Abstract: A soccer shoe includes an upper and a cleat assembly coupled to the upper. The cleat assembly further includes a medial support bar located on the medial side and a lateral support bar located on the lateral side. A portion of the cleat assembly located near a midfoot section of the medial support bar is stiffer than a portion of the cleat assembly located near a midfoot section of the lateral support bar. The medial support bar extends approximately from a region corresponding to the rear of the calcaneous of a properly fitted wearer to approximately the head of the first metatarsal of the wearer. The lateral support bar extends approximately from a region corresponding to the rear of the calcaneous of the wearer to approximately the head of the fifth metatarsal of the wearer. The cleat assembly is bonded to a cushioning midsole formed from heated and compressed ethylene vinyl acetate foam. The upper lacks a full-length lasting board and is bonded directly to the cushioning midsole.

Abstract: An article of footwear provided with snap-fit replaceable ground-engaging members, particularly snap-fit tips, and a kit and method for altering ground-engaging characteristics of an article of footwear such as an athletic shoe. An article of footwear according to the present invention includes a sole (and/or a footplate) having at least one ground-engaging member in snap-fit engagement therewith. In particular, the ground-engaging member is engageable under the application of a non-rotational force (especially a manual force). According to one aspect of the present invention, a clearly discernible feedback (especially an audible feedback, such as a click or a snapping sound) is provided to clearly indicate engagement between the ground-engaging member and the sole.

Abstract: An article of footwear provided with snap-fit replaceable ground-engaging members, particularly snap-fit tips, and a kit and method for altering ground-engaging characteristics of an article of footwear such as an athletic shoe. An article of footwear according to the present invention includes a sole (and/or a footplate) having at least one ground-engaging member in snap-fit engagement therewith. In particular, the ground-engaging member is engageable under the application of a non-rotational force (especially a manual force). According to one aspect of the present invention, a clearly discernible feedback (especially an audible feedback, such as a click or a snapping sound) is provided to clearly indicate engagement between the ground-engaging member and the sole.

Abstract: Compounds according to general formulae (1 and 2), wherein G1 is an azepine derivative and G2 is a group according to general formulae (9-11) are new. Compounds according to the invention are vasopressin V2 receptor agonists. Pharmaceutical compositions of the compounds are useful as antidiuretic agents.

Abstract: An article of footwear includes an upper for holding a foot of a wearer and a sole having an outsole plate. Several ground engaging members extends downwardly from the outsole plate to provide traction. The outsole plate includes a flex control member composed of a superelastic shape memory material or a nickel-titanium alloy. The flex control member can be coupled to an inside surface, or bottom surface of the outsole plate. The outsole plate may include a rearfoot region, a midfoot region, and a first metatarsal head region, in which the regions generally correspond to the skeletal structure of a human foot. The flex control member extends from a medial side of the rearfoot region through the midfoot region and into the first metatarsal head region of the outsole plate. The ground engaging members may be positioned to extend from the location of the flex control member.

Abstract: An article of cleated footwear comprises an upper for holding a foot of a wearer to a sole having an outsole plate. The outsole plate includes a predetermined first metatarsal region that generally overlies the respective skeletal structure of a human foot. Several ground engaging members extend downwardly from the outsole plate to provide traction on a ground surface. The outsole plate includes a downwardly extending metatarsal head cradle located on a lateral side and a medial side of the first metatarsal region to reduce stud pressure and provide traction control. The outsole plate may include a distal phalanx region and a predetermined proximal phalanx region. A first ground engaging member is located in the distal phalanx region and a second ground engaging member is located in the proximal phalanx region for toe off movements.

Abstract: An article of footwear includes a sole having a different performing lateral and medial regions. Ground engaging members, such as cleats, provide traction and one of the regions, preferably the lateral region, includes a stability member extending from the sole and spanning between a pair of adjacent ground engaging members in a heel to toe direction. The ground engaging members may have a body and a tip portion. Each tip portion may be integrally formed with all or a portion of its respective body. The medial and lateral regions include buttressing member having different characteristics and dimensions for strengthening the ground engaging members with providing enhanced flexibility.

Abstract: Compounds according to general formula (1), and pharmaceutically acceptable salts thereof, wherein V is a covalent bond or NH, X is selected from CH2, O and N-alkyl, Z is either S or —CH═CH—, R1 and R2 are independently selected from H, F, Cl, Br and alkyl, R3 is selected from OH, O-alkyl and NR4R5, R4 and R5 are each independently H or alkyl, or together are —(CH2)q—, p is 0, 1, 2, 3 or 4, and q is 4 or 5, are new. They are agonists at the asopressin V2 receptor and are useful as antidiuretics and pro-coagulants.

Abstract: An article of footwear provided with snap-fit replaceable ground-engaging members, particularly snap-fit tips, and a kit and method for altering ground-engaging characteristics of an article of footwear such as an athletic shoe. An article of footwear according to the present invention includes a sole (and/or a footplate) having at least one ground-engaging member in snap-fit engagement therewith. In particular, the ground-engaging member is engageable under the application of a non-rotational force (especially a manual force). According to one aspect of the present invention, a clearly discernible feedback (especially an audible feedback, such as a click or a snapping sound) is provided to clearly indicate engagement between the ground-engaging member and the sole.

Abstract: This invention provides novel compounds according to general formula (1) wherein A is a bicyclic or tricyclic azepine derivative, V1 and V2 are both H, OMe or F, or one of V1 and V2 is Br, Cl, F, OH, OMe, OBn, OPh, O-acyl, N3, NH2, NHBn or NH-acyl and the other is H, or V1 and V2 together are ═O, —O(CH2)pO— or —S(CH2)pS—; W1 is either O or S; X1 and X2 are both H, or together are ═O or ═S; Y is OR5 or NR6R7; R1, R2, R3 and R4 are independently selected from H, lower alkyl, lower alkyloxy, F, Cl and Br; R5 is selected from H and lower alkyl; R6 and R7 are independently selected from H and lower alkyl, or together are —(CH2)n; n=3, 4, 5, 6; and p is 2 or 3. The compounds are agonists at the vasopressin V2 receptor and are useful as antidiuretics and procoagulants.

Abstract: An improved article of footwear, specifically for use in the sport of tennis. The article of footwear addresses motions prevalent in the sport of tennis by enhancing performance and preventing injuries. The article of footwear is asymmetrical and the lateral and medial portions have features to performs different functions to enhance flexibility, balance control, propulsion, stability and support in the specific areas where needed. In part, the medial portion of the article of footwear is designed to provide flexibility while the lateral portion is designed to create stability. These differences in the medial and lateral portions of the article of footwear exist in the upper, e.g., lacing system, material composition, and material thickness differences, and/or in the sole, e.g., different midsole materials, supporting elements effecting only the lateral side.