Abstract: A launched zipline amusement ride has a carrier 200 carrying a rider 202. The carrier 200 is adapted to move along a tensioned, suspended cable 102. A launch mechanism 300 engages with the carrier 200 between an engagement and a release position 304 to accelerate the carrier 200 along the cable 102, and to disengage from the carrier 200 at the release position 304.

Abstract: A passenger seating arrangement includes at least one seat unit configurable into a disabled-access configuration in which an access opening is temporarily widened to enable a disabled passenger to access the seat unit. The seat unit is arranged with other seat units in a column, and each seat unit is configurable between a seating configuration and a flat-bed configuration. The seat units are arranged in an inwardly facing herringbone. A method of providing access for a disabled passenger to a seat unit includes temporarily widening an access opening.

Abstract: An irrigation communicates wirelessly with irrigation control valves. A wireless controller transceiver unit obtains signals from the irrigation controller and transmits these signals wirelessly to a valve transceiver. The irrigation control valves open or close according to the signals received by the valve transceiver. The irrigation system also includes an auxiliary communication device that communicates user commands to the controller transceiver. The user commands are used to create associations between the controller transceiver and each of the valve transceivers. The communication link between the auxiliary communication device and the communication transceiver or the valve transceiver can be an RF communication link such as Bluetooth, a close field communication link such as an inductive communication link, or an optical communication link.

Abstract: Methods for establishing a second database and maintaining synchronization between a first database and the second database in a data management system are described. According to the method, a snapshot of a state of the first database may be acquired and mounted to a second server. The second database may be restored to the second server based on the mount. The second database may replicate the state of the first database. Synchronization may be enabled between the first database and the second database. One or more metrics associated with replication of data between the databases may be identified. A backup process for transaction logs associated with the first database may be initiated and the transaction logs may be mounted to the second server based on the metrics. One or more transactions may be applied to the second database based on the transaction logs mounted to the second server.

Abstract: A combination therapy including one or more compounds of formula (I): wherein R represents hydrogen, halo, cyano, C1-4 haloalkyl, C1-4 haloalkoxy, or SO2NR5R6, R1a and R1b independently represent hydrogen or halo; R2 represents hydrogen, halo, cyano, C1-4 alkyl, C1-4 alkoxy, or C1-4 haloalkoxy; R3 represents halo, cyano, C1-4 alkyl, or C1-4 hydroxyalkyl; R4 represents hydrogen or C1-4 alkyl; X represents CH or N; Y represents N or CH which carbon atom may optionally be substituted by R, R1a or R1b; R5 and R6 independently represent hydrogen or C1-4 alkyl; or a pharmaceutically acceptable salt thereof; and a second or further active ingredient.

Abstract: This invention relates to a therapeutic composition comprising i) at least two immune checkpoint inhibitors, ii) at least one drug selected from a cytokine a cytotoxic or cytostatic chemotherapeutic drug, and combinations thereof, and iii) a cancer vaccine prepared from tumor or cancer cells, or derivatives thereof, that have been prepared through an ex vivo treatment that creates necrotic and/or necroptotic cancer cells while minimizing destruction of cancer antigens. This invention also relates to a method of treating a tumor or a cancer in a patient comprising administering to a patient in need thereof the therapeutic composition in an amount effective to treat the tumor or cancer.

Abstract: Nonwoven fabrics may be fashioned as topical delivery systems with increased and controllable rate of product release, while still possessing the requisite strength and durability for mass production and distribution. Such delivery systems comprise fabrics that are fashioned from micro-denier fibers that are produced by fibrillating bicomponent island-in-the-sea fibers. Facial masks made from these fabrics can achieve adequate product delivery in 3-5 minutes or less.

Abstract: A linerbolt removal tool, including: a housing; a moil supported for reciprocating movement by the housing; an inertial body located within the housing; a gas charged accumulator extending from the inertial body away from the moil; a piston moveable within the inertial body between a striking position at which the piston strikes the moil and a retracted position, whereby firing the piston from its retracted position to its striking position includes causing pressurised gas within the accumulator to accelerate the piston toward the moil, wherein the piston has a striking end for striking the moil and an opposing rear end; and a piston cap that encloses the rear end of the piston, wherein during firing, the piston and the piston cap initially accelerate together and prior to the piston reaching its striking position the piston cap separates from the piston, whereby the piston cap isolates the piston from the accumulator.

Abstract: An oral appliance and a method of making the oral appliance for delivering a medicament to an oral cavity are provided. The method comprises forming a non-porous material into a portion of the oral appliance; and applying a porous material to one or more discrete regions of the portion of the oral appliance to make the one or more discrete regions of the oral appliance porous thereby forming the oral appliance.

Abstract: A method for generating and providing artificial intelligence assisted surgical guidance includes analyzing video images from surgical procedure and training a neural network to identify at least one of anatomical objects, surgical objects, and tissue manipulation in video images. The method includes receiving, by the neural network, a live feed of video images from the surgery. The method further includes classifying, by the neural network, at least one of anatomical objects, surgical objects, and tissue manipulation in the live feed of video images. The method further includes outputting, in real time, surgical guidance based on algorithms created using the classified at least on of anatomical objects, surgical objects, and tissue manipulations in the live feed of video images.

Abstract: Disclosed is a dry powder inhaler for delivering medicament from at least one blister pack, each blister pack having a plurality of spaced-apart blister pockets containing doses of the medicament. The inhaler comprises: a housing for accommodating unused and used portions of the at least one blister pack together with a dispensing mechanism for simultaneously opening at least two blister pockets at a time; and a manifold component through which air can be drawn in use of the inhaler.

Abstract: The present disclosure relates to antibiotic compositions and administration methods for treatment of chronic low back pain.

Abstract: Systems and method for determining a topic cohesion measurement between a content item and a hyperlinked landing page are presented. In one embodiment, a plurality of content item signals is generated for the content item and a corresponding plurality of signals are generated for the hyperlinked landing page. An analysis of the corresponding signals is conducted to determine a measurement of topic cohesion, a topic cohesion score, between the content item and the hyperlinked landing page. A cohesion predictor model is trained to generate the predictive topic cohesion score between an input content item and a hyperlinked landing page. Upon a determination that the topic cohesion score is less than a predetermined threshold, remedial actions are taken regarding the hyperlink of the content item. Alternatively, positive actions may be carried out, including promoting the content item to others, associating advertisements with the content item, and the like.

Abstract: Techniques for performing distributed rate limiting in networks in a cloud environment are described for determining an amount of network bandwidth available to be processed by flow control nodes within a cloud network for a first time period, determining a bandwidth allocation for traffic classes for the first time period, determining, a portion of the bandwidth allocation for the flow control nodes, providing, data to the flow control nodes, where the data indicates the portion of the bandwidth allocation for the traffic classes, and receiving, second data that indicates an amount of network traffic routed during the first time period by individual ones of the flow control nodes.

Abstract: Implementations described herein relate to methods, systems, and computer-readable media to localize dynamic content. In some implementations, a computer-implemented method includes receiving visual content associated with a game from a first client locale, the visual content including text being represented at the first client locale by a first language, converting the text to generate translated text in at least a second language associated with a second client locale, and storing the translated text in a database in association with the visual content.

Abstract: A method for determining a condition of a quantum computer is described. The method includes the steps of: providing a quantum computing system having a cryogenic chamber with at least one quantum computing chip inside the cryogenic chamber, wherein the at least one quantum computing chip is connected to at least one cable running through the cryogenic chamber; performing a time-domain reflectometry measurement on the cable, thereby obtaining measurement data; and determining a condition of the quantum computing system based on the measurement data obtained from the time-domain reflectometry measurement.

Abstract: Aspects of this disclosure relate to assigning scrambling identifiers to user equipments. A first scrambling identifier can be assigned to each user equipment of a group, such that the first scrambling identifier is the same for each of the user equipments of the group. A second scrambling identifier can be assigned to each of the user equipments of the group, such that the second scrambling identifier is different for each of the user equipments of the group. A selected scrambling identifier can be used to generate a reference signal sequence.

Abstract: A midsole for a shoe, where the midsole is 3D printed from an elastic polymeric material, the midsole comprising: a sole facing surface, a foot facing surface, a plurality of walls that in a first position are substantially perpendicular to the sole facing surface that extend from the sole facing surface to the foot facing surface where each wall has a height, where the plurality walls define a plurality of cells having a central axis that is substantially parallel to the walls and having a radius from a wall to the central axis, where the walls in a second position are configured to elastically deform upon application of an external force so that the deformation provides a change in the radius and/or the height, and where the walls are adapted to return to their first position upon removal of the external force.

Abstract: Techniques are described for deploying a virtualized computing environment configured in a user-specific configuration, the virtualized network function comprising a plurality of virtual machines. A solution definition file (SDF) identifies a configuration for the deployment. The SDF replaces each secret needed for the deployment with an identifier for the secret. A schema defines a format for each identifier for each secret included in the SDF and a format of the secrets. The secrets and corresponding identifiers are stored in a secure storage. The identifiers are sent to the deployed virtual machines, the identifiers being usable by the virtual machines to obtain the secrets from the secure storage.

Abstract: The methods and apparatus described enable automatic configuration, or commissioning, of controller devices and load control devices through a low voltage communication network controlled by one or more controller devices. These methods and apparatus further enable expansion of the load control system by connection of additional loads and or load control devices and or controller devices which will reinitialize the low voltage communication network and automatically reconfigure the controller devices and load control devices connected to the network.