Abstract: Methods and systems for peptide generation include training a peptide mutation policy neural network using reinforcement learning that includes a peptide presentation score as a reward. New peptides are generated using the peptide mutation policy. A binding motif of a major histocompatibility complex is calculated using the new peptides. Library peptides are screened in accordance with the binding motif.

Abstract: A method for implementing deep reinforcement learning with T-cell receptor (TCR) mutation policies to generate binding TCRs for immunotherapy includes extracting peptides to identify a virus or tumor cells, collecting a library of TCRs from patients, predicting interaction scores between the extracted peptides and the TCRs from the patients, developing a deep reinforcement learning framework with TCR mutation policies to generate TCRs with maximum binding scores, defining reward functions, outputting mutated TCRs, ranking the outputted TCRs to utilize top-ranked TCR candidates to target the virus or the tumor cells, and for each top-ranked TCR candidate, repeatedly identifying a set of self-peptides that the top-ranked TCR candidate binds to and further optimizing it greedily by maximizing a sum of its interaction scores with a given set of peptide antigens while minimizing a sum of its interaction scores with the set of self-peptides until stopping criteria of efficacy and safety are met.

Abstract: A method for using a multi-hop reasoning framework to perform multi-step compositional long-term reasoning is presented. The method includes extracting feature maps and frame-level representations from a video stream by using a convolutional neural network (CNN), performing object representation learning and detection, linking objects through time via tracking to generate object tracks and image feature tracks, feeding the object tracks and the image feature tracks to a multi-hop transformer that hops over frames in the video stream while concurrently attending to one or more of the objects in the video stream until the multi-hop transformer arrives at a correct answer, and employing video representation learning and recognition from the objects and image context to locate a target object within the video stream.

Abstract: A method for implementing deep reinforcement learning with T-cell receptor (TCR) mutation policies to generate binding TCRs recognizing target peptides for immunotherapy is presented. The method includes extracting peptides to identify a virus or tumor cells, collecting a library of TCRs from target patients, predicting, by a deep neural network, interaction scores between the extracted peptides and the TCRs from the target patients, developing a deep reinforcement learning (DRL) framework with TCR mutation policies to generate TCRs with maximum binding scores, defining reward functions based on a reconstruction-based score and a density estimation-based score, randomly sampling batches of TCRs and following a policy network to mutate the TCRs, outputting mutated TCRs, and ranking the outputted TCRs to utilize top-ranked TCR candidates to target the virus or the tumor cells for immunotherapy.

Abstract: A method is provided that includes training a CLIP model to learn embeddings of images and text from matched image-text pairs. The text represents image attributes. The method trains a StyleGAN on images in a training dataset of matched image-text pairs. The method also trains, using a CLIP model guided contrastive loss which attracts matched text embedding pairs and repels unmatched pairs, a text-to-direction model to predict a text direction that is semantically aligned with an input text responsive to the input text and a random latent code. A triplet loss is used to learn text directions using the embeddings learned by the trained CLIP model. The method generates, by the trained StyleGAN, positive and negative synthesized images by respectively adding and subtracting the text direction in the latent space of the trained StyleGAN corresponding to a word for each of the words in the training dataset.

Abstract: A method for implementing source-free domain adaptive detection is presented. The method includes, in a pretraining phase, applying strong data augmentation to labeled source images to produce perturbed labeled source images and training an object detection model by using the perturbed labeled source images to generate a source-only model. The method further includes, in an adaptation phase, training a self-trained mean teacher model by generating a weakly augmented image and multiple strongly augmented images from unlabeled target images, generating a plurality of region proposals from the weakly augmented image, selecting a region proposal from the plurality of region proposals as a pseudo ground truth, detecting, by the self-trained mean teacher model, object boxes and selecting pseudo ground truth boxes by employing a confidence constraint and a consistency constraint, and training a student model by using one of the multiple strongly augmented images jointly with an object detection loss.

Abstract: A method for compositional reasoning of group activity in videos with keypoint-only modality is presented. The method includes obtaining video frames from a video stream received from a plurality of video image capturing devices, extracting keypoints all of persons detected in the video frames to define keypoint data, tokenizing the keypoint data with time and segment information, clustering groups of keypoint persons in the video frames and passing the clustering groups through multi-scale prediction, and performing a prediction to provide a group activity prediction of a scene in the video frames.

Abstract: An optical element for a lithography system comprises an optical surface and a photoresistor having an electric photoresistor value that varies according to an amount of light incident on a region of the optical surface.

Abstract: Systems and methods for predicting T-Cell receptor (TCR)-peptide interaction, including training a deep learning model for the prediction of TCR-peptide interaction by determining a multiple sequence alignment (MSA) for TCR-peptide pair sequences from a dataset of TCR-peptide pair sequences using a sequence analyzer, building TCR structures and peptide structures using the MSA and corresponding structures from a Protein Data Bank (PDB) using a MODELLER, and generating an extended TCR-peptide training dataset based on docking energy scores determined by docking peptides to TCRs using physical modeling based on the TCR structures and peptide structures built using the MODELLER. TCR-peptide pairs are classified and labeled as positive or negative pairs using pseudo-labels based on the docking energy scores, and the deep learning model is iteratively retrained based on the extended TCR-peptide training dataset and the pseudo-labels until convergence.

Abstract: A system for binding peptide search for immunotherapy is presented. The system includes employing a deep neural network to predict a peptide presentation given Major Histocompatibility Complex allele sequences and peptide sequences, training a Variational Autoencoder (VAE) to reconstruct peptides by converting the peptide sequences into continuous embedding vectors, running a Monte Carlo Tree Search to generate a first set of positive peptide vaccine candidates, running a Bayesian Optimization search with the trained VAE and a Backpropagation search with the trained VAE to generate a second set of positive peptide vaccine candidates, using a sampling from a Position Weight Matrix (sPWM) to generate a third set of positive peptide vaccine candidates, screening and merging the first, second, and third sets of positive peptide vaccine candidates, and outputting qualified peptides for immunotherapy from the screened and merged sets of positive peptide vaccine candidates.

Abstract: A method for generating binding peptides presented by any given Major Histocompatibility Complex (MHC) protein is presented. The method includes, given a peptide and an MHC protein pair, enabling a Reinforcement Learning (RL) agent to interact with and exploit a peptide mutation environment by repeatedly mutating the peptide and observing an observation score of the peptide, learning to form a mutation policy, via a mutation policy network, to iteratively mutate amino acids of the peptide to obtain desired presentation scores, and generating, based on the desired presentation scores, qualified peptides and binding motifs of MHC Class I proteins.

Abstract: A method for measuring experience quality. The method including: receiving key experience aspects (“KEAs”); administering pre-surveys to a representative subset of the experience audience, including an importance pre-survey requesting relative importance between the KEAs; and perception pre-survey requesting how closely perceptions align with each KEAs; calculating importance weights and perception weights based on the pre-surveys; performing a general survey process that includes surveying the experience audience to provide a quality rating indicating how well each of the KEAs was delivered based on their own experience; and calculating an Experience Index score as a measure of the quality of the experience that is an aggregation of the received quality ratings weighted by at least one of the importance weights or the perception weights.

Abstract: A computer-implemented method executed by at least one processor for performing mini-batching in deep learning by improving cache utilization is presented. The method includes temporally localizing a candidate clip in a video stream based on a natural language query, encoding a state, via a state processing module, into a joint visual and linguistic representation, feeding the joint visual and linguistic representation into a policy learning module, wherein the policy learning module employs a deep learning network to selectively extract features for select frames for video-text analysis and includes a fully connected linear layer and a long short-term memory (LSTM), outputting a value function from the LSTM, generating an action policy based on the encoded state, wherein the action policy is a probabilistic distribution over a plurality of possible actions given the encoded state, and rewarding policy actions that return clips matching the natural language query.

Abstract: A method for evaluating the behavior of a vehicle component, including: issuing a control signal by a control unit of a motor vehicle to a vehicle component; detecting a response of the motor vehicle to the control signal; determining the behavior of the vehicle component; classifying the behavior of the vehicle component; and adapting the actuation of the motor vehicle component by the control unit. Also described is a related system.

Abstract: An apparatus, method, and system assess the trustworthiness of a design representation while maintaining its confidentiality and thwarting attempts at unauthorized access, misappropriation, and reverse engineering of confidential proprietary aspects of the design representation and/or its bit stream. A utility/tool is provided for trust assessment and verification of designs and/or bit streams. The utility/tool may be instantiated on a semiconductor device or implemented as a utility executable on a mobile computing device or other information processing system, apparatus, or network.

Abstract: Aspects of the present disclosure describe systems, methods and structures for an efficient multi-person posetracking method that advantageously achieves state-of-the-art performance on PoseTrack datasets by only using keypoint information in a tracking step without optical flow or convolution routines. As a consequence, our method has fewer parameters and FLOPs and achieves faster FPS. Our method benefits from our parameter-free tracking method that outperforms commonly used bounding box propagation in top-down methods. Finally, we disclose tokenization and embedding multi-person pose keypoint information in the transformer architecture that can be re-used for other pose tasks such as pose-based action recognition.

Abstract: A computer-implemented method is provided for generating new binding peptides to Major Histocompatibility Complex (MHC) proteins. The method includes training, by a processor device, a Generative Adversarial Network GAN having a generator and a discriminator only on a set of binding peptide sequences given training data comprising the set of binding peptide sequences and a set of non-binding peptide sequences. A GAN training objective includes the discriminator being iteratively updated to distinguish generated peptide sequences from sampled binding peptide sequences as fake or real and the generator being iteratively updated to fool the discriminator. The training includes optimizing the GAN training objective while learning two projection vectors for a binding class with two cross-entropy losses. A first loss discriminating binding peptide sequences in the training data from non-binding peptide sequences in the training data.

Abstract: Systems and methods for matching job descriptions with job applicants is provided. The method includes allocating each of one or more job applicants' curriculum vitae (CV) into sections; applying max pooled word embedding to each section of the job applicants' CVs; using concatenated max-pooling and average-pooling to compose the section embeddings into an applicant's CV representation; allocating each of one or more job position descriptions into specified sections; applying max pooled word embedding to each section of the job position descriptions; using concatenated max-pooling and average-pooling to compose the section embeddings into a job representation; calculating a cosine similarity between each of the job representations and each of the CV representations to perform job-to-applicant matching; and presenting an ordered list of the one or more job applicants or an ordered list of the one or more job position descriptions to a user.

Abstract: Methods and systems for training a machine learning model include embedding a state, including a peptide sequence and a protein, as a vector. An action, including a modification to an amino acid in the peptide sequence, is predicted using a presentation score of the peptide sequence by the protein as a reward. A mutation policy model is trained, using the state and the reward, to generate modifications that increase the presentation score.

Abstract: Methods and systems for training a model include encoding training peptide sequences using an encoder model. A new peptide sequence is generated using a generator model. The encoder model, the generator model, and the discriminator model are trained to cause the generator model to generate new peptides that the discriminator mistakes for the training peptide sequences, including learning projection vectors with respective cross-entropy losses for binding sequences and non-binding sequences.