Abstract: A tissue fixation system is provided for dynamic and rigid fixation of tissue. A fastener connected with an elongate fastening member, such as a cable, wire, suture, rod, or tube, is moved through a passage between opposite sides of tissue. A medical device is used to secure the fastener to the elongate fastening member. The medical device includes a tensioning mechanism for tensioning the elongate fastening member. As crimping mechanism is used to secure the fastener to the elongated member, where a cutting mechanism cut the excess portion of the elongated member.

Abstract: The present disclosure relates to compounds that are capable of penetrating the blood brain barrier to modulate the activity of EGFR tyrosine kinase. The disclosure further relates to methods of treating glioblastoma and other EGFR-mediated cancers, such as those that have been determined to have altered glucose metabolism in the presence of inhibitors. The present disclosure also provides methods of administering to a subject a glucose metabolism inhibitor and a cytoplasmic p53 stabilizer.

Abstract: An ankle stretch orthosis includes a foot assembly having a ball support assembly adjustably mounted on a foot plate. The foot assembly includes an adjustment mechanism for selectively adjusting a position of ball support assembly relative to the foot plate to align the ball support assembly with a ball portion of a foot that is one of supinated and pronated.

Abstract: Embodiments may include an expandable access system having contracted and expanded configurations. The system and methods may include an expandable access device having a helix or wrapped shape. Embodiments may include a cannula, stent, needle, trocar, introducer, fastener, and/or any other devices disclosed herein. Embodiments may also include an expandable trocar positionable in at least a portion of the access device. A sleeve or band may be disposed over at least a portion of the access device and configured to resist radial expansion of the access device. Expansion of the trocar and/or receipt of an object may radially expand the access device between a contracted configuration and an expanded configuration.

Abstract: A ring for wearing by a user may include a rigid outer annular body and a flexible inner annular body. The outer annular body may be a rigid material, and the inner annular body may be flexible and formed from an injection molded process. The outer annular body may be attached to the inner annular body. The inner annular body may be machined to curve from longitudinal ends of the inner annular body to an inner surface after the inner annular body is joined to the outer annular body in order to provide a comfort fit. The inner annular body may be molded with the comfort fit curvature. The outer annular body may have at least one strain relief recess in an inner surface thereof, and the inner annular body may fill the at least one strain relief recess.

Abstract: A system for predicting and/or managing physiological responses is configurable to (i) access one or more images depicting one or more consumables able to influence a physiological condition of a user, the one or more images being associated with one or more timepoints; (ii) access user state information associated with the user; (iii) determine a predicted physiological response to consumption of the one or more consumables by the user based on at least the one or more images and the user state information; and (iv) present an output based on the predicted physiological response to the user via a user interface.

Abstract: A resealable package configured for heating in a microwave oven having at least one vent capable of relieving an internal pressure from an interior space of the package during heating. To protect the integrity of a resealable fastener, such as a zipper reclose feature, the at least one vent is capable of functioning at a low pressure below about 3.0 psi and preferably below about 1.4 psi. The at least one vent includes a specifically shaped outer portion and inner portion integrated into a package seal to allow for a controlled rupture or separation of this seal at the location of the at least one vent. This at least one vent can be formed directly into a seal of the package through a specifically shaped seal bar used during package formation.

Abstract: A method executed by a computing entity includes identifying, using a securely passing process and based on at least one of a public benefit project type and a public benefit project geographic location of selection criteria for a set of public benefit credit assets, a secure first token on an object distributed ledger representing the set of public benefit credit assets. The method further includes establishing, using the securely passing process, control over the secure first token representing the set of public benefit credit assets, where only a device possessing control over the secure first token may modify the secure first token.

Abstract: An end effector assembly for use with a forceps includes a pair of jaw members, a knife assembly, and one or more cam assemblies. One or more of the jaw members are moveable relative to the other about a pivot between open and closed positions. One or more of the jaw members include a knife channel. The pivot includes first and second sections defining a passage therebetween. The knife assembly includes a knife blade and an actuation shaft. The knife blade is disposed distally relative to the pivot. The actuation shaft is configured for slidable translation through the passage to allow selective advancement of the knife blade through the knife channel. The one or more cam assemblies are operably coupled to the one or more moveable jaw members and are actuatable to move the one or more jaw members between the open and closed positions for grasping tissue therebetween.

Abstract: An absorbent article comprising a chassis comprising a central longitudinal axis and an absorbent core is provided. The chassis comprises a front waist region, and a landing zone and an elastic waist feature both positioned in the front waist region. The elastic waist feature comprises a first end edge that is positioned proximate to a front waist edge. The elastic waist feature is: in an overlapping relationship with a portion of the landing zone by longitudinal distance, Y; and in an overlapping relationship with a portion of the absorbent core in the front waist region by a longitudinal distance, X. The elastic waist feature has a longitudinal distance, W, between the first end edge and a second end edge. A ratio of the distance, X, to the distance, W, is at least 0.4 and a ratio of the distance, Y, to the distance, W, is at least 0.4.

Abstract: A pressure output device (POD) assembly used for measuring fluid pressure in a fluid processing system is described. The fluid processing system may be or may include a dialysis machine. In one example, the POD assembly may include a connector configured to be coupled to a measurement port arranged on an outer surface of a fluid processing system, a POD receptacle configured to be installed on the outer surface over the connector, the POD receptacle may be configured to be coupled to the connector, and a POD may include an inlet port, an outlet port, and a sensor port, the POD may be configured to be removably installed within a POD seat formed in the POD receptacle, the sensor port may be arranged within a POD opening of the POD receptacle and coupled to the connector to fluidically couple the POD to the measurement port. Other embodiments are described.

Abstract: A system for external rotational deformity correction of an intact bone may include: a first frame member and a second frame member rotatably coupled therewith, a first bone fixation member coupled to the first frame member and to a distal segment of the intact bone, a second bone fixation member coupled to the second frame member and to a proximal segment of the intact bone at a first angle, an automated control mechanism coupled to the first and second frame members, and a power source for the automated control mechanism. The automated control mechanism may: receive power from the power source, rotate the first frame member to a desired relative rotational position, and position the first bone fixation member at a desired second angle to exert torsional force on the intact bone and externally reduce rotational deformity of the intact bone.

Abstract: Terpene-containing lipidoid compounds, methods of preparing such compositions, and the use of these, compositions in gene delivery applications are disclosed.

Abstract: A system for visualizing a surgical site is provided. The system includes a robotic mechanism for performing a procedure on a patient, an imaging device coupled to the robotic mechanism, the imaging device configured to provide image data of a site of interest, and a computing device coupled to the imaging device. The computing device includes one or more processors and at least one memory device configured to store executable instructions. The executable instructions, when executed by the processor, are configured to receive the image data of the site of interest, track motion patterns of the site of interest in the received image data, filter the received image data to remove line-of-sight restrictions therein and alter pixels therein based on the tracked motion patterns, and generate an output frame from the filtered image data. The system also includes a presentation interface device coupled to the computing device and configured to present the output frame for visualization of the site of interest.

Abstract: This invention relates to a lubricating oil composition comprising or resulting from the admixing of: (i) at least 50 mass %, based upon the weight of the lubricating oil composition, of base oil, (ii) at least one capped dispersant having number average molecular weight (Mn) of less than 1600 g/mol, (iii) at least one magnesium containing detergent, (iv) at least one calcium containing detergent, (v) at least one copolymer viscosity modifier that has: 1) a ratio of relative KV140/relative KV20 of 1.9 or more; 2) a ratio of relative KV100/relative KV70 or 1.30 or more; and 3) a viscosity index (ASTM 2270D) of 320 or more, when 1), 2) and 3) are measured on blend, having a KV100 of about 8 cSt, of the copolymer viscosity modifier and a group III base oil having a KV100 (ASTM D445) of about 4 cSt and a viscosity index (ASTM D2270) of about 120.

Abstract: A dual-use battery-operated portable grinder is utilized for the railway industry, specifically for grinding the web of railroad rails post-welding. The battery-operated portable grinder can be employed in a hand-held configuration or seamlessly integrated with a quick-connect mechanism onto a specialized frame device, serving as both a support structure for the grinder and a means for reducing worker strain by eliminating the need for bending. The battery-operated portable grinder may include: battery-powered operation, a robust brushless motor, a built-in handle-incorporated base portion for safeguarding the motor from potential damage, a lightweight design, an anti-vibration handle to alleviate operator fatigue and ensure proper balance during usage, a reinforced shaft to enhance operational durability, improved grinding wheel stability to minimize vibration and wear during use, and its versatility in performing rail head and web grinding tasks.

Abstract: The present disclosure provides compositions and vectors comprising a transgene(s) encoding more than one isoform of Crumbs homologue-1 (CRB1) (e.g., CRB1-A and CRB1-B), and compositions thereof, for use in the treatment or prevention of CRB1-related diseases and disorder (e.g., autosomal recessive retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA)).

Abstract: Compositions comprising terpene-containing lipidoid compounds, methods of preparing such compositions, and the use of these compositions in gene delivery applications are disclosed.

Abstract: A sorbent composition comprises activated carbon with at least most of the particulates of the sorbent composition have a sphericity in the range of about 0.75 to about 1.0 and/or an aspect ratio greater than about 0.71.