Abstract: The use of a calcium intracellular store inactivator for inhibiting cell growth is disclosed; for example, thapsigargin or a derivative may be used to inhibit intraocular lens cell growth. Formulations include an emulsion of the compound for coating an IOL, either ex vivo or in vivo.

Abstract: The invention provides a process for producing an aluminium-based matrix melt, having boride particles dispersed therein, which is castable, and yet when cast produces a product having a surprisingly good combination of mechanical properties such as stiffness, strength, and elongation at failure. In the process, precursors for boride particles are reacted within an aluminium-based melt to produce boride ceramic particles such as titanium diboride, the process being carried out under conditions such that the melt remains fluid.

Abstract: The invention provides a method of making a titanium carbide metal matrix alloy, by firing a particulate reaction mixture comprising carbon, titanium and matrix material, under conditions such that the titanium and carbon react exothermically to form a dispersion of fine particles comprising titanium carbide (preferably less than 10 microns) in a predominantly metal matrix. The titanium and matrix are preferably added as a titanium alloy such as ferrotitanium, e.g. eutectic ferrotitanium. The reaction conditions are preferably selected so that during the reaction a molten zone moves through the body of the reaction mixture; the resulting hard particles are of globular form; and their average size is uniform throughout the resulting dispersion.

Abstract: The invention provides a method of making a titanium boride metal matrix alloy, by firing a particulate reaction mixture comprising titanium, matrix material and a source of boron (e.g. boron carbide), under conditions such that the titanium and boron react exothermically to form a dispersion of fine particles (preferably greater than 1 micron and less than 10 microns in size) comprising titanium boride (plus titanium carbide where the source of boron is boron carbide) in a predominantly metal matrix. The titanium and matrix are preferably added as a titanium alloy such as ferrotitanium (e.g. eutectic ferrotitanium) or titanium-aluminium. The reaction conditions are preferably selected so that during the reaction a molten zone moves through the body of the reaction mixture, and the average size of the resulting hard particles is uniform throughout the resulting dispersion.

Abstract: The present invention relates to particular forms of a novel 1-substituted-N-[2-methyl-1-(trifluoroacetyl)propyl]pyrrolidine-2-carboxam ide which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes pharmaceutical compositions containing such forms, processes for preparing the forms and intermediates useful in the synthesis of the forms.

Abstract: The present invention relates to particular forms of a novel 1-substituted-N-[2-methyl-1-(trifluoroacetyl)propyl]pyrrolidine-2-carboxam ide which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes pharmaceutical compositions containing such forms, processes for preparing the forms and intermediates useful in the synthesis of the forms.

Abstract: The present invention relates to pyrrolidine derivative compounds, and more particularly to the compound (S)-1-[(S)-2-(4-methoxybenzamido)-3-methylbutyryl]-N-[(S)-2-methyl-1-(trif luoroacetyl)propyl]pyrrolidine-2-carboxamide, shown by the formula I, a pharmaceutical composition comprising this compound in a crystalline form and a process for preparing the pharmaceutical composition. The compound of formula I is an inhibitor of human neutrophil elastase and is useful in the treatment of diseases in which the enzyme is implicated, such as, for example, emphysema and acute respiratory distress syndrome (ARDS).

Abstract: The present invention relates to pyrrolidine derivatives, and more particularly to the compound (S)-1-?(S)-2-(4-methoxybenzamido)-3-methylbutyryl!-N-?(S)-2-methyl-1-(trif luoroacetyl)propyl!pyrrolidine-2-carboxamide, shown by formula I, and solvates thereof. The present invention also provides pharmaceutical compositions, intermediates and methods of preparation of the compound. The compound of formula I is an inhibitor of human neutrophil elastase and is useful in the treatment of diseases in which the enzyme is implicated, such as, for example, emphysema and acute respiratory distress syndrome (ARDS).

Abstract: A process for preparing an antifungal azole compound of formula (I) by reacting an epoxide with hydrazine to from a hydrazino compound which is subsequently reacted with an iminoether. The amidrazone product is subsequently reacted with an orthoformate to provide the antifungal azole. The azole, known as ZD0870, shows good activity against human fungal infections including Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus.

Abstract: The invention relates to an antigen associated with Alzheimer's disease and to antibodies specific for said antigen. This invention further relates to methods for diagnosing Alzheimer's disease utilizing assays containing Alzheimer's associated antigen, antibodies specific for said antigen and samples from an individual suspected of having Alzheimer's disease.

Abstract: The present invention relates to particular forms of a novel 1-substituted-N-?2-methyl-1-(trifluoroacetyl)propyl!pyrrolidine-2-carboxam ide which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes pharmaceutical compositions containing such forms, processes for preparing the forms and intermediates useful in the synthesis of the forms.

Abstract: The present invention relates to pyrrolidine derivatives, and more particularly to the compound (S)-1-?(S)-2-(4-methoxybenzamido)-3-methylbutyryl!-N-?(S)-2-methyl-1-(trif luoroacetyl)propyl!pyrrolidine-2-carboxamide, shown by formula I, and solvates thereof. The present invention also provides pharmaceutical compositions, intermediates and methods of preparation of the compound. The compound of formula I is an inhibitor of human neutrophil elastase and is useful in the treatment of diseases in which the enzyme is implicated, such as, for example, emphysema and acute respiratory distress syndrome (ARDS).

Abstract: The present invention relates to particular forms of a novel 1-substituted-N-?2-methyl-1-(trifluoroacetyl)propyl!pyrrolidine-2-carboxam ide which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes pharmaceutical compositions containing such forms, processes for preparing the forms and intermediates useful in the synthesis of the forms.

Abstract: A device which connects to standard telephone lines and automatically dials into, and receives information from, an automated tee time scheduling system. The device may be programed with information for a specific tee time request in advance of the day selected to play. Information stored in the unit includes day to play, particular course, time requested to play, number of players, and other information. The unit may be programmed with multiple options of the above information, each configured to suit the operation of a given golf club or group of clubs.

Abstract: A method of treating mineral tailings such as those derived from mining operations includes the steps of separating the slimes, forming alternate layers of slimes and a coarse material between peripheral berms and intermediate berms, the berms being of a coarse material, and allowing water to pass therethrough and away from the berms. The water moves through the berms by virtue of the pressure exerted on the lower layers by the mass of the layers above. The coarse material may be the coarse fraction of the mineral tailings.

Abstract: Apparatus for sealing an electrode in an electric arc furnace comprises an annular chamber which is adapted to encompass the electrode and includes a ring-shaped cover member of a refractory material which is supported above or is formed integrally with an upstanding cylindrical wall member. The wall member has a passageway which is inclined with respect to the radius of the chamber and is connected to receive gas under pressure and to discharge such gas on to and around the encompassed electrode effectively to seal the space around the electrode.

Abstract: Apparatus for sealing an electrode in an electric arc furnace comprises an annular chamber which is adapted to encompass the electrode and includes a ring-shaped cover member of a refractory material which is supported above or is formed integrally with an upstanding cylindrical wall member. The wall member has a passageway which is inclined with respect to the radius of the chamber and is connected to receive gas under pressure and to discharge such gas on to and around the encompassed electrode effectively to seal the space around the electrode.

Abstract: At least part of the weight of a structure (such as a bank of heat recovery tubes) exposed to a hot environment (e.g. the convection region of a furnace) is supported by a multi-pipe heat exchanger of which the outer pipe has dimensions at least adequate to bear the imposed load, and the inner pipe(s) are so dimensioned in relation to the outer pipe as to maintain the outer pipe at a temperature at which its load-bearing strength is maintained for a reasonable and/or acceptable cooling fluid flow rate through the heat exchanger. In one embodiment, the heat exchanger is of the double pipe type, and the cooling fluid may be circulated from the heat exchanger to the bank of heat recovery tubes.

Abstract: A method of electrically and hydraulically connecting a conductor bar having a plurality of hollow water-cooled conductors involves compressing the conductor bar and shims of brazing material in a connector clip formed of a pair of mating clip members. Brazing shims (strips and bands) are placed in desired positions, and then the components are heated and hydraulically compressed. The conductor bar and brazing material assembly is sized for a tight fit in one dimension, but oversized in another dimension so that compression results in a desired distribution of the molten brazing material. During compression, the clip members are secured from relative motion, other than displacement toward one another, and air is passed through the hollow conductors to prevent the accumulation of brazing material in the open ends thereof. In addition to the clip members, the connector device includes a water inlet member with a stem that is inserted between and brazed to the clip members after the compression step.