Abstract: A central hub includes a plate and a sleeve attached to the plate and adapted to receive a sprinkler head. The sleeve may be a telescoping sleeve. By providing a central hub with the plate and sleeve, the central hub provides increased stability and versatility to the sprinkler head. The plate provides additional stability and support to the sleeve, and thus the sprinkler head, rendering the combination better able to operate effectively when high fluid pressures are utilized. The central hub is generally attached to a support structure by some mechanism, such as a leg. The addition of the plate adds versatility by increasing the number and variety of legs that can be used to attach the central hub to the support structure.

Abstract: The invention encompasses a crystalline form of ciclesonide characterized by an XRD pattern having peaks at about 11.0, 14.8, 15.7, 16.5, and 22.8 degrees two-theta±0.2 degrees two-theta, methods of its preparation and pharmaceutical compositions thereof.

Abstract: A post and beam furniture system having a plurality of horizontally-extending beams having a longitudinally-extending T-shaped first channel and a longitudinally, T-shaped second channel, and a plurality of vertical posts each having a lower portion thereof adapted to be abuttingly supported on a floor surface of an office space, and an upper portion thereof adapted to be connected with the horizontally-extending beams, and a longitudinally-extending T-shaped channel. The channels of the beams and posts receiving a plurality of connectors and accessories, including a multiple bracket post and beam connectors, a T-nut connector, and T-connector, an infill panel, a horizontally-extending two-part wire manager, a vertically extending wire manager, a vertically adjustable worksurface, a transactional surface, a swivel support for supporting a post thereon, and a universal utility hook.

Abstract: Provided is a process for increasing the 22R/22S epidemic ratio of ciclesonide.

Abstract: A central hub includes a plate and a sleeve attached to the plate and adapted to receive a sprinkler head. The sleeve may be a telescoping sleeve. By providing a central hub with the plate and sleeve, the central hub provides increased stability and versatility to the sprinkler head. The plate provides additional stability and support to the sleeve, and thus the sprinkler head, rendering the combination better able to operate effectively when high fluid pressures are utilized. The central hub is generally attached to a support structure by some mechanism, such as a leg. The addition of the plate adds versatility by increasing the number and variety of legs that can be used to attach the central hub to the support structure.

Abstract: The invention provides devices for the disruption of one or more layers of skin and methods of their use to administer therapeutic agents, e.g., antigens or drugs. The devices are designed to disrupt a defined area of skin. The defined area can approximate the area that a patch or other suitable vehicle for therapeutic agent, e.g., drug or vaccine, delivery is designed to contact. Exemplary devices employ a mask to define the area to be disrupted. Other devices disrupt a defined area by rotating in place. For devices that employ a mask that is secured to the skin, the invention provides methods of disrupting the stratum corneum by first securing the mask to the skin and then disrupting the skin. For rotating devices, the disrupting member is simply placed against the skin and actuated to effect disruption.

Abstract: The invention provides a high-yield process for the preparation of letrozole having a high purity, without the need for removal of the 4-[1-(1,3,4-triazolyl)methyl]benzonitrile impurity at the intermediate stage. The invention also provides a process for the synthesis of letrozole in which formation of the impurity 4-[1-(1,3,4-triazolyl)methyl]benzonitrile during the first stage is minimized. In the process, a 4-(halomethyl)benzonitrile is reacted with a salt of 1H-1,2,4-triazole, reducing the formation of the impurity. Preferably, the preparation is conducted as a one-pot process.

Abstract: The invention provides new crystalline forms of fenoldopam mesylate, i.e. fenoldopam mesylate Type I, fenoldopam mesylate Type III, fenoldopam mesylate Type V, and fenoldopam mesylate Type VI, methods of preparing the crystalline forms, and pharmaceutical compositions comprising the fenoldopam mesylate crystalline forms of the invention.

Abstract: A central hub includes a plate and a sleeve attached to the plate and adapted to receive a sprinkler head. The sleeve may be a telescoping sleeve. By providing a central hub with the plate and sleeve, the central hub provides increased stability and versatility to the sprinkler head. The plate provides additional stability and support to the sleeve, and thus the sprinkler head, rendering the combination better able to operate effectively when high fluid pressures are utilized. The central hub is generally attached to a support structure by some mechanism, such as a leg. The addition of the plate adds versatility by increasing the number and variety of legs that can be used to attach the central hub to the support structure.

Abstract: Apparatus for and a method of rotating microscopic objects uses a beam of electromagnetic radiation. A microscopic, non-circularly symmetric distribution of electro-magnetic radiation is projected on to a region containing an object to be rotated so as to cause photons in the beam to refract around the objects. Rotating means then rotate that distribution and so rotate the objects. The distribution may be formed on the interference pattern between a beam having a Laguerre-Gaussian wave fronts and either a plane wave or a further Laguerre-Gaussian beam of opposite helicity.

Abstract: An improved stereoselective process for the preparation of 6?-fluoropregnane derivatives of formula (I), comprising the reaction of 3-benzoyloxy ?3,5-pregnane derivatives of formula (II), with an electrophilic fluorination agent in a substantially water-free reaction mixture and in the presence of a salt of a strong acid with a nitrogenous base.

Abstract: Methods and intermediates for the preparation of Fenoldopam mesylate and intermediates thereof are provided.

Abstract: Processes useful in the preparation of pharmaceutical compounds such as fulvestrant and processes for the preparation of fulvestrant.

Abstract: A fire suppression sprinkler system, and method for installing a sprinkler system in new and existing buildings. The system includes a manifold that supplies fire suppression fluid to a set of wall-mounted sprinkler heads via flexible sprinkler head conduits through an unobstructed path. The installation and retrofit methods include determining the location of the sprinkler head, installing the manifold, making sure that there is an unobstructed path between the manifold and the sprinkler head location, running the conduit through the path by snaking it where necessary through the wall to which the sprinkler head is mounted, connecting the conduit to the manifold and sprinkler head, and then mounting the sprinkler head.

Abstract: The invention features an apparatus and method for positioning and supporting a sprinkler head in a ceiling, floor, or wall. In one aspect of the invention, a sprinkler head may be received by a sleeve extending through a broad surface of the plate. The plate may be configured to be removably attached to a support structure in the ceiling, floor, or wall and having an exterior surface exposed to the room or the plate may be attached to a decorative panel which is configured to be removably attached to a support structure in the ceiling, floor, or wall and having an exterior surface exposed to the room. The sleeve may be defined by an opening in the plate or it may be a separate structure permanently or removably attached to the plate.

Abstract: Apparatus for and a method of rotating microscopic objects uses a beam of electromagnetic radiation. A microscopic, non-circularly symmetric distribution of electro-magnetic radiation is projected on to a region containing an object to be rotated so as to cause photons in the beam to refract around the objects. Rotating means then rotate that distribution and so rotate the objects. The distribution may be formed on the interference pattern between a beam having a Laguerre-Gaussian wave fronts and either a plane wave or a further Laguerre-Gaussian beam of opposite helicity.

Abstract: Demethylepipodophyllotoxin-.beta.-glucosides are prepared by allowing demethylepipodophyllotoxin to react with a 2,3-di-O-ester of a 1-O-trialkylsilyl-4,6-O-alkylidene-.beta.-D-glucose derivative in the presence of a Lewis acid. The 4,6-O-alkylidene group can be alkylidene, arylalkylidene, or heteroarylalkylidene and the 2,3-ester can be lower alkanoyl or haloacetyl. In a typical embodiment, demethylepipodophyllotoxin is allowed to react with 4,6-O-ethylidene-2,3-di-O-acetyl-1-O-trimethylsilyl-.beta.-D-glucose in the presence of boron trifluoride etherate to yield etoposide 2",3"-diacetate.

Abstract: An improved process for the preparation of doxorubicin, by means of hydrolysis of a doxorubicin ester of a dicarboxylic acid, in acid medium.

Abstract: A compound exhibiting anti-inflammatory properties having the formula ##STR1## in which X is H, Hal or CH.sub.3 COO--; R.sub.1 is CH.sub.3 (CH.sub.2).sub.2 CH--; and R.sub.2 and R.sub.3 are separately H or Hal; and a pharmaceutical composition containing the same.

Abstract: A mop of the "butterfly" type has a flat sponge releasably secured to the lower faces of a pair of base plates mounted for pivotal movement relative to the mop handle, a slide is telescopically sleeved on the handle, a yoke-shaped compression member is pivoted to the slide and slidable relative to the handle and base plates in a camming motion as the slide is moved relative to the handle causing the base plates to pivot relative to the handle to force the sponge into a U-shaped, folded, or face-to-face position to compress the sponge and extract liquid therefrom.