Abstract: A valve includes a valve body including a housing. The housing has a first internal housing surface defining an internal chamber. The valve further includes a valve assembly including a cartridge and a sleeve fixedly secured to the cartridge. The sleeve has an internal sleeve surface defining an interior cavity. The valve assembly further includes a plug positioned within the interior cavity and including a plug body. The plug body has an external plug surface configured to sealingly engage the internal sleeve surface. The cartridge is removably coupled to the housing such that the sleeve is disposed within the internal chamber of the housing.

Abstract: A safety apparatus is provided for use in a procedure comprising at least first and second devices, wherein the first device and second device are for use in a medical procedure. The apparatus includes a disabling mechanism that is adapted to releasably retain and thereby prevent use of the said second device until release by a release procedure using the first device. A method is provided of carrying out a procedure comprising the steps of using the first device, applying the first device to a disabling mechanism to release the second device, and using the second device.

Abstract: The use of direct factor Xa inhibitors, administered in a dose sufficient to reduce the activity of factor Xa to about 25% less than normal or lower, has the effect of preventing the onset of atherosclerosis, and stabilizing atherosclerotic lesions, and preventing the occurrence or recurrence of atherosclerotic events.

Abstract: A safety apparatus for use in a procedure comprises at least first and second devices, wherein the first device and second device are for use in a medical procedure, the apparatus comprising a disabling mechanism that is adapted to releasably retain and thereby prevent use of the said second device until release by a release procedure using the first device. A method of carrying out a procedure comprises the steps of using the first device, applying the first device to a disabling mechanism to release the second device, and using the second device.

Abstract: The use of direct factor Xa inhibitors, administered in a dose sufficient to reduce the activity of factor Xa to about 25% less than normal or lower, has the effect of preventing the onset of atherosclerosis, and stabilizing atherosclerotic lesions, and preventing the occurrence or recurrence of atherosclerotic events.

Abstract: A regional anaesthesia injection apparatus comprising an injection volume determiner. The apparatus configured to determine a volume of a regional anaesthetic injection into a target tissue; an injection pressure determiner configured to determine a pressure of the injection; and a controller coupled to the injection volume determiner and to the injection pressure determiner and configured to provide an injection signal to control injection of fluid into the target tissue based on the determined pressure and the determined volume.

Abstract: Inside a connector body (112, 114; 300) of a medical connector providing a fluid flow conduit, a one-way valve (118) is fitted directly into one end of a stop valve (116) in a manner providing a fluid tight seal between these valves. The stop valve (116) prevents fluid flowing out of the end (111; 311) of the connector body (112, 114; 300) unless a complementary end of a separate device (not shown), typically a Luer lock connector, engages the end of the connector body and opens the stop valve (116). To facilitate manufacture and assembly, the one-way valve (118) and the stop valve (116) can be formed as parts of a single piece of elastomeric material, the parts being hingedly connected so that the one-way valve part (118) can be folded over to be fitted directly into the end of the stop valve part (116). A further possibility, also applicable when only a stop valve (116) is provided, is that the connector body (300) may be formed in one piece with a folding, snap fit closure (312).

Abstract: An apparatus for performing laryngoscopy is provided, the apparatus comprising a blade, a handle, and a medical gas supply device for provision of gas to a patient during laryngoscopy, wherein the medical gas supply device includes an outlet disposed on or in the handle of the device, or within the proximal half of the blade. A gas supply conduit supplies gas from a proximal aperture to outlet.

Abstract: A blower includes a housing including an inlet and an outlet, a bearing-housing structure provided to the housing and adapted to rotatably support a rotor, a motor provided to the bearing-housing structure and adapted to drive the rotor, and an impeller provided to the rotor. The bearing-housing structure includes a bearing shaft having a bearing surface that rotatably supports the rotor. The bearing shaft provides only a single bearing of the non-ball bearing type for the rotor.

Abstract: A cap for a fluid line connector having a male luer lock fitting, the cap having a first side and a second side opposite the first side, the cap comprising a barrier and a stopper extending axially from the barrier towards the first side of the cap. The barrier defines a keyway centred on a longitudinal axis. The shape of the keyway is configured to permit a correspondingly-shaped female luer lock fitting to pass axially therethrough to engage the male luer lock fitting of the fluid line connector. The stopper is configured to prevent rotation of the correspondingly-shaped female luer lock fitting in the first circumferential direction when a lug of the correspondingly-shaped female luer lock fitting is circumferentially aligned with the stopper.

Abstract: Methods of assessing, such as characterizing or determining, condensate-associated characteristics of a compound, such as a test compound, and applications thereof are provided. For example, methods of determining a partition characteristic of a test compound in a target condensate, methods of determining a relative partition characteristic of a test compound in a target condensate, and methods of determining a condensate preference profile of a test compound are provided. Additionally, methods of designing and/or identifying and/or making a compound, or portion thereof, with a desired relative condensate partition characteristic are provided.

Abstract: An anesthetic administration device comprising an infusion device, which is in fluid connection with a regional anesthetic needle by means of a feed tube. The infusion device comprises one or more anesthetic flow devices capable of triggering forward flow, and optionally backward flow, of the local anesthetic through the regional anesthetic needle. Forward, and optionally backward flow, of the local anesthetic through the regional anesthetic needle is controlled by a controller that comprises one or more actuator switches. The one or more actuator switches are positioned on the device 1 such that they may be operated by hand.

Abstract: Methods for treating Down syndrome and improving cognitive function of a patient with an intellectual disability are disclosed. 5-hydroxytryptamine sub-receptor six (5-HT6) receptor antagonists are provided for improving the cognition of a Down syndrome patient.

Abstract: The present invention relates to novel hair treatment materials, and in particular materials for shaping hair and/or strengthening the hair. Also described are the use of these compounds in hair care formulations for shaping, straightening, strengthening or treating the hair, and the use of the compounds for hair straightening and/or hair strengthening.

Abstract: A blower includes a housing including an inlet and an outlet, a bearing-housing structure provided to the housing and adapted to rotatably support a rotor, a motor provided to the bearing-housing structure and adapted to drive the rotor, and an impeller provided to the rotor. The bearing-housing structure includes a bearing shaft having a bearing surface that rotatably supports the rotor. The bearing shaft provides only a single bearing of the non-ball bearing type for the rotor.

Abstract: A device for the detection of an open and unattended closure of an enclosure to prevent theft comprises a detector adapted to detect if the closure is open and a detector adapted to detect if the closure is unattended, the detectors being operably connected to an effector adapted to alert a user to the open and unattended condition of the closure.

Abstract: A regional anaesthesia injection apparatus comprising an injection volume determiner. The apparatus configured to determine a volume of a regional anaesthetic injection into a target tissue; an injection pressure determiner configured to determine a pressure of the injection; and a controller coupled to the injection volume determiner and to the injection pressure determiner and configured to provide an injection signal to control injection of fluid into the target tissue based on the determined pressure and the determined volume.

Abstract: An anesthetic administration device comprising an infusion device, which is in fluid connection with a regional anesthetic needle by means of a feed tube. The infusion device comprises one or more anesthetic flow devices capable of triggering forward flow, and optionally backward flow, of the local anesthetic through the regional anesthetic needle. Forward, and optionally backward flow, of the local anesthetic through the regional anesthetic needle is controlled by a controller that comprises one or more actuator switches. The one or more actuator switches are positioned on the device 1 such that they may be operated by hand.

Abstract: A needle retraction medical device including a hollow body (10) and a plunger (20). The hollow body (10) has a first end (11) provided with a needle mounting hub (13) and a plurality of releasable latches (15) holding the needle mounting hub (13) against spring (14) bias. The latches (15) are formed integrally with the hollow body (10) and project longitudinally inside the hollow body (10) from a proximal end at or adjacent the first end (11) of the hollow body (10) to a free end. A respective opening (35) is provided in the body (10) radially inwards of each of the latches (15). The plunger (20) has a forward end insertable into the body (10) from a second end thereof, a hollow interior and a closed rear end.

Abstract: Methods for treating Down syndrome and improving cognitive function of a patient with an intellectual disability are disclosed. 5-hydroxytryptamine sub-receptor six (5-HT6) receptor antagonists are provided for improving the cognition of a Down syndrome patient.