Abstract: A system and method for monitoring a fluid filter of a handling apparatus includes at least one fluid filter installed in the handling apparatus. The system further includes a sensor arrangement comprising a first sensor assembly configured and arranged to monitor a parameter associated with the condition of the at least one fluid filter. The system further includes a telemetry module configured to transmit condition data related to the parameter associated with the first sensor assembly to a processor at a different location to the handling apparatus. The processor is configured to analyze the condition data over a predetermined period to determine an expected change in fluid filter condition. The processor is also configured to compare the expected change in fluid filter condition with the condition data, and to provide an output when the condition data differs from the expected change in fluid filter condition by a predetermined amount.

Abstract: A system for managing a CNV reference panel is disclosed, wherein the system includes a database arrangement configured to store a plurality of sample genomic DNA sequences and metadata associated with each of plurality of sample genomic DNA sequences. The system further includes a computing arrangement communicatively coupled to the database arrangement. The computing arrangement is configured to render a user interface to receive a target genomic DNA sequence along with interpretation request for calling CNVs in target genomic DNA sequence. The computing arrangement compares the plurality of characteristic attributes in the interpretation request with the metadata associated with each of plurality of sample genomic DNA sequences. Furthermore, the computing arrangement identifies a set of sample genomic DNA sequences as a reference panel, based on the comparison. Moreover, the computing arrangement utilise the reference panel for calling CNVs in the target genomic DNA sequence.

Abstract: To attain the advantages and in accordance with the purpose of the technology of the present application, apparatuses, systems, and methods to evaluate a user audio profile are provided. The evaluation of a user audio profile allows for identification of potential causes of poor performing user audio profiles and potential types of remediation to increase the performance of the user audio profile.

Abstract: Disclosed are methods and compositions for preventing cerebrovascular function dysfunction in a patient who has been identified as an ApoE4 carrier. The disclosed methods and compositions include rapamycin, a rapamycin analog, or another such inhibitor of the target of rapamycin (TOR).

Abstract: Disclosed are methods and compositions for the treatment or prevention of vascular cognitive impairment. The disclosed methods and compositions include rapamycin, a rapamycin analog, or another such inhibitor of the target of rapamycin (TOR).

Abstract: The disclosure relates to the manufacture of metal articles, more specifically the manufacture of metal articles by additive manufacturing techniques, and in particular to the manufacture of metal articles by an additive manufacturing technique that may involve the selective melting or sintering of a metal powder. Examples of such techniques may include selective laser melting (SLM), selective laser sintering (SLS) and techniques that use an electron beam rather than a laser. Exemplary embodiments include a method of manufacture of an article including selective melting and/or sintering of a powder including an alloy containing aluminium, wherein the alloy contains bismuth.

Abstract: An audio quality feedback system and method is provided. The system receives audio from a client via a communication device such as a microphone, The audio quality feedback system compares the received audio to one or more parameters regarding the quality of the feedback. The parameters include, for example, clipping, periods of silence, signal to noise ratios. Based on the comparison, feedback is generated to allow adjustment of the communication device or use of the communication device to improve the quality of the audio.

Abstract: A vascular graft prosthesis having a reinforced margin designed and configured to strengthen the margin for various purposes, such as to minimize suture hole elongation and prevent suture line tearing during vessel anastomosis, thereby enhancing the vessel anastomosis and the anastomotic site.

Abstract: A powered steering mechanism can operate in a steering mode or in a powered self-centering mode. The mechanism of the present invention includes a cylinder into and out of which can reciprocate a rod. The rod is provided with a fixed piston that defines a first pressure chamber and a second pressure chamber. First and second inlet/outlet steering ports are provided in the pressure chambers through which a pressurizing fluid can flow into or out. The cylinder is also adapted to provide powered self-centering of the fixed piston and thereby the steering mechanism itself by the floating pistons that are located within the pressure chambers. First and second inlet/outlet centering ports are also provided in pressure chambers, through which fluid can flow into the chambers, causing floating pistons to move towards a central position and enabling the fixed piston to be moved and retained.

Abstract: Disclosed are apparatus and methods for delivery of transcranial magnetic stimulation. The apparatus includes a TMS coil which when energized generates an electric field substantially parallel to a long axis of the coil and substantially normal to a surface of the coil. Furthermore disclosed an apparatus for delivery of TMS in which a coil is adapted to a robotic member for computer-aided control and delivery. Further disclosed are methods of TMS planning and delivery in which subject images are utilized to plan, position and orient the TMS coil for precise delivery. Disclosed also are TMS coils having unique designs to better focus and direct magnetic stimulation.

Abstract: Steric features inherent in the three dimensional disposition of atoms in molecules can be represented as multiplets using a defined set of steric descriptors. The resulting multiplets can be encoded in a compressed form of bitstring known as a bitmap. Such bitmaps can be generated in compressed form and used to compare individual conformers or ensembles of conformers of molecules to each other without decompression. Such comparisons are useful in molecular similarity analysis, in molecular diversity analysis, in database searching, and in conformational analysis.

Abstract: A powered steering mechanism can operate in a steering mode or in a powered self-centering mode. The mechanism of the present invention includes a cylinder into and out of which can reciprocate a rod. The rod is provided with a fixed piston that defines a first pressure chamber and a second pressure chamber. First and second inlet/outlet steering ports are provided in the pressure chambers through which a pressurizing fluid can flow into or out. The cylinder is also adapted to provide powered self-centering of the fixed piston and thereby the steering mechanism itself by the floating pistons that are located within the pressure chambers. First and second inlet/outlet centering ports are also provided in pressure chambers, through which fluid can flow into the chambers, causing floating pistons to move towards a central position and enabling the fixed piston to be moved and retained.

Abstract: Steric features inherent in the three dimensional disposition of atoms in molecules can be represented as multiplets using a defined set of steric descriptors. The resulting multiplets can be encoded in a compressed form of bitstring known as a bitmap. Such bitmaps can be generated in compressed form and used to compare individual conformers or ensembles of conformers of molecules to each other without decompression. Such comparisons are useful in molecular similarity analysis, in molecular diversity analysis, in database searching, and in conformational analysis.

Abstract: Olefinic interpolymer compositions comprising the olefinic interpolymer, residuals from a transition metal catalyst and boron containing activator package, and a charge dissipation modifier and methods for making them. The compositions have dissipation factors that are at least 50% less than the corresponding olefinic interpolymer compositions which have not been treated with charge dissipation modifiers. The compositions are useful in wire and cable applications.

Abstract: A method and system for securing the exposed valve actuation portion of the valve system in order to restrict the unauthorized use therefrom; including a first device keying the exposed valve actuation portion, a second devise containing the exposed portion of the keyed valve actuation portion, a third keyed device for locking the valve actuation portion within the second device, a fourth keyed device for actuating the pressure adjustment portion, a fifth devise for maintaining ease of rotation, a sixth device for securing the third device to the existing valve system, and a seventh device for engaging and operating the first and/or third devices.

Abstract: Steric features inherent in the three dimensional disposition of atoms in molecules can be represented as multiplets using a defined set of steric descriptors. The resulting multiplets can be encoded in a compressed form of bitstring known as a bitmap. Such bitmaps can be generated in compressed form and used to compare individual conformers or ensembles of conformers of molecules to each other without decompression. Such comparisons are useful in molecular similarity analysis, in molecular diversity analysis, in database searching, and in conformational analysis.

Abstract: A system and methods of use for assembling packages has one or more conveyors for advancing one or more product flavors into an accumulation of product units. At an accumulation area the accumulated product units are separated into a subset of pack units by a pack splitter which are then deposited onto an indexing conveyor. The pack units may be supported by a substrate. The pack units are advanced along the indexing conveyor for final package assembly.

Abstract: Olefinic interpolymer compositions comprising the olefinic interpolymer, residuals from a transition metal catalyst and boron containing activator package, and a charge dissipation modifier and methods for making them. The compositions have dissipation factors that are at least 50% less than the corresponding olefinic interpolymer compositions which have not been treated with charge dissipation modifiers. The compositions are useful in wire and cable applications.

Abstract: Disclosed are apparatus and methods for delivery of transcranial magnetic stimulation. The apparatus includes a TMS coil which when energized generates an electric field substantially parallel to a long axis of the coil and substantially normal to a surface of the coil. Furthermore disclosed an apparatus for delivery of TMS in which a coil is adapted to a robotic member for computer-aided control and delivery. Further disclosed are methods of TMS planning and delivery in which subject images are utilized to plan, position and orient the TMS coil for precise delivery. Disclosed also are TMS coils having unique designs to better focus and direct magnetic stimulation.

Abstract: A product container package assembly comprises a tray, a plurality of product containers positioned on a support surface of the tray, and an adhesive positioned between at least one of the product containers and the support surface. The tray having a support surface, front side, a back side, a left side and a right side. The tray has a back side wall, right side wall and a left side wall extending in a substantially vertical direction from the support surface. The front side defines an opening between the right side wall, the left side wall and the support surface. The adhesive is positioned at least between the product container(s) immediately adjacent to the front side opening and the support surface.