Abstract: Prodrugs of glutamine analogs, such as prodrugs of acivicin, are disclosed.

Abstract: An electronic system such as an imaging system may include processing circuitry and memory circuitry. Data replacement circuitry may be interposed between the processing circuitry and the memory circuitry. In some implementations, the memory circuitry may be a read-only memory, and data replacement circuitry may be used to selectively replace executable firmware instructions stored on the read-only memory. The selective replacement operations may be based on an address that processing circuitry provides to access the memory circuitry. The data replacement circuitry may be implemented separately from the processing circuitry and the memory circuitry and may include a comparator block, registers, and switching circuitry.

Abstract: The present disclosure relates to determining the position of an X-ray focal spot in real time during an imaging process and using the focal spot position to ensure alignment of the focal spot and high-aspect detector elements or to correct for focal spot misalignment, thereby mitigating image artifacts. For example, the focal spot position may be monitored and may be adjusted in real-time using electromagnetic electron beam steering during a scan. Alternatively, previously determined functional relationships between focal spot position and measured data may be applied to address or correct for focal spot misalignment in the acquired data.

Abstract: Embodiments are directed to stateless communication using a stateful protocol. One or more NTMAs may establish a connection with a client computer based on data exchanged with a the client computer using the stateful protocol. The exchanged data may include validation information provided by the one or more NTMAs. The exchanged data and other information associated with the connection may be discarded from one or more memories of the one or more NTMAs. A network packet communicated over the network using the stateful protocol may be obtained. Verification information and candidate validation information may be generated based on one or more characteristics of the network packet. The network packet may be validated based on a comparison of the verification information and the candidate validation information. A reply that adheres to the stateful protocol may be provided to the client computer based on the validated network packet.

Abstract: Disclosed are genetic control circuits, cells, and methods that use a repressor polypeptide to reduce the transcription rate of an exogenous therapeutic polypeptide encoding gene in response to a change in condition.

Abstract: The present invention relates to anti-VEGF/anti-IL-1beta antibodies and methods of using the same.

Abstract: A method for imaging an object to be reconstructed includes acquiring projection data corresponding to the object. Furthermore, the method includes generating a measured sinogram based on the acquired projection data and formulating a forward model, where the forward model is representative of a characteristic of the imaging system. In addition, the method includes generating an estimated sinogram based on an estimated image of the object and the forward model and formulating a statistical model based on at least one of pile-up characteristics and dead time characteristics of a detector of the imaging system. Moreover, the method includes determining an update corresponding to the estimated image based on the statistical model, the measured sinogram, and the estimated sinogram and updating the estimated image based on the determined update to generate an updated image of the object. Additionally, the method includes outputting a final image of the object.

Abstract: The subject matter described herein is directed to Ferroportin inhibitor compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis.

Abstract: A skin engaging member suitable for use in a hair removal device, said skin engaging member comprising ethyl vinyl acetate having a low level of vinyl acetate and a water soluble polymer.

Abstract: A method including developing a representation of a set of services where each service relates to other services via different types of relationships and applying a set of dependency rules for each type of relationship within the set of services such that the application of the dependency rules creates inter-step dependencies between state transitions of the set of services. The method further including developing a step graph for the set of services based on the inter-step dependencies, identifying a common step in the step graph that is relevant to a first process and a second process, and removing any steps from the step graph for the first process that are relevant to the second process and not relevant to the first process.

Abstract: A method for imaging an object to be reconstructed includes acquiring projection data corresponding to the object. Furthermore, the method includes generating a measured sinogram based on the acquired projection data and formulating a forward model, where the forward model is representative of a characteristic of the imaging system. In addition, the method includes generating an estimated sinogram based on an estimated image of the object and the forward model and formulating a statistical model based on at least one of pile-up characteristics and dead time characteristics of a detector of the imaging system. Moreover, the method includes determining an update corresponding to the estimated image based on the statistical model, the measured sinogram, and the estimated sinogram and updating the estimated image based on the determined update to generate an updated image of the object. Additionally, the method includes outputting a final image of the object.

Abstract: The present approach provides a non-invasive methodology for estimation of coronary flow and/or fractional flow reserve. In certain implementations, various approaches for personalizing blood flow models of the coronary vasculature are described. The described personalization approaches involve patient-specific measurements and do not assume or rely on the resting coronary flow being proportional to myocardial mass. Consequently, there are fewer limitations in using these approaches to obtain coronary flow and/or fractional flow reserve estimates non-invasively.

Abstract: A signal processing method is disclosed, which includes detecting a total intensity of X-rays passing through an object comprising multiple materials; obtaining at least one set of basis information of basis material information of the multiple materials and basis component information of photon-electric absorption basis component and Compton scattering basis component of the object; estimating a scatter intensity component of the detected X-rays based on the at least one set of basis information and the detected total intensity; and obtaining an intensity estimate of primary X-rays incident on a detector based on the detected total intensity and the estimated scatter intensity component. An imaging system adopting the above signal processing method is also disclosed.

Abstract: A method of managing virtual network functions for a network, the method including providing a virtual network function (VNF) including a number of virtual network function components (VNFCs) of a number of different types, each VNFC comprising a virtual machine (VM) executing application software. The method further includes creating for up to all VNFC types a number of deactivated VMs having application software, monitoring at least one performance level of the VNF, and scaling-out the VNF by activating a number of deactivated VMs of a number of VNFC types when the at least one performance level reaches a scale-out threshold.

Abstract: Methods to execute an orchestration of computing services concurrently, the method including developing a representation of a set of services where each service relates to other services via different types of relationships. Also, applying a set of dependency rules for each type of relationship within the set of services such that the application of the dependency rules creates inter-step dependencies between steps representing state transitions of the set of services and developing the orchestration plan based on the inter-step dependencies that allows for concurrent execution of nondependent steps.

Abstract: The present disclosure relates to training one or more neural networks for vascular vessel assessment using synthetic image data for which ground-truth data is known. In certain implementations, the synthetic image data may be based in part, or derived from, clinical image data for which ground-truth data is not known or available. Neural networks trained in this manner may be used to perform one or more of vessel segmentation, decalcification, Hounsfield unit scoring, and/or estimation of a hemodynamic parameter.

Abstract: A system and method for cleaning a sintered filter includes a cleaning fluid source and a cleaning nozzle. The cleaning nozzle includes an inlet end coupled to the cleaning fluid source and at least one outlet port for outputting the cleaning fluid injected through the cleaning nozzle. The outlet port is disposed proximate to an outlet end of the cleaning nozzle. The cleaning nozzle has an external width less than an internal width of the sintered filter to be cleaned. The cleaning nozzle has a nozzle length greater than a full depth of the sintered filter to be cleaned. The outlet port can be disposed in a side of the cleaning nozzle proximate to the outlet end of the cleaning nozzle. The outlet port can include more than one outlet ports.

Abstract: A signal processing method is disclosed, which includes detecting a total intensity of X-rays passing through an object comprising multiple materials; obtaining at least one set of basis information of basis material information of the multiple materials and basis component information of photon-electric absorption basis component and Compton scattering basis component of the object; estimating a scatter intensity component of the detected X-rays based on the at least one set of basis information and the detected total intensity; and obtaining an intensity estimate of primary X-rays incident on a detector based on the detected total intensity and the estimated scatter intensity component. An imaging system adopting the above signal processing method is also disclosed.