Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases.

Abstract: A combustor includes a wall that defines a combustor interior to receive a fluid. The combustor also includes a slot that extends through the wall. The combustor also includes a resonator coupled to the wall. The resonator includes a resonator box defining a resonator interior between the wall and the resonator box, and a resonator segment disposed within the resonator box. The resonator segment includes a resonator neck having a resonator inlet and resonator outlet, the resonator inlet positioned within the resonator interior, the resonator outlet in flow communication with the combustor interior through the slot. The resonator neck defines a nonlinear flow path between the resonator inlet and the resonator outlet.

Abstract: A cartridge for a laundry appliance includes an outer housing having an interior chamber therein. The outer housing includes a primary axis and a secondary axis that is perpendicular to the primary axis. A pump is contained within the outer housing that selectively delivers a laundry chemistry from the interior chamber to a dispensing outlet of the outer housing. The dispensing outlet is defined within a contoured edge of the outer housing and orients the dispensing outlet at an oblique angle with respect to the primary and secondary axes. A rotational drive is operated by an external actuator. The rotational drive is positioned within the outer housing and in operable communication with the pump. The rotational drive aligns with a drive aperture defined within a wall of the outer housing for receiving the external actuator.

Abstract: Compounds of Formula Ia or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases.

Abstract: The invention relates to a side-channel machine having a housing (4a), located in the housing (4a) a side-channel (28) for guiding a gas, and at least one gas inlet opening (34) which is formed in the housing (4a) and is fluidically connected to the side-channel (28). Furthermore, the side-channel machine has at least one gas inlet pipe (29a) which connects to the at least one gas inlet opening (34), The side-channel machine further comprises at least one gas outlet opening (33) and at least one gas outlet pipe (31a) which connects to the at least one gas outlet opening (33). Furthermore, the side-channel machine has an impeller that can be made to rotate in the housing (4a), with impeller blades, which bound impeller cells arranged in the side-channel (28), for delivering the gas in the impeller cells from the at least one gas inlet opening (34) to the at least one gas outlet opening (33).

Abstract: An electric motor includes a stator body that defines a rotor bore and a plurality of stator fluid channels; a plurality of electrically conductive windings forming a plurality of first winding loops extending axially outward from a first axial end of the stator body; and a generally annular body, unitarily formed from a thermally conductive and electrically insulating material, that surrounds the plurality of first winding loops and couples to the first axial end of the stator body, such that the generally annular body includes a plurality of first pins, attached to the generally annular body at a distal end of the plurality of first pins; and the plurality of first pins are configured to receive fluid from a cooling system.

Abstract: A detector stack includes a first detector and a second detector arranged along a first direction. Each of the first detector and second detector comprise a generator and a collector. The generator is configured to generate photons or charged particles when interacting with incident particles, the photons or charged particles being indicative of energies of the respective incident particles. The collector is configured to collect the generated photons or charged particles and output an output signal representing information of a one-dimensional travelling direction of the incident particles. The collector of the first detector and the collector of the second detector are configured to respectively output output signals representing different one-dimensional travel directions of the incident particles.

Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The invention relates to a side-channel machine having a housing (4a), located in the housing (4a) a side-channel (28) for guiding a gas, and at least one gas inlet opening (34) which is formed in the housing (4a) and is fluidically connected to the side-channel (28). Furthermore, the side-channel machine has at least one gas inlet pipe (29a) which connects to the at least one gas inlet opening (34), The side-channel machine further comprises at least one gas outlet opening (33) and at least one gas outlet pipe (31a) which connects to the at least one gas outlet opening (33). Furthermore, the side-channel machine has an impeller that can be made to rotate in the housing (4a), with impeller blades, which bound impeller cells arranged in the side-channel (28), for delivering the gas in the impeller cells from the at least one gas inlet opening (34) to the at least one gas outlet opening (33).

Abstract: An electric motor can include a stator body defining fluid channels extending axially for fluid communication between axial ends of the stator body. Conductive windings can form first loops extending axially outward from the first end of the stator body and second loops extending axially outward from the second end of the stator body. A first cap can be coupled to the first end of the stator body and can include a first wall. The first wall can be between the first loops and the channels. Pins can extend from a side of the first wall that is opposite the first loops. The second cap can be coupled to the second end of the stator body and include a second wall. The second wall can be between the second loops and the channels. Pins can extend from a side of the second wall that is opposite the second loops.

Abstract: An electrolyte solution for a vanadium redox flow battery, wherein the electrolyte solution comprises vanadium ions, sulfate ions, and phosphoric acid; and further wherein the conductivity a of the electrolyte solution is in the range of 280 mS·cm?1 to 420 mS·cm?1.

Abstract: Provided is a vacuum assisted resin transfer molding method for producing a component, in particular a spar cap, of a rotor blade including a lightning protection system, wherein the vacuum assisted resin transfer molding method includes the steps of: a) placing) an electrically conductive beam fiber material of an electrically conductive beam, an electrically conductive fiber mat and an electrical conductor of the component in a mold arrangement electrically connecting the electrically conductive beam fiber material to the electrical conductor by means of the electrically conductive fiber mat, wherein an electrical connection between the electrical conductor and the electrically conductive fiber mat is generated, c) subjecting the mold arrangement to underpressure, d) applying an external pressure on the electrical connection from outside the mold arrangement, e) injecting resin into the underpressurized mold arrangement, and f) applying heat to the mold arrangement for curing the resin.

Abstract: An electrolyte solution for a vanadium redox flow battery, wherein the electrolyte solution comprises vanadium ions, sulfate ions, and phosphoric acid; and further wherein the conductivity a of the electrolyte solution is in the range of 280 mS·cm?1 to 420 mS·cm?1.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The aim of the invention is to allow a reliable quantification and classification of brake abrasion of a brake system of a vehicle and simultaneously reduce the complexity in a practical application. This is achieved by a measuring rim with a rim interior, in which a collecting housing is arranged that extends in the circumferential direction of the measuring rim over an extension angle (?). A collecting housing interior is formed in the collecting housing, and the collecting housing is at least partly open towards the collecting housing interior on a radially inner circumferential surface extending in the circumferential direction of the measuring rim. A discharge area is provided on the rim flange on the measuring rim, and a collecting channel which connects the collecting housing interior of the collecting housing to the discharge area is provided on the measuring rim.

Abstract: An ablation system includes a retractable sheath including a lumen; a first electrode in the lumen; a pre-bent telescopic tube extendable from the lumen and including a second electrode, wherein the first electrode and the second electrode are configured to deliver an electric field energy to target tissue in a patient.

Abstract: An assembly includes a frame and a conveyor mat configured to transition between a retracted state in which the conveyor mat is disposed within a footprint of the frame, and a deployed state in which the conveyor mat is disposed at least partially disposed outside the footprint of the frame. The conveyor mat has a plurality of linkages, a plurality of rollers, a plurality of supports, and a plurality of axles. Individual axles couple to individual linkages of the plurality of linkages, individual rollers of the plurality of rollers, and individual supports of the plurality of supports together. A tensioning system is configured to control the conveyor mat transitioning between the retracted state and the deployed state.

Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: An output module includes an output for switching a load and includes a switch that switches a switching voltage to the output to cause a load current to flow, wherein the module includes a measuring device that provides a monitoring signal profile that maps a signal profile of the load current based on the switching voltage, an analyzer that compares, at least at points, the monitoring signal profile with a switch-on characteristic curve characterizing the load, and a diagnostic device that generates a maintenance notification when the comparison exceeds a specifiable deviation.

Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.