Abstract: The present invention relates to novel agonistic anti-TrkB antibodies and therapeutic and diagnostic methods and compositions for using the same.

Abstract: The present invention relates to anti-VEGF/anti-IL-1beta antibodies and methods of using the same.

Abstract: A magnetic bistable hinge system includes a hinge bracket, first and second magnets, and a rotatable member. The first magnet may be coupled to the hinge bracket and be configured to rotate about an axis of the hinge bracket from a first bistable position to a second bistable position. When the south pole of the first magnet is at a first angle relative to the south pole of the second magnet, the first magnet and the second magnets are in the first bistable position and the rotatable member is in a closed position relative to the hinge bracket. When the south pole of the first magnet is at a second angle relative to the south pole of the second magnet, the first and second magnets are at the second bistable position, and the rotatable member is rotated to an open position relative to the hinge bracket.

Abstract: A milking system includes a milking device, a milk line, and a sampling and analysis device for the milk that includes a control unit, a tape mover to move and unwind a tape wound on a tape reel and with a base material with reagent pads, that detect a substance in the sample, and a dosing device to provide the sample onto a reagent pad, and a sensor to detect radiation from said reagent pad, and to analyse the detected radiation to indicate a presence or concentration of said substance. The reagent pad is facing downward during provision of the sample. In this way, the chance of excess liquid falling from the reagent, and possibly onto a camera, is reduced. Smaller reagent pads may be used, it reduces the chance of supplied liquid spilling over to a neighbouring reagent pad, the measures preventing this spilling may be limited, and it is easier to suck away excess fluid.

Abstract: Techniques are described for a social networking system to provide community profiles that allow for multiple holders, editors, and/or managers. In some cases, the social networking system may be configured to distribute content associated with the community profiles based on metrics and relationships associated with accounts of the collaborators to the community profile as well as the community profile itself.

Abstract: A milking system includes a milking device with a milking control, a milk line, and a sampling/analysis device. The milking control controls the milking based on said analysis. The sampling/analysis device includes a reagent carrier, including a tape with a first side with a reagent pad that detects the presence of a substance in the milk sample and a second side, a dosing device to provide a droplet of said sample onto the reagent pad, a source for emitting source radiation onto the reagent pad, and a sensor to detect response radiation emitted by the reagent pad, and to analyse the detected response radiation to indicate the presence or concentration of said substance. The first side faces away from the sensor during analysing by the sensor. By viewing “from below”, the observed reaction in the reagent is cleaner, and suffers less from artefacts, and the camera will stay cleaner.

Abstract: A joist assembly system that is structured for dynamic retrieval of components, dynamic and precise positioning and location of retrieved components, assembly of the components to form a joist, and delivery of the assembled joist. The joist assembly system has a plurality of material handling systems, a plurality of welding systems, and a rigging table system. The material handling systems are structured to load and position the components such as chords and webs onto the rigging table. The rigging table in turn supports the chords or webs. Subsequently, the plurality of welding systems weld the webs to the chords to form the joist.

Abstract: The invention describes a robot (5) and/or robot controller (17) and a method for validation of programmed workflow sequences or teaching programs (20) of a robot (5) preferably with a robot controller (17), wherein the robot (5) is preferably mounted on or next to a processing machine, in particular an injection molding machine (4), and serves for the extraction, handling, manipulation or further processing of injection-molded parts (3) which have just been produced. The travel parameters, equipment features and functionalities of the physical robot (5) are stored in a configuration file (27) on the control side. The robot controller (17) creates a virtual robot model (21) from these stored data. For validation of a workflow sequence, the robot controller (17) uses the current teaching program (20) in the robot controller (17) whereby the visualization of the workflow sequence is displayed directly on an output unit of the robot controller (17).

Abstract: Various methods and systems are provided for stationary computed tomography (CT) imaging. In one embodiment, a stationary CT system includes one or more detector arrays extending around at least a portion of an imaging volume, a stationary distributed x-ray source unit comprising a plurality of emitters including a first set of emitters configured to operate at a first voltage and a second set of emitters configured to operate at a second voltage, different than the first voltage, and a source controller for triggering the first set of emitters for acquiring first projection data by the one or more detector arrays and triggering the second set of emitters for acquiring second projection data by the one or more detector arrays, the first projection data and the second projection data usable to reconstruct one or more basis material composition images or monochromatic images of an object within the imaging volume.

Abstract: Examples of an apparatus and method for provisioning a service are described. Descriptors are described that represent the service. These are accessed and used to determine a reference required to implement the service. The reference indicates a type of entity and an entity to be passed to a function. The descriptor for the service is instantiated to obtain an instance of the service. This includes obtaining an instance of the type of entity indicated by the reference.

Abstract: A system aids in the cessation of a nicotine dependency. The system has a nicotine cessation device having a device housing including a plurality of pod receiving sockets and a plurality of fluid pods. A respective fluid pod is removably coupled with a respective pod receiving socket of the plurality of pod receiving sockets. Each respective fluid pod of the plurality of fluid pods receives a nicotine fluid having a predetermined concentration of nicotine therein and each respective fluid pod receives a nicotine fluid concentration that is different than at least one other fluid pod. The device housing may further include a printed circuit board (PCB) including a processor and a memory, and a power source.

Abstract: The disclosure relates to an electronic apparatus for a magnetic resonance tomography unit, a system including an electronic apparatus, a magnetic resonance tomography unit, and a method for operation. The apparatus has a detector for detecting a source of interference. The detected signal interferes with image acquisition.

Abstract: A method for controlling vehicle propulsion may include identifying at least one route characteristic of a portion of a route being traversed by a vehicle and determining a profile for a target vehicle speed based on the at least one route characteristic and a vehicle energy consumption profile. The method may also include, in response to detecting a lead vehicle, determining a vehicle speed of the lead vehicle and determining whether to avoid triggering initiation of the vehicle follow mode by the vehicle propulsion controller based on (i) a distance between the vehicle and a triggering threshold and (ii) the vehicle speed of the vehicle. The method may also include, in response to not triggering vehicle follow mode, determining, based on the vehicle speed of the lead vehicle and the profile for the target vehicle speed, a traveling distance between the vehicle and a trigger threshold.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable media for routing provider queues. A message routing system receives a request to transmit a message to a destination device and selects a first routing provider from a plurality of routing providers that each have a separate message queue of a plurality of message queues, wherein the first routing provider is selected based on one or more characteristics of each of the plurality of routing providers. The message routing system adds the message into a first message queue designated to the first routing provider, and causes the message to be dequeued from the first message queue to the first routing provider for delivery to the destination device.

Abstract: The present disclosure provides a magnetic system within a case for an electronic accessory. The case may include a housing portion and a lid coupled to the housing portion. Within the housing portion may be a housing magnet. The housing magnet may be oriented such that the magnetic field of the housing magnet is oriented transverse to a longitudinal axis of the case. The housing magnet may have a size and strength to magnetically couple the electronic accessory within a cavity of the housing. A hinge magnet may be located along an axis of rotation of the lid with respect to the housing. The hinge magnet and housing magnet may magnetically interact to form a bistable magnetic hinge. Thus, the one housing magnet may be large enough and have a strong enough magnetic field to perform various functions.

Abstract: The present invention relates to novel agonistic anti-TrkB antibodies and therapeutic and diagnostic methods and compositions for using the same.

Abstract: The present invention relates to anti-VEGF/anti-IL-1beta antibodies and methods of using the same.

Abstract: Herein a modular and efficient method for cloning multigene plasmids containing only a single cloning step without the use of preliminary single-gene vectors is reported. In the first step, PCR-produced DNAblocks carrying genes for different antibody chains are ligated with the respective adaptors, which serve as connectors of the different DNAblocks. In the second step, the PCR-produced fragments of the first step are assembled in the correct arrangement via the unique recombination sites located at one end of each backbone, DNAblock and adaptor fragment. This new strategy results in a modular and efficient method, which allows direct cloning of expression cassettes into the respective backbone without intermediate cloning steps and enable fast cloning of variable gene configurations of diverse antibody formats. This new cloning method according to the current invention provides considerable advantages in terms of time, work labor and costs.

Abstract: Disclosed is a metrology apparatus and method for measurement of a diffractive structure on a substrate. The metrology apparatus comprises a radiation source operable to provide first radiation for excitation of the diffractive structure such that high harmonic second radiation is generated from said diffractive structure and/or substrate; and a detection arrangement operable to detect said second radiation, at least a portion of which having been diffracted by said diffractive structure.

Abstract: Disclosed is a metrology apparatus for measurement of a target formed on a substrate by a lithographic process and associated method. The metrology apparatus comprises a radiation source operable to provide first radiation; a configured solid high harmonic generation medium being configured to receive and be excited by said first radiation to generate high harmonic second radiation from an output surface of the configured solid high harmonic generation medium; and a detection arrangement operable to detect said second radiation, at least a portion of which having been scattered by said target. The configured solid high harmonic generation medium is configured to shape the beam of said second radiation and/or separate said first and second radiation.