Abstract: A respiratory assistance apparatus has a gases inlet configured to receive a supply of gases, a blower unit configured to generate a pressurised gases stream from the supply of gases; a humidification unit configured to heat and humidify the pressurised gases stream; and a gases outlet for the heated and humidified gases stream. A flow path for the gases stream extends through the respiratory device from the gases inlet through the blower unit and humidification unit to the gases outlet. A sensor assembly is provided in the flow path before the humidification unit. The sensor assembly has an ultrasound gas composition sensor system for sensing one or more gas concentrations within the gases stream.

Abstract: NK cells and NK cell lines are modified to increase their cytotoxicity. proliferation. metabolic profile and persistence. wherein the cells and compositions thereof have a use in the treatment of cancer.

Abstract: A breathing assistance apparatus user interface is described which presents animated information related to the management of the apparatus. The user interface is provided on a display screen of the apparatus. The animated illustrations can correspond to operational modes, warnings, user instructions, fault conditions, status, menu options, and the like. The animations can include a sequence of images shown in rapid succession which depict moving icons or objects, scrolling text, flashing colors, or any combination of these or the like. The user interface can combine static information along with animations.

Abstract: Method for active battery management to optimize battery performance. The method includes providing signal injections for charging and discharging of a battery. The signal injections include various charging and discharging profiles, rates, and endpoints. Response signals corresponding with the signal injections are received, and a utility of those signals is measured. Based upon the utility of the response signals, data relating to charging and discharging of the battery is modified to optimize battery performance and to determine when to discharge the battery into a power grid in order to return power to the grid in exchange for an economic benefit such as a payment or rebate from a utility company.

Abstract: Embodiments are disclosed for machine learning-based generation of recommended layouts. The method includes receiving a set of design elements for performing generative layout recommendation. A number of each type of design element from the set of design elements is determined. A set of recommended layouts are generated using a trained generative layout model and the number and type of design elements. The set of recommended layouts are output.

Abstract: The invention comprises a method of operating a breathing apparatus comprising measuring a baseline breath flow parameter being respiratory rate and/or tidal volume or a parameter derived therefrom, varying the flow rate provided by the breathing apparatus, measuring a current breath flow parameter being respiratory rate and/or tidal volume or a parameter derived therefrom, comparing the baseline and current breath flow parameters, and altering operation of the breathing apparatus based on the comparison. The invention also comprises a breathing apparatus that implements the above method.

Abstract: The breathing assistance apparatus of the present invention includes a manifold that is provided with or retrofittable to gases supply and humidifying devices. The manifold allows gases from an oxygen concentrator to be combined with the flow through a gases supply and humidifying device, most usually air. The combined output of oxygen and other breathing gases (air) is then humidified. The breathing assistance apparatus and manifold of the present invention provides a safe method to add oxygen to the input air stream of a gases supply and humidifying device and reduces the amount of accumulation of oxygen within the gases supply device, reducing fire risk should sparking occur within the device.

Abstract: The present invention provides a breathing assistance apparatus that has a convenient and effective method of cleaning internal conduits inside the apparatus. The breathing assistance apparatus is preferably a gases supply and humidification device. The cleaning method is a method of disinfection that is automated so minimal training is required to disinfect in particular an internal elbow conduit within the device. It is therefore not necessary to dismantle the gases supply and humidification device, therefore, inadvertent damage to the internal parts of the device is avoided. The present invention also provides a method of disinfecting a heated breathing conduit and a patient interface.

Abstract: A method of controlling a flow rate of gases supplied to a patient by a respiratory assistance device includes controlling the supply gases flow rate so as to deliver gases to the patient according to a predetermined gases pressure/flow rate profile for at least a portion of the breathing cycle. A profile may be achieved that provides the patient with a particular benefit or therapy.

Abstract: Embodiments of a respiratory support apparatus are disclosed comprising features configured to minimize, reduce or contain aerosols carrying pathogens that can cause diseases such as COVID 19, SARS, MERS, Tuberculosis, or any other infectious diseases. Embodiments of a respiratory support apparatus are also provided configured to at least reduce the amount of oxygen required, during use of the apparatus, from an external oxygen supply such as an oxygen tank or hospital wall supply. Embodiments of such apparatus are provided with means to recirculate expiratory gases, and/or redirect leak flow. Embodiments of such apparatus are provided in which expiratory gases are sucked away from the patient. Embodiments of such apparatus are provided comprising a first flow generator for delivering inspiratory gases, and a second flow generator for removing expiratory gases.

Abstract: Patient interfaces for respiratory therapy in the form of nasal interfaces or nasal masks include features that enhance or provide lateral stability of the interface. At least some of the embodiments provide multiple facial contact points or areas located in the general areas of the user's cheeks and/or upper lip. Some embodiments of the nasal interfaces provide advantageous sealing characteristics. The nasal interfaces may provide a controlled expiratory flow to reduce noise. Some embodiments include nasal pillows instead of or in addition to nasal prongs. The nasal pillows can have exhaust vents or can change in length in response to a pressure level within the nasal pillow.

Abstract: High-power light absorbers (HPLAs) can exhibit low back-scattered light, mitigate stray light, and withstand high optical power. The absorbers can be used with or without baffling as beam dumps for high-power lasers. An HPLA may include a substrate made of high thermally conductive material with an anti-reflection (AR) coating formed on the substrate. A thin layer of highly absorbing material may be located between the AR coating and substrate. The substrate can be cooled with a fluid, such as water or air.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining causal models for controlling environments.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining causal models for controlling environments. One of the methods includes repeatedly selecting, by a control system for the environment, control settings for the environment based on internal parameters of the control system, wherein: at least some of the control settings for the environment are selected based on a causal model, and the internal parameters include a first set of internal parameters that define a number of previously received performance metric values that are used to generate the causal model for a particular controllable element; obtaining, for each selected control setting, a performance metric value; determining that generating the causal model for the at particular controllable element would result in higher system performance; and adjusting, based on the determining, the first set of internal parameters.

Abstract: The invention relates to a virtual queuing system for managing a virtual queue for a resource, the system comprising a plurality of user devices and a virtual queue management unit, where each user device is configured to: allow a user to join a virtual queue for the resource by creating a virtual queue entry associated with the user device; wherein the virtual queue management unit is configured to: maintain a virtual queue comprising a sequence of virtual queue entries; and manage the virtual queue by sequentially removing virtual queue entries from the virtual queue and providing each user device associated with a removed virtual queue entry with an access pass allowing the user to access the resource; wherein the virtual queue management unit is further configured to: receive user behaviour data associated with one or more virtual queue entries that are within the virtual queue or that have been removed from the virtual queue; and vary the management of the virtual queue in response to the received user b