Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: A graspable handle which incorporates a force indicator with attachment to secure said device to provide resistance for purposes of exercise.

Abstract: A cooking appliance includes an oven body having an interior compartment and a door panel for accessing the interior compartment, wherein the interior compartment is sized to receive a food product; a removable heated tray positionable within the interior compartment, wherein the heated tray includes a top tray surface and a first heating source positioned below the top tray surface; and a second heating source positioned within the interior compartment.

Abstract: Some embodiments provide a breathing assistance apparatus comprising a conduit for conveying gases therein, the conduit comprising circuitry. The circuitry may comprise at least one heater wire part to heat gases in the conduit, in use, and at least one sensor wire part comprising at least one sensor for monitoring a parameter of the gases in the conduit. There is also provided a controller to control provision of AC power or AC voltage to the heater wire part; and control selective reading of the sensor. The controller may be configured to read the sensor at or about a particular portion of the AC power waveform provided to the heater wire part.

Abstract: An image sensor having a set of pixels making up the image sensor to capture an image. Two or more pixels in the set of pixels each have an architecture that includes multiple photodiodes configurable to form an individual pixel. A control system can cooperate with the multiple photodiodes to form the individual pixel. Each of the multiple photodiodes can have a transfer gate electrically coupled to that photodiode. A common region can hold or transfer charge at least during or after an integration time. A read gate electrically coupled to the common region and a sense node, can supply charge from the common region through the read gate to the sense node.

Abstract: Techniques for implementing a last known good (LKG) client-side cache for DNS resiliency are disclosed. A first DNS request is submitted to a DNS server. A first DNS resolution that resolves an IP address for a domain name is received. A service stores the first DNS resolution in an LKG cache residing on the local host. A second DNS request is sent, where the second DNS request again requests to resolve the same domain name. In response to determining that a second DNS resolution for the second DNS request has not been received, the service obtains the IP address for the domain name from the LKG cache.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: The present invention relates to genetically engineered yeasts having a heterologous trehalase gene and fermentation processes for using such yeasts. The yeasts can express trehalase in a quantity sufficient to convert significant amounts of trehalose to glucose, thereby improving the yield of the product in a fermentation, and/or reducing or eliminating the need to add exogenous trehalase to the fermentation. The yeasts can also include other heterologous genes for expressing enzymes useful for improving yield and/or for reducing or eliminating the need to add exogenous enzymes to the fermentation.

Abstract: An apparatus for sealing a puncture through tissue having an introducer sheath therein includes an elongate positioning member including a housing on a proximal end and an expandable member on a distal end, and a cartridge advanceable along the positioning member from a proximal position to a distal position. The cartridge includes a tubular member including a sealant and an advancer member disposed within lumen of the tubular member. A sleeve is slidably disposed over the tubular member distal end such that, when the tubular member is advanced over the positioning member, the tubular member distal end enters the introducer sheath while the sleeve is stopped and slides over the tubular member to expose the tubular member distal end within the introducer sheath. The introducer sheath and cartridge are then withdrawn, exposing the sealant within the puncture.

Abstract: Various control methods can indirectly determine incorrect connections between components in a respiratory therapy system. For example, errors in the connections can occur between a patient interface, a humidifier and/or a gases source. The methods can indirectly detect if a reverse flow condition exists or other error conditions. A reverse flow condition can occur when gases flows in a direction different from an intended direction of flow. The detection of the reverse flow condition can be indicative of likely errors in connections between the humidifier, patient interface and/or gases source.

Abstract: Some embodiments provide a breathing assistance apparatus comprising a conduit for conveying gases therein, the conduit comprising circuitry. The circuitry may comprise at least one heater wire part to heat gases in the conduit, in use, and at least one sensor wire part comprising at least one sensor for monitoring a parameter of the gases in the conduit. There is also provided a controller to control provision of AC power or AC voltage to the heater wire part; and control selective reading of the sensor. The controller may be configured to read the sensor at or about a particular portion of the AC power waveform provided to the heater wire part.

Abstract: The present disclosure provides an engineered microorganism capable of producing malonic acid, malonate, esters of malonic acid, or mixtures thereof. The engineered microorganism includes a malonate-semialdehyde dehydrogenase that is heterologous to a native form of the engineered microorganism and comprises at least 90% sequence identity to SEQ ID NO: 6, wherein the engineered microorganism is capable of producing 3 g/L to 250 g/L of malonic acid, malonate, esters of malonic acid, or mixtures thereof.

Abstract: The present disclosure provides an engineered microorganism capable of producing malonic acid, malonate, esters of malonic acid, or mixtures thereof. The engineered microorganism includes a malonate-semialdehyde dehydrogenase that is heterologous to a native form of the engineered microorganism and comprises at least 80% sequence identity to SEQ ID NO: 6, wherein the engineered microorganism is capable of producing about 3 g/L to about 250 g/L of malonic acid, malonate, esters of malonic acid, or mixtures thereof.

Abstract: A system and method are provided for operating a power generating asset. Accordingly, at least one external data set indicative of a plurality of variables affecting the performance of the power generating asset is received by the controller. The controller also receives at least one operational data set indicative of the performance of the power generating asset. A plurality of production-assessment models for the power generating asset are generated and trained based on the data sets. A performance prediction is then generated for each of a plurality of model-variable combinations and a control action is implemented based on one of the performance predictions.

Abstract: Systems and methods for associating single cell imaging data with RNA transcriptomics. Single cells are isolated into microwells with a microbead having oligonucleotides conjugated on its surface. Each oligonucleotide includes a cell identifying optical barcode that is unique to that bead and binding sequence for RNA capture after cell lysis. The system is configured for loading single cells into the microarray and for flowing cell lysis buffers and other reagents into the microarray for performing RNA library sample preparation. The system is also configured for lowing optical hybridization probes that are complementary to the cell identifying optical barcodes and optically labeled onto the microwell array and for obtaining images of the microwells in response to the probes. The system and unique cell identifying optical barcodes and complementary optical hybridization probes facilitate a link between phenotypic imaging of cells resident on the microwell array with single cell whole transcriptome sequencing.

Abstract: The present disclosure provides an engineered microorganism capable of producing malonic acid, malonate, esters of malonic acid, or mixtures thereof. The engineered microorganism includes a malonate-semialdehyde dehydrogenase that is heterologous to a native form of the engineered microorganism and comprises at least 90% sequence identity to any one of SEQ ID Nos: 7, 9, 11, 13, 15, 17, 19, 21, 23, 27, 29, and 31, wherein the engineered microorganism is capable of producing about 9 g/L to about 250 g/L of malonic acid, malonate, esters of malonic acid, or mixtures thereof.

Abstract: Various control methods can indirectly determine incorrect connections between components in a respiratory therapy system. For example, errors in the connections can occur between a patient interface, a humidifier and/or a gases source. The methods can indirectly detect if a reverse flow condition exists or other error conditions. A reverse flow condition can occur when gases flows in a direction different from an intended direction of flow. The detection of the reverse flow condition can be indicative of likely errors in connections between the humidifier, patient interface and/or gases source.

Abstract: A method of delivering location-specific content by a content processing server is disclosed. A request for web content is received by the content processing server. A location of an originator of the received request for web content is identified. A local proxy server is selected based on the identified location of the originator of the received request for web content. The web content is requested via the selected local proxy server. Location-specific web content from the content provider is received via the selected local proxy server. The received local-specific web content is sent to the originator of the received request in response to the received request.

Abstract: Detection of moisture conditions in a conduit, particularly a gases supply system conduit for supplying respiratory or surgical gases, using an electrical property of the conduit.