Abstract: A thrombectomy assembly includes a sheath catheter having a sheath lumen and a trumpet catheter including a trumpet lumen. The trumpet catheter is received in the sheath lumen. A manipulation controller is coupled with the trumpet catheter and the sheath catheter. The manipulation controller includes a sheath actuator coupled with the sheath catheter and a catheter lock. The catheter lock includes a deformable collet having a collet passage configured to receive a capture catheter therein. The sheath actuator is configured to move the sheath catheter between a deployed configuration with the sheath actuator retracted from a deployable trumpet of the trumpet catheter and a stored configuration with the sheath actuator covering the deployable trumpet. The deformable collet is configured to transition between a locked configuration with the deformable collet compressed around the capture catheter and an unlocked configuration with the deformable collet expanded around the capture catheter.

Abstract: A method for cleaning an off-gas from viscose production, essentially containing H2S and CS2, comprises passing the gas through a catalytic reactor containing a direct oxidation type catalyst, such as V2O5 on silica, to convert H2S in the gas to elemental sulfur, SO2 or mixtures thereof, either via the oxygen present in the gas or via oxygen added to the gas stream. Elemental sulfur and SO2 are removed from the effluent gas from the catalytic reactor, and the unconverted CS2 is recycled to the viscose production process.

Abstract: Catheters and methods for supporting a guidewire or delivering a radiopaque, diagnostic or therapeutic agent through a vessel stenosis or other tortuous anatomy are disclosed. A catheter can comprise an elongate shaft body and a tip member disposed at a distal end of the shaft body. The shaft body can extend from a proximal end to the distal end and can define an inner lumen. The shaft body can include a liner, a braid member surrounding the liner, a multi-layer coil surrounding the braid member, and a polymer cover surrounding the multi-layer coil. An outer surface portion of the polymer cover can include one or more helical threads, which can be enveloped in an outer wrapper. The tip member can be made from a metal or a polymer. Polymer tip members can include a hard or semi-hard distal tip.

Abstract: The present application relates to a process for treating the off gas from a carbon black process, said process comprising the steps of: providing an off gas from a carbon black process, reacting said off gas in a first reaction step forming water and S, and condensing the S at a temperature Tcon where S is in a liquid phase and the water is in gas form thereby achieving a gaseous stream comprising water and a liquid stream comprising S, and wherein the first reaction step is carried out over a monolith catalyst.

Abstract: Disclosed herein are systems and methods for reducing the particulate matter content of an exhaust gas from a carbon black process.

Abstract: The present application relates to a process for treating the off gas from a carbon black process, said process comprising the steps of: providing an off gas from a carbon black process, reacting said off gas in a first reaction step forming water and S, and condensing the S at a temperature Tcon where S is in a liquid phase and the water is in gas form thereby achieving a gaseous stream comprising water and a liquid stream comprising S, and wherein the first reaction step is carried out over a monolith catalyst.

Abstract: The present invention relates to antibodies (and fragments, variants, fusions and derivatives thereof) with multivalent binding specificity for CD40, which have a potency for dendritic cell activation which is higher than, or is equal to, the potency for B cell activation and wherein the antibody, antigen-binding fragment, or fusion, variant or derivative thereof has an affinity (KD) for CD40 of less than 1×10?10 M, which have utility in the treatment of diseases such as cancer. The invention also relates to pharmaceutical compositions, uses, methods and kits comprising such antibodies.

Abstract: A method for cleaning an off-gas from viscose production, essentially containing H2S and CS2, comprises passing the gas through a catalytic reactor containing a direct oxidation type catalyst, such as V2O3 on silica, to convert H2S in the gas to elemental sulfur, SO2 or mixtures thereof, either via the oxygen present in the gas or via oxygen added to the gas stream. Elemental sulfur and SO2 are removed from the effluent gas from the catalytic reactor, and the unconverted CS2 is recycled to the viscose production process.

Abstract: Catheters and methods for supporting a guidewire or delivering a radiopaque, diagnostic or therapeutic agent through a vessel stenosis or other tortuous anatomy are disclosed. A catheter can comprise an elongate shaft body and a tip member disposed at a distal end of the shaft body. The shaft body can extend from a proximal end to the distal end and can define an inner lumen. The shaft body can include a liner, a braid member surrounding the liner, a multi-layer coil surrounding the braid member, and a polymer cover surrounding the multi-layer coil. An outer surface portion of the polymer cover can include one or more helical threads, which can be enveloped in an outer wrapper. The tip member can be made from a metal or a polymer. Polymer tip members can include a hard or semi-hard distal tip.

Abstract: Catheters and methods for supporting a guidewire or delivering a radiopaque, diagnostic or therapeutic agent through a vessel stenosis or other tortuous anatomy are disclosed. A catheter can comprise an elongate shaft body and a tip member disposed at a distal end of the shaft body. The shaft body can extend from a proximal end to the distal end and can define an inner lumen. The shaft body can include a liner, a braid member surrounding the liner, a multi-layer coil surrounding the braid member, and a polymer cover surrounding the multi-layer coil. An outer surface portion of the polymer cover can include one or more helical threads, which can be enveloped in an outer wrapper. The tip member can be made from a metal or a polymer. Polymer tip members can include a hard or semi-hard distal tip.

Abstract: Catheters and methods for supporting a guidewire or delivering a radiopaque, diagnostic or therapeutic agent through a vessel stenosis or other tortuous anatomy are disclosed. A catheter can comprise an elongate shaft body and a tip member disposed at a distal end of the shaft body. The shaft body can extend from a proximal end to the distal end and can define an inner lumen. The shaft body can include a liner, a braid member surrounding the liner, a multi-layer coil surrounding the braid member, and a polymer cover surrounding the multi-layer coil. An outer surface portion of the polymer cover can include one or more helical threads, which can be enveloped in an outer wrapper. The tip member can be made from a metal or a polymer. Polymer tip members can include a hard or semi-hard distal tip.

Abstract: The present invention relates to antibodies (and fragments, variants, fusions and derivatives thereof) with multivalent binding specificity for CD40, which have a potency for dendritic cell activation which is higher than, or is equal to, the potency for B cell activation and wherein the antibody, antigen-binding fragment, or fusion, variant or derivative thereof has an affinity (KD) for CD40 of less than 1×10?10 M, which have utility in the treatment of diseases such as cancer. The invention also relates to pharmaceutical compositions, uses, methods and kits comprising such antibodies.

Abstract: The present invention relates to antibodies (and fragments, variants, fusions and derivatives thereof) with multivalent binding specificity for CD40, which have a potency for dendritic cell activation which is higher than, or is equal to, the potency for B cell activation and wherein the antibody, antigen-binding fragment, or fusion, variant or derivative thereof has an affinity (KD) for CD40 of less than 1×10?10 M, which have utility in the treatment of diseases such as cancer. The invention also relates to pharmaceutical compositions, uses, methods and kits comprising such antibodies.

Abstract: The present invention provides pharmaceutical compositions comprising an immunostimulatory polypeptide and polyglutamic acid (PGA) nanoparticles, formulated in a pharmaceutically acceptable diluent, carrier or excipient. Such compositions have utility in stimulating the immune system in subjects, with the components capable of interacting synergistically. The invention further provides uses of the compositions of the invention, for example in the treatment of cancer, and kit and components for use in the same.

Abstract: The present invention relates to antibodies (and fragments, variants, fusions and derivatives thereof) with multivalent binding specificity for CD40, which have a potency for dendritic cell activation which is higher than, or is equal to, the potency for B cell activation and wherein the antibody, antigen-binding fragment, or fusion, variant or derivative thereof has an affinity (KD) for CD40 of less than 1×10?10 M, which have utility in the treatment of diseases such as cancer. The invention also relates to pharmaceutical compositions, uses, methods and kits comprising such antibodies.

Abstract: The present invention provides pharmaceutical compositions comprising an immunostimulatory polypeptide and polyglutamic acid (PGA) nanoparticles, formulated in a pharmaceutically acceptable diluent, carrier or excipient. Such compositions have utility in stimulating the immune system in subjects, with the components capable of interacting synergistically. The invention further provides uses of the compositions of the invention, for example in the treatment of cancer, and kit and components for use in the same.

Abstract: Described herein is a process and apparatus for the production of an article made of moulded plastic material including a first component formed in a first step of injection and possible compression, and at least one second component overmoulded on said first component in a second step of injection and possible compression step. The two steps of injection and possible compression are carried out within the same moulding cavity defined between a mould and a countermould in a single station, without any need for displacing the countermould into a second station.

Abstract: A flue gas desulfurization process is disclosed. Specifically the use of carboxylic acids to modify gypsum crystal habit in limestone forced oxidation. The technique is also applicable to other technologies where gypsum is produced as for example in phosphate fertilizer or paper industry.

Abstract: A transmitter for improving the spectral characteristics of a transmitted output signal includes a phase modulator for receiving a signal and modifying the phase of the signal, a power amplifier for receiving the phase modified signal from the first operation and amplifying the phase modified signal, and an amplitude modulator for receiving the amplified phase modified signal and modifying the amplitude of the amplified phase modified signal. Although the phase and amplitude modulation are performed separately in order to minimize the amplitude distortion without complicating the design of the phase modulator, the combined effect of the phase and amplitude modulation is to filter the out of band spectral emissions of the transmitted output signal.

Abstract: A phase digitizer and method with error compensation is provided that utilizes recordings from a digitally generated phase reference to measure the relative time between events, such as, for example, between the input zero crossing and sample pulse events. The digital reference has a constant frequency which is equal to the desired signal frequency, and thus the phase of the reference can be used to measure the time between events. Consequently, by using the existing digitally generated phase reference, the hardware "costs" associated with implementing the prior phase digitizer error compensation approaches can be significantly reduced and/or eliminated.