Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: The disclosure relates to a gradient coil unit comprising a hollow cylindrical primary coil longitudinally surrounding a cylinder axis and designed to generate a magnetic field gradient in a first spatial direction, which primary coil comprises two primary conductor pattern pairs. Each primary conductor pattern pair of the two primary conductor pattern pairs is separately drivable, spans one half of the primary coil in each case, and comprises two spiral conductor patterns, which are formed by an electrical conductor implemented as a hollow conductor.

Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: A gradient coil unit is described that is designed as a hollow cylinder surrounding a patient receiving region in the longitudinal direction and is subdivisible into four quadrants, comprising a primary coil including a conductor structure that includes a geometric arrangement of an electrical conductor with a conductor cross-section arranged within a quadrant of the four quadrants. The quadrant comprises at least one neutral region, which is defined in the longitudinal direction between a first longitudinal position and a second longitudinal position, and characterized in that the current density averaged over the neutral region is less than 25% of the maximum current density averaged over the conductor cross-section within the neutral region. The gradient coil unit is free of a secondary coil and/or free of an active screening.

Abstract: A magnetic resonance imaging (MRI) device may include a superconducting main field coil assembly inside a vacuum vessel of a cryogenic assembly and a cylindrical gradient coil assembly. The vacuum vessel may define a cylindric patient bore in which a homogeneity volume of a main field created by the superconducting main field coil assembly is located. The superconducting main field coil assembly includes multiple superconducting coils including at least two main superconducting coils located in opposing longitudinal end regions of the cryogenic assembly. The cylindrical gradient coil assembly may have at least one transversal gradient coil and may be located inside the cylindric patient bore. The transversal gradient coil may generate a gradient field perpendicular to a longitudinal direction of the patient bore. Conductors of the transversal gradient coil may only extend in a longitudinal conductor region between the two longitudinal end regions.

Abstract: A magnetic resonance ‘MR’ scanner utilizing a passive magnetic shielding technique. The scanner includes a gradient coil inductively coupled to a managed eddy current structure which establishes passive magnetic shielding for the gradient coil due to the inductive coupling.

Abstract: A device for use in magnetic resonance imaging (MRI) systems may include a superconducting main magnet coil; and a thermal radiation shield that encloses the superconducting main magnet coil. The shield may include an inner cylindrical bore tube, an outer cylindrical wall, and annular end walls welded between the annular cylindrical bore tube and the outer cylindrical wall to form a closed, hollow cylindrical vessel. A distribution of a position and length of welds that affix the annular end walls to the inner cylindrical bore tube may include a predetermined arrangement of welds of varying lengths interspersed with gaps of varying lengths.

Abstract: An electric rotation machine comprises a rotor shaft and a rotor, which is arranged on the rotor shaft, of a rotor position sensor device. The electric rotation machine additionally has a static element, on which a stator of the rotor position sensor device is arranged, and a holding element, which is mechanically fixed to the static element and which blocks the translational degree of freedom of the stator of the rotor position sensor device in a first axial direction, wherein the translational degree of freedom of the stator of the rotor position sensor device is blocked by the static component in the opposite axial direction. By virtue of the electric rotation machine, a method for producing the electric rotation machine and a drive system are provided which allow an inexpensive arrangement of the rotor position sensor device with the smallest possible required installation space and the lowest possible weight.

Abstract: A gradient coil unit may include a hollow cylinder surrounding a cylinder axis, delimited perpendicularly to the cylinder axis by a first longitudinal end and a second longitudinal end opposing the first longitudinal end. The hollow cylinder may include a first hollow cylinder region and a second hollow cylinder region separated from the first hollow cylinder region by a sectional plane perpendicular to the cylinder axis. The first hollow cylinder region may be delimited by the first longitudinal end and the second hollow cylinder region by the second longitudinal end. The gradient coil unit may also include a conductor structure configured to generate magnetic field gradients in three mutually different directions. The gradient coil unit may have a length corresponding to a distance between the first longitudinal end and the second longitudinal end of at least 140 cm.

Abstract: A method for determining peripheral nerve stimulation during MR imaging of a patient in a MR scan unit for a MR pulse sequence is described. In the method, a plurality of model-based candidate stimulations are determined dependent on a unit vector potential of the gradient magnet field generated during MR imaging and dependent on candidate data models for different object parameter values. A model-based candidate data stimulation is selected as a stimulation model for the patient dependent on an individual patient model. A distribution of a vector potential of a gradient magnetic field acting on the patient is determined as a function of a unit gradient current for a determined position of the patient in the MR scanning unit. The nerve stimulation of the patient is determined for the determined position based on the selected candidate stimulation and a gradient current of a gradient pulse of the MR pulse sequence.

Abstract: A gradient coil unit includes a primary coil, a secondary coil and a carrier unit. The carrier unit stabilizes the primary coil and the secondary coil, and is formed from an encapsulating material. The carrier unit may include at least two encapsulating pockets that each include a delimiting structure and a filling. A thermoset component unit includes an electronic component and a carrier unit surrounding the electronic component, and being formed from an encapsulating material. The carrier unit may include at least one encapsulating pocket that includes a delimiting structure having a first material, and a filling having a second material.

Abstract: A gradient coil having a coil body made from a cured casting compound and at least one cooler embedded in the casting compound, serving to conduct a fluid coolant, wherein the cooler and the casting compound do not adhere to each other.

Abstract: A device for use in magnetic resonance imaging (MRI) systems may include a superconducting main magnet coil; and a thermal radiation shield that encloses the superconducting main magnet coil. The shield may include an inner cylindrical bore tube, an outer cylindrical wall, and annular end walls welded between the annular cylindrical bore tube and the outer cylindrical wall to form a closed, hollow cylindrical vessel. A distribution of a position and length of welds that affix the annular end walls to the inner cylindrical bore tube may include a predetermined arrangement of welds of varying lengths interspersed with gaps of varying lengths.

Abstract: The disclosure relates to a gradient coil unit comprising at least one first conductor structure, which is configured to generate a magnetic field gradient in a first direction, and an eddy current compensating conductor structure, which is configured to compensate for a first magnetic field. The first magnetic field is generated by a current induced in the first conductor structure as a result of activation of a conductor structure comprised by the gradient coil unit.

Abstract: A method for determining peripheral nerve stimulation during MR imaging of a patient in a MR scan unit for a MR pulse sequence is described. In the method, a plurality of model-based candidate stimulations are determined dependent on a unit vector potential of the gradient magnet field generated during MR imaging and dependent on candidate data models for different object parameter values. A model-based candidate data stimulation is selected as a stimulation model for the patient dependent on an individual patient model. A distribution of a vector potential of a gradient magnetic field acting on the patient is determined as a function of a unit gradient current for a determined position of the patient in the MR scanning unit. The nerve stimulation of the patient is determined for the determined position based on the selected candidate stimulation and a gradient current of a gradient pulse of the MR pulse sequence.

Abstract: A magnetic resonance device (1), having a main magnet unit (2) with a cylindrical patient aperture (3), wherein at least one radial gradient coil (9) is provided in the patient aperture (3) which generates a gradient field having, at least in regions, a radial gradient in relation to its own central axis parallel to the longitudinal axis of the patient aperture (3), the radial gradient coil (9) being embodied as a cylinder coil.

Abstract: A gradient coil unit includes a primary coil, a secondary coil and a carrier unit. The carrier unit stabilizes the primary coil and the secondary coil, and is formed from an encapsulating material. The carrier unit may include at least two encapsulating pockets that each include a delimiting structure and a filling. A thermoset component unit includes an electronic component and a carrier unit surrounding the electronic component, and being formed from an encapsulating material. The carrier unit may include at least one encapsulating pocket that includes a delimiting structure having a first material, and a filling having a second material.

Abstract: A magnetic resonance device comprising a gradient coil assembly having gradient coils is described. The gradient coils are supported by at least one cylindrical coil carrier for generating gradient fields. As part of the gradient coil assembly, at least one vibration sensor is provided for measuring vibrations of the gradient coil assembly at least in a radial direction of oscillation.

Abstract: A directly coolable multifilament conductor or a magnetic coil, having at least two electric conductors and at least one cooling tube disposed between the conductors adapted to carry a fluid coolant, wherein the cooling tube is a metal conductor having a lower conductivity than the conductors surrounding the tube.

Abstract: The disclosure relates to a gradient coil unit comprising at least one first conductor structure, which is configured to generate a magnetic field gradient in a first direction, and an eddy current compensating conductor structure, which is configured to compensate for a first magnetic field. The first magnetic field is generated by a current induced in the first conductor structure as a result of activation of a conductor structure comprised by the gradient coil unit.