Abstract: An optical cleaning cartridge for automated cleaning of optical components of analysis instruments is disclosed.

Abstract: A system includes a plurality of modular subassemblies and a plate; wherein each modular subassembly comprises an enclosure and a plurality of optical components aligned to the enclosure, and each enclosure comprises a plurality of mounting structures; and wherein each modular subassembly is mechanically coupled to the plate by attachment of a mounting structure of the modular subassembly directly to a corresponding mounting structure located on the plate, such that by mechanically coupling each modular subassembly to the plate using the mounting structure of the modular subassembly and the corresponding mounting structure on the plate, adjacent modular subassemblies are aligned to each other upon such attachment, and wherein two of the modular subassemblies mechanically coupled to the plate are also attached to each other by mechanically coupling an alignment structure on one of the two modular subassemblies to a respective alignment structure on the other of the two modular subassemblies.

Abstract: Imaging systems including an objective lens and a line generation module are described herein. The objective lens may focus a first light beam emitted by the line generation module and a second light beam emitted by the line generation module at a focal point external to a sample so as to adjust line width. Line width may be increased to lower overall power density of a light beam on a surface of the sample such that the power density of the light beam on the surface of the sample is below a photosaturation threshold of a dye on the sample.

Abstract: The concepts relate to data handling, and more specifically to data handling scenarios where data is revised on one computer and stored on another computer. One example can obtain a set of blobs relating to revisions of a file. The example can determine a target size of datastore blobs. In an instance where a total size of the set of blobs is less than the target size, this example can aggregate the set of blobs into an individual datastore blob. Otherwise, the example can identify new or edited individual blobs of the set and aggregate the new or edited individual blobs into first datastore blobs. The example can also aggregate other individual blobs of the set into second datastore blobs.

Abstract: For wellbore operations, a pipe handler moves pipe up to a rig floor. A pipe loader moves pipe from a presented position into alignment with well center. The pipe handler moves pipe up to a slanted presented position. The slanted presented position can be adjusted by manipulating the drive system.

Abstract: A system for biological sample analysis includes a plurality of modular subassemblies and a precision mounting plate, wherein each modular subassembly includes an enclosure and a plurality of optical components pre-aligned to the enclosure, and the enclosure includes a plurality of precision mounting structures, and each modular subassembly is mechanically coupled to the precision mounting plate, such that each precision mounting structure from a modular subassembly attaches directly to a corresponding precision mounting structure located on the precision mounting plate or an adjacent modular subassembly to optimize optomechanical tolerance.

Abstract: The disclosure provides for structured illumination microscopy (SIM) imaging systems. In one set of implementations, a SIM imaging system may be implemented as a multi-arm SIM imaging system, whereby each arm of the system includes a light emitter and a beam splitter (e.g., a transmissive diffraction grating) having a specific, fixed orientation with respect to the system's optical axis. In a second set of implementations, a SIM imaging system may be implemented as a multiple beam splitter slide SIM imaging system, where one linear motion stage is mounted with multiple beam splitters having a corresponding, fixed orientation with respect to the system's optical axis. In a third set of implementations, a SIM imaging system may be implemented as a pattern angle spatial selection SIM imaging system, whereby a fixed two-dimensional diffraction grating is used in combination with a spatial filter wheel to project one-dimensional fringe patterns on a sample.

Abstract: The disclosure provides for structured illumination microscopy (SIM) imaging systems. In one set of implementations, a SIM imaging system may be implemented as a multi-arm SIM imaging system, whereby each arm of the system includes a light emitter and a beam splitter (e.g., a transmissive diffraction grating) having a specific, fixed orientation with respect to the system's optical axis. In a second set of implementations, a SIM imaging system may be implemented as a multiple beam splitter slide SIM imaging system, where one linear motion stage is mounted with multiple beam splitters having a corresponding, fixed orientation with respect to the system's optical axis. In a third set of implementations, a SIM imaging system may be implemented as a pattern angle spatial selection SIM imaging system, whereby a fixed two-dimensional diffraction grating is used in combination with a spatial filter wheel to project one-dimensional fringe patterns on a sample.

Abstract: Accurate mapping of RNA-Seq reads to the reference genome is critical for accurate identification and quantification of miRNA transcripts. The miRNA transcriptome of two homozygous lymphoblastoic cell lines with completely characterized MHC haplotypes (PGF and COX) was analyzed and revealed 89 novel mature miRNA transcripts originating from within the MHC, including three mature miRNA that are haplotype specific, one of which originates from within intron 5 of HLA-DRB5. This is a novel way to identify miRNA transcripts originating from the MHC in a variety of tissue types and disease states, and can be utilized to prepare personal genome assemblies.

Abstract: A tool carrier, which is also known as a top drive or a power swivel, for a well operation rig includes link arms coupled between the rotating hook assembly and the lower pipe gripping structure, the link arms each secured to the rotating hook assembly by a first rigid connection and secured to the lower pipe gripping structure by a second rigid connection such that the link arms can extend along well center even when operating in slant. Another tool carrier includes a hinge between the mast and the main housing. The hinge permits the tool carrier to be moved into a more central position when folded onto the rig chassis for transport.

Abstract: The invention relates to a shaving razor. The shaving razor includes a handle having an elongated body having a proximal end and an opposing distal end. The proximal end has a cartridge connection mechanism and a razor cartridge connected to the cartridge connection mechanism. The elongated body has a first section nearest the proximal end and a second section nearest the distal end and a movement member connecting the first section to the second section. The movement member includes a unitary member having a central core extending along a longitudinal axis. A plurality of spaced apart projections extend outward from the central core and perpendicular to the longitudinal axis of the central core. Adjacent projections are spaced apart from one another to form open slots between adjacent projections.

Abstract: A novel razor cartridge includes at least one non-cutting element disposed anywhere within a blade array between a guard and a cap and/or in a blade position of a frame providing skin/hair management. This non-cutting element allows the fine-tuning of parameters such as blade-skin contact, hair orientation, blade spans and rinse-through gaps in manners that improve shaving comfort, closeness, efficiency, and/or rinse-ability. The non-cutting element may include projections, fin-like elements, comb-like features having teeth, exfoliation or lubricating capabilities. By having a fixed non-cutting element disposed midway in a blade array, a multi-stage cartridge is provided with a middle control point with potentially different functionality before and after the non-cutting element. The non-cutting element is not attached to another blade in the blade array though it may be manufactured as a modified blade support, attached to a blade support, or as part of the frame or the clips.

Abstract: A bit for drilling a wellbore includes: a shank having a coupling formed at an upper end thereof; a body mounted to a lower end of the shank; and a cutting face forming a lower end of the bit. The cutting face includes: a blade protruding from the body; a leading cutter including: a substrate mounted in a pocket formed in a leading edge of the blade; and a cutting table made from a superhard material, mounted to the substrate, and having a non-planar working face with a cutting feature; and a backup cutter mounted in a lower face of the blade at a position trailing the leading cutter and made from a composite material including a ceramic or cermet matrix impregnated with a superhard material.

Abstract: A liquid crystal optical device is provided including at least two LC cells. A first LC cell layer has a predominant director orientation imparting a transversally non-uniform phase delay to a first polarization of an unpolarized incident light field passing therethrough while incident light of a second polarization orthogonal to the first light polarization passes therethrough undergoing transversally uniform phase delay. The first LC cell is configured to project a center extraordinary ray onto an optical axis of the device at the image surface. A second LC cell layer has a predominant director oriented orthogonally to the other predominant director in a plane perpendicular to the optical axis. The second LC layer imparts a transversally non-uniform phase delay to the second polarization of the incident light passing therethrough, the second LC cell being configured to project a center ordinary ray onto the optical axis at the image surface.

Abstract: A tool carrier, which is also known as a top drive or a power swivel, for a well operation rig includes link arms coupled between the rotating hook assembly and the lower pipe gripping structure, the link arms each secured to the rotating hook assembly by a first rigid connection and secured to the lower pipe gripping structure by a second rigid connection such that the link arms can extend along well center even when operating in slant. Another tool carrier includes a hinge between the mast and the main housing. The hinge permits the tool carrier to be moved into a more central position when folded onto the rig chassis for transport.

Abstract: A composition comprising: (a) an acyl isethionate surfactant; (b) a cationic polymer; and (c) a water insoluble benefit agent: wherein the composition comprises less than 3 wt % amphoteric or zwitterionic surfactants.

Abstract: An optical cleaning cartridge for automated cleaning of optical components of analysis instruments is disclosed.