Abstract: The present disclosure provides a RF ablation catheter for treatment of atrial fibrillation of the heart, the RF ablation catheter including: a body part which has one or more ablation electrodes formed on a distal part and which constitutes a catheter body made of a soft material; and a tapered tip which is connected to the body part and becomes thinner toward an end thereof, wherein a guidewire lumen into which a guidewire is inserted is formed to be connected to the tip and the body part. The present disclosure provides a method for treatment of atrial fibrillation of the heart, the method including: inserting a guidewire from the superior vena cava or inferior vena cava into the vein of Marshall via a coronary sinus; placing a RF ablation catheter, which has an ablation electrode formed on a distal part, in the vein of Marshall according to guidance of the guidewire; and performing RF ablation around the vein of Marshall after connecting the RF ablation catheter to a RF generator.

Abstract: The present disclosure relates to a RF ablation catheter for septal reduction therapy having a cooling effect, and more particularly, to a RF ablation catheter for septal reduction therapy that is for performing RF ablation, in which RF energy is applied to an interventricular septum, for septal reduction therapy such as therapy for hypertrophic cardiomyopathy, which is a disease in which an interventricular septum of the left ventricle of the heart of the animal or human body thickens, therapy that requires reduction of an interventricular septum, or therapy for ventricular tachycardia. Also, the present disclosure relates to a RF ablation catheter for septal reduction therapy having a cooling effect that is for preventing carbonization of a tissue of the body (interventricular septum) around an electrode.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of CD137. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CD137.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.

Abstract: A snare-integrated myocardial electrical signal-detecting catheter is proposed. The snare-integrated myocardial electrical signal-detecting catheter enables a cerclage wire to pass through the His bundle by way of detecting an electrical signal from the myocardium, and safely guides the cerclage wire into a patient's body by capturing the cerclage wire, which has passed through the His bundle, with a snare built in the catheter. The snare-integrated myocardial electrical signal-detecting catheter includes: a catheter having a hollow space to insert a guidewire thereinto, and having a distal part thereof coupled to at least one or more electrodes to detect an electrical signal of the myocardium; a snare lumen built along a longitudinal direction in a sidewall of the catheter, and having a hollow space therein; and a snare inserted into the snare lumen and having one end thereof provided with at least one or more annular wires.

Abstract: The present invention relates to heterotandem bicyclic peptide complexes which comprise a first peptide ligand, which binds to a component present on an immune cell, conjugated via a linker to a second peptide ligand, which binds to a component present on a cancer cell. The invention also relates to the use of said heterotandem bicyclic peptide complexes in preventing, suppressing or treating cancer.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4.The invention also includes drug conjugates comprising said peptides,conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.

Abstract: Various examples are directed to a rotary coupler and methods of use thereof. The rotary data coupler may comprise a transmitter and receiver. The transmitter may comprise a first band and a second transmitter band. The receiver may comprise a receiver housing positioned to rotate relative to the first transmitter band and the second transmitter band. A first receiver band may be positioned opposite the first transmitter band to form a first capacitor and a second receiver band may be positioned opposite the second transmitter band to form a second capacitor. The receiver may also comprise a resistance electrically coupled between the first receiver band and the second receiver band and a differential amplifier. The differential amplifier may comprise an inverting input and a non-inverting input, with the non-inverting input electrically coupled to the first receiver band and the inverting input electrically coupled to the second receiver band.

Abstract: The present invention relates to a method of treating a cancer in a patient.

Abstract: A vessel that is made of metal materials and can be used for microwave oven, including a container having a double-layered structure with an inner shell and an outer shell. The inner shell and said outer shell are joined by a joint in such a way that a cavity is provided therebetween, and a heat transfer medium is filled to at least part of said cavity. A microwave-heating plate is provided between the inner and outer shells and the microwave-heating plate comprises a MnZn-Ferrite-rubber fuse-compounded thereto. A thermochromic paint is disposed on one side of said outer shell. A pressure release device is provided at one side of said outer shell.

Abstract: Various examples are directed to a rotary coupler and methods of use thereof. The rotary data coupler may comprise a transmitter and receiver. The transmitter may comprise a first band and a second transmitter band. The receiver may comprise a receiver housing positioned to rotate relative to the first transmitter band and the second transmitter band. A first receiver band may be positioned opposite the first transmitter band to form a first capacitor and a second receiver band may be positioned opposite the second transmitter band to form a second capacitor. The receiver may also comprise a resistance electrically coupled between the first receiver band and the second receiver band and a differential amplifier. The differential amplifier may comprise an inverting input and a non-inverting input, with the non-inverting input electrically coupled to the first receiver band and the inverting input electrically coupled to the second receiver band.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of CD137. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CD137.

Abstract: Some embodiments provide a multi-purpose microwave cooking apparatus. The cooking apparatus has a metallic vessel having a bottom surface, a side wall, and an edge. An open region is defined with the side wall extending from the bottom surface to the outer edge. In some embodiments, at least a portion of the outer side wall is coated with a layer of exothermic coating to insulate the vessel and generate thermal energy from microwave radiation.

Abstract: Some embodiments provide a multi-layered exothermic microwave cooking apparatus. The apparatus includes an inner cooking plate shell having top and bottom faces. The apparatus also includes an exothermic plastic outer shell to generate heat from microwave radiation. The outer exothermic shell of the vessel has a bottom surface and at least one side wall, and the inner cooking plate shell closes the vessel to create a cooking surface, and to form an inner space between the bottom surface and the plate. The apparatus also includes a safety valve, which is installed on the side wall of the vessel, to release excess pressure from the inner space during microwave cooking.

Abstract: A position-adjustable device for treatment of tricuspid regurgitation is proposed. The position-adjustable device for the treatment of tricuspid regurgitation is used to verify whether heart failure of the right ventricle may occur, and includes: a first catheter provided with a first lumen; a second catheter inserted into the first lumen and provided with a second lumen into which a guidewire is inserted; an adjusting part coupled to a lower side of the first catheter and the second catheter, wherein the adjusting part is provided with a first direction-adjusting device adjusting a direction of an upper end of the first catheter; and a blocking part coupled to an upper outer side surface of the second catheter, capable of adjusting a position according to a movement of the upper end of the first catheter, and obliquely penetrating and blocking the orifice formed by the incomplete closing of the tricuspid valve.

Abstract: A cryoablation catheter for treatment of hypertrophic cardiomyopathy is disclosed. The cryoablation catheter includes: a vacuum zone provided therein with an inlet into which liquid coolant is injected and an outlet from which the liquid coolant discharged, wherein rest parts other than the inlet and the outlet therein are maintained in a vacuum state; a body part separated from the vacuum zone and provided at the front end thereof, wherein an end of the inlet and an end of the outlet communicate with each other, and wherein the body part includes a freeze zone for cooling surroundings by expanding of the liquid coolant exiting through a tip provided at the end of the inlet; and a tapered tip provided at an end of the body part, wherein a guidewire lumen for insertion of a guidewire thereinto is provided, and wherein the tapered tip is tapered toward an end thereof.

Abstract: A pacemaker lead for cerclage pacing includes a lead fixing part including a fixing tip whose diameter becomes gradually smaller toward an end of a distal part thereof, a plurality of bipolar electrodes that come into close contact with heart muscle, in an outer circumference of the lead fixing part, and a guide wire insertion through hole through which a guide wire can be inserted thereinto, a lead body part configured to be extended to the lead fixing part, having a stylet insertion through hole formed therein, and a body fixing part formed in a bent shape so as to be fixed to an inner wall of the coronary sinus, and a stylet inserted into the stylet insertion through hole, enabling the pacemaker lead for cerclage pacing to be easily moved within the body of the patient.

Abstract: An RF catheter for treating hypertrophic cardiomyopathy includes: a body part constituting a catheter body made of a flexible and soft material; and an intraseptal insertion part provided at a distal part of the body part and having one or more electrodes, a tapered tip gradually becoming thinner toward an end thereof, and a guidewire lumen therein, into which a guidewire is inserted, so that during hypertrophic cardiomyopathy treatment, the intraseptal insertion part is inserted into the interventricular septum along the guidewire. A method of treating hypertrophic cardiomyopathy by using an RF ablation catheter includes: i) positioning the guidewire to a hypertrophied septum through a coronary sinus and a septal vein; ii) transferring the RF ablation catheter to the hypertrophied septum; and iii) performing RF ablation by applying RF energy to the electrodes provided at an end part of the RF ablation catheter by using an RF generator.

Abstract: Various examples are directed to a rotary coupler and methods of use thereof. The rotary data coupler may comprise a transmitter and receiver. The transmitter may comprise a first band and a second transmitter band. The receiver may comprise a receiver housing positioned to rotate relative to the first transmitter band and the second transmitter band. A first receiver band may be positioned opposite the first transmitter band to form a first capacitor and a second receiver band may be positioned opposite the second transmitter band to form a second capacitor. The receiver may also comprise a resistance electrically coupled between the first receiver band and the second receiver band and a differential amplifier. The differential amplifier may comprise an inverting input and a non-inverting input, with the non-inverting input electrically coupled to the first receiver band and the inverting input electrically coupled to the second receiver band.

Abstract: Some embodiments provide a microwaveable vessel that can quickly and evenly heat or cook different types of food. In some embodiments, the vessel includes a metallic body adapted to hold food or drinks. The outer portion of the body is coated with a layer of heat-generating glaze. In some embodiments, the vessel also includes a heat-resistant outer cover that covers the heat-generation layer. The vessel of some embodiments has a multi-layered structure with inner and outer shells that are joined together to form a cavity between the shells.