Abstract: An apheresis system at least partially defines a chamber and includes centrifuge that is movable between lock and unlock states. The centrifuge includes a base, cover, lock assembly, and latch assembly. The cover engages the base and defines slots. The lock assembly is coupled to the base and rotates between latched and unlatched states. The lock assembly includes tabs and a protrusion. The tabs are in the slots of the cover. The protrusion at least partially defines a receptacle. The latch assembly is coupled to the base and includes a lever and engagement component attached thereto. In the latched state, the protrusion engages the engagement component to reduce or prevent rotation of the lock assembly. In the unlatched state, the lock assembly can rotate. In the lock state, the tabs are at least partially within the slots. In the unlock state, the cover is movable with respect to the base.

Abstract: A flow cell for a liquid chromatography detector comprises a substrate formed of a glass material; a fluidic channel extending through the substrate; and at least one gas filled region formed in the substrate along at least a portion of a length of the fluidic channel. A portion of the glass material separates the fluidic channel and the gas filled region. An interface between the gas filled region and the portion of the glass material separating the fluidic channel and the gas filled region enables total internal reflection of light propagating along the fluidic channel.

Abstract: The present invention relates to a device for measuring a person's ventilation. The device includes a conduit with an exhaled-air receiving portion and an inhaled-air receiving portion. The device includes pressure and oxygen sensor sampling ports. The sampling ports are in fluid communication with the conduit. The device includes a deflector disposed within the conduit. The deflector is configured to deflect air exhaled into the exhaled-air receiving portion of the conduit away from the sensor ports.

Abstract: There is provided a device for measuring a person's ventilation or metabolism metrics. The device includes a conduit shaped to receive an exhalation of air therethrough. The device includes at least one gas sensor passively sampling said exhalation of air by means of a positive or negative pressure differential. The device includes a pump configured to assist in said passive sampling. The pump is configured to adjust the flow rate of a sample portion of said exhalation of air passing through to the at least one gas sensor, so as to be proportional or linear within a predetermined threshold, to the flow rate of the exhalation of air passing through the conduit. The device is configured to operate via both breath-mixing and breath-by-breath modes using a single flow path. The device is configured to change between the breath-mixing and breath-by-breath modes as a function of operation of the pump.

Abstract: The present disclosure is directed towards aligning a photonic integrated circuit (PIC) through providing a PIC with a marker waveguide, wherein a marker waveguide is a waveguide having: a first end located at the edge of the PIC wherein the first end is coupled to an edge coupling; and a second end coupled to a grating coupler or a device coupler, wherein: the grating coupler or device coupler is configured to receive light and couple the light to the waveguide to illuminate the waveguide to facilitate the correct alignment of the edge coupler to an external component.

Abstract: There is accordingly provided a device for measuring a person's ventilation including oxygen consumption. The device includes a breathing conduit with at least one sensor sampling port. The device includes a dehumidification conduit extending from the sensor sampling port towards a sensor. The dehumidification conduit has a proximal end portion flush with the sensor sampling port. The dehumidification conduit has a longitudinal axis about which the proximal end portion thereof extends. The breathing conduit is shaped to promote a flow of air adjacent the sensor sampling port in one or more directions perpendicular to the longitudinal axis.

Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

Abstract: High-power light absorbers (HPLAs) can exhibit low back-scattered light, mitigate stray light, and withstand high optical power. The absorbers can be used with or without baffling as beam dumps for high-power lasers. An HPLA may include a substrate made of high thermally conductive material with an anti-reflection (AR) coating formed on the substrate. A thin layer of highly absorbing material may be located between the AR coating and substrate. The substrate can be cooled with a fluid, such as water or air.

Abstract: There is provided a device for measuring a person's ventilation or metabolism metrics. The device includes a conduit shaped to receive an exhalation of air therethrough. The device includes at least one gas sensor passively sampling said exhalation of air by means of a positive or negative pressure differential. The device includes a pump configured to assist in said passive sampling. The pump is configured to adjust the flow rate of a sample portion of said exhalation of air passing through to the at least one gas sensor, so as to be proportional or linear within a predetermined threshold, to the flow rate of the exhalation of air passing through the conduit. The device is configured to operate via both breath-mixing and breath-by-breath modes using a single flow path. The device is configured to change between the breath-mixing and breath-by-breath modes as a function of operation of the pump.

Abstract: A fluid collection loop includes a flexible tube having a first end and a second end, a connector, and a fluid component collection bladder. The connector is configured to couple the first end of the flexible loop and the fluid component collection bladder. The fluid component collection bladder includes a first chamber defined between a top end and a flow chamber separator, and a second chamber defined between a bottom end and the flow chamber separator. The flow chamber separator extends from a first end of the fluid component collection bladder towards a second end of the fluid component collection bladder and a gap exists between the fluid component collection bladder and the second end of the fluid component collection bladder.

Abstract: An apheresis system at least partially defines a chamber and includes centrifuge that is movable between lock and unlock states. The centrifuge includes a base, cover, lock assembly, and latch assembly. The cover engages the base and defines slots. The lock assembly is coupled to the base and rotates between latched and unlatched states. The lock assembly includes tabs and a protrusion. The tabs are in the slots of the cover. The protrusion at least partially defines a receptacle. The latch assembly is coupled to the base and includes a lever and engagement component attached thereto. In the latched state, the protrusion engages the engagement component to reduce or prevent rotation of the lock assembly. In the unlatched state, the lock assembly can rotate. In the lock state, the tabs are at least partially within the slots. In the unlock state, the cover is movable with respect to the base.

Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

Abstract: A flow cell for a liquid chromatography detector comprises a substrate formed of a glass material; a fluidic channel extending through the substrate; and at least one gas filled region formed in the substrate along at least a portion of a length of the fluidic channel. A portion of the glass material separates the fluidic channel and the gas filled region. An interface between the gas filled region and the portion of the glass material separating the fluidic channel and the gas filled region enables total internal reflection of light propagating along the fluidic channel.

Abstract: A photonic integrated circuit (PIC) assembly that includes a PIC, and a light source mounted on a first carrier substrate, and optically coupled and aligned with the PIC. The first carrier substrate includes a wrap-around metal, that enables the first carrier substrate to be bonded electrically with the PIC using solder bumps, and wherein the wrap-around metal enables the first carrier substrate to be electrically controlled by an external device for facilitating alignment and optical coupling process with the PIC.

Abstract: This invention relates to gels encapsulating organometallic reagents, particularly organolithium reagents. The invention also relates to methods of making said gels and methods of using said gels. The gels are particularly useful in organic synthesis being easier to handle than the organometallic reagent solutions typically used.

Abstract: The present disclosure is directed towards aligning a photonic integrated circuit (PIC) through providing a PIC with a marker waveguide, wherein a marker waveguide is a waveguide having: a first end located at the edge of the PIC wherein the first end is coupled to an edge coupling; and a second end coupled to a grating coupler or a device coupler, wherein: the grating coupler or device coupler is configured to receive light and couple the light to the waveguide to illuminate the waveguide to facilitate the correct alignment of the edge coupler to an external component.

Abstract: There is accordingly provided a device for measuring a person's ventilation including oxygen consumption. The device includes a breathing conduit with at least one sensor sampling port. The device includes a dehumidification conduit extending from the sensor sampling port towards a sensor. The dehumidification conduit has a proximal end portion flush with the sensor sampling port. The dehumidification conduit has a longitudinal axis about which the proximal end portion thereof extends. The breathing conduit is shaped to promote a flow of air adjacent the sensor sampling port in one or more directions perpendicular to the longitudinal axis.

Abstract: The catheter probe comprises a catheter tip and a catheter body. The catheter tip comprises a plurality of channels for housing a plurality of optical sensors. Each one of said plurality of optical sensors comprises a ferrule comprising a via, a microlens aligned with said via and attached to said ferrule and an optical fiber for optically coupling said microlens to a monitoring means.

Abstract: At least one embodiment of the invention provides a photonic subsystem for integrating onto a photonic platform. The subsystem comprises a laser source and a plurality of optical components for focusing and directing a laser beam emitted from the laser source into a photonic platform. The laser source and plurality of optical components are mounted to a substrate and encapsulated.