Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.

Abstract: A method of implanting and securing an implantable flow connector in a body of a patient for providing communication of a first space within the body of the patient with a second space within the body of the patient. The method includes providing a flow connector having a lumen having a first orifice and a second orifice, inserting a retention device into the first space within the body, subsequently inserting the flow connector through an opening in the retention device so the second portion of the flow connector extends into the first space within the body and placing the second space within the body over the retention device.

Abstract: Wireless communication devices, systems, and methods related to power saving, including during connected mode operation and for extended reality (XR) data communications with or without discontinuous reception (DRX), are provided. For example, a method of wireless communication includes receiving, while in a connected mode, a configuration based on data traffic for the wireless communication device, the configuration indicating: a first zone associated with a first set of operating parameters for the wireless communication device; and a second zone associated with a second set of operating parameters for the wireless communication device, the second set of operating parameters being different than the first set of operating parameters; operating in the first zone with the first set of operating parameters to monitor for a first downlink communication signal; and operating in the second zone with the second set of operating parameters.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of CD137. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CD137.

Abstract: A multifunction peripheral (MFP) includes user selectable functions that call home applications on the device that direct it to work cooperatively with cloud service providers. To avoid requiring users to login to each cloud service each time they use it, they are registered with an authorization server to establish and grant identity and authorization tokens. When a user logs in to an MFP, they are redirected to login to the authorization server which then sends tokens to the MFP identifying the user and their permissions and licenses. Home applications associated by the tokens are displayed for selection. Each time a home application using a cloud service is selected, a background application sends the user's session tokens with a service request to an associated cloud service resource server. The resource servers processes authenticated requests and return the result to the MFP which completes the selected home application function.

Abstract: Methods, systems, and devices for wireless communications are described. A first wireless device may be configured to transmit one or more reference signals to a second wireless device using a first antenna array at the first wireless device and in accordance with a first precoder matrix. The first wireless device may receive, from the second wireless device based on the one or more reference signals, a feedback message indicating an estimated rotational misalignment, an estimated spatial misalignment, or both, between the first antenna array at the first wireless device and a second antenna array at the second wireless device. The first wireless device may then transmit a message to the second wireless device in accordance with a second precoder matrix that is modified relative to the first precoder matrix based at least in part on the estimated rotational misalignment, the estimated spatial misalignment, or both.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may receive a configuration for a bandwidth part (BWP). The BWP may overlap with one or more first frequency resources associated with a cell-defining synchronization signal block (CD-SSB) and one or more second frequency resources associated with a non-cell-defining synchronization signal block (NCD-SSB). The UE may perform a measurement using the NCD-SSB (and not the CD-SSB) during an active state of the BWP. Numerous other aspects are described.

Abstract: Aspects are provided to support payloads for msgA transmission in a two-step random access (RACH) procedure by providing a one-to-many mapping arrangement between preambles and physical uplink shared channel (PUSCH) resource units (PRUs). A preamble is determined by the UE which is mapped to one or more groups of PRUs to support piggybacking of uplink control information (UCI), frequency hopping on PUSCH, and multiple-slot repetition for msgA transmissions. By piggybacking UCI to a payload in msgA, flexibility may be provided in the selection of MCS and waveform as well as resource allocation for demodulation reference signals (DMRS) and PUSCH in PRUs. Moreover, by allowing a payload to hop to different frequencies on PUSCH during the transmission of msgA, a gain in frequency diversity and interference averaging may be provided, and by enabling a payload to repeat across multiple slots in msgA transmission, coverage enhancement and/or reliability may be increased.

Abstract: Systems, methods, and devices for secondary cell activation using temporary reference signals are provided. In one aspect, a method of wireless communication performed by a user equipment (UE), includes receiving, from a base station (BS) via a first cell, an activation command to activate a second cell different from the first cell, and receiving, from the BS via the second cell during an activation period, a first reference signal different from a synchronization signal block (SSB). The method further includes performing a measurement of the first reference signal, and operating in the second cell based on the measurement. In some aspects, using reference signals different from SSBs may reduce the delay associated with activating the secondary cell.

Abstract: The invention relates to various aspects of a ?-LED or a ?-LED array for augmented reality or lighting applications, in particular in the automotive field. The ?-LED is characterized by particularly small dimensions in the range of a few ?m.

Abstract: The present disclosure relates to a RF ablation catheter for septal reduction therapy having a cooling effect, and more particularly, to a RF ablation catheter for septal reduction therapy that is for performing RF ablation, in which RF energy is applied to an interventricular septum, for septal reduction therapy such as therapy for hypertrophic cardiomyopathy, which is a disease in which an interventricular septum of the left ventricle of the heart of the animal or human body thickens, therapy that requires reduction of an interventricular septum, or therapy for ventricular tachycardia. Also, the present disclosure relates to a RF ablation catheter for septal reduction therapy having a cooling effect that is for preventing carbonization of a tissue of the body (interventricular septum) around an electrode.

Abstract: The present disclosure provides a method for treatment of atrial fibrillation of the heart, the method including: inserting a guidewire from the superior vena cava or inferior vena cava into the vein of Marshall via a coronary sinus; placing a RF ablation catheter, which has an ablation electrode formed on a distal part, in the vein of Marshall according to guidance of the guidewire; and performing RF ablation around the vein of Marshall after connecting the RF ablation catheter to a RF generator.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.

Abstract: A pacemaker lead for cerclage pacing includes a lead fixing part including a fixing tip whose diameter becomes gradually smaller toward an end of a distal part thereof, a plurality of bipolar electrodes that come into close contact with heart muscle, in an outer circumference of the lead fixing part, and a guide wire insertion through hole through which a guide wire can be inserted thereinto, a lead body part configured to be extended to the lead fixing part, having a stylet insertion through hole formed therein, and a body fixing part formed in a bent shape so as to be fixed to an inner wall of the coronary sinus, and a stylet inserted into the stylet insertion through hole, enabling the pacemaker lead for cerclage pacing to be easily moved within the body of the patient.

Abstract: Grape seed extract compositions and related systems and methods for manufacture are provided. The methods can include obtaining a grape seed extract source material; filtering the grape seed extract source material to obtain a first retentate and a first permeate; drying the first retentate to obtain a first grape seed extract having a first mean degree of polymerization; filtering the first permeate to obtain a second retentate and a second permeate; drying the second retentate to obtain a second grape seed extract having a second mean degree of polymerization less than the first mean degree of polymerization; purifying the second permeate to obtain a purified liquid; and drying the purified liquid to obtain a third grape seed extract having a third mean degree of polymerization less than the second mean degree of polymerization.

Abstract: A pacemaker lead for cerclage pacing includes a lead fixing part including a fixing tip whose diameter becomes gradually smaller toward an end of a distal part thereof, a plurality of bipolar electrodes that come into close contact with heart muscle, in an outer circumference of the lead fixing part, and a guide wire insertion through hole through which a guide wire can be inserted thereinto, a lead body part configured to be extended to the lead fixing part, having a stylet insertion through hole formed therein, and a body fixing part formed in a bent shape so as to be fixed to an inner wall of the coronary sinus, and a stylet inserted into the stylet insertion through hole, enabling the pacemaker lead for cerclage pacing to be easily moved within the body of the patient.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of CD137. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CD137.

Abstract: The present invention relates to a method of treating a cancer in a patient.

Abstract: An RF catheter for treating hypertrophic cardiomyopathy includes: a body part constituting a catheter body made of a flexible and soft material; and an intraseptal insertion part provided at a distal part of the body part and having one or more electrodes, a tapered tip gradually becoming thinner toward an end thereof, and a guidewire lumen therein, into which a guidewire is inserted, so that during hypertrophic cardiomyopathy treatment, the intraseptal insertion part is inserted into the interventricular septum along the guidewire. A method of treating hypertrophic cardiomyopathy by using an RF ablation catheter includes: i) positioning the guidewire to a hypertrophied septum through a coronary sinus and a septal vein; ii) transferring the RF ablation catheter to the hypertrophied septum; and iii) performing RF ablation by applying RF energy to the electrodes provided at an end part of the RF ablation catheter by using an RF generator.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.