide thickness that may reduce programming voltage or increase device reliability of the programmable memory devices.

Abstract: This document relates to materials and methods for modulating ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.

Abstract: A computer-implemented method for supporting disease diagnosis is provided that includes: a) generating and storing a list of user-selected broad symptoms; b) using the list of user-selected broad symptoms to generate and store a list of related disease presentations or diseases; c) using at least one machine knowledge system to identify a collection of disease-specific symptoms that are related to the disease presentations or diseases of the list of related disease presentations or diseases; d) presenting to the user disease-specific symptoms belonging to the collection of disease-specific symptoms for associated user input; e) using the user input associated with the disease-specific symptoms to determine matching scores for diseases presentations or diseases of the list of related disease presentations or diseases; and f) using the matching scores for the diseases presentations or diseases to present to the user rankings or groupings for diseases corresponding to the of the list of related disease presenta

Abstract: Provided herein are methods for determining the presence or absence of an enteroviruses and parechoviruses in a biological sample. The methods involve identifying the presence or absence of a target nucleic acids from the viruses using direct amplification from a biological sample without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids. Also provided are methods of diagnosis using the methods provided and compositions and kits for the practice of the methods.

Abstract: Provided are a microorganism of the genus Corynebacterium having an enhanced activity to produce L-lysine as a result of inactivating a secretory protein and a method for producing L-lysine using the microorganism.

Abstract: An in vitro assay is provided for determining the effect of an immune cell on a cell from an infectious or neoplastic disease. Also provided is an in vitro assay for determining the effect of an activated CD8+ T-cell on a sensitized melanoma cell. A method for improving the specific cytolytic activity (SCA) of an immune cell comprising contacting an immune cell with an antigen and an antigen-independent pro-inflammatory agent is provided. A method for ex vivo expansion of antigen-specific CD8+ T-cells with enhanced specific cytolytic activity (SCA) comprising culturing the antigen-specific CD8+ T-cells in a suitable culture media comprising an amino acid. An in vitro assay is provided for determining the effect of an immune cell on a cell from an infectious or neoplastic disease. A method of treating a subject suffering from an infectious or neoplastic disease with immuno therapy is described.

Abstract: A system for controlling a gas burning appliance is disclosed. The system includes a central control unit. A pilot valve and main valve controls the flow of fuel from a fuel source to the pilot and main valve, respectively, and are configured for accepting an electrical current from a thermopile and from a power source. A spark generator generates for igniting fuel received by the pilot thereby generating a pilot flame. A flame sensor is adapted for monitoring the presence of a pilot flame. A thermopile proximate to the pilot burner is configured for generating an output electrical current for powering the pilot and main valve control devices. A relay routes electrical current between the power source and thermopile to the pilot and main valve control devices. A flame height regulating device conductively coupled with the power source is configured for adjusting a height of a main flame.

Abstract: A system for assessment of irregularity in wooden material below the surface of a substrate, from above the surface of the substrate. The wooden material extending from below to above the surface of the substrate and surrounded by the substrate below the surface of the substrate. The system comprising at least one transmitter and receiver or transducer arranged to transmit energy through the material from above the surface of the substrate towards the part of the material below the surface, and to receive energy reflected from the material back through the surface, and a processor arranged to analyse the reflected energy and provide an indication of irregularity in the material below the surface of the substrate.

Abstract: A method is provided for treating a subject suffering from an infectious or neoplastic disease with immunotherapy. The method comprises determining the critical concentration of immune cells required to treat or eradicate an infectious or neoplastic disease in the subject using an in vitro assay of the present invention; and administering to the subject the critical concentration of immune cells determined in the assay.

Abstract: Provided herein are methods for determining the presence or absence of an enteroviruses and parechoviruses in a biological sample. The methods involve identifying the presence or absence of a target nucleic acids from the viruses using direct amplification from a biological sample without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids. Also provided are methods of diagnosis using the methods provided and compositions and kits for the practice of the methods.

Abstract: The present disclosure is directed towards having a user interface that displays a number of cards or windows. A user can implement a command where the user interface will automatically change the position of the displayed cards to show regions of interest which are the parts of the cards that a user may have interested in. The user interest can be determined in accordance with user preference information. Optionally, cards which do not have regions of interest are removed from a display area and such cards are replaced with new cards that do have regions of interest.

Abstract: In some implementations, a method of fabricating an integrated circuit includes obtaining first data for a first chip containing a first version of the integrated circuit, determining that a transistor should be coupled with another transistor, selecting one or more masks for coupling the transistor with the other transistor to adjust the threshold voltage of the transistor, obtaining second data for a second chip containing a second version of the integrated circuit, determining that the second version of the integrated circuit meets one or more requirements, and preparing a final integrated circuit design for production based on the second version of the integrated circuit.

Abstract: A dual-port memory including a first memory array and at least one address decoder. The first memory array includes memory cells and two ports for each of the memory cells. The at least one address decoder generates word line signals for concurrent access to two ports of one or more cells of the memory cells in a same row of the first memory array. Each of the word line signals is generated to perform a read operation. Pulse widths of the word line signals for the read operations are proportional to a ratio of (i) a reference amount of cell current of a cell of a reference memory array to (ii) an amount of cell current of the one or more cells of the plurality of memory cells in a same row of the first memory array.