Abstract: The present invention relates to a conditioning regimen for the transplant of a cell to a subject, optionally wherein the cell is a hematopoietic stem/progenitor cells (HSPC), a CAR cell or a platelet. The invention also relates to methods for the prevention or treatment of a disease or condition in a subject by administration of a cell transplant, wherein said administration comprises the conditioning regimen of the invention.

Abstract: A heat pipe for a small modular reactor includes: an evaporator portion fabricated of a first material; and a condenser portion fabricated of a second material, the evaporator portion and the condenser portion being joined to define an interior containing a working fluid. The first material has a lower neutron capture cross section than the second material. The second material has a higher oxidation resistance above 150° C. than the first material.

Abstract: A circuit for controlling a switch of a power converter. The circuit includes loop control circuitry configured to generate a control signal based on a feedback signal for the power converter and undervoltage circuitry. The undervoltage circuitry is configured to compare a voltage for a capacitor of the power converter with a voltage threshold. The undervoltage circuitry is further configured to, in response to the voltage for the capacitor of the power converter being greater than the voltage threshold, generate a switching signal to drive a switch of the power converter based on the control signal. The undervoltage circuitry is further configured to, in response to the voltage for the capacitor of the power converter being less than the voltage threshold, generate the switching signal to drive the switch of the power converter to the switched-in state until an inductor current is greater than an electrical current threshold.

Abstract: A filter system for use with a suction canister or suction bag is disclosed, where the filter system includes a first filter and a second filter for retention of particles, smoke aerosols, liquids, aerosolized viruses, and aerosolized bacteria, while maintaining high airflow and liquid retention. The first filter and the second filter are each multi-layered for performance. In various examples, the first and second filters are configured to integrate directly with the vacuum port of a suction canister lid.

Abstract: Methods of performing neural experiments on neuron-bearing living (NBL) organisms that include tracking movement of one or more NBL organisms via at least one first imaging objective and simultaneously collecting neural activity data via at least one second imaging objective. In some embodiments, the at least one first imaging objective is positioned along a first optical microscope light path and the at least one second imaging objective is positioned along a second optical microscope light path. In some embodiments, the first optical microscope light path is one of an inverted light path and an upright light path, and the second optical microscope light path is the other of the inverted light path and the upright light path. Various related methods, hardware, and software are also disclosed.

Abstract: A circuit for controlling a switch of a power converter. The circuit includes loop control circuitry configured to generate a control signal based on a feedback signal for the power converter and undervoltage circuitry. The undervoltage circuitry is configured to compare a voltage for a capacitor of the power converter with a voltage threshold. The undervoltage circuitry is further configured to, in response to the voltage for the capacitor of the power converter being greater than the voltage threshold, generate a switching signal to drive a switch of the power converter based on the control signal. The undervoltage circuitry is further configured to, in response to the voltage for the capacitor of the power converter being less than the voltage threshold, generate the switching signal to drive the switch of the power converter to the switched-in state until an inductor current is greater than an electrical current threshold.

Abstract: The present disclosure pertains to systems and methods for providing search results. A database server may include both a database and a search engine. The database server can receive a search request from an application of a remote computer. The search request can include one or more search terms and permission information. The database server can determine adapting information using the permission information. The database server can provide a search call based on the search request and the adapting information to the search engine. The search engine can determine one or more search statements for the search call. The search engine can execute the one or more search statements on one or more stored search models to obtain database results reflecting the permission information. The database server can provide search results based on the database results to the application of the remote computer.

Abstract: The present disclosure pertains to systems and methods for providing search results. A database server can include both a database and a search engine. The database server can receive, from a software service server, storage metadata indicating a plurality of tables of the database and fields of each of the plurality of tables. The database can generate a metadata search index, including tables and fields populated based on the storage metadata, and store it on the database. The database server may receive a search request including one or more search terms from a query-building application of a remote computer. The search engine can determine search statements based on the search request and execute the search statements on a view of the stored metadata search index to obtain index search results. Metadata search results based on the index search results can be provided to the query-building application.

Abstract: The present disclosure pertains to systems and methods for providing search results. A database server may include both a database and a search engine. The database server can receive a search request from an application of a remote computer. The search request can include one or more search terms and permission information. The database server can determine adapting information using the permission information. The database server can provide a search call based on the search request and the adapting information to the search engine. The search engine can determine one or more search statements for the search call. The search engine can execute the one or more search statements on one or more stored search models to obtain database results reflecting the permission information. The database server can provide search results based on the database results to the application of the remote computer.

Abstract: The present disclosure pertains to systems and methods for providing search results. A database server can include both a database and a search engine. The database server can receive, from a software service server, storage metadata indicating a plurality of tables of the database and fields of each of the plurality of tables. The database can generate a metadata search index, including tables and fields populated based on the storage metadata, and store it on the database. The database server may receive a search request including one or more search terms from a query-building application of a remote computer. The search engine can determine search statements based on the search request and execute the search statements on a view of the stored metadata search index to obtain index search results. Metadata search results based on the index search results can be provided to the query-building application.

Abstract: The present invention provides an extracellular anti-linker/label epitope chimeric antigen receptor (anti-LLE CAR) comprising I) a linker/label epitope (LLE) binding domain, II) a transmembrane domain, and III) a signal transduction domain, wherein said extracellular LLE binding domain binds a target cell binding molecule (TCBM) comprising i) an antigen binding moiety (ABM), wherein said ABM binds specifically to an antigen expressed on a target cell, ii) a label moiety (LaM), wherein said LaM is a naturally occurring molecule in a subject or a derivative thereof, iii) a linker moiety (LiM) conjugating said ABM and said LaM, thereby forming a linker/label epitope (LLE), wherein said extracellular LLE binding domain binds said LLE with a higher preference than said naturally occurring molecule.

Abstract: The present invention discloses a device for rolling up and unrolling a material web (2) on a shaft (1, 15). The device is distinguished by the fact that a first radial spacing (R1) of the material web (2) from a rotational axis of the shaft (1, 15), which first radial spacing (R1) is assigned to any desired unrolled length (L) of the material web (2), differs from a second radial spacing (R2) of a tensioning cable (3, 16) from the rotational axis of the shaft (1, 15), which second radial spacing (R2) is assigned to said unrolled length (L), with the result that the direction and magnitude of a first torque which is exerted on the shaft (1, 15) via the material web (2) differ from those of a second torque which is exerted on the shaft (1, 15) via the tensioning cables (3, 16), in such a way that, on account of the torque difference between the first torque and the second torque, the shaft (1, 15) is driven by a force (F) which is transmitted by means of the tensioning cables (3, 16).

Abstract: The present invention discloses a device for rolling up and unrolling a material web (2) on a shaft (1, 15). The device is distinguished by the fact that a first radial spacing (R1) of the material web (2) from a rotational axis of the shaft (1, 15), which first radial spacing (R1) is assigned to any desired unrolled length (L) of the material web (2), differs from a second radial spacing (R2) of a tensioning cable (3, 16) from the rotational axis of the shaft (1, 15), which second radial spacing (R2) is assigned to said unrolled length (L), with the result that the direction and magnitude of a first torque which is exerted on the shaft (1, 15) via the material web (2) differ from those of a second torque which is exerted on the shaft (1, 15) via the tensioning cables (3, 16), in such a way that, on account of the torque difference between the first torque and the second torque, the shaft (1, 15) is driven by a force (F) which is transmitted by means of the tensioning cables (3, 16).

Abstract: Determining the association between data objects may be accomplished using any of a variety of systems and techniques. In particular implementations, a system and technique may have the ability to receive a group of data objects and execute a matching algorithm to determine duplicate data object propositions between the data objects. The system and technique also may have the ability determine whether a data object is a potential duplicate data object and, if a data object is a potential duplicate data object, determine whether the data object is a duplicate data object by examining duplicate data object propositions of a plurality of data objects that are associated with the data object through duplicate data object propositions.

Abstract: The present document describes a sensing apparatus for lowering into a well and cementing therein at a certain depth. The sensing apparatus comprises an elongated casing and a sensor device protruding from an outside surface of the elongated casing for generating measurement data and sending the data to the surface of the well using a cable extending from the sensor device along the outside surface of the casing. A flow of cement is provided between the outside surface of the casing and the well for cementing the casing in place and isolating different layers of the well. Presence of the sensor device and the cable creates an obstruction within the flow path of the cement which may result in the formation of micro-annulus around the sensor device and the cable.

Abstract: A method is provided for determination of an operating temperature in a thermally highly loaded device. Multiple individual passive measurement elements, having a measurable physical parameter depending on a constant temperature set during heat treatment, are provided. The parameter is set differently for each of the different measurement elements which are combined to form an array. In a first measurement, values of the physical parameter for the array are determined before the array is subjected to the operating temperature. The array is subjected to the operating temperature in the device and in a second measurement, values are determined for all the measurement elements in the array. First and second measurement values of the physical parameter for each of the measurement elements are compared and the temperature of the heat treatment of that measurement element whose value of the physical parameter has changed the least is taken as the measured temperature.

Abstract: A fuel-injection device includes at least one fuel injector, one receiving bore-hole for the fuel injector, and one pipe-shaped pipe connection of a fuel rail. The fuel injector is pushed into the interior of the pipe connection by an upstream inlet connection. A bayonet closure ensures that the fuel injector is fastened in the pipe connection of the fuel rail in a secure and detachable manner.

Abstract: Various type of jackpot systems are disclosed wherein visible jackpots are replenished after a win by an invisible jackpot. Some embodiments include: replenishing the visible jackpot with less than 100% of the invisible jackpot; increasing the invisible jackpot at a rate faster than the rate at which the visible jackpot is increased; having a criteria for a win of the jackpot based on the amount of the invisible jackpot; and using multiple visible and invisible jackpots in various ways.

Abstract: The present document describes a sensing apparatus for lowering into a well and cementing therein at a certain depth. The sensing apparatus comprises an elongated casing and a sensor device protruding from an outside surface of the elongated casing for generating measurement data and sending the data to the surface of the well using a cable extending from the sensor device along the outside surface of the casing. A flow of cement is provided between the outside surface of the casing and the well for cementing the casing in place and isolating different layers of the well. Presence of the sensor device and the cable creates an obstruction within the flow path of the cement which may result in the formation of micro-annulus around the sensor device and the cable.

Abstract: A sniffer leak detector comprising a detector with a quartz window, the window being selectively permeable to a tracer gas. The quartz window is located in a suction chamber that is connected to a vacuum pump. To reduce the response time, a gas guidance plate is situated in the suction chamber, the guidance plate and quartz window together delimiting a narrow gas guidance chamber.