Abstract: System for electrically ablating tissue of a patient through a plurality of electrodes includes a memory, a processor and a treatment control module stored in the memory and executable by the processor. The treatment control module generates an estimated treatment region based on the number of electrical pulses to be applied.

Abstract: A tissue fixation system is provided for dynamic and rigid fixation of tissue. A fastener connected with an elongate fastening member, such as a cable, wire, suture, rod, or tube, is moved through a passage between opposite sides of tissue. A medical device is used to secure the fastener to the elongate fastening member. The medical device includes a tensioning mechanism for tensioning the elongate fastening member. As crimping mechanism is used to secure the fastener to the elongated member, where a cutting mechanism cut the excess portion of the elongated member.

Abstract: An ankle stretch orthosis includes a foot assembly having a ball support assembly adjustably mounted on a foot plate. The foot assembly includes an adjustment mechanism for selectively adjusting a position of ball support assembly relative to the foot plate to align the ball support assembly with a ball portion of a foot that is one of supinated and pronated.

Abstract: The present disclosure relates to compounds that are capable of penetrating the blood brain barrier to modulate the activity of EGFR tyrosine kinase. The disclosure further relates to methods of treating glioblastoma and other EGFR-mediated cancers, such as those that have been determined to have altered glucose metabolism in the presence of inhibitors. The present disclosure also provides methods of administering to a subject a glucose metabolism inhibitor and a cytoplasmic p53 stabilizer.

Abstract: Embodiments may include an expandable access system having contracted and expanded configurations. The system and methods may include an expandable access device having a helix or wrapped shape. Embodiments may include a cannula, stent, needle, trocar, introducer, fastener, and/or any other devices disclosed herein. Embodiments may also include an expandable trocar positionable in at least a portion of the access device. A sleeve or band may be disposed over at least a portion of the access device and configured to resist radial expansion of the access device. Expansion of the trocar and/or receipt of an object may radially expand the access device between a contracted configuration and an expanded configuration.

Abstract: Medical devices coupled to a sensor, and systems including such devices, can generate data and analysis based on that data, which may be used to identify and/or address problems associated with the implanted medical device, including incorrect placement of the device, unanticipated degradation of the device, and undesired movement of the device. Also provided are medical devices coupled to a sensor, and devices and methods to address problems that have been identified with an implanted medical device.

Abstract: The invention disclosed herein relates to a dry sensor for measuring the concentration of an analyte in a liquid beverage sample. Described herein is a novel dry sensor which is able to receive a liquid sample and adjust the pH of the liquid to be suitable for assaying an analyte of interest without the need to add reagents to the sample and/or to perform manually timed operations and able to detect a redox reaction in the presence of a liquid sample. The meter disclosed herein, when connected to the sensor disclosed herein is able to adjust the temperature of the liquid to be suitable for the assay, apply a series of potentials, measure the current at several times, measure the diffusion coefficient of the limiting electrochemical species, calculate the concentration of one or more analytes, and rapidly provide the user with the required information on the liquid sample.

Abstract: The invention discloses an implant. The implant may include a first flap and a second flap. The first flap may further include a first portion, a second portion and a transition region. The first portion may be configured to be attached proximate a sacrum. The second portion may be configured to be attached to an anterior vaginal wall. The transition region lies between the first portion and the second portion. The second flap may be fabricated such that a portion of the second flap is configured to be attached to a posterior vaginal wall. The implant may be configured such that a value corresponding to a biomechanical parameter defining a biomechanical attribute of the portion of the first flap attaching to the anterior wall is different from a value of the biomechanical parameter defining the biomechanical attribute of the portion of the second flap attaching to the posterior wall.

Abstract: A system for predicting and/or managing physiological responses is configurable to (i) access one or more images depicting one or more consumables able to influence a physiological condition of a user, the one or more images being associated with one or more timepoints; (ii) access user state information associated with the user; (iii) determine a predicted physiological response to consumption of the one or more consumables by the user based on at least the one or more images and the user state information; and (iv) present an output based on the predicted physiological response to the user via a user interface.

Abstract: Embodiments described herein may be directed to systems, methods, apparatuses, devices, computer program products, computer-executable instructions, and/or applications for providing a remote cloud browsing session. A remote cloud browsing session may receive a request for Internet content from a user device, access the Internet content from an Internet content source, and transmit second Internet content to the user device based on the requested Internet content.

Abstract: A method for controlling a construction robot which has a manipulator and wherein the manipulator has an end effector is disclosed, wherein the end effector is moved from a starting position to a working position, wherein an obstacle is identified, and the identified obstacle is bypassed. A construction robot is also disclosed.

Abstract: This disclosure teaches a system and method for monitoring an extracorporeal blood circuit of a patient and identifying a needle dislodgement. The method includes identifying a potential needle dislodgement event based on changes in pressure of the extracorporeal blood circuit, searching for a heart rate of a patient by analyzing an optical backscatter signal from an optical sensor attached to the extracorporeal blood circuit or by analyzing a pressure signal representative of the pressure in the extracorporeal blood circuit, and verifying the potential needle dislodgement event is a needle dislodgement based on the absence of the heart rate.

Abstract: A ring for wearing by a user may include a rigid outer annular body and a flexible inner annular body. The outer annular body may be a rigid material, and the inner annular body may be flexible and formed from an injection molded process. The outer annular body may be attached to the inner annular body. The inner annular body may be machined to curve from longitudinal ends of the inner annular body to an inner surface after the inner annular body is joined to the outer annular body in order to provide a comfort fit. The inner annular body may be molded with the comfort fit curvature. The outer annular body may have at least one strain relief recess in an inner surface thereof, and the inner annular body may fill the at least one strain relief recess.

Abstract: The present disclosure relates to antisense oligonucleotides, which target SNCA mRNA (e.g., at an intron exon junction) in a cell, leading to reduced expression of SNCA protein. Reduction of SNCA protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder.

Abstract: A combine harvester includes a housing having a rear hood and defining an interior, a blower for generating an air stream in a substantially rearward direction, and a cleaning system separating residue from a crop material such that the residue is transported via the air stream rearwardly to be discharged from the housing. A chopper rotor assembly is disposed within the interior below the rear hood and includes a chopper rotor having a plurality of blades for chopping the residue as it is received via the air stream. A chopper housing is disposed within the interior and defines an inlet of the chopper rotor for receiving the residue and an outlet spaced rearward from the chopper rotor for discharge of the chopped residue from the interior of the housing. An air gap through which the air stream may exit the interior is defined between the rear hood and chopper rotor.

Abstract: Three compounds having a common molecular template of 2-(5-(N-acylamino)pyridin-2-yl)-N-benzylacetamide (Compounds I, II and I) are identified as potential anticancer therapeutic agents, and for the treatment of Acute Myeloid Leukemia (AML) in particular. Compound I was specifically designed to target AML cells, inhibit growth, and induce cell death. Compound I demonstrated a dose-dependent effect on AML cell lines HL-60, Mv4-11, KG-1a, and K562.

Abstract: A method of fabricating a variable geometry space filling insert for a ceramic matrix composite component includes arranging a plurality of fiber bodies into a preform insert, applying a polymer binder to the plurality of fiber bodies, trimming at least a first subset of the plurality of fiber bodies such that each of the first subset of fiber bodies is shorter than at least a second subset of fiber bodies, shaping the insert with a forming tool to form a shaped insert.

Abstract: A resealable package configured for heating in a microwave oven having at least one vent capable of relieving an internal pressure from an interior space of the package during heating. To protect the integrity of a resealable fastener, such as a zipper reclose feature, the at least one vent is capable of functioning at a low pressure below about 3.0 psi and preferably below about 1.4 psi. The at least one vent includes a specifically shaped outer portion and inner portion integrated into a package seal to allow for a controlled rupture or separation of this seal at the location of the at least one vent. This at least one vent can be formed directly into a seal of the package through a specifically shaped seal bar used during package formation.

Abstract: Disclosed are novel fused mescaline derivative compounds, notably C1-substituted isopropylamine fused heterocyclic mescaline derivatives, including C1-substituted isopropylamine fused dioxolane and fused dioxane mescaline derivatives, and pharmaceutical and recreational drug formulations containing the same. Methods of making and using these compounds are also disclosed.