Patents by Inventor Peter James Facchini

Peter James Facchini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FUSED HETEROCYCLIC MESCALINE DERIVATIVES
    Publication number: 20240116907
    Abstract: Disclosed are novel fused heterocyclic mescaline derivative compounds, notably fused heterocyclic mescaline derivatives and pharmaceutical and recreational drug formulations containing the same. Methods of making and using these compounds are also disclosed.
    Type: Application
    Filed: August 4, 2023
    Publication date: April 11, 2024
    Inventors: Peter J. Facchini, Jillian M. Hagel, Chang-Chun Ling, Charlie Cai, David James Press, Glynnis Elizabeth Jensen, Jessica Bik-Jing Lee, Kaveh Matinkhoo
  • COMPOSITIONS AND METHODS FOR MAKING (R)-RETICULINE AND PRECURSORS THEREOF
    Publication number: 20240002894
    Abstract: Methods that may be used for the manufacture of the chemical compound (R)-Reticuline and synthesis precursors thereof. Compositions useful for the synthesis (R)-Reticuline and synthesis precursors are also provided.
    Type: Application
    Filed: March 6, 2023
    Publication date: January 4, 2024
    Inventors: Peter James Facchini, Scott Cameron Farrow, Guillaume Arthur Welch Beaudoin
  • POLYNUCLEOTIDES AND POLYPEPTIDES USEFUL FOR MAKING ALKALOID COMPOUNDS
    Publication number: 20230303639
    Abstract: Polynucleotides and polypeptides useful in the manufacture of a class of chemical compounds known as alkaloids are provided. The polynucleotides and polypeptides may be used to synthesize alkaloids, including reticuline, thebaine and morphine, in vivo and in vitro. The polynucleotides further may be used to examine the presence of the polynucleotides in a cell or a cell extract, and to modulate expression thereof in living cells.
    Type: Application
    Filed: October 20, 2022
    Publication date: September 28, 2023
    Inventors: Peter James FACCHINI, Joseph E. TUCKER
  • Compositions and methods for making (R)-reticuline and precursors thereof
    Patent number: 11613770
    Abstract: Methods that may be used for the manufacture of the chemical compound (R)-Reticuline and synthesis precursors thereof. Compositions useful for the synthesis (R)-Reticuline and synthesis precursors are also provided.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: March 28, 2023
    Assignee: ANTHEIA, INC.
    Inventors: Peter James Facchini, Scott Cameron Farrow, Guillaume Arthur Welch Beaudoin
  • Polynucleotides and polypeptides useful for making alkaloid compounds
    Patent number: 11479586
    Abstract: Polynucleotides and polypeptides useful in the manufacture of a class of chemical compounds known as alkaloids are provided. The polynucleotides and polypeptides may be used to synthesize alkaloids, including reticuline, thebaine and morphine, in vivo and in vitro. The polynucleotides further may be used to examine the presence of the polynucleotides in a cell or a cell extract, and to modulate expression thereof in living cells.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: October 25, 2022
    Assignee: Antheia, Inc.
    Inventors: Peter James Facchini, Joseph E. Tucker
  • COMPOSITIONS AND METHODS FOR MAKING BENZYLISOQUINOLINE ALKALOIDS, MORPHINAN ALKALOIDS, THEBAINE, AND DERIVATIVES THEREOF
    Publication number: 20220205004
    Abstract: Disclosed herein are methods that may be used for the synthesis of benzylisoquinoline alkaloids (“BIAs”) such as alkaloid morphinan. The methods disclosed can be used to produce thebaine, oripavine, codeine, morphine, oxycodone, hydrocodone, oxymorphone, hydromorphone, naltrexone, naloxone, hydroxycodeinone, neopinone, and/or buprenorphine. Compositions and organisms useful for the synthesis of BIAs, including thebaine synthesis polypeptides, purine permeases, and polynucleotides encoding the same, are provided.
    Type: Application
    Filed: October 7, 2021
    Publication date: June 30, 2022
    Inventors: Peter James FACCHINI, Xue CHEN, Jeffrey C. COLBECK, Joseph E. TUCKER
  • Compositions and methods for making benzylisoquinoline alkaloids, morphinan alkaloids, thebaine, and derivatives thereof
    Patent number: 11142780
    Abstract: Disclosed herein are methods that may be used for the synthesis of benzylisoquinoline alkaloids (BIAs) such as alkaloid morphinan. The methods disclosed can be used to produce thebaine, oripavine, codeine, morphine, oxycodone, hydrocodone, oxymorphone, hydromorphone, naltrexone, naloxone, hydroxycodeinone, neopinone, and/or buprenorphine. Compositions and organisms useful for the synthesis of BIAs, including thebaine synthesis polypeptides, purine permeases, and polynucleotides encoding the same, are provided.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: October 12, 2021
    Assignee: Antheia, Inc.
    Inventors: Peter James Facchini, Xue Chen, Jeffrey C. Colbeck, Joseph Tucker
  • Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds
    Publication number: 20210198706
    Abstract: Novel methods that may be used for the manufacture of plant alkaloid compounds and novel polynucleotide compounds are provided. The plant alkaloid compounds are useful as medicinal compounds.
    Type: Application
    Filed: October 18, 2019
    Publication date: July 1, 2021
    Inventor: Peter James Facchini
  • COMPOSITIONS AND METHODS FOR MAKING NOSCAPINE AND SYNTHESIS INTERMEDIATES THEREOF
    Publication number: 20210155963
    Abstract: Methods that may be used for the manufacture of the therapeutic chemical compound noscapine and noscapine synthesis intermediates. Compounds useful for the synthesis of noscapine are also provided.
    Type: Application
    Filed: August 27, 2020
    Publication date: May 27, 2021
    Inventors: Peter James Facchini, Xue Chen, Thi Thu Thuy Dang
  • Compositions and methods for making noscapine and synthesis intermediates thereof
    Patent number: 10793885
    Abstract: Methods for the manufacture of the therapeutic chemical compound noscapine and noscapine synthesis intermediates comprising contacting a noscapine pathway precursor selected from a first canadine derivative, a first papaveroxine derivative and narcotine hemiacetal with at least one of the enzymes selected from the group CYP82Y1, CYP82X1, AT1, CYP82X2, OMT, CXE1 and NOS.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: October 6, 2020
    Assignee: Willow BioSciences Inc.
    Inventors: Peter James Facchini, Xue Chen, Thi Thu Thuy Dang
  • Methods and compositions for making ephedrine and related alkaloid compounds
    Patent number: 10676767
    Abstract: Methods for making alkaloid compounds, including ephedrine and derivatives thereof. The methods involve the performance of an N-methyltransferase catalyzed chemical reaction.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: June 9, 2020
    Assignee: Willow BioSciences Inc.
    Inventors: Peter James Facchini, Jillian Hagel
  • Compositions and methods for making (S)-norcoclaurine and (S)-norlaudanosoline, and synthesis intermediates thereof
    Patent number: 10662453
    Abstract: Methods that may be used for the manufacture of the chemical compound (S)-norcoclaurine, (S)-norlaudanosoline, and (S)-norcoclaurine or (S)-norlaudanosoline synthesis intermediates are provided. (S)-Norcoclaurine, (S)-norlaudanosoline, and (S)-norcoclaurine or (S)-norlaudanosoline synthesis intermediates are useful as precursor products in the manufacture of certain medicinal agents.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: May 26, 2020
    Assignee: Willow BioSciences Inc.
    Inventor: Peter James Facchini
  • COMPOSITIONS AND METHODS FOR MAKING BENZYLISOQUINOLINE ALKALOIDS, MORPHINAN ALKALOIDS, THEBAINE, AND DERIVATIVES THEREOF
    Publication number: 20200140906
    Abstract: Disclosed herein are methods that may be used for the synthesis of benzylisoquinoline alkaloids (BIAs) such as alkaloid morphinan. The methods disclosed can be used to produce thebaine, oripavine, codeine, morphine, oxycodone, hydrocodone, oxymorphone, hydromorphone, naltrexone, naloxone, hydroxycodeinone, neopinone, and/or buprenorphine. Compositions and organisms useful for the synthesis of BIAs, including thebaine synthesis polypeptides, purine permeases, and polynucleotides encoding the same, are provided.
    Type: Application
    Filed: June 27, 2017
    Publication date: May 7, 2020
    Applicants: INTREXON CORPORATION, SERTURNER CORP.
    Inventors: Peter James FACCHINI, Xue CHEN, Jeffrey C. COLBECK, Joseph TUCKER
  • Methods for making and using polynucleotide sequences in the synthesis of alkaloid compounds
    Patent number: 10487345
    Abstract: Novel methods that may be used for the manufacture of plant alkaloid compounds and novel polynucleotide compounds are provided. The plant alkaloid compounds are useful as medicinal compounds.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: November 26, 2019
    Assignee: Epimeron Inc.
    Inventor: Peter James Facchini
  • Compositions and Methods For Making (R)-Reticuline and Precursors Thereof
    Publication number: 20190241919
    Abstract: Methods that may be used for the manufacture of the chemical compound (R)-Reticuline and synthesis precursors thereof. Compositions useful for the synthesis (R)-Reticuline and synthesis precursors are also provided.
    Type: Application
    Filed: December 7, 2018
    Publication date: August 8, 2019
    Inventors: Peter James Facchini, Scott Cameron Farrow, Guillaume Arthur Welch Beaudoin
  • POLYNUCLEOTIDES AND POLYPEPTIDES USEFUL FOR MAKING ALKALOID COMPOUNDS
    Publication number: 20190194269
    Abstract: Polynucleotides and polypeptides useful in the manufacture of a class of chemical compounds known as alkaloids are provided. The polynucleotides and polypeptides may be used to synthesize alkaloids, including reticuline, thebaine and morphine, in vivo and in vitro. The polynucleotides further may be used to examine the presence of the polynucleotides in a cell or a cell extract, and to modulate expression thereof in living cells.
    Type: Application
    Filed: June 27, 2017
    Publication date: June 27, 2019
    Applicants: INTREXON CORPORATION, SERTURNER CORP.
    Inventors: Peter James FACCHINI, Joseph E. TUCKER
  • Compositions and Methods For Making Alkaloid Morphinans
    Publication number: 20190152981
    Abstract: Methods that may be used for the manufacture of a class of chemical compounds known as morphinans, including neopine, are provided. Compositions useful for the synthesis of morphinans, including neopine, are also provided.
    Type: Application
    Filed: January 15, 2019
    Publication date: May 23, 2019
    Inventor: Peter James Facchini
  • Compositions and methods for making alkaloid morphinans
    Patent number: 10227353
    Abstract: Methods that may be used for the manufacture of a class of chemical compounds known as morphinans, including neopine, are provided. Compositions useful for the synthesis of morphinans, including neopine, are also provided.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: March 12, 2019
    Assignee: Epimeron Inc.
    Inventor: Peter James Facchini
  • Compositions and Methods For Making (S)-Norcoclaurine and (S)-Norlaudanosoline, and Synthesis Intermediates Thereof
    Publication number: 20190062793
    Abstract: Methods that may be used for the manufacture of the chemical compound (S)-norcoclaurine, (S)-norlaudanosoline, and (S)-norcoclaurine or (S)-norlaudanosoline synthesis intermediates are provided. (S)-Norcoclaurine, (S)-norlaudanosoline, and (S)-norcoclaurine or (S)-norlaudanosoline synthesis intermediates are useful as precursor products in the manufacture of certain medicinal agents.
    Type: Application
    Filed: September 5, 2018
    Publication date: February 28, 2019
    Inventor: Peter James Facchini
  • Compositions and methods for making (R)-Reticuline and precursors thereof
    Patent number: 10190141
    Abstract: Methods that may be used for the manufacture of the chemical compound (R)-Reticuline and synthesis precursors thereof. Compositions useful for the synthesis (R)-Reticuline and synthesis precursors are also provided.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: January 29, 2019
    Assignee: Epimeron Inc.
    Inventors: Peter James Facchini, Scott Cameron Farrow, Guillaume Arthur Welch Beaudoin