Patents by Inventor Peter A. Materna
Peter A. Materna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10707802Abstract: An energy or water storage system can comprise a storage reservoir, a discharge reservoir, a pump for charging the storage reservoir, and a turbine or similar discharge device. The storage reservoir can comprise a flexible bag covered by overburden that creates pressure inside the bag. Energy is stored by raising the overburden. The bag can comprise a shaped internal filler piece to prevent formation of a crease at the bag edge. Solar panels can be mounted above any bag to make additional use of the land. Solar panels mounted on overburden can have tracking mechanisms and controls suitable to achieve desired orientation regardless of the slope of overburden. Elevation difference between the storage reservoir and discharge reservoir can be used, including an underground cavity. The bag can have internal tethers to influence bag shape.Type: GrantFiled: March 12, 2018Date of Patent: July 7, 2020Inventors: Peter A Materna, Ralph L Hensler, Leonid Lozinsky
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Publication number: 20200197595Abstract: Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration.Type: ApplicationFiled: September 26, 2019Publication date: June 25, 2020Inventors: Mohamed E. Labib, Stanislav S. Dukhin, Thomas Kelly, Peter Materna
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Publication number: 20200138708Abstract: Hollow fiber drug delivery devices are described. Device can contain structural or solid fibers. Fabric can be formed by fibers being interwoven or joined to each other. All or some of the fibers can be resorbable. Fibers can be subdivided, by deformations or closure points, into numerous compartments that separately deliver drug. Deformations can be located at points of fiber intersection or joining. Different drug or drug formulation can be provided in different places. Fibers can be given appropriate surface treatments or coatings to achieve desired properties such as wetting of pores and surfaces. Different release characteristics in different directions can be achieved. The hollow fibers can contain solid particles of drug, and can contain gel. Possible applications include hernia meshes, pouches, sutures, catheters, wound dressings, stents, nerve regrowth guides, refillable/drainable devices, and devices that deliver drug to lymphatic flow.Type: ApplicationFiled: December 12, 2019Publication date: May 7, 2020Inventors: Mohamed E. LABIB, Stanislav S. DUKHIN, Peter MATERNA, Jeffrey C. ROBERTSON, Ching-Yue LAI, Yacoob TABANI
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Publication number: 20200054415Abstract: Provided among other things is a sampling system for determining an amount or type of contamination a narrow, elongated passageway in a medical device, said sampling system comprising: (a) a fluid supply system that supplies to said passageway a sampling liquid for flowing through said passageway and a gas for flowing through said passageway; and (b) a receiving container that receives liquid from said passageway, wherein said sampling liquid is sterile, wherein said sampling liquid is configured to allow recovery of viable pathogens from the passageway, and wherein said sampling liquid comprises an amount and selection of surfactant effective to enhance the dislodgement of Enterococcus faecalis and Pseudomonas aeruginosa bacteria from the narrow passageways.Type: ApplicationFiled: August 29, 2019Publication date: February 20, 2020Inventors: Mohamed E. Labib, Stanislav S. Dukhin, Jeffrey C. Robertson, Peter Materna, Ching-Yue Lai, Yacoob Tabani
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Patent number: 10512523Abstract: Provided among other things is a sampling system for determining an amount or type of contamination a narrow, elongated passageway in a medical device, said sampling system comprising: (a) a fluid supply system that supplies to said passageway a sampling liquid for flowing through said passageway and a gas for flowing through said passageway; and (b) a receiving container that receives liquid from said passageway, wherein said sampling liquid is sterile, wherein said sampling liquid is configured to allow recovery of viable pathogens from the passageway, and wherein said sampling liquid comprises an amount and selection of surfactant effective to enhance the dislodgement of Enterococcus faecalis and Pseudomonas aeruginosa bacteria from the narrow passageways.Type: GrantFiled: August 24, 2017Date of Patent: December 24, 2019Assignee: Novaflux, Inc.Inventors: Mohamed E. Labib, Stanislav S. Dukhin, Jeffrey C. Robertson, Peter Materna, Ching-Yue Lai, Yacoob Tabani
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Patent number: 10426884Abstract: Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration.Type: GrantFiled: June 26, 2015Date of Patent: October 1, 2019Assignee: Novaflux Inc.Inventors: Mohamed E. Labib, Stanislav S. Dukhin, Thomas Kelly, Peter Materna
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Publication number: 20190249115Abstract: Provided among other things is a cleaning composition comprising: a carrier fluid; and Minute Fibrils suspended in the carrier fluid, wherein the composition is protein cleaning effective.Type: ApplicationFiled: February 19, 2019Publication date: August 15, 2019Inventors: Mohamed Emam Labib, Stanislav S. Dukhin, Yacoob Tabani, Ching-Yue Lai, James L. Manganaro, Peter Materna, Jeffrey C. Robertson
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Patent number: 10266793Abstract: Provided among other things is a cleaning composition comprising: a carrier fluid; and Minute Fibrils suspended in the carrier fluid, wherein the composition is protein cleaning effective.Type: GrantFiled: September 28, 2017Date of Patent: April 23, 2019Assignee: Novaflux, Inc.Inventors: Mohamed Emam Labib, Stanislav S. Dukhin, Yacoob Tabani, Ching-Yue Lai, James L. Manganaro, Peter Materna, Jeffrey C. Robertson
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Publication number: 20190002815Abstract: In an embodiment of the invention, there may be provided a bioreactor having tissue scaffolds and having culture medium perfused therethrough. There may be multiple independent culture chambers and reservoirs or sub-reservoirs. Sensors can provide for individually controlling conditions in various culture chambers, and various culture chambers can be operated differently or for different durations. It is possible to infer the number of cells or the progress toward confluence from the fluid resistance of the scaffold, based on flowrate and pressure drop. Harvesting may include any combination or sequence of; exposure to harvesting reagent; vibration; liquid flow that is steady, pulsatile or oscillating; passage of gas-liquid interface through the scaffold. Vibration and flow can be applied so as to reinforce each other.Type: ApplicationFiled: September 11, 2018Publication date: January 3, 2019Applicant: 3D Biotek, LLCInventors: Zongsen Wang, Wing Lau, Faribourz Payvandi, Peter Materna
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Publication number: 20180200185Abstract: Hollow fiber drug delivery devices are described. Device can contain structural or solid fibers. Fabric can be formed by fibers being interwoven or joined to each other. All or some of the fibers can be resorbable. Fibers can be subdivided, by deformations or closure points, into numerous compartments that separately deliver drug. Deformations can be located at points of fiber intersection or joining. Different drug or drug formulation can be provided in different places. Fibers can be given appropriate surface treatments or coatings to achieve desired properties such as wetting of pores and surfaces. Different release characteristics in different directions can be achieved. The hollow fibers can contain solid particles of drug, and can contain gel. Possible applications include hernia meshes, pouches, sutures, catheters, wound dressings, stents, nerve regrowth guides, refillable/drainable devices, and devices that deliver drug to lymphatic flow.Type: ApplicationFiled: July 22, 2016Publication date: July 19, 2018Inventors: Mohamed E. LABIB, Stanislav S. DUKHIN, Peter MATERNA, Jeffrey C. ROBERTSON, Ching-Yue LAI, Yacoob TABANI
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Publication number: 20180125606Abstract: Provided among other things is a sampling system for determining an amount or type of contamination a narrow, elongated passageway in a medical device, said sampling system comprising: (a) a fluid supply system that supplies to said passageway a sampling liquid for flowing through said passageway and a gas for flowing through said passageway; and (b) a receiving container that receives liquid from said passageway, wherein said sampling liquid is sterile, wherein said sampling liquid is configured to allow recovery of viable pathogens from the passageway, and wherein said sampling liquid comprises an amount and selection of surfactant effective to enhance the dislodgement of Enterococcus faecalis and Pseudomonas aeruginosa bacteria from the narrow passageways.Type: ApplicationFiled: August 24, 2017Publication date: May 10, 2018Inventors: Mohamed E. Labib, Stanislav S. Dukhin, Jeffrey C. Robertson, Peter Materna, Ching-Yue Lai, Yacoob Tabani
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Publication number: 20180094214Abstract: Provided among other things is a cleaning composition comprising: a carrier fluid; and Minute Fibrils suspended in the carrier fluid, wherein the composition is protein cleaning effective.Type: ApplicationFiled: September 28, 2017Publication date: April 5, 2018Inventors: Mohamed Emam Labib, Stanislav S. Dukhin, Yacoob Tabani, Ching-Yue Lai, James L. Manganaro, Peter Materna, Jeffrey C. Robertson
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Publication number: 20160375188Abstract: Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration.Type: ApplicationFiled: June 26, 2015Publication date: December 29, 2016Inventors: Mohamed E. Labib, Stanislav S. Dukhin, Thomas Kelly, Peter Materna
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Patent number: 8758658Abstract: A uniaxially compressed dosage form manufactured by three-dimensional printing that preserves the predetermined internal architecture of the dosage form while producing an improved surface finish. The compression compacts the dosage form, eliminating at least some of the void space that remains at the end of conventional three-dimensional printing. Surface finish obtained as a result of the uniaxial compression process can be essentially equal to that obtained from conventional tablet pressing. Additionally, the internal structure or spatial variation of composition of the dosage form is preserved during the pressing operation, with geometric shrinkage occurring mostly in the direction of the axis of pressing. Further, as a result of compression, a greater quantity of API can be packed into a given final volume of dosage form.Type: GrantFiled: December 28, 2010Date of Patent: June 24, 2014Assignee: Massachusetts Institute of TechnologyInventors: Wendy E. Pryce Lewis, Michael J Cima, Charles W Rowe, Peter A. Materna
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Patent number: 8753396Abstract: A spinal implant for implantation in an intervertebral space is provided, such that the implant may provide a back-out prevention feature and may also provide a visual indication of whether the back-out prevention feature is engaged. The visual indication may be a contrast between a circular visible shape of the screw head and a non-circular visible shape of the screw head. The back-out prevention feature may provide engagement of a tapered thread in the screw head with an internal thread of the implant. A hard stop may also be provided. Such back-out prevention feature may also provide a torque-based indication of engagement or non-engagement of the back-out prevention feature. The implant may possess a polymeric posterior body joined to a metallic anterior body.Type: GrantFiled: August 17, 2011Date of Patent: June 17, 2014Assignee: Theken Spine, LLCInventors: Brian E. Hockett, Abid Qureshi, Steven Lee, Jeffrey A. Russo, Peter A. Materna
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Patent number: 8545562Abstract: An implant may provide a body capable of being fit in an intervertebral space and a spin-plate rotatable with respect to the body. The spin-plate may a blade. The blade may possess grooves in its flat faces, or may be provided with an overhang. The path of the overhang or groove may be such that as the spin-plate advances in its rotation, a vertebra engaged with the blade is drawn toward the body of the implant. Pins may be placed in adjacent vertebrae such as to engage the spin-plate. Surgical methods are also described.Type: GrantFiled: March 31, 2010Date of Patent: October 1, 2013Assignee: Theken Spine, LLCInventors: Peter A. Materna, James Bruffey, Bret Hartzell, Dale G. Davison
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Patent number: 8197517Abstract: Various embodiments are provided with a polyaxial spinal screw assembly that comprise a threaded screw having a bulbous or curvate head, and a receiver for receiving the head of the screw, and a slotted collet between the receiver and the screw head. The collet may, in an un-locked condition, bear against the head of the screw to frictionally retain the screw's angular position. The collet may have a lip that may engage with a corresponding internal feature of the receiver. The screw head may be able to be inserted into the receiver through the bottom of the receiver. The screw may be cannulated and also may be fenestrated. Embodiments may also include a bone screw having fenestration holes that include a component in the rotational direction, such as backward-facing with respect to the forward-rotational direction of the screw.Type: GrantFiled: May 8, 2008Date of Patent: June 12, 2012Assignee: Theken Spine, LLCInventors: Eric A. Lab, Peter A. Materna
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Publication number: 20110187015Abstract: A uniaxially compressed dosage form manufactured by three-dimensional printing that preserves the predetermined internal architecture of the dosage form while producing an improved surface finish. The compression compacts the dosage form, eliminating at least some of the void space that remains at the end of conventional three-dimensional printing. Surface finish obtained as a result of the uniaxial compression process can be essentially equal to that obtained from conventional tablet pressing. Additionally, the internal structure or spatial variation of composition of the dosage form is preserved during the pressing operation, with geometric shrinkage occurring mostly in the direction of the axis of pressing. Further, as a result of compression, a greater quantity of API can be packed into a given final volume of dosage form.Type: ApplicationFiled: December 28, 2010Publication date: August 4, 2011Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: WENDY E. PRYCE LEWIS, MICHAEL J. CIMA, CHARLES W ROWE, PETER A. MATERNA
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Patent number: 7931914Abstract: A uniaxially compressed dosage form manufactured by three-dimensional printing that preserves the predetermined internal architecture of the dosage form while producing an improved surface finish. The compression compacts the dosage form, eliminating at least some of the void space that remains at the end of conventional three-dimensional printing. Surface finish obtained as a result of the uniaxial compression process can be essentially equal to that obtained from conventional tablet pressing. Additionally, the internal structure or spatial variation of composition of the dosage form is preserved during the pressing operation, with geometric shrinkage occurring mostly in the direction of the axis of pressing. Further, as a result of compression, a greater quantity of API can be packed into a given final volume of dosage form.Type: GrantFiled: October 29, 2002Date of Patent: April 26, 2011Assignee: Massachusetts Institute of TechnologyInventors: Wendy E. Pryce Lewis, Charles William Rowe, Michael J. Cima, Peter A. Materna
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Patent number: 7820201Abstract: The present invention includes controlled release dosage forms and methods of designing and manufacturing dosage forms to obtain specific release profiles, for example, zero-order release profiles, escalating release profiles or decreasing release profiles. The dosage forms of the present invention can include spatial variation of API concentration in the dosage form and can include nested regions. Dosage forms according to the present invention may be manufactured by any appropriate method for obtaining the internal structure as disclosed herein for producing zero-order release profiles and increasing or decreasing release profiles. The invention further includes methods of manufacturing such dosage forms, such as by three-dimensional printing, possibly also including compression of the dosage form after three-dimensional printing. The invention further includes methods of designing such dosage forms.Type: GrantFiled: October 22, 2007Date of Patent: October 26, 2010Assignee: Massachusetts Institute of TechnologyInventors: Wendy E. Pryce Lewis, Charles W. Rowe, Michael J. Cima, Peter A. Materna