Abstract: A method for detecting degradation intermittencies in an electrical connection in a steering system of a vehicle includes, using a processor configured to execute instructions, receiving an input indicative of a plurality of measurements of resistance associated with the electrical connection, calculating, based on the received input, at least one adaptive control threshold, comparing a first measurement of the plurality of measurements to the at least one adaptive control threshold, determining whether the electrical connection has a degradation intermittency in response to the comparison between the first measurement and the at least one adaptive control threshold, and performing at least one action in response to determining that the electrical connection has the degradation intermittency.

Abstract: A method for detecting early life failure of an electrical connection of a power harness for a steering system of a vehicle including, using a processor configured to execute instructions, obtaining a resistance measurement associated with an electrical power delivery system including the electrical connection, obtaining historical resistance data obtaining at least one limit based on at least one of the historical resistance data and a functional limit, detecting an early life failure of the electrical connection based on a comparison between the resistance measurement and the at least one limit, performing at least one action in response to detecting the early life failure.

Abstract: Provided are methylcytosine-selective deaminases, compositions, kits, and methods employing them, including a sequencing method involving (a) contacting a DNA substrate comprising cytosine (C) and at least one methylcytosine nucleobase selected from 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) or comprising C and both 5mC and 5hmC, with a methylcytosine-selective deaminase to produce a deamination product, wherein the methylcytosine-selective deaminase (i) is capable of deaminating 5mC to thymidine (T) and/or 5hmC to hydroxymethyluridine (hmU) and (ii) preferentially deaminates the at least one methylcytosine nucleobase relative to cytosine (C); and (b) sequencing the deamination product, or amplifying the deamination product to produce an amplification product, and sequencing the amplification product, in each case, to produce sequence reads, wherein positions of Cs and position of the at least one methylcytosine nucleobase in the DNA substrate is determined based on the sequence reads.

Abstract: A method for determining a state of health (SOH) of an electrical connection in a steering system includes, using a processor configured to execute instructions, receiving an input indicative of the SOH of the electrical connection, the input including a resistance associated with the electrical connection, and the SOH corresponding to at least one of an accumulated health (AH) of the electrical connection and a remaining usable life (RUL) of the electrical connection, calculating, based on the received input and usage associated with the vehicle, a first SOH value, calculating, based on the received input and behavior associated with the vehicle, a second SOH value, calculating, based on the first SOH value and the second SOH value, a third SOH value, the third SOH value being an indicator of the AH or the RUL of the electrical connection, and performing at least one action based on the third SOH value.

Abstract: Terpene-containing lipidoid compounds, methods of preparing such compositions, and the use of these, compositions in gene delivery applications are disclosed.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for generating an output sequence from an input sequence. One of the methods includes, at each of a plurality of generation time steps: generating a combined sequence for the generation time step that includes the input sequence followed by the output tokens that have already been generated as of the generation time step; processing the combined sequence using a self-attention decoder neural network to generate a time step output that defines a score distribution over a set of possible output tokens; and selecting, using the time step output, an output token from the set of possible output tokens as the next output token in the output sequence.

Abstract: This document relates to shape memory compositions containing a sliding-ring polymer (polyrotaxane) additive and a thermally-curable epoxy resin. The shape memory compositions are able to deform and reform in response to external stimuli. This document also relates to 3D-printed shape memory compositions containing a sliding-ring polymer (polyrotaxane) additive and a thermally-curable epoxy resin.

Abstract: Disclosed is a valve assembly, having: a valve duct having an upstream end, a downstream end and a duct wall extending from the upstream end to the downstream end; a first conduit extending from a first end at the valve duct to a second end spaced apart from the first end, the first conduit terminating at a valve assembly component; and a washing filter that includes filer media, wherein the filter media extends into the valve duct to remove particles and provide a clean flow to the first conduit.

Abstract: A system for visualizing a surgical site is provided. The system includes a robotic mechanism for performing a procedure on a patient, an imaging device coupled to the robotic mechanism, the imaging device configured to provide image data of a site of interest, and a computing device coupled to the imaging device. The computing device includes one or more processors and at least one memory device configured to store executable instructions. The executable instructions, when executed by the processor, are configured to receive the image data of the site of interest, track motion patterns of the site of interest in the received image data, filter the received image data to remove line-of-sight restrictions therein and alter pixels therein based on the tracked motion patterns, and generate an output frame from the filtered image data. The system also includes a presentation interface device coupled to the computing device and configured to present the output frame for visualization of the site of interest.

Abstract: Various embodiments include a parallel processing computer system that enables parallel instances of a program to synchronize at disparate addresses in memory. When the parallel program instances need to exchange data, the program instances synchronize based on a mask that identifies the program instances that are synchronizing. As each program instance reaches the point of synchronization, the program instance blocks and waits for all other program instances to reach the point of synchronization. When all program instances have reached the point of synchronization, at least one program instance executes a synchronous operation to exchange data. The program instances then continue execution at respective and disparate return addresses.

Abstract: Vaccines that elicit broadly protective anti-influenza antibodies. Some vaccines comprise nanoparticles that display HA trimers from influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to the stem region of an influenza HA protein. The fusion proteins self-assemble to form the HA-displaying nanoparticles. The vaccines comprise only the stem region of an influenza HA protein joined to a trimerization domain. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.

Abstract: Provided herein are peptide compositions derived from regenerative species regenerative proteins, and methods of making and use thereof, that seek to reduce fibrosis. The disclosed peptide formulations and compositions may be used to reduce fibrosis resulting from any disease or disorder, e.g., fibrosis associated with tissue inflammation, wounds, disease, or infection.

Abstract: The present disclosure provides compositions and vectors comprising a transgene(s) encoding more than one isoform of Crumbs homologue-1 (CRB1) (e.g., CRB1-A and CRB1-B), and compositions thereof, for use in the treatment or prevention of CRB1-related diseases and disorder (e.g., autosomal recessive retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA)).

Abstract: A retrofit mining haul truck includes a hybrid hydrogen fuel cell/battery-based powerplant in place of a carbon fuel-based powerplant. The retrofit mining haul truck includes a frame, a tray coupled to the frame, and a deck coupled to the frame forward of at least a portion of the tray. A battery system is mounted to the deck of the retrofit mining haul truck. A hydrogen storage system (HSS) is installed in an engine bay volume of the retrofit mining haul truck. The engine bay was configured to contain a combustion engine (e.g., a diesel engine) prior to retrofitting the retrofit mining haul truck. At least a portion of a fuel cell system is installed in a wheel pocket of the retrofit mining haul truck. The wheel pocket was configured to contain a diesel tank prior to retrofitting the retrofit mining haul truck.

Abstract: Examples can provide extended-range high-speed interconnect by providing microcoax cables in a hybrid flexible circuit board, which can be referred to as a hybrid flex or microcoax flex. This hybrid flex can be used to convey signals an extended distance within an electronic device. Multiple signals can be conveyed using corresponding microcoax cables. The microcoax cables can include a center conductor, an insulating layer, and an outside shield layer. The cables can be held in position in the hybrid flex relative to each other by a polyimide or other insulative layer. Copper layers can be provided on either or both the top and bottom of the polyimide or other insulative layer. Additional conductors can be embedded in the polyimide other insulative layer to convey power and ground. The microcoax and other conductors can be soldered to a flexible circuit board or other substrate using jet soldering.

Abstract: Some embodiments described in this disclosure are directed to one or more computer systems that display virtual environments associated with a presentation application. In some embodiments, the computer system displays a virtual environment selected by a user of the computer system that simulates a real-world setting in which a presentation would be delivered in.

Abstract: This invention relates to a lubricating oil composition comprising or resulting from the admixing of: (i) at least 50 mass %, based upon the weight of the lubricating oil composition, of base oil, (ii) at least one capped dispersant having number average molecular weight (Mn) of less than 1600 g/mol, (iii) at least one magnesium containing detergent, (iv) at least one calcium containing detergent, (v) at least one copolymer viscosity modifier that has: 1) a ratio of relative KV140/relative KV20 of 1.9 or more; 2) a ratio of relative KV100/relative KV70 or 1.30 or more; and 3) a viscosity index (ASTM 2270D) of 320 or more, when 1), 2) and 3) are measured on blend, having a KV100 of about 8 cSt, of the copolymer viscosity modifier and a group III base oil having a KV100 (ASTM D445) of about 4 cSt and a viscosity index (ASTM D2270) of about 120.

Abstract: A dual-use battery-operated portable grinder is utilized for the railway industry, specifically for grinding the web of railroad rails post-welding. The battery-operated portable grinder can be employed in a hand-held configuration or seamlessly integrated with a quick-connect mechanism onto a specialized frame device, serving as both a support structure for the grinder and a means for reducing worker strain by eliminating the need for bending. The battery-operated portable grinder may include: battery-powered operation, a robust brushless motor, a built-in handle-incorporated base portion for safeguarding the motor from potential damage, a lightweight design, an anti-vibration handle to alleviate operator fatigue and ensure proper balance during usage, a reinforced shaft to enhance operational durability, improved grinding wheel stability to minimize vibration and wear during use, and its versatility in performing rail head and web grinding tasks.

Abstract: A computer system displays a first view of a user interface of a first application with a first size at a first position corresponding to a location of at least a portion of a palm that is currently facing a viewpoint corresponding to a view of a three-dimensional environment provided via a display generation component. While displaying the first view, the computer system detects a first input that corresponds to a request to transfer display of the first application from the palm to a first surface that is within a first proximity of the viewpoint. In response to detecting the first input, the computer system displays a second view of the user interface of the first application with a second size and an orientation that corresponds to the first surface at a second position defined by the first surface.

Abstract: Disclosed herein are novel solid forms of FXR agonists. The disclosure also relates to pharmaceutical compositions containing one or more of the solid forms disclosed herein, as well as methods of using the solid forms in the treatment of conditions mediated by FXR. The disclosure also relates to methods for obtaining such solid forms.