Patents by Inventor Peter Collins

Peter Collins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11027007
    Abstract: Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: June 8, 2021
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Institute for Research in Biomedicine
    Inventors: Peter Kwong, Michael Gordon Joyce, Baoshan Zhang, Yongping Yang, Peter Collins, Ursula Buchholz, Davide Corti, Antonio Lanzavecchia, Guillaume Stewart-Jones
  • Publication number: 20210032366
    Abstract: The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.
    Type: Application
    Filed: March 13, 2020
    Publication date: February 4, 2021
    Inventors: Lloyd J. Old, Terrance Grant Johns, Con Panousis, Andrew M. Scott, Christoph Renner, Gerd Ritter, Achim Jungbluth, Elisabeth Stockert, Vincent Peter Collins, Webster K. Cavenee, Huei-Jen Su Huang, Antony Wilks Burgess, Edouard Collins Nice, Anne Murray, George Mark
  • Publication number: 20200277338
    Abstract: Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.
    Type: Application
    Filed: May 18, 2020
    Publication date: September 3, 2020
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Peter Collins, Bo Liang, Shirin Munir, Anne Schaap Nutt, Ursula Buchholz, Natalie Mackow, Peter Kwong, Barney Graham, Jason McLellan
  • Patent number: 10654898
    Abstract: Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: May 19, 2020
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Serices
    Inventors: Peter Collins, Bo Liang, Shirin Munir, Anne Schaap Nutt, Ursula Buchholz, Natalie Mackow, Peter Kwong, Barney Graham, Jason McLellan
  • Publication number: 20200101086
    Abstract: Embodiments of a method for inhibiting viral infection in a subject are provided herein. In some embodiments, the method comprises administration of a competitive antagonist of ouabain binding to ATP1A1 to inhibit respiratory syncytial virus infection in the subject.
    Type: Application
    Filed: September 26, 2019
    Publication date: April 2, 2020
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Peter Collins, Matthias Lingemann, Shirin Munir
  • Publication number: 20200055271
    Abstract: A heat sealing product suitable for seating one or more individual containers, said heat sealing product comprising: (i) a plurality of individual heat seals set out in a configuration substantially corresponding to the shape and configuration of the container(s) to be sealed, the size and shape of the individual heat seals corresponding substantially to the size and shape of the tops of the individual container(s) to be sealed; (ii) a peelable support film layer coated on one side with a low tack adhesive, the low tack adhesive serving to hold the individual heat seals in place on the support film layer in the desired configuration prior to the sealing process; (iii) alignment points in the sealing product adapted to enable the heat sealing product and therefore the individual heat seals of the heat sealing product to be aligned substantially exactly with respect to the individual containers to be sealed.
    Type: Application
    Filed: December 27, 2017
    Publication date: February 20, 2020
    Inventor: Peter Collins
  • Patent number: 10564314
    Abstract: There is disclosed an automatic door installation 10 comprising: a door opening 16; and an optical door sensor comprising: a plurality of transmitters 30 arranged in a transmitter array 22, each transmitter 30 being configured to transmit an optical beam across the door opening along a respective beam path; a plurality of receivers 32 arranged in a receiver array 24, each receiver 32 being configured to generate a receiver output signal based on an intensity of light received. The plurality of receivers 32 are arranged in at least one set of receivers, the receivers of the or each set being linked so that the respective sensor output signals are combined into a compound signal for the respective set.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: February 18, 2020
    Assignee: Ensota(Guangzhou) Technologies Ltd.
    Inventors: Peter Collins, John Curzon
  • Publication number: 20200009243
    Abstract: Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
    Type: Application
    Filed: September 23, 2019
    Publication date: January 9, 2020
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Servic, Institute for Research in Biomedicine
    Inventors: Peter Kwong, Michael Gordon Joyce, Baoshan Zhang, Yongping Yang, Peter Collins, Ursula Buchholz, Davide Corti, Antonio Lanzavecchia, Guillaume Stewart-Jones
  • Patent number: 10420834
    Abstract: Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: September 24, 2019
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Institute for Research in Biomedicine
    Inventors: Peter Kwong, Michael Gordon Joyce, Baoshan Zhang, Yongping Yang, Peter Collins, Ursula Buchholz, Davide Corti, Antonio Lanzavecchia, Guillaume Stewart-Jones
  • Patent number: 10190353
    Abstract: There is disclosed an automatic door installation 100 configured to determine the presence of an obstacle 150 in one or more detection zones remote from a door opening, comprising: at least a first door 104 slidable in a door opening along a horizontal door axis from an open configuration to a closed configuration during a door closing operation; a plurality of transmitter-receiver pairs, each transmitter-receiver pair comprising: a transmitter 116 for transmitting a beam 140 and a receiver 118 for receiving a reflection of the beam, wherein one of the transmitter 116 and the receiver 118 is coupled to the first door so that, in use, the transmitter and receiver move closer together during the door closing operation; wherein the transmitter 116 defines a transmitter axis 120 corresponding to the optical axis of the beam; wherein the receiver 118 has a field of view 142 for receiving the beam, which is oriented around a receiver axis; and wherein the transmitter axis 120 and the receiver axis 122 are configure
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: January 29, 2019
    Assignee: Ensota (Guangzhou) Technologies Ltd.
    Inventors: Peter Collins, John Curzon
  • Publication number: 20180312544
    Abstract: Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.
    Type: Application
    Filed: January 20, 2016
    Publication date: November 1, 2018
    Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Peter Collins, Bo Liang, Shirin Munir, Anne Schaap Nutt, Ursula Buchholz, Natalie Mackow, Peter Kwong, Barney Graham, Jason McLellan
  • Patent number: 10087049
    Abstract: There is disclosed a method of testing an optical door sensor 100 having an emitter 102 for emitting a light signal 104 and a receiver 106 for detecting the light signal 104, the optical door sensor 100 having at least one sensor operating parameter and further having a baseline state in which the receiver 102 can detect a light signal from the emitter 106. The method comprises setting the optical door sensor in an offset state 204, 304, in which a sensor operating parameter is offset from a baseline setting by an offset amount, the baseline setting corresponding to the baseline state of the optical door sensor; conducting a signal test 206 with the optical door sensor in the offset state; and generating an alert 216 when the signal test result is negative for the offset state and the offset amount is less than or equal to a limit margin. The signal test comprises: emitting a light signal from the emitter 208 and determining whether the light signal is detected by the receiver 210.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: October 2, 2018
    Assignee: Ensota Limited
    Inventors: Peter Collins, John Curzon
  • Patent number: 9964664
    Abstract: A method and sensing apparatus for elevators that detects an intrusion into a volume defined relative to a path across an opening. The sensing apparatus has a closure member for the opening that can be controllably displaced to define a gap in the opening. A first group of at least two emitters of electromagnetic signals located on either the closure member or a boundary member are directed into the volume and a second group of at least two receivers for electromagnetic signals located on the opposite side of the gap to the emitters. The method causes at least one of the emitters to emit a primary beam along a first axis into the volume, allows at least one of the receivers to receive a secondary beam of radiation, and enables one or more of the receivers to provide an output signal into the network.
    Type: Grant
    Filed: September 3, 2012
    Date of Patent: May 8, 2018
    Assignee: Airdri Ltd
    Inventor: Peter Collins
  • Publication number: 20180057606
    Abstract: The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.
    Type: Application
    Filed: July 27, 2017
    Publication date: March 1, 2018
    Inventors: Lloyd J. Old, Terrance Grant Johns, Con Panousis, Andrew M. Scott, Christoph Renner, Gerd Ritter, Achim Jungbluth, Elisabeth Stockert, Vincent Peter Collins, Webster K. Cavenee, Huei-Jen Su Huang, Antony Wilks Burgess, Edouard Collins Nice, Anne Murray, George Mark
  • Publication number: 20180008697
    Abstract: Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
    Type: Application
    Filed: December 24, 2015
    Publication date: January 11, 2018
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human, Institute for Research in Biomedicine
    Inventors: Peter Kwong, Michael Gordon Joyce, Baoshan Zhang, Yongping Yang, Peter Collins, Ursula Buchholz, Davide Corti, Antonio Lanzavecchia, Guillaume Stewart-Jones
  • Publication number: 20170315262
    Abstract: There is disclosed an automatic door installation 10 comprising: a door opening 16; and an optical door sensor comprising: a plurality of transmitters 30 arranged in a transmitter array 22, each transmitter 30 being configured to transmit an optical beam across the door opening along a respective beam path; a plurality of receivers 32 arranged in a receiver array 24, each receiver 32 being configured to generate a receiver output signal based on an intensity of light received. The plurality of receivers 32 are arranged in at least one set of receivers, the receivers of the or each set being linked so that the respective sensor output signals are combined into a compound signal for the respective set.
    Type: Application
    Filed: April 18, 2017
    Publication date: November 2, 2017
    Inventors: Peter COLLINS, John CURZON
  • Publication number: 20170314314
    Abstract: There is disclosed an automatic door installation 100 configured to determine the presence of an obstacle 150 in one or more detection zones remote from a door opening, comprising: at least a first door 104 slidable in a door opening along a horizontal door axis from an open configuration to a closed configuration during a door closing operation; a plurality of transmitter-receiver pairs, each transmitter-receiver pair comprising: a transmitter 116 for transmitting a beam 140 and a receiver 118 for receiving a reflection of the beam, wherein one of the transmitter 116 and the receiver 118 is coupled to the first door so that, in use, the transmitter and receiver move closer together during the door closing operation; wherein the transmitter 116 defines a transmitter axis 120 corresponding to the optical axis of the beam; wherein the receiver 118 has a field of view 142 for receiving the beam, which is oriented around a receiver axis; and wherein the transmitter axis 120 and the receiver axis 122 are configure
    Type: Application
    Filed: April 18, 2017
    Publication date: November 2, 2017
    Inventors: Peter COLLINS, John CURZON
  • Patent number: 9797184
    Abstract: A method is disclosed of operating an automatic door installation comprising door sensor equipment including a door sensor. The automatic door installation is operable in at least a standard mode, in which the door sensor equipment conducts an obstacle check to determine whether an obstacle is present according to a first obstacle check procedure, and a contingency mode, in which the door sensor equipment conducts the obstacle check according to a different second obstacle check procedure. The method includes the steps of evaluating an operating condition of the automatic door installation; determining whether the operating condition lies within a standard operating range; and operating the automatic door installation in the contingency mode when the operating condition lies outside a respective standard operating range.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: October 24, 2017
    Assignee: Ensota Limited
    Inventors: Peter Collins, John Curzon
  • Publication number: 20160185571
    Abstract: A method of hazard highlighting for drawing visual attention to the alignment of first and second members, the first member having a first plane working surface and a first working edge; the second member having a second plane working surface and a second working edge; the first and second working edges being separated by a working clearance; the first and second members being displaceable relative to one another wherein, in a first operating configuration, the first and second plane working surfaces lie in a common plane with the first and second working edges juxtaposed with the working clearances separated by a minimum distance; and, in a second configuration, the first and second plane working surfaces do not lie in the common plane and the first and second working edges are displaced from one another to a greater or lesser degree with the working edges being separated by a distance greater than minimum; the method including the step of projecting a light ray or pattern from a location associated with the
    Type: Application
    Filed: June 28, 2011
    Publication date: June 30, 2016
    Applicant: AIRDRI LIMITED
    Inventors: John Virgurs CURZON, Peter COLLINS
  • Publication number: 20160125728
    Abstract: An activation device for a patient alarm system. The activation device comprises a resiliently deformable bladder defining an internal volume and a pressure switch in fluid communication with the internal volume and connected to an alarm system. Squeezing the resiliently deformable bladder operates the pressure switch, which activates the alarm system.
    Type: Application
    Filed: October 29, 2015
    Publication date: May 5, 2016
    Inventors: Alexander William Walker, Robert William White, Daniel Weiss, Peter Collin Schumacher, Daniel McLean, Martin Howard Priestman Freney, Stephen Geoffrey Brown, Timothy John Hooper