Abstract: Provided herein are conformation-specific antibodies which bind to protein aggregates, such as amyloid fibrils, including aggregates of glucagon and liraglutide. Also provided are methods of using the antibodies to detect protein aggregates in samples, and methods for identifying aggregate-binding antibodies.

Abstract: In a set-top-box system, messages from a service provider are stored and delayed until activity from a set-top-box remote is detected. Messages are then generated and provided to a television associated with the set-top-box. Delaying of the message display until set-top-box activity is detected allows short display times, thus preventing burn-in on some television screens, while providing a greater likelihood that messages will be viewed.

Abstract: A computing device harmonizes output image properties displayed on a graphical user interface (GUI) when a user switches between two or more images of different image formats to display on the GUI. When a user interacts with a user interface to change one or more display properties of an image, a system modifies displayed image properties based on the user's modifications. If the user selects another image with different dynamic range than the first image, the system performs a backend image conversion so that the displayed properties of the second image correspond to the user-selected modifications to the displayed properties of the first image.

Abstract: In one or more embodiments, a computing device is configured to present playback of a media composition on a touchscreen display. Concurrently with presenting the playback, the computing device receives, via the touchscreen display during a first time period, a touch input that includes a series of motions that start when a particular frame of the media composition is being presented. Responsive to receiving the touch input: the computing device adds a media clip to the media composition, with the media clip including a graphical representation of the touch input, having a duration corresponding to the first time period, and being stored in association with the particular frame. Subsequent to adding the media clip, the computing device presents a second playback of the media composition where playback of the media clip is initiated when playback of the particular frame is started during the second playback of the media composition.

Abstract: A method of detecting drug-resistant cancer in a subject is described. The method includes contacting a tissue of the subject with an effective amount of a molecular probe, detecting the amount of the molecular probe present in the tissue, comparing the amount of molecular probe detected to a control value, and detecting drug-resistant cancer in the subject if the amount of the molecular probe present in the tissue is higher than the control value. The molecular probe includes the following formula: P-L-C wherein P is a EDB-FN targeting peptide, C is a contrast agent; and L is a non-peptide linker that covalently links the peptide to the contrast agent. Methods of monitoring the treatment of drug resistant cancer are also described.

Abstract: A seeding system includes a commodity tank configured to store a commodity, the commodity tank having an outlet. A meter has a meter inlet at the outlet of the commodity tank, a meter outlet, and a metering device between the meter inlet and the meter outlet. A manifold has a commodity inlet at the meter outlet, a first shoot having a first air inlet and a first manifold outlet, and a second shoot having a second air inlet and a second manifold outlet. A valve is positioned upstream of the first and second air inlets and configured to selectively direct an airflow to the first air inlet and to selectively direct the airflow to the second air inlet. Each of the first shoot and the second shoot are in selective communication with the commodity inlet to receive the commodity therefrom.

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl) pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

Abstract: A linear transfer system for a collaborative robot includes a linear bearing extending along a linear axis. A carriage on the linear bearing moves along the linear axis and supports a collaborative robot. One or more load cells are supported on either axial end of the carriage. A motor causes movement of the carriage along the linear axis under the control of a motor control circuit. The circuit receives input signals indicative of forces applied to the load cells. During a programming mode for the system, the circuit may generate control signals for the motor causing movement of the carriage along the linear axis corresponding to the forces applied to the load cells. During an operating mode of the system, the circuit may detect collisions by comparing the forces to a threshold and generating control signals to halt movement of the carriage if a predetermined condition is met.

Abstract: Medical devices coupled to a sensor, and systems including such devices, can generate data and analysis based on that data, which may be used to identify and/or address problems associated with the implanted medical device, including incorrect placement of the device, unanticipated degradation of the device, and undesired movement of the device. Also provided are medical devices coupled to a sensor, and devices and methods to address problems that have been identified with an implanted medical device.

Abstract: Systems and methods herein provide for improving visibility in a scene. In one embodiment, a system includes a first camera device operable to capture images of a scene at a first band of wavelengths, and a second camera device operable to capture images of the scene at a second band of wavelengths. The first and second bands are different. The system also includes a processor communicatively coupled to the first and second camera devices, the processor being operable to detect an object in the scene based on a first of the images from the first camera device and based on a first of the images from the second camera device that was captured at substantially a same time as the first image from the first camera device, to estimate an obscurant in the scene based on the first images, and to estimate a visibility parameter of the scene based on the object and the estimated obscurant.

Abstract: A tissue fixation system is provided for dynamic and rigid fixation of tissue. A fastener connected with an elongate fastening member, such as a cable, wire, suture, rod, or tube, is moved through a passage between opposite sides of tissue. A medical device is used to secure the fastener to the elongate fastening member. The medical device includes a tensioning mechanism for tensioning the elongate fastening member. As crimping mechanism is used to secure the fastener to the elongated member, where a cutting mechanism cut the excess portion of the elongated member.

Abstract: Medical devices coupled to a sensor, and systems including such devices, can generate data and analysis based on that data, which may be used to identify and/or address problems associated with the implanted medical device, including incorrect placement of the device, unanticipated degradation of the device, and undesired movement of the device. Also provided are medical devices coupled to a sensor, and devices and methods to address problems that have been identified with an implanted medical device.

Abstract: Disclosed are novel halogenated psilocybin derivative compounds and pharmaceutical and recreational drug formulations containing the same. The compounds may be produced using a biosynthetic system which comprises cells comprising a psilocybin biosynthetic enzyme complement.

Abstract: An ankle stretch orthosis includes a foot assembly having a ball support assembly adjustably mounted on a foot plate. The foot assembly includes an adjustment mechanism for selectively adjusting a position of ball support assembly relative to the foot plate to align the ball support assembly with a ball portion of a foot that is one of supinated and pronated.

Abstract: The invention relates to an initiator system for curing a dental composition, the initiator system comprising a hydroperoxide component, a transition metal component, a polymerizable thiourea component, the polymerizable thiourea component comprising a thiourea moiety which is attached to a (meth)acrylate moiety through a C3-11 alkyl chain. The invention also relates to a dental composition comprising such an initiator system, and curable components, in particular curable components comprising acidic moieties.

Abstract: Methods of forming microelectronic structures are described. Embodiments of those methods include forming a nanowire device comprising a substrate comprising source/drain structures adjacent to spacers, and nanowire channel structures disposed between the spacers, wherein the nanowire channel structures are vertically stacked above each other.

Abstract: Example motor assemblies for architectural coverings are described herein. An example architectural covering assembly includes an architectural covering movable between an upper limit position, a lower limit position, and a transition limit position between the upper limit position and the lower limit position. The example architectural covering assembly also includes a motor, a consumer touchpoint, and an architectural covering controller. In response to detecting a first gesture at the consumer touchpoint, the architectural covering controller is to activate the motor to move the architectural covering to the transition limit position and stop, and in response to detecting a second gesture at the consumer touchpoint, different from the first gesture, the architectural covering controller is to activate the motor to move the architectural covering through the transition limit position and to the upper limit position or the lower limit position.

Abstract: A method and apparatus for processing documents are provided. The apparatus includes a feeder for receiving a packet of a plurality of documents and separating the documents to serially feed the documents to a scanner. A drop feeder conveys the document packets to the feeder. A sensor provides information related to the thickness of the document packets and the drop feeder is controlled in response to the information related to the thickness of a packet in the feeder. The method includes the control of the drop feeder in response to information related to the thickness of a document packet at the feeder.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for optimizing a process of manufacturing a product. In one aspect, the method comprises repeatedly performing the following: i) selecting a configuration of input settings for manufacturing a product, based on a causal model that measures causal relationships between input settings and a measure of a quality of the product; ii) determining the measure of the quality of the product manufactured using the configuration of input settings; and iii) adjusting, based on the measure of the quality of the product manufactured using the configuration of input settings, the causal model.

Abstract: A single photon avalanche diode (SPAD) device is presented. The SPAD device comprising: a Si-based avalanche layer formed over an n-type semiconductor contact layer; a p-type charge sheet layer formed in or on the avalanche layer, the p-type charge sheet layer having an in-plane width; a Ge-based absorber layer, formed over the charge sheet layer and/or the avalanche layer, and overlapping the charge sheet layer, the Ge-based absorber layer having an in-plane width; wherein, at least in one in-plane direction, the in-plane width of the Ge-based absorber layer is greater than the in-plane width of the p-type charge sheet layer.