Patents by Inventor Peter Probst

Peter Probst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HUMAN CD163 ANTIBODIES AND USES THEREOF
    Publication number: 20260103535
    Abstract: Provided herein are antibodies and methods of use thereof. The antibodies as disclosed herein bind to CD163+ on cells, such as on macrophages. These antibodies can be used in methods of treatment, such as methods of treating cancer.
    Type: Application
    Filed: October 22, 2025
    Publication date: April 16, 2026
    Inventors: Kamal D. Puri, Siddarth Chandrasekaran, Melissa L. Conerly, Randi M. Simmons, Tyrel T. Smith, Mark E. Branum, Peter Probst
  • COMBINATIONS OF IMMUNOTHERAPIES AND USES THEREOF
    Publication number: 20260000756
    Abstract: Provided herein are uses of antibodies that bind to CD163 expressed on a human myeloid cell in combination with checkpoint inhibitors. Among other things, these CD163 antibodies can be used with checkpoint inhibitors in methods of treatment of humans, such as methods of treating a cancer or methods of relieving T cell suppression.
    Type: Application
    Filed: January 24, 2025
    Publication date: January 1, 2026
    Inventors: Siddarth Chandrasekaran, Tyrel T. Smith, Kamal D. Puri, Randi M. Simmons, Peter Probst
  • Piston diaphragm seal and system comprising a pressure transducer and a piston diaphragm seal
    Patent number: 12411052
    Abstract: The present disclosure relates to a piston diaphragm seal for transmitting a pressure of a medium to a pressure-measuring sensor a base body having a recess and a bore which is connected to the recess. The recess and the bore can be filled with a pressure transfer medium. A piston is arranged in the recess and can be moved within a predetermined region in the recess. A surface of the piston facing the medium can be loaded with the pressure of the medium, wherein the piston is separated by at least two sealing elements from the medium and the pressure transfer medium. A cavity is arranged in the piston between the at least two sealing elements. An attachment region is provided for connecting the piston diaphragm seal to the pressure-measuring sensor. A monitoring unit is designed to determine and/or monitor entry of medium and/or pressure transfer medium into the cavity.
    Type: Grant
    Filed: February 6, 2023
    Date of Patent: September 9, 2025
    Assignee: Endress+Hauser SE+Co. KG
    Inventors: Dietmar Leuthner, Klaus Behrendt, Jacobo Carrasco Heres, Peter Probst, Alfred Schmelzle
  • Immunomodulatory antibodies and methods of use thereof
    Patent number: 12195549
    Abstract: Provided herein are antibodies and methods of use thereof. The antibodies as disclosed herein bind to CD163+ on cells, such as on macrophages. These antibodies can be used in methods of treatment, such as methods of treating cancer.
    Type: Grant
    Filed: March 17, 2023
    Date of Patent: January 14, 2025
    Assignee: OncoResponse, Inc.
    Inventors: Kamal D. Puri, Siddarth Chandrasekaran, Melissa L. Conerly, Peter Probst, Tyrel T. Smith, Mark E. Branum, Randi M. Simmons
  • LILRB2/1 ANTIBODY PRODUCTS AND METHODS
    Publication number: 20250002577
    Abstract: The disclosure relates to LILRB2/1 antibody products and methods of use thereof. The antibody products specifically bind to LILRB1 and LILRB2 on cells such as myeloid cells, lymphocytes, or cancer cells. The antibody products can be used in methods of treatment of disease, such as methods cancer immunotherapy.
    Type: Application
    Filed: April 12, 2024
    Publication date: January 2, 2025
    Inventors: Meghan Zuck, Peter Probst, Thomas J. Graddis, Myriam N. Bouchlaka Bay, Kamal D. Puri
  • HUMAN CD163 ANTIBODIES AND USES THEREOF
    Publication number: 20240239914
    Abstract: Provided herein are antibodies and methods of use thereof. The antibodies as disclosed herein bind to CD163+ on cells, such as on macrophages. These antibodies can be used in methods of treatment, such as methods of treating cancer.
    Type: Application
    Filed: October 20, 2023
    Publication date: July 18, 2024
    Inventors: Kamal D. Puri, Siddarth Chandrasekaran, Melissa L. Conerly, Randi M. Simmons, Tyrel T. Smith, Mark E. Branum, Peter Probst
  • LILRB2 ANTIBODY PRODUCTS AND METHODS
    Publication number: 20240132589
    Abstract: The disclosure relates to LILRB2 antibody products and methods of use thereof. The antibody products specifically bind to LILRB2 on cells such as myeloid cells or cancer cells. The antibody products can be used in methods of treatment of disease, such as methods cancer immunotherapy.
    Type: Application
    Filed: October 17, 2023
    Publication date: April 25, 2024
    Inventors: Meghan Zuck, Peter Probst, Thomas J. Graddis, Myriam N. Bouchlaka Bay, Kamal D. Puri
  • IMMUNOMODULATORY ANTIBODIES AND METHODS OF USE THEREOF
    Publication number: 20240101696
    Abstract: Provided herein are antibodies and methods of use thereof. The antibodies as disclosed herein bind to CD163+ on cells, such as on macrophages. These antibodies can be used in methods of treatment, such as methods of treating cancer.
    Type: Application
    Filed: March 17, 2023
    Publication date: March 28, 2024
    Inventors: Kamal D. Puri, Siddarth Chandrasekaran, Melissa L. Conerly, Peter Probst, Tyrel T. Smith, Mark E. Branum, Randi M. Simmons
  • Human CD163 antibodies and uses thereof
    Patent number: 11827715
    Abstract: Provided herein are antibodies and methods of use thereof. The antibodies as disclosed herein bind to CD163+ on cells, such as on macrophages. These antibodies can be used in methods of treatment, such as methods of treating cancer.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: November 28, 2023
    Assignee: OncoResponse, Inc.
    Inventors: Kamal D. Puri, Siddarth Chandrasekaran, Melissa L. Conerly, Randi M. Simmons, Tyrel T. Smith, Mark E. Branum, Peter Probst
  • PISTON DIAPHRAGM SEAL AND SYSTEM COMPRISING A PRESSURE TRANSDUCER AND A PISTON DIAPHRAGM SEAL
    Publication number: 20230251156
    Abstract: The present disclosure relates to a piston diaphragm seal for transmitting a pressure of a medium to a pressure-measuring sensor a base body having a recess and a bore which is connected to the recess. The recess and the bore can be filled with a pressure transfer medium. A piston is arranged in the recess and can be moved within a predetermined region in the recess. A surface of the piston facing the medium can be loaded with the pressure of the medium, wherein the piston is separated by at least two sealing elements from the medium and the pressure transfer medium. A cavity is arranged in the piston between the at least two sealing elements. An attachment region is provided for connecting the piston diaphragm seal to the pressure-measuring sensor. A monitoring unit is designed to determine and/or monitor entry of medium and/or pressure transfer medium into the cavity.
    Type: Application
    Filed: February 6, 2023
    Publication date: August 10, 2023
    Inventors: Dietmar Leuthner, Klaus Behrendt, Jacobo Carrasco Heres, Peter Probst, Alfred Schmelzle
  • COMBINATIONS OF IMMUNOTHERAPIES AND USES THEREOF
    Publication number: 20230181732
    Abstract: Provided herein are uses of antibodies that bind to CD163 expressed on a human myeloid cell in combination with checkpoint inhibitors. Among other things, these CD163 antibodies can be used with checkpoint inhibitors in methods of treatment of humans, such as methods of treating a cancer or methods of relieving T cell suppression.
    Type: Application
    Filed: September 2, 2022
    Publication date: June 15, 2023
    Inventors: Siddarth Chandrasekaran, Tyrel T. Smith, Kamal D. Puri, Randi M. Simmons, Peter Probst, Robert J. Lechleider
  • Immunomodulatory antibodies and methods of use thereof
    Patent number: 11634501
    Abstract: Provided herein are antibodies and methods of use thereof. The antibodies as disclosed herein bind to CD163+ on cells, such as on macrophages. These antibodies can be used in methods of treatment, such as methods of treating cancer.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: April 25, 2023
    Assignee: OncoResponse, Inc.
    Inventors: Kamal D. Puri, Siddarth Chandrasekaran, Melissa L. Conerly, Peter Probst, Tyrel T. Smith, Mark E. Branum, Randi M. Simmons
  • IMMUNOMODULATORY ANTIBODIES AND METHODS OF USE THEREOF
    Publication number: 20220289861
    Abstract: Provided herein are antibodies and methods of use thereof. The antibodies as disclosed herein bind to CD163+ on cells, such as on macrophages. These antibodies can be used in methods of treatment, such as methods of treating cancer.
    Type: Application
    Filed: July 17, 2020
    Publication date: September 15, 2022
    Inventors: Kamal D. Puri, Siddarth Chandrasekaran, Melissa L. Conerly, Peter Probst, Tyrel T. Smith, Mark E. Branum, Randi M. Simmons
  • IMMUNOMODULATORY ANTIBODIES AND METHODS OF USE THEREOF
    Publication number: 20210253733
    Abstract: Provided herein are antibodies and methods of use thereof. The antibodies as disclosed herein bind to CD163+ on cells, such as on macrophages. These antibodies can be used in methods of treatment, such as methods of treating cancer.
    Type: Application
    Filed: April 22, 2021
    Publication date: August 19, 2021
    Inventors: Kamal D. PURI, Siddarth Chandrasekaran, Melissa L. Conerly, Randi M. Simmons, Tyrel T. Smith, Mark E. Branum, Peter Probst
  • Immunomodulatory antibodies and methods of use thereof
    Patent number: 11034770
    Abstract: Provided herein are antibodies and methods of use thereof. The antibodies as disclosed herein bind to CD163+ on cells, such as on macrophages. These antibodies can be used in methods of treatment, such as methods of treating cancer.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: June 15, 2021
    Assignee: OncoResponse, Inc.
    Inventors: Kamal D. Puri, Siddarth Chandrasekaran, Melissa L. Conerly, Randi M. Simmons, Tyrel T. Smith, Mark E. Branum, Peter Probst
  • IMMUNOMODULATORY ANTIBODIES AND METHODS OF USE THEREOF
    Publication number: 20210047424
    Abstract: Provided herein are antibodies and methods of use thereof. The antibodies as disclosed herein bind to CD163+ on cells, such as on macrophages. These antibodies can be used in methods of treatment, such as methods of treating cancer.
    Type: Application
    Filed: July 22, 2020
    Publication date: February 18, 2021
    Inventors: Kamal D. PURI, Siddarth CHANDRASEKARAN, Melissa L. CONERLY, Randi M. SIMMONS, Tyrel T. SMITH, Mark E. BRANUM, Peter PROBST
  • ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE "RIG-I" PATHWAY AND METHODS OF USE THEREOF
    Publication number: 20200071316
    Abstract: The present invention is directed to compounds of Formula (I), which are activators of the RIG-I pathway.
    Type: Application
    Filed: August 9, 2019
    Publication date: March 5, 2020
    Inventors: Daniel R. Goldberg, Peter Probst, Kristin M. Bedard
  • ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE "RIG-I" PATHWAY AND METHODS OF USE THEREOF
    Publication number: 20200055871
    Abstract: The present invention is directed to compounds of Formula (I), which are activators of the RIG-I pathway.
    Type: Application
    Filed: August 9, 2019
    Publication date: February 20, 2020
    Inventors: Daniel R. Goldberg, Peter Probst, Kristin M. Bedard
  • Seat rail for a vehicle seat of a motor vehicle and retaining arrangement of a retaining element of a vehicle seat on a seat rail
    Patent number: 9114729
    Abstract: A seat rail for a vehicle seat of a motor vehicle, including a seat rail profiled element, which has at least one profile region into which at least one corresponding retaining element of the vehicle seat can be inserted in at least one retaining position. The seat rail includes at least one ramp element extending at an angle from the longitudinal extension of the seat rail profiled element, by which ramp element the retaining element can be moved out of the profile region from the retaining position to at least one removal position by moving the retaining element along the ramp element.
    Type: Grant
    Filed: November 12, 2011
    Date of Patent: August 25, 2015
    Assignee: KEIPER GMBH & CO. KG
    Inventors: Andreas Kinzer, Joachim Mühlberger, Jürgen Nasshan, Peter Probst, Boris Willems
  • SEAT RAIL FOR A VEHICLE SEAT OF A MOTOR VEHICLE AND RETAINING ARRANGEMENT OF A RETAINING ELEMENT OF A VEHICLE SEAT ON A SEAT RAIL
    Publication number: 20140292018
    Abstract: A seat rail for a vehicle seat of a motor vehicle, including a seat rail profiled element, which has at least one profile region into which at least one corresponding retaining element of the vehicle seat can be inserted in at least one retaining position. The seat rail includes at least one ramp element extending at an angle from the longitudinal extension of the seat rail profiled element, by which ramp element the retaining element can be moved out of the profile region from the retaining position to at least one removal position by moving the retaining element along the ramp element.
    Type: Application
    Filed: November 12, 2011
    Publication date: October 2, 2014
    Inventors: Andreas Kinzer, Joachim Mühlberger, Jürgen Nasshan, Peter Probst, Boris Willems