Patents by Inventor Peter A. Sims

Peter A. Sims has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Single Cell Nucleic Acid Detection and Analysis
    Publication number: 20210277466
    Abstract: Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
    Type: Application
    Filed: May 14, 2021
    Publication date: September 9, 2021
    Inventors: Xiaoliang Sunney Xie, Katsuyuki Shiroguchi, Peter A. Sims, Tony Z. Jia
  • RNA Printing and Sequencing Devices, Methods, and Systems
    Publication number: 20210254143
    Abstract: Described herein are devices, systems, and methods for trapping single-cell lysates in sealed, microwells capable of printing RNA on glass or capturing RNA on beads. These provide efficient, inexpensive manipulation of RNA from individual cells suitable for single-cell transcriptomics on a large scale. Also described are dual barcode capture beads and merged barcode capture beads.
    Type: Application
    Filed: November 27, 2018
    Publication date: August 19, 2021
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Peter A. SIMS, Sayantan BOSE, Jinzhou YUAN
  • Single cell nucleic acid detection and analysis
    Patent number: 11078533
    Abstract: Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: August 3, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Xiaoliang Sunney Xie, Katsuyuki Shiroguchi, Peter A. Sims, Tony Z. Jia
  • Single cell nucleic acid detection and analysis
    Patent number: 11035001
    Abstract: Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: June 15, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Xiaoliang Sunney Xie, Katsuyuki Shiroguchi, Peter A. Sims, Tony Z. Jia
  • Single Cell Nucleic Acid Detection and Analysis
    Publication number: 20200291473
    Abstract: Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
    Type: Application
    Filed: April 14, 2020
    Publication date: September 17, 2020
    Inventors: Xiaoliang Sunney Xie, Katsuyuki Shiroguchi, Peter A. Sims, Tony Z. Jia
  • Single Cell Nucleic Acid Detection and Analysis
    Publication number: 20200277674
    Abstract: Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
    Type: Application
    Filed: May 12, 2020
    Publication date: September 3, 2020
    Inventors: Xiaoliang Sunney Xie, Katsuyuki Shiroguchi, Peter A. Sims, Tony Z. Jia
  • HIGH-THROUGHPUT SINGLE MOLECULE PROTEIN IDENTIFICATION
    Publication number: 20200271661
    Abstract: The present invention is methods and assays for identifying single proteins from a sample, without the use of affinity reagents. The methods and assays combine endopeptidase-based component of conventional peptide mapping with single molecule labeling and a microreactor array platform. The invention also includes kits for performing the methods and assays.
    Type: Application
    Filed: May 18, 2020
    Publication date: August 27, 2020
    Inventor: Peter A. Sims
  • Single Cell Nucleic Acid Detection and Analysis
    Publication number: 20200157621
    Abstract: Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
    Type: Application
    Filed: January 28, 2020
    Publication date: May 21, 2020
    Inventors: Xiaoliang Sunney Xie, Katsuyuki Shiroguchi, Peter A. Sims, Tony Z. Jia
  • Single cell nucleic acid detection and analysis
    Patent number: 10584382
    Abstract: Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: March 10, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: Xiaoliang Sunney Xie, Katsuyuki Shiroguchi, Peter A. Sims, Tony Z. Jia
  • High-throughput single molecule protein identification
    Patent number: 10466248
    Abstract: The present invention is methods and assays for identifying single proteins from a sample, without the use of affinity reagents. The methods and assays combine endopeptidase-based component of conventional peptide mapping with single molecule labeling and a microreactor array platform. The invention also includes kits for performing the methods and assays.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: November 5, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventor: Peter A. Sims
  • Single Cell Nucleic Acid Detection and Analysis
    Publication number: 20190211394
    Abstract: Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
    Type: Application
    Filed: March 26, 2019
    Publication date: July 11, 2019
    Inventors: Xiaoliang Sunney Xie, Katsuyuki Shiroguchi, Peter A. Sims, Tony Z. Jia
  • Single cell nucleic acid detection and analysis
    Patent number: 10287630
    Abstract: Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: May 14, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Xiaoliang Sunney Xie, Katsuyuki Shiroguchi, Peter A. Sims, Tony Z. Jia
  • Single Cell Nucleic Acid Detection and Analysis
    Publication number: 20180030533
    Abstract: Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
    Type: Application
    Filed: October 11, 2017
    Publication date: February 1, 2018
    Inventors: Xiaoliang Sunney Xie, Katsuyuki Shiroguchi, Peter A. Sims, Tony Z. Jia
  • HIGH-THROUGHPUT SINGLE MOLECULE PROTEIN IDENTIFICATION
    Publication number: 20160238612
    Abstract: The present invention is methods and assays for identifying single proteins from a sample, without the use of affinity reagents. The methods and assays combine endopeptidase-based component of conventional peptide mapping with single molecule labeling and a microreactor array platform. The invention also includes kits for performing the methods and assays.
    Type: Application
    Filed: September 22, 2014
    Publication date: August 18, 2016
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventor: Peter A. Sims
  • Single Cell Nucleic Acid Detection and Analysis
    Publication number: 20160130649
    Abstract: Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
    Type: Application
    Filed: January 7, 2016
    Publication date: May 12, 2016
    Inventors: Xiaoliang Sunney Xie, Katsuyuki Shiroguchi, Peter A. Sims, Tony Z. Jia
  • Single cell nucleic acid detection and analysis
    Patent number: 9260753
    Abstract: Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: February 16, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: Xiaoliang Sunney Xie, Katsuyuki Shiroguchi, Peter A. Sims, Tony Z. Jia
  • Single Cell Nucleic Acid Detection and Analysis
    Publication number: 20140155274
    Abstract: Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
    Type: Application
    Filed: March 22, 2012
    Publication date: June 5, 2014
    Applicant: President and Fellows of Harvard College
    Inventors: Xiaoliang Sunney Xie, Katsuyuki Shiroguchi, Peter A. Sims, Tony Z Jia
  • NUCLEIC ACID AMPLIFICATION AND SEQUENCING BY SYNTHESIS WITH FLUOROGENIC NUCLEOTIDES
    Publication number: 20130053252
    Abstract: In general, the invention features methods and systems for sequencing of nucleic acids based on the measurement of the incorporation of fluorogenic nucleotides in microreactors. The invention provides numerous advantages over previous systems such as unambiguous determination of sequence, fast cycle time, long read lengths, low overall cost of reagents, low instrument cost, and high throughput. The invention also features methods and kits for nucleic acid amplification. The amplification and sequencing aspects of the invention may or may not be employed in conjunction with one another. The invention also features fluorogenic nucleotides that may be used in the sequencing methods of the invention.
    Type: Application
    Filed: September 24, 2010
    Publication date: February 28, 2013
    Applicant: President & Fellows of Harvard College
    Inventors: Xiaoliang Sunney Xie, Peter A. Sims, William J. Greenleaf, Haifeng Duan
  • METHODS AND COMPOSITIONS FOR CONTINUOUS SINGLE-MOLECULE NUCLEIC ACID SEQUENCING BY SYNTHESIS WITH FLUOROGENIC NUCLEOTIDES
    Publication number: 20100227327
    Abstract: Disclosed herein are methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides.
    Type: Application
    Filed: March 5, 2010
    Publication date: September 9, 2010
    Inventors: Xiaoliang Sunney Xie, Peter A. Sims, William J. Greenleaf
  • METHODS AND COMPOSITIONS FOR CONTINUOUS SINGLE-MOLECULE NUCLEIC ACID SEQUENCING BY SYNTHESIS WITH FLUOROGENIC NUCLEOTIDES
    Publication number: 20100036110
    Abstract: The invention features compositions, methods, and systems for single-molecule sequencing of nucleic acids based on the continuous measurement of the incorporation of fluorogenic nucleotides in microreactors. In particular, the invention features fluorogenic compounds for use in nucleic acid sequencing. The invention provides numerous advantages over previous systems such as unambiguous determination of sequence, continuous sequencing, long read lengths, low overall cost, and ease of sample preparation.
    Type: Application
    Filed: March 19, 2009
    Publication date: February 11, 2010
    Inventors: Xiaoliang Sunney Xie, Peter A. Sims, William J. Greenleaf