Abstract: The present disclosure relates to the reversal of T cell exhaustion using aplysiatoxin analogs or PKC theta agonist compounds for anti-cancer immunotherapy. The treatment with aplysiatoxin analogs or PKC theta agonist compounds improve the anti-tumour activity of a T cell, inducing a NFAT-dependent T cell activation, increasing the pool of immune-checkpoint inhibitor responsive T cells, increasing lymphocyte infiltration and increasing the population of activated CD4+ and/or CD8+ cells. The methods of the present disclosure provide treatment of tumors and infections.

Abstract: In the field of aeronautics, there is disclosed an aircraft with reduced installation noise and specifically an aircraft wing and jet engine system including an aircraft wing and at least one jet engine with high bypass ratio attached to the wing, suitable for emitting a jet intercepted by a first portion of the trailing edge of the wing. The range formed by the set of angles with orientation ? defined by a vector following the direction of the jet and by a vector following the tangent at a point of the first portion of the trailing edge and oriented towards the wing tip of the wing, is included within a range of angles selected from the range delimited by 5° and 65°, and the range delimited by 115° and 175°.

Abstract: The invention relates generally to monitoring and managing network components, such as monitoring the network components to determine the vulnerabilities of network components, implementing remediation plans for the vulnerabilities, instituting remediation suppression for the vulnerabilities, and taking consequence actions for the vulnerabilities when remediation is no longer suppressed and fails to be implemented. Remediation suppression may be implemented for the vulnerability when the vulnerability is determined to be an acceptable vulnerability. The remediation suppression may be based on a request from a user, based on organization policy, and/or based on logic determining that the vulnerability is acceptable. When the remediation suppression occurs at least a part of the remediation plan, consequence action, and/or reporting is suppressed.

Abstract: The present disclosure provides methods of treating a viral infection comprising administering a protease inhibitor, optionally conjointly with an anticoagulant therapy and/or antiviral agent.

Abstract: The invention relates generally to monitoring and managing network components, such as monitoring the network components to determine the vulnerabilities of network components, implementing remediation plans for the vulnerabilities, instituting remediation suppression for acceptable uses, instituting network component exceptions and rolling exceptions to other network components automatically, and taking consequence actions for the vulnerabilities. A network component exception may be implemented for a network component when the network component data meets custom criteria. When the custom criteria is met, the network component is automatically rolled into the network component exception process to automatically associate network component exceptions with network components that have data that meets the custom criteria. The network component exceptions prevent vulnerability actions from being taken with respect to the associated network components.

Abstract: The invention relates generally to monitoring and managing network components, such as monitoring the network components to determine the vulnerabilities of network components, implementing remediation plans for the vulnerabilities, instituting remediation suppression for the vulnerabilities, and taking consequence actions for the vulnerabilities when remediation is no longer suppressed and fails to be implemented. Remediation suppression may be implemented for the vulnerability when the vulnerability is determined to be an acceptable vulnerability. The remediation suppression may be based on a request from a user, based on organization policy, and/or based on logic determining that the vulnerability is acceptable. When the remediation suppression occurs at least a part of the remediation plan, consequence action, and/or reporting is suppressed.

Abstract: The invention relates generally to monitoring and managing network components, such as monitoring the network components to determine the vulnerabilities of network components, implementing remediation plans for the vulnerabilities, instituting remediation suppression for acceptable uses, instituting network component exceptions and rolling exceptions to other network components automatically, and taking consequence actions for the vulnerabilities. A network component exception may be implemented for a network component when the network component data meets custom criteria. When the custom criteria is met, the network component is automatically rolled into the network component exception process to automatically associate network component exceptions with network components that have data that meets the custom criteria. The network component exceptions prevent vulnerability actions from being taken with respect to the associated network components.

Abstract: A traffic routing display system provides a visual display of a speed or series of speeds suggested to the driver such that the driver may pass through multiple consecutive traffic signal devices without stopping at a red light. In one aspect, the display depicts the expected state of an upcoming traffic light. In another aspect, the display is an icon colored to correspond to the expected state. In another aspect, the time remaining before the state of a traffic light changes is displayed. The effect that an indicator has on driver behavior is used to determine the type of indicator to provide to the driver. Certain indicators may not be displayed by the system depending on the effect they have on the driver.

Abstract: In the field of aeronautics, there is disclosed an aircraft with reduced installation noise and specifically an aircraft wing and jet engine system including an aircraft wing and at least one jet engine with high bypass ratio attached to the wing, suitable for emitting a jet intercepted by a first portion of the trailing edge of the wing. The range formed by the set of angles with orientation ? defined by a vector following the direction of the jet and by a vector following the tangent at a point of the first portion of the trailing edge and oriented towards the wing tip of the wing, is included within a range of angles selected from the range delimited by 5° and 65°, and the range delimited by 115° and 175°.

Abstract: A traffic routing display system provides a visual display of a speed or series of speeds suggested to the driver such that the driver may pass through multiple consecutive traffic signal devices without stopping at a red light. In one aspect, the display depicts the expected state of an upcoming traffic light. In another aspect, the display is an icon colored to correspond to the expected state. In another aspect, the time remaining before the state of a traffic light changes is displayed. The effect that an indicator has on driver behavior is used to determine the type of indicator to provide to the driver. Certain indicators may not be displayed by the system depending on the effect they have on the driver.

Abstract: The invention relates to a rear casing for a turbine engine comprising a primary body generating a primary flow (10) to be ejected through a primary nozzle (6), said rear casing (7) being shaped so as to be positioned downstream from the primary body and to define, on the inside of the turbine engine, the path followed by the primary flow downstream from the primary nozzle (6). The tail cone is characterised in that it comprises a connection to a system for supplying a pressurised gas and at least one perforation (8) for injecting the pressurised gas through the perforation and into the primary flow. The casing preferably comprises at least one means for rotating same about the axis of rotation of the mobile elements of the primary body.

Abstract: A valve assembly for high pressure applications includes a pre-charge chamber in fluid communication with a first bellows, at least one inlet for pressurized gas to enter the assembly, a system poppet and an outlet for releasing pressurized gas into a desired environment. The pre-charge chamber and first bellows are filled with pre-charge gas to a threshold pressure. Pressurized gas can flow through access channels into a second bellows, which expands to move a valve shaft connected to the poppet assembly to open the poppet and allow the release of gas. The expansion of the second bellows pushes incompressible fluid disposed between the two bellows against the first bellows, thus contracting the first bellows. The gas within each bellows maintains an internal pressure equal to the pressure exerted upon each bellows by the incompressible fluid, so as to minimize differential pressure across the bellows in the extended position.

Abstract: A valve assembly for high pressure applications includes a pre-charge chamber, at least one inlet for pressurized gas to enter the assembly, a system poppet and an outlet for releasing pressurized gas into a desired environment. Pressurized gas can flow through access channels into a single bellows, which expands to move a shaft connected to the system poppet to open the poppet. In another embodiment, the pre-charge chamber compresses a first bellows to expand a second bellows, and vice versa upon reciprocation. The two bellows are hydraulically connected and filled with incompressible fluid. Each bellows has an internal limiting valve to retain incompressible fluid therewithin, and to preclude the complete nesting of either of the bellows. The retained fluid within the bellows maintains an internal pressure to minimize differential pressure, thereby minimizing the risk of bellows failure.

Abstract: An electrical connector for terminating an electrical cable and for engaging with a mating electrical connector comprises a body, resilient member, and a collar. The body has an engagement portion including a sleeve which extends in a longitudinal direction for engaging with the mating electrical connector. The sleeve comprises a keyway configured to receive a keyed mating connector. The resilient member is arranged on the sleeve and can deform in a transverse direction perpendicular to the direction and provide a reaction force for maintaining the engagement of the connector with the mating connector. The collar is configured to rotate about the sleeve, and comprises a radially inwardly protruding pin which extends into the sleeve and can be moved between two positions. One position is within the keyway between the key of the mating connector and the keyway opening such that the pin prevents axial disengagement of the connector.

Abstract: An electrical connector for mounting to a flexible substrate and for coupling with a mating connector having a low-profile. The connector comprises a cover portion arranged to extend in a plane parallel to the substrate so as to cover a mounting hole in the substrate. The connector further comprises a body portion comprising a connection port projecting from the cover portion, the connection port having electrical contacts within an end face of the port. The body portion further comprising an alignment collar arranged circumferentially around the connection port, the alignment collar being provided with an alignment feature at a discrete circumferential position for angularly aligning the mating connector with respect to the connection port.

Abstract: An angled electrical connector has a body having an engagement portion including a sleeve which extends in a longitudinal first direction for engaging with a mating electrical connector. The sleeve has a cylindrical inner portion at the base of the sleeve and a tapered portion, such that the opening of the sleeve is larger than the base. A corresponding receptacle part is also provided, having a projecting connection port, with a corresponding cylindrical portion at or near the end.

Abstract: The present invention provides processing system that comprises an issuer function and a merchant function as part of a card processor. The issuer function is arranged to receive a first authorisation request from a first card scheme administrator associated with a first transaction card, the first authorisation request relating to a card transaction made by a cardholder using the first transaction card at a card acceptor and including a number of data elements. A mapping function is provided in the card processor that is arranged to convert the first authorisation request into a second authorisation request, the second authorisation request relating to a transaction associated with an account held with an institution, wherein the mapping function is arranged to use contents of at least some of the data elements of the first authorisation request to form the second authorisation request.

Abstract: An electrical connector for mounting to a flexible substrate and for coupling with a mating connector having a low-profile. The connector comprises a cover portion arranged to extend in a plane parallel to the substrate so as to cover a mounting hole in the substrate. The connector further comprises a body portion comprising a connection port projecting from the cover portion, the connection port having electrical contacts within an end face of the port. The body portion further comprising an alignment collar arranged circumferentially around the connection port, the alignment collar being provided with an alignment feature at a discrete circumferential position for angularly aligning the mating connector with respect to the connection port.

Abstract: An electrical connector for terminating an electrical cable and for engaging with a mating electrical connector comprises a body, resilient member, and a collar. The body has an engagement portion including a sleeve which extends in a longitudinal direction for engaging with the mating electrical connector. The sleeve comprises a keyway configured to receive a keyed mating connector. The resilient member is arranged on the sleeve and can deform in a transverse direction perpendicular to the direction and provide a reaction force for maintaining the engagement of the connector with the mating connector. The collar is configured to rotate about the sleeve, and comprises a radially inwardly protruding pin which extends into the sleeve and can be moved between two positions. One position is within the keyway between the key of the mating connector and the keyway opening such that the pin prevents axial disengagement of the connector.

Abstract: A valve assembly for high pressure applications includes a pre-charge chamber in fluid communication with a first bellows, at least one inlet for pressurized gas to enter the assembly, a system poppet and an outlet for releasing pressurized gas into a desired environment. The pre-charge chamber and first bellows are filled with pre-charge gas to a threshold pressure. Pressurized gas can flow through access channels into a second bellows, which expands to move a valve shaft connected to the poppet assembly to open the poppet and allow the release of gas. The expansion of the second bellows pushes incompressible fluid disposed between the two bellows against the first bellows, thus contracting the first bellows. The gas within each bellows maintains an internal pressure equal to the pressure exerted upon each bellows by the incompressible fluid, so as to minimize differential pressure across the bellows in the extended position.