Publication number: 20080260719
Abstract: The present invention relates to regulation of lymphocyte activation and migration. More particularly, the present invention is directed to nucleic acids encoding EDG family GPCR proteins, e.g., EDG-1, 2, 3, 4, 5, 6, 7, or 8, which are involved in modulation of lymphocyte activation and migration. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, sphingolipid analogs, and ribozymes, that modulate lymphocyte activation or migration via modulation of EDG GPCRs and EDG related signal transduction; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression, and lymphocyte migration.
Type:
Application
Filed:
December 6, 2006
Publication date:
October 23, 2008
Applicant:
Rigel Pharmaceuticals, Inc.
Inventors:
X. Charlene Liao, Esteban Masuda, Peter Chu, Jorge Pardo, Congfen Li, Haoran Zhao, Ying-Ping Jiang, Collin Spencer