Abstract: Ablation systems, components thereof, and related methods are disclosed. An example ablation system may include a first ablation component including a first ablation component end effector configured to be positioned on a first side of a target tissue and a second ablation component including a second ablation component end effector configured to be positioned on a second side of the target tissue. The first ablation component may include a first ablation component permanent magnet that is translationally repositionable between an engaged configuration and a disengaged configuration. The second ablation component may include a second ablation component permanent magnet that is freely rotatable and is configured to rotatably self-orient into a magnetically attractive orientation with the first ablation component permanent magnet.

Abstract: Medical devices for applying a cinch to a suture and methods for making and using such devices are disclosed. An example medical device may include an elongated shaft including a proximal region and a distal region. The distal region may define a lumen having a lumen dimeter, and a distally facing end surface. The medical device may also include an outer cinch member defining a bore and having an outer surface defining a shoulder. An elongated inner shaft may extend through and be longitudinally movable within the lumen and the bore and including a distal end section. An inner cinch member may be engaged with the distal end section of the elongated inner shaft.

Abstract: A technique updates a first data-processing engine based on reference information produced by a second data-processing engine. The technique involves obtaining ordered sets of result items from both engines, where the result items produced by the second engine serve the role of the reference information. The technique then produces accuracy information by assessing the accuracy of the first-set result items relative to the second-set result items. The accuracy information is a set-wide assessment that reflects how well the first-set result items match the second-set result items, taking into account the similarity between pairs of result items and the ordering of result items in the ordered sets. The technique then modifies a configuration of the first data-processing engine based on the accuracy information to improve its quality. In some implementations, the first and second data-processing engines are first and second map engines that generate routes through a physical space.

Abstract: Methods, devices and kits for sampling, releasing and stabilizing nucleic acid, including RNA and DNA, from virus, bacteria yeast and other cells is described. The released and stabilized nucleic acid may be analyzed and quantified without further sample preparation at the point of care or may be transported to a testing laboratory by shipment and analyzed directly. The nucleic acid, which can be RNA, remains safe and stable so that shipping by normal means including government postal service may be used. In addition, the RNA sample remains stable so that analysis can be performed immediately after receipt of sample or after storage for days, weeks or months. Storage may be at room or ambient temperature or cooler temperatures. The sampling apparatus used to acquire samples can interface with nucleic detection and measurement instrumentation including high throughput, parallel processing instruments.

Abstract: Disclosed herein are devices, apparatuses and methods for generating self-sustaining gaseous and non-gaseous gradients across a cell support structure and for culturing one or more cells or tissues under hypoxic conditions. Methods of generating one or more gas gradients across a cell support structure include providing a luminal container having a bottom wall that is a gas permeable membrane, positioning a cell support structure above the bottom wall, positioning one or more cells or tissues on the cell support structure, and generating one or more gas gradients between the bottom wall, across the cell support structure and into a luminal reservoir. An apparatus to produce hypoxic conditions for cell cultures includes a luminal container having a bottom wall, a cell support structure on the bottom wall, and a cover that sealably closes the open top, such that a hypoxic condition can be generated in the luminal reservoir.

Abstract: In certain aspects, the disclosure relates to an immune cell that has been engineered to comprise one or more heterologous polynucleotides that promote thanotransmission by the immune cell. The immune cell may also comprise one or more nucleic acid sequences that encode a chimeric antigen receptor (CAR). Methods of promoting thanotransmission, promoting immune response, and treating cancer using the engineered immune cells are also disclosed.

Abstract: In embodiments, a glass includes from 45 mol % to 70 mol % SiO2; from 11.5 mol % to 25 mol % Al2O3; from 2 mol % to 20 mol % Li2O; from greater than 0 mol % to 10 mol % Na2O; from 9 mol % to 19 mol % MgO; from 4 mol % ZrO2; and from 0 mol % to 0.5 mol % TiO2. In other embodiments, a glass includes from 45 mol % to 70 mol % SiO2; from 4 mol % to 25 mol % Al2O3; from 5 mol % to 20 mol % Li2O; from 0.1 mol % to 10 mol % Na2O; from 6 mol % to 25 mol % MgO; from 0.1 mol % to 4 mol % ZrO2; from 0.1 mol % to 5 mol % K2O; and from 0.05 mol % to 0.5 mol % SnO2.

Abstract: A training process produces a machine-learned model that, once trained, can be applied to process different types of data items. The training process accomplishes this result by combining data items in a training set with type-specific parameter information, to produce supplemented data items. The training process then trains a model based on the supplemented data items. Training involves adjusting model weights together with the type-specific parameter information. In an inference stage of processing, the technology combines a new data item with an appropriate type of trained parameter information, and then maps the resultant supplemented data item to an output data item. The technology is particularly effective in adapting an initial model to a new subject matter domain in those situations in which a robust set of data items that pertain to the subject matter domain and which have a desired type is lacking.

Abstract: An embodiment of the present invention is a liquid ejection head, including: multiple ejection ports; multiple pressure chambers; a printing element substrate on which a printing element is arrayed in which a supply flow channel that extends in a direction in which the multiple pressure chambers are arrayed and that supplies the multiple pressure chambers with a liquid and a collection flow channel that extends in the direction and that collects the liquid from the multiple pressure chambers are provided; and at least two or more bypasses as flow channels that do not pass through the pressure chambers, in which the at least two or more bypasses include at least one of two or more bypasses for each supply flow channel and two or more bypasses for each collection flow channel.

Abstract: A computing system includes a processor, a network interface controller configured to communicate via a black network, a gray network and a red network; a virtual desktop infrastructure application including computer-executable instructions configured to: perform systematic monitoring; remediate a network vulnerability finding; and notify a user; and a service management application. A computer-implemented method includes configuring a network interface controller to communicate via a black network, a gray network and a red network; accessing a service management application; performing systematic monitoring; remediating a network vulnerability finding; and notifying a user.

Abstract: The disclosed invention relates to a padlock comprising a U-shaped-shackle. The invention discloses a sleeve that fits tightly, mostly covering or surrounding a portion of the straight portion of the shackle-toe and wherein the sleeve also fits loosely and mostly covering or surrounding a small portion of the U-shaped-shackle-head nearest the shackle-toe. The sleeve being designed to deter a jawed manual bolt-cutting tool from cutting apart the shackle-toe of a padlock that comprises a U-shaped shackle. The sleeve also being designed large enough to be prevented from being pulled through the hole, staple, or link the padlock shackle is secured therein, therefore, mandating the shackle-toe remains in the hole, staple, or link the shackle-toe is secured therein.

Abstract: Ion-exchanged alkali aluminosilicate glass articles with a ratio of peak compressive stress value to Young's modulus value of 14 or more. The glass articles may include Al2O3 mol %+RO mol %?18 mol %, where RO mol %=MgO mol %+CaO mol %, and be substantially free of ZnO, SrO, BaO, B2O3, P2O5, Li2O, and K2O. The glass articles may have a peak compressive stress value in a range of 850 MPa to 1400 MPa. The glass articles are suitable for various high-strength applications, including cover glass applications that experience significant bending stresses during use, for example, cover glasses for flexible displays.

Abstract: A microprocessor system comprises a computational array and a vector computational unit. The computational array includes a plurality of computation units. The vector computational unit is in communication with the computational array and includes a plurality of processing elements. The processing elements are configured to receive output data elements from the computational array and process in parallel the received output data elements.

Abstract: Glass-based articles are provided that exhibit improved fracture resistance. The relationships between properties attributable to the glass composition and stress profile of the glass-based articles are provided that indicate improved fracture resistance.

Abstract: Disclosed herein are testing apparatuses for testing stresses in substrates. The testing apparatus includes a base, a first plate coupled to the base, the first plate being movable relative to the base along a first axis, a second plate coupled to the base, the second plate being movable relative to the base and relative to the first plate along a second axis that is perpendicular to the first axis, a first actuator operable to move the first plate along the first axis towards or away from the second plate, a second actuator operable to move the second plate along the second axis relative to the first plate, and a controller operatively connected to the first actuator and the second actuator operable to control movement of the first plate and the second plate.

Abstract: A laminated glass article comprises a core layer comprising a core glass composition having an average core coefficient of thermal expansion (CTEcore) and a clad layer directly adjacent to the core layer and comprising a clad glass composition having an average clad coefficient of thermal expansion (CTEclad) that is less than the CTEcore such that the clad layer is in compression and the core layer is in tension. A compressive stress of the clad layer increases with increasing distance from the outer surface of the clad layer, transitions to a minimum tensile stress as a step-change at an interface region between the core layer and the clad layer, and a magnitude of the tensile stress increases continuously to a maximum tensile stress in the core layer. Other stress profiles, and methods of preparing laminated glass articles are also disclosed.

Abstract: The invention relates to a method for arranging an element, such as a shower board or shower drain, in a floor, which method includes the steps of: providing an element which has an upper surface with at least two straight edges lying at an angle, preferably an angle of 90 degrees. The element has a strip of a flexible watertight layer standing upright from the upper surface along the corner of the two straight edges; folding the upright strip downward, wherein the folding edge is shaped adjacently of the two straight edges of the corner and wherein the strip of the flexible watertight layer hangs downward from this folding edge; and arranging the element in the floor. The upper surface of the floor lies flush with the upper surface of the element.

Abstract: A system for controlling a plurality of motors includes: a variable frequency drive (VFD) configured to control at least one property of the motors, the VFD having a current interruption rating that is greater than a continuous current rating of all of the plurality of motors combined; a bus electrically connected to the VFD; and a plurality of protection modules, each protection module including: a motor overload device electrically connected to a particular one of the plurality of motors; and a switching relay in series with the motor overload device, the switching relay configured to connect the protection module to and disconnect the protection module from the bus. A state of the switching relay determines whether the protection module is electrically connected to the bus, the VFD is configured to control the state of the switching relay, and the switching relay has a current interruption rating that is less than the continuous current rating of the particular one of the plurality of motors.

Abstract: An extruder or other similar tool head of a three-dimensional printer is slidably mounted along a feedpath of build material so that the extruder can move into and out of contact with a build surface according to whether build material is being extruded. The extruder may be spring-biased against the forward feedpath so that the extruder remains above the build surface in the absence of applied forces, and then moves downward into a position for extrusion when build material is fed into the extruder. In another aspect, modular tool heads are disclosed that can be automatically coupled to and removed from the three-dimensional printer by a suitable robotics system. A tool crib may be provided to store multiple tool heads while not in use.

Abstract: A laminated glass article comprises a core layer comprising a core glass composition, and a cladding layer directly adjacent to the core layer and comprising a clad glass composition. A stress of the cladding layer increases with increasing distance from an outer surface of the cladding layer from a compressive stress to a tensile stress, transitions to a compressive stress as a step-change at an interface region between the core layer and the cladding layer, and increases with increasing distance from the interface region to a center of the core layer from the compressive stress to a tensile stress.