Abstract: A cleaning card for use in cleaning internal surfaces of machine components, including internal, rotatable idler rolls, includes a substrate having a central plane between opposed surfaces thereof, a machine direction dimension defined between opposed end edges and a transverse direction dimension defined between opposed side edges. The substrate includes an angled embossment forming angled, substantially non-collapsible, elongate raised ridges on opposite sides of the cleaning card substrate, with the raised ridges being oriented at an angle to the machine direction for incrementally engaging an idler roll surface along its axial extent as the raised ridges pass through a nip including the idler roll to aid in both rotating and cleaning one or more idler rolls. In preferred embodiments the opposed surfaces of the substrate each have a plurality of discrete, raised and collapsible working areas for engaging and cleaning internal surfaces of machine components in addition to idler rolls.

Abstract: The invention provides polyglutamic acid-therapeutic agent conjugates and methods for their preparation and use.

Abstract: In an interface circuit for connection to an output of a frequency converter, at least two current paths are coupled to one another in parallel. Each current path includes at least one cascode stage for signal processing. The circuit compensates for DC voltage offsets of the frequency converter, and has a gain ratio that can be changed over for signals with a large dynamic range.

Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-? activity.

Abstract: Disclosed are compounds having selective hydrolytic potential. The disclosed compounds are useful as compounds having selective stability and are capable of undergoing programmed hydrolysis in biologic systems.

Abstract: A transdermal therapeutic system in patch form for the controlled delivery of active substances to the human or animal skin comprises a backing layer, an active substance-containing reservoir attached thereto and a detachable protective layer, is characterized in that the active substance-containing reservoir contains as main components thereof at least one film former as well as at least one polymer which prevents or suppresses the crystallisation of the active substance or active substances.

Abstract: The invention relates to a method for the production of biperiden by reacting an exo/endo mixture of 1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone with a phenyl magnesium compound to form an isomer mixture of 1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-piperidino-1-propanol, whereby biperiden is obtained therefrom by conversion of said mixture into corresponding hydrochloride, isolation of said hydrochloride, reconversion to the free base and crystallization of said biperiden.

Abstract: A method of endovenous laser treatment in disclosed. An introducer sheath 40 is introduced into a vein and an optical fiber 12 is introduced through the introducer sheath until a first marking 45 on the optical fiber 12 indicates that the distal end of the optical fiber 12 is substantially in alignment with the distal end of the introducer sheath 40. The introducer sheath 40 is then withdrawn relative to the optical fiber 12 until a second marking 46 on the optical fiber 12 indicates that the distal end of the optical fiber 12 extends a predetermined distance beyond the distal end of said introducer sheath 40. Laser radiation is passed down the optical fiber 12 so that laser radiation is delivered to the inner wall of the vein and the introducer sheath 40 together with the optical fiber 12 are withdrawn a certain distance along the vein.

Abstract: A medical laser device is disclosed comprising an optical fiber 12 having markings 45, 46 which enable the optical fiber 12 to be accurately positioned relative to an introducer sheath 40. The introducer sheath 40 may also have graduated markings to enable the sheath 40 to be withdrawn at a controlled rate. A pulsed or continuous laser source may be provided.

Abstract: A cleaning card for cleaning internal surfaces of a machine-actuating mechanism includes a substrate having a central plane between opposed surfaces thereof, a machine direction dimension defined between opposed end edges and a transverse direction dimension defined between opposed side edges. The opposed surfaces each have a plurality of discrete raised areas providing a plurality of transversely extending rows of discrete raised areas. At least some of the discrete raised areas in at least some of the transversely extending rows extend outwardly on each side of the central plane. The discrete raised areas each include a peak and a peripheral wall joined at one edge to the peak and having an opposed edge that is closer to the central plane than the peak. The cleaning substrate has an effective thickness between the opposed surfaces that is greater than the nominal thickness between those surfaces.

Abstract: An automated device for collecting breath samples, which includes pre-programmed protocols for specified breath collection procedures and pre-programmed voice chips connected to a speaker that audibly guide a patient or subject through the breath collection process. The device includes an inlet and a breath reservoir for collecting a sample before diverting it to a vessel via a valve manifold with a plurality of valves, each associated with breath collection vessel.

Abstract: A dispersion powder composition based on water-insoluble polymers with particularly low water absorption comprises, based on the total weight of the polymer, an amount in the range from 0.1 to 30% by weight of at least one carboxylic ester whose acid component has at least 6 carbon atoms and whose alcohol component is a polyhydroxy compound, preferably glycerol, diglycerol, or triglycerol. This is prepared by mixing polymer and protective colloid with the carboxylic ester to prepare a dispersion and then, where appropriate, drying this with simultaneous admixing of an anticaking agent, and gives good results when used for modifying wallpaper pastes, mortars, or concrete.

Abstract: An automated method for dispensing pharmaceuticals particularly tablets and capsules, and other small discrete objects, includes: receiving prescription information, selecting a container, labeling the container, dispensing the tablets or capsules into the labeled container, applying a closure to the filled, labeled container, and offloading the container to a designated location. Preferably, the tablets are dispensed with high speed dispensing bins that employ forced air to agitate and singulate the tablets. The other functions within the system are typically carried out at stations designed to offer speed, flexibility and precision to the dispensing operation.

Abstract: In an interface circuit for connection to an output of a frequency converter, at least two current paths are coupled to one another in parallel. Each current path includes at least one cascode stage for signal processing. The circuit compensates for DC voltage offsets of the frequency converter, and has a gain ratio that can be changed over for signals with a large dynamic range.

Abstract: Novel heterocyclic compounds having a six membered ring structure fused to a five membered ring structure are found to be useful for the treatment and prevention of symptoms or manifestations associated with disorders affected by Interleukin-12 (“IL-12”) intracellular signaling, such as, for example, Th1 cell-mediated disorders. The therapeutic compounds, pharmaceutically acceptable derivatives (e.g., resolved enantiomers, diastereomers, tautomers, salts and solvates thereof) or prodrugs thereof, have the following general formula: Each X, Y and Z are independently selected from a member of the group consisting of C(R3), N, N(R3) and S.

Abstract: The invention relates to pyridines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity and/or proliferation of cells such as tumor cells.

Abstract: The invention relates to a flat and activable drying device for reducing the moisture content of a gas space surrounding said device and to a method for producing a device of this type. The inventive drying device contains a flat matrix with at least one regenerable drying agent.

Abstract: The invention refers to a method which generates an IC tester control consisting of numerous test instructions for a plurality of specific test environments, which can generate and measure analog and digital signals for an IC, in particular a mixed-signal IC. The method obtains data and control instructions from multidimensional test matrices independent of the test environment, such as matrix-like databases or libraries. The data and control instructions independent of the test environment are converted by means of a code generator into a syntax which is dependent on the test environment and which can be integrated into a general syntax dependent on the test environment, so that the syntax dependent on the test environment and the general syntax dependent on the test environment together form a complete control, comprising analog and digital signals, for one of the specific test environments.

Abstract: The invention relates to a method for the production of biperiden by reacting an exo/endo mixture of 1-(bicyclo[2.2.1.]hept-5-en-2-yl) 3-piperidino-1-propanone with a phenyl magnesium compound, wherein the exo/endo ratio of 1-(bicylo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone is at least 4.5:1.

Abstract: Novel pyridopyrimidine-based compounds are found to be useful for the treatment or prevention of symptoms or manifestations associated with diseases or disorders affected by cytokine intracellular signaling.