Patents by Inventor Peter Laurence
Peter Laurence has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140315203Abstract: The present invention relates generally to nucleic acid molecules in respect of which changes to DNA methylation levels are indicative of the onset or predisposition to the onset of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules in respect of which changes to DNA methylation levels are indicative of the onset and/or progression of a large intestine or breast neoplasm, such as an adenoma or adenocarcinoma. The DNA methylation status of the present invention is useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal or breast neoplasms, such as colorectal or breast adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in DNA methylation of one or more nucleic acid molecules.Type: ApplicationFiled: August 24, 2012Publication date: October 23, 2014Applicants: Commonwealth Scientific and Industrial Research Organisation, Clinical Genomics Pty. Ltd.Inventors: Peter Laurence Molloy, Lawrence Charles Lapointe, Susanne Kartin Pedersen, Susan Margaret Mitchell
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Publication number: 20140287940Abstract: The present invention relates generally to nucleic acid molecules in respect of which changes to the DNA or to the RNA or protein expression profiles are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules in respect of which changes to the DNA or to the RNA or protein expression profiles are indicative of the onset and/or progression of a large intestine neoplasm, such as an adenoma or an adenocarcinoma. The DNA or the expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenocarcinomas.Type: ApplicationFiled: October 18, 2013Publication date: September 25, 2014Applicants: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION, CLINICAL GENOMICS PTY. LTD.Inventors: Lawrence C. LAPOINTE, Robert DUNNE, Graeme P. YOUNG, Trevor John LOCKETT, William J. WILSON, Peter Laurence MOLLOY
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Publication number: 20140088093Abstract: Described herein are antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical composition.Type: ApplicationFiled: September 24, 2013Publication date: March 27, 2014Applicant: Zoetis LLCInventors: Michael Curtis, Timothy Allan Johnson, Manjinder S. Lall, Peter Laurence Toogood, Joseph S. Warmus
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Publication number: 20130338020Abstract: The present invention relates generally to nucleic acid molecules in respect of which changes to DNA methylation levels are indicative of the onset or predisposition to the onset of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules in respect of which changes to DNA methylation levels are indicative of the onset and/or progression of a large intestine neoplasm, such as an adenoma or adenocarcinoma. The DNA methylation status of the present invention is useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in DNA methylation of one or more nucleic acid molecules.Type: ApplicationFiled: September 13, 2011Publication date: December 19, 2013Applicants: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION, CLINICAL GENOMICS PTY. LTD.Inventors: Jason Peter Ross, Michael Buckley, Peter Laurence Molloy, Susan Margaret Mitchell, Konsta Rainer Duesing, Zheng-Zhou Xu
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Patent number: 8604023Abstract: The invention provides a family of 1,4-benzodiazepinone compounds and methods for their use as therapeutic agents in treating cancer. Pharmaceutical compositions and methods of making the 1,4-benzodiazepinone compounds are provided.Type: GrantFiled: April 16, 2010Date of Patent: December 10, 2013Assignee: The Regents of the University of MichiganInventors: Gary D. Glick, Clarke Bentley Taylor, Peter Laurence Toogood, Chad Alan Van Huis
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Patent number: 8501403Abstract: A method for detecting a nucleic acid molecule having a target sequence adjacent a 3? terminus is provided. Also provided is a method for differentiating nucleic acid molecules having a target sequence adjacent a 3? terminus from nucleic acid molecules in which the same sequence is embedded within the molecule.Type: GrantFiled: March 28, 2007Date of Patent: August 6, 2013Assignee: Commonwealth Scientific and Industrial Research OrganisationInventors: Peter Laurence Molloy, Keith Rand
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Publication number: 20130121763Abstract: A method for repairing roadway and pathway defects utilizes a filling material and a primer. The method calls for applying the primer to an edge of the defect; pouring the filling material into the defect; and curing the filling material to form a patch that is even with the road.Type: ApplicationFiled: June 10, 2011Publication date: May 16, 2013Applicant: Polylast Systems, LLCInventors: Herman D. Phillips, Peter Laurence
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Patent number: 8420646Abstract: The present invention is directed to tricyclic tetrahydroquinoline compounds of formula I, and pharmaceutically acceptable salts thereof wherein the variables R1, R2, R3, R4, R5, R20 and X are as described herein and to pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.Type: GrantFiled: December 20, 2010Date of Patent: April 16, 2013Assignee: PAH P&U LLCInventors: Michael Robert Barbachyn, Paul Joseph Dobrowolski, Alexander Ross Hurd, Dennis Joseph McNamara, John Raymond Palmer, Arthur Glenn Romero, J. Craig Ruble, Debra Ann Sherry, Lisa Marie Thomasco, Peter Laurence Toogood
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Publication number: 20130078736Abstract: This disclosure provides systems, apparatuses, and methods for liquid transfer and performing reactions. In one aspect, a system includes a liquid transfer device having a housing having a pipette tip and a plunger assembly; and a reaction chamber, wherein the housing of the liquid transfer device is configured to sealably engage with the reaction chamber. In another aspect, a liquid transfer device including a housing having a pipette tip; and a plunger assembly disposed within the housing and the pipette tip, wherein a portion of the plunger assembly is configured to engage a fluid reservoir such that the plunger assembly remains stationary relative to the fluid reservoir and the housing moves relative to the plunger assembly.Type: ApplicationFiled: September 23, 2011Publication date: March 28, 2013Inventors: Simon Roderick Grover, Paul Graham Wilkins, Nick David Rollings, Peter Laurence Mayne, Wai Ting Chan, Natalie Frances Scott, Olivier Fernand Flick, Henry Charles Innes, Martyn Gray Darnbrough Beedham, Nicholas David Long, Richard John Hammond
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Publication number: 20120094982Abstract: The invention provides a family of 1,4-benzodiazepinone compounds and methods for their use as therapeutic agents in treating cancer. Pharmaceutical compositions and methods of making the 1,4-benzodiazepinone compounds are provided.Type: ApplicationFiled: April 16, 2010Publication date: April 19, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Gary D. Glick, Clarke Bentley Taylor, Peter Laurence Toogood, Chad Alan Van Huis
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Patent number: 7958590Abstract: A cleaning tool is disclosed for cleaning adjacent surfaces. In one embodiment, for instance, the cleaning tool may be used as a toilet bowl brush. The cleaning tool includes a handle comprised of a first handle member pivotally attached to a second handle member. Each handle member terminates in a clamping plate. The clamping plates move towards and away from each other as the handle members are likewise moved towards and away from each other. The handle can include a locking member that engages the first handle member with the second handle member in order to clamp or hold a cleaning pad in between the clamping plates. The clamping plates can include raised wave-like protrusions that further assist in gripping a cleaning pad.Type: GrantFiled: December 29, 2006Date of Patent: June 14, 2011Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Susan M. Trefethren, Craig M. Thoms, Brian James Ludka, Maggie VanderHeiden Berger, Christopher James Uecker, Carl Gerard Rippl, Peter Laurence
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Publication number: 20110098189Abstract: The present invention relates generally to nucleic acid molecules in respect of which changes to the DNA or to the RNA or protein expression profiles are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules in respect of which changes to the DNA or to the RNA or protein expression profiles are indicative of the onset and/or progression of a large intestine neoplasm, such as an adenoma or an adenocarcinoma. The DNA or the expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenocarcinomas.Type: ApplicationFiled: October 23, 2008Publication date: April 28, 2011Applicants: CLINICAL GENOMICS PTY. LTD.Inventors: Lawrence C. Lapointe, Robert Dunne, Graeme P. Young, Trevor John Lockett, William J. Wilson, Peter Laurence Molloy
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Publication number: 20110092494Abstract: The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.Type: ApplicationFiled: December 20, 2010Publication date: April 21, 2011Inventors: Michael Robert Barbachyn, J. Craig Ruble, Arthur Glenn Romero, Lisa Marie Thomasco, Alexander Ross Hurd, John Raymond Palmer, Peter Laurence Toogood, Dennis Joseph McNamara, Debra Ann Sherry, Paul Joseph Dobrowolski
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Patent number: 7863278Abstract: Disclosed are polymorphs of the isethionate salt of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, which is a selective cyclin-dependent kinase 4 (CDK4) inhibitor useful for treating inflammation and cell proliferative diseases such as cancer and restenosis.Type: GrantFiled: September 26, 2007Date of Patent: January 4, 2011Assignee: Warner-Lambert CompanyLLCInventors: Vladimir Genukh Beylin, Anthony Clyde Blackburn, David Thomas Erdman, Peter Laurence Toogood
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Publication number: 20100233683Abstract: A method for detecting a nucleic acid molecule having a target sequence adjacent a 3? terminus is provided. Also provided is a method for differentiating nucleic acid molecules having a target sequence adjacent a 3? terminus from nucleic acid molecules in which the same sequence is embedded within the molecule.Type: ApplicationFiled: March 28, 2007Publication date: September 16, 2010Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATIONInventors: Peter Laurence Molloy, Keith Rand
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Patent number: 7744481Abstract: According to the present invention there is provided a method for positioning a person in an optimal stance for hitting a golf ball along an intended path toward a target. The method including the steps of: (a) holding an end of a golf club in one hand that is used by the person as a lower hand in a conventional golf grip; (b) positioning the club such that a striking surface of the club faces the target and is spaced behind the ball relative to the target; (c) placing both feet side-by-side at a distance from the ball and lateral to the intended path; (d) orienting the person's arm by which the club is held so as to locate the person's elbow of the arm as close as possible to the navel and/or spine of the person; (e) re-gripping the club with both hands; and (f) moving said feet apart so as to locate the front foot further forward of the ball and said back foot further rearward of the ball prior to swinging the club.Type: GrantFiled: March 9, 2006Date of Patent: June 29, 2010Inventor: Peter Laurence Canney
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Publication number: 20100022524Abstract: The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.Type: ApplicationFiled: August 28, 2009Publication date: January 28, 2010Inventors: Michael Robert Barbachyn, J. Craig Ruble, Arthur Glenn Romero, Lisa Marie Thomasco, Alexander Ross Hurd, John Raymond Palmer, Peter Laurence Toogood, Dennis Joseph McNamara, Debra Ann Sherry, Paul Joseph Dobrowolski
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Patent number: 7618773Abstract: A method for the selective amplification of a target nucleic acid in a sample comprising the target nucleic acid and at least one non-target nucleic acid, the method comprising amplifying the nucleic acids by means of at least one oligonucleotide primer comprising: a primer region that can prime and extend on the target and non-target nucleic acids; and a region that is an inverted repeat of an internal sequence of an amplicon of the at least one non-target nucleic acid but which contains at least one mismatch to the corresponding internal sequence, if present, of an amplicon of the target nucleic acid.Type: GrantFiled: February 26, 2003Date of Patent: November 17, 2009Assignee: Commonwealth Scientific and Industrial Research OrganisationInventors: Keith Rand, Peter Laurence Molloy
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Publication number: 20090275536Abstract: Described herein are antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical composition.Type: ApplicationFiled: July 15, 2009Publication date: November 5, 2009Inventors: Timothy A. Johnson, Dennis J. McNamara, Debra A. Sherry, Peter Laurence Toogood
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Patent number: 7605157Abstract: The invention includes tetrahydroquinoline and related compounds of formula I and pharmaceutical compositions thereof, that exhibit useful antibacterial activity again a wide range of human and veterinary pathogensType: GrantFiled: March 7, 2007Date of Patent: October 20, 2009Assignee: Pharmacia & Upjohn Company LLCInventors: Michael Robert Barbachyn, J. Craig Ruble, Arthur Glenn Romero, Lisa Marie Thomasco, Alexander Ross Hurd, John Raymond Palmer, Peter Laurence Toogood, Dennis Joseph McNamara, Debra Ann Sherry, Paul Joseph Dobrowolski