Abstract: A scraper body adapted to be attached to a furrow opener assembly with a disc rotatably mounted on an arm and oriented at a horizontal angle to create a disc furrow. The scraper body has an attachment body portion adapted to be attached to the furrow opener assembly such that a forward scraping edge of the scraper body scrapes soil from the disc face. A wing member extends from a lower rear portion of the scraper body, and has a top wing member edge oriented in alignment with the disc furrow and with the operating travel direction. Right and left wings extending downward and outward from the top wing member edge to bottom wing edges located above a bottom edge of the disc such that in operation the wings push soil to corresponding right and left sides of the disc furrow to create right and left wing furrows.

Abstract: The invention provides a method for the treatment of Ph+ leukemia in a patient comprising administering to the patient (i) a BCR-ABL tyrosine kinase inhibitor, and (ii) an agent which selectively binds to a cell surface receptor expressed on Ph+ leukemic stem cells. The invention further provides for the use of (i) and (ii) in, or in the manufacture of a medicament for, the treatment of Ph+ leukemia in a patient; and a composition for the treatment of Ph+ leukemia in a patient comprising (i) and (ii); and kits comprising (i) and (ii). In some embodiments, the tyrosine kinase inhibitor is or is not imatinib; or is selected from the group consisting of dasatinib, nilotinib, bosutinib, axitinib, cediranib, crizotinib, damnacanthal, gefitinib, lapatinib, lestaurtinib, neratinib, semaxanib, sunitinib, toceranib, tyrphostins, vandetanib, vatalanib, INNO-406, AP24534, XL228, PHA-739358, MK-0457, SGX393 and DC2036; or is selected from the group consisting of dasatinib and nilotinib.

Abstract: Apparatuses and methods (including methods of using such apparatuses) for de-noising electrocardiograms (ECGs) by manually or automatically adjusting the amount of filtering of an ECG signal. For example, real-time ECG signals may be filtered by combining in a weighted fashion an unfiltered portion of an ECG (or a filtered portion of the same ECG) with the same portion of the ECG that has been filtered. The weighting may be adjusted manually and/or automatically. Also described herein are methods for real-time filtering of ECG signals using a combination of filtering techniques including filtering to correct baseline wander, Savitzky-Golay denoising, and threshold smoothing. Multiple filtering techniques may be combined in a weighed manner to provide signal de-noising.

Abstract: A scraper body adapted to be attached to a furrow opener assembly with a disc rotatably mounted on an arm and oriented at a horizontal angle to create a disc furrow. The scraper body has an attachment body portion adapted to be attached to the furrow opener assembly such that a forward scraping edge of the scraper body scrapes soil from the disc face. A wing member extends from a lower rear portion of the scraper body, and has a top wing member edge oriented in alignment with the disc furrow and with the operating travel direction. Right and left wings extending downward and outward from the top wing member edge to bottom wing edges located above a bottom edge of the disc such that in operation the wings push soil to corresponding right and left sides of the disc furrow to create right and left wing furrows.

Abstract: A multistage vacuum pump includes a stator housing a multistage rotor assembly, each stage having intermeshing Roots rotor components, wherein the tip radius of the rotor components at an inlet stage of the pump is larger than the tip radius of the rotor components at an exhaust stage of the pump, wherein a meshing clearance between the rotor components at the inlet stage of the pump is greater than a meshing clearance between the rotor components at the exhaust stage of the pump.

Abstract: Automatic pool cleaners and associated hoses are detailed. Hoses may contract and expand in use and include sections of differing compliancies. Such contractions and expansions may be intensified in more compliant portions and attenuated in less compliant portions. Also discussed are positive locking mechanisms for adjacent hose sections.

Abstract: Automatic pool cleaners and associated hoses are detailed. Hoses may contract and expand in use and include sections of differing compliancies. Such contractions and expansions may be intensified in more compliant portions and attenuated in less compliant portions. Also discussed are positive locking mechanisms for adjacent hose sections.

Abstract: A tracheal tube (40) or laryngeal mask has a sealing cuff (41, 2) with a surface covered by a brush-like material (44, 24) provided by closely-packed fibers (25) between 1 mm and 5 mm in length. The brush-like surface (44, 24) may be provided by coating the surface with an adhesive and using an electrostatic charge to draw fibers (25) to adhere to the adhesive.

Abstract: A vacuum pump housing comprises first (12) and second half-shell stator components (14) defining a plurality of pumping chambers separated by partition members (26, 28, 30, 32). Each pumping chamber comprises an inlet port (42, 44, 46, 48, 50) for receiving fluid and an outlet port (54, 56, 58, 60, 62) through which pumped fluid is exhausted from the chamber. The inlet ports are open on an external surface of the first stator component, and the outlet ports are open on an opposing external surface of the second stator component. The stator components further define transfer channels (66, 68, 70, 72) for conveying fluid between the pumping chambers. Each transfer channel preferably comprises first and second portions located on opposite sides of the housing.

Abstract: The invention provides a method for the treatment of Ph+ leukemia in a patient comprising administering to the patient (i) a BCR-ABL tyrosine kinase inhibitor, and (ii) an agent which selectively binds to a cell surface receptor expressed on Ph+ leukemic stem cells. The invention further provides for the use of (i) and (ii) in, or in the manufacture of a medicament for, the treatment of Ph+ leukemia in a patient; and a composition for the treatment of Ph+ leukemia in a patient comprising (i) and (ii); and kits comprising (i) and (ii). In some embodiments, the tyrosine kinase inhibitor is or is not imatinib; or is selected from the group consisting of dasatinib, nilotinib, bosutinib, axitinib, cediranib, crizotinib, damnacanthal, gefitinib, lapatinib, lestaurtinib, neratinib, semaxanib, sunitinib, toceranib, tyrphostins, vandetanib, vatalanib, INNO-406, AP24534, XL228, PHA-739358, MK-0457, SGX393 and DC2036; or is selected from the group consisting of dasatinib and nilotinib.

Abstract: A laminated sensor comprises a base stratum and a terminal stratum. The base stratum has a first surface that is affixed to a surface of a structure to be monitored. The terminal stratum is affixed to the opposite second surface of the base stratum. A connector is attached to the terminal stratum. The base stratum is provided with first and second channels and that are cut through the thickness of the base stratum. The terminal stratum is provided with holes that extend through the thickness of the terminal stratum. A first pair of the holes are positioned to register with the first channel, while a second pair of the holes are positioned to register with the second channel. A first conduit is formed by the first channel and the holes; while a second conduit is formed by the second channel and the holes. The connector connects with tubes to provide fluid communication between the conduits and a differential pressure monitoring system.

Abstract: Automatic pool cleaners and associated hoses are detailed. Hoses may contract and expand in use and include sections of differing compliancies. Such contractions and expansions may be intensified in more compliant portions and attenuated in less compliant portions. Also discussed are positive locking mechanisms for adjacent hose sections.

Abstract: A multistage vacuum pump includes a stator housing a multistage rotor assembly, each stage having intermeshing Roots rotor components, wherein the tip radius of the rotor components at an inlet stage of the pump is larger than the tip radius of the rotor components at an exhaust stage of the pump, wherein a meshing clearance between the rotor components at the inlet stage of the pump is greater than a meshing clearance between the rotor components at the exhaust stage of the pump.

Abstract: The present invention relates to a method of treating Philadelphia-positive leukemia (Ph+ leukemia), in a particular chronic myeloid leukemia (CML), in a human patient population. More specifically, the present invention pertains to a method of treating Ph+ leukemia, such as CML or Ph+ ALL, in a human patient suffering from Ph+ leukemia comprising the steps of (a) administering a predetermined fixed amount of Imatinib as a free base or in the form of a pharmaceutically acceptable salt thereof to the human patient, (b) collecting at least one blood sample from the patient, e.g.

Abstract: Apparatus for converting kinetic energy into usable power (200), comprises a frame (204) arranged to be fixed in a vehicle running track (202) and a plurality of plates (211 to 219 inclusive, and 221 to 229 inclusive) mounted to the frame. Each plate being movable in relation to the frame so as to drive an energy conversion means (232, 234). The energy conversion means has a rotating member (293 in FIG. 19) having variable inertia.

Abstract: The present invention relates to a method for evaluating patients to help optimizing the treatment of chronic myeloid leukemia (CML) in a human patient population. More specifically, the method comprises the steps of (a) determining the OCT-1 Activity in pre-therapy blood of a warm-blooded animal suffering from CML, and (b) administering a daily dose between about 500 and 1200 mg of Imatinib mesylate to the warm-blooded animal suffering from CML showing an OCT-1 Activity corresponding to Imatinib intracellular concentration to below about 6.0 to 10.0 ng/200,000 cells, especially about 8.0 to 8.5 ng/200,000 cells.

Abstract: The process for converting a copper sulphide matte to blister copper, is achieved by adding the copper sulphide matte and flux to a suitable agitated slag phase; and injecting, from a discharge tip at the lower end of a top-submerged lance, an oxidizing gas suitable for reacting with the matte to produce blister copper which forms or adds to a continuous blister copper phase below the slag phase. The lance tip is located within the slag phase at a depth enabling the injected gas to agitate the slag phase, and to react with copper sulphide matte dispersed therein, while precluding a substantial proportion of the gas from contacting the continuous blister copper phase.

Abstract: A multistage vacuum pump comprises a stator housing a multistage rotor assembly, each stage comprising inter-meshing Roots rotor components, wherein the tip radius of the rotor components at an inlet stage of the pump is larger than the tip radius of the rotor components at an exhaust stage of the pump.

Abstract: A process for producing iron metal and slag by smelting iron-containing source material, having iron present as oxide and/or a partially metalized state, in a reactor containing a molten bath comprising or having a slag phase, utilises injection of fuel/reductant and oxygen-containing gas into the slag, by at least one top-submerged lance, to generate heating and reducing conditions in at least one reducing region in the bath. The source material is fed to the reactor, together with additional reductant and with flux, at or adjacent to the at least one reducing region, to subject the source material to smelting reduction which generates combustion gases comprising CO and H2. The rates of injection of the oxygen-containing gas and fuel/reductant by said at least one lance are controlled to achieve required, sufficient reducing conditions; and, in the reactor above the bath, the combustion gases generated by the smelting are post-combusted.

Abstract: The process for converting a copper sulphide matte to blister copper, is achieved by adding the copper sulphide matte and flux to a suitable agitated slag phase; and injecting, from a discharge tip at the lower end of a top-submerged lance, an oxidizing gas suitable for reacting with the matte to produce blister copper which forms or adds to a continuous blister copper phase below the slag phase. The lance tip is located within the slag phase at a depth enabling the injected gas to agitate the slag phase, and to react with copper sulphide matte dispersed therein, while precluding a substantial proportion of the gas from contacting the continuous blister copper phase.