Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers.

Abstract: To allow simple creation of three-dimensional documentation for a utility article (1) made up of multiple parts (T), image parameters (BP) of at least one illustration (A) of the utility article (1) in existing two-dimensional documentation (2) are ascertained, a 3D model (M) of the utility article (1) with the ascertained image parameters (BP) is aligned with the illustration (A), and, based on a comparison of the two-dimensional illustration (A) and of the 3D model (M) to the ascertained image parameters (BP) from the two-dimensional illustration (A), additional information is obtained, which together with the 3D model (M) forms the three-dimensional documentation (10) of the utility article (1).

Abstract: The present invention relates to solid forms of (S)-2-methoxy-3-{442-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxyl-benzo[b]thiophen-7-yl}-propionic acid, and of salts of (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid.

Abstract: For an image processing concept, a database is provided in a device, the database comprising data derived from a plurality of frames of a video sequence. A live video feed is obtained from a camera of the device. Information is extracted from a selected image of the live video feed. A search is performed in the database based on the extracted information to retrieve a list of potential frames out of the plurality of frames. An initial pose of the selected image is estimated with respect to one frame of the list of potential frames as a function of the extracted information and the data derived from the one frame. Respective subsequent poses for subsequent images from the live video feed are iteratively estimated, wherein for each of the subsequent images the associated subsequent pose is estimated based on said subsequent image and a respective previously estimated pose. The live video feed is augmented on the device with virtual information based on the estimated initial pose and the subsequent poses.

Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.

Abstract: A clamping device for clamping a workpiece or a tool or a tool holder to a machine component of a machine tool, having an axially movable tension rod, a clamping assembly which can be moved by the tension rod between a clamped position and a released position, a spring assembly dedicated to the tension rod with a plurality of series-connected spring units for generating the clamping and draw-in force of the clamping assembly, and a releasing unit by which the clamping assembly can be moved by the tension rod against the force of the spring assembly into the released position. To ensure the most uniform load possible, the axial spring deflection of the spring units is limited by a stop when the spring assembly is compressed.

Abstract: A clamping device for clamping a workpiece or a tool or a tool holder to a machine component of a machine tool, including an axially movable tension rod, a clamping assembly which can be moved by the tension rod between a clamped position and a released position, a spring assembly dedicated to the tension rod for generating the clamping and draw-in force of the clamping assembly, and a releasing unit by which the clamping assembly can be moved by the tension rod against the force of the spring assembly into the released position. The spring assembly has a minimum of one spring unit with a plurality of flexible spring members disposed between a first and a second spring holder, with the first and second spring holders being secured against torsion relative to the tension rod.

Abstract: The invention provides novel compounds and conjugates of these compounds useful for the delivery of biologically active substances. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to a delivery polymer to achieve in vivo mRNA knock down are disclosed therein.

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3 and R4 n are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1, A2 A3 and n are as described herein, compositions including the compounds and methods of using the compounds. The compounds of the present invention are useful as inhibitors of aldosterone synthase. The compounds may be used, for example, in the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.

Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers.

Abstract: The invention provides novel compounds and conjugates of these compounds useful for the delivery of biologically active substances. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to a delivery polymer to achieve in vivo mRNA knock down are disclosed therein.

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, A1, A2 and A3 are as described herein, compositions including the compounds and methods of using the compounds. These compounds are useful for therapy or prophylaxis in a mammal, and in particular as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.

Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers.

Abstract: The invention provides use of novel compounds for delivery of nucleic acids, and conjugates of these compounds with nucleic acids. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to said compounds and co-administered with a delivery polymer to achieve mRNA knock down in vivo are disclosed therein.

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A and n are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, A1, A2, A3, A4, A5 and n are as described herein, compositions including the compounds and methods of using the compounds. The compounds are useful, for example, as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.