Patents by Inventor Peter Probst
Peter Probst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8263089Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.Type: GrantFiled: October 30, 2007Date of Patent: September 11, 2012Assignee: Corixa CorporationInventors: Ajay Bhatia, Yasir A. W. Skeiky, Peter Probst
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Publication number: 20120114684Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.Type: ApplicationFiled: September 30, 2011Publication date: May 10, 2012Applicant: CORIXA CORPORATIONInventors: Ajay Bhatia, Yasir A.W. Skeiky, Peter Probst
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Publication number: 20110300206Abstract: The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.Type: ApplicationFiled: December 21, 2010Publication date: December 8, 2011Applicants: GlaxoSmithKline Biologicals, sa, Corixa CorporationInventors: Mark ALDERSON, Ajay BHATIA, Yves LOBET, Brenda MAISONNEUVE, Jean-Francois L. MAISONNEUVE, Martine MARCHAND, Pascal METTENS, Florence Bernadette NOZAY, Peter PROBST, Yasir A. SKEIKY, Samira H. SKEIKY
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Patent number: 8052975Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.Type: GrantFiled: October 30, 2007Date of Patent: November 8, 2011Assignee: Corixa CorporationInventors: Ajay Bhatia, Yasir A. W. Skeiky, Peter Probst
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Publication number: 20110142872Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.Type: ApplicationFiled: October 30, 2007Publication date: June 16, 2011Applicant: CORIXA CORPORATIONInventors: Ajay Bhatia, Yasir A.W. Skeiky, Peter Probst
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Publication number: 20100239579Abstract: Provide herein are fusion polypeptides that comprise a CD47 extracellular domain or a variant thereof that is fused to a Fc polypeptide. The fusion polypeptides are useful for treating an immunological disease or disorder in a subject according to the methods described herein. The fusion polypeptides are capable of suppressing immunoresponsiveness of an immune cell, inhibiting production of proinflammatory cytokines, including inhibiting immune complex-induced production of cytokines.Type: ApplicationFiled: January 14, 2010Publication date: September 23, 2010Applicant: VIRAL LOGIC SYSTEMS TECHNOLOGY CORP.Inventors: Craig A. Smith, Steven Wiley, Ajamete Kaykas, Peter Probst
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Publication number: 20100172927Abstract: Methods and compositions for the treatment or prevention of ocular Chlamydia trachomatis infection. Compositions comprise one or more Chlamydia trachomatis proteins, immunogenic fragments thereof or polynucleotides encoding such proteins or fragments.Type: ApplicationFiled: October 3, 2007Publication date: July 8, 2010Inventors: Mark Alderson, Rhea Coler, Yves Lobet, Jean-Francois L. Maisonneuve, Pascal Mettens, Peter Probst, Steven Reed
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Publication number: 20090117112Abstract: The poxvirus proteins designated A41L and 130L bind to three receptor-like protein tyrosine phosphatases (RPTP), leukocyte common antigen related protein (LAR), RPTP-?, and RPTP-?, that are present on the cell surface of immune cells. When a host is infected with the poxvirus, binding of A41L to cell surface proteins on the host cells results in suppression of the immune response. The present invention provides agents such as antibodies, and antigen-binding fragments thereof, small molecules, aptamers, small interfering RNAs, and peptide-IgFc fusion polypeptides that interact with one or more of LAR, RPTP-?, and RPTP-? expressed by immune cells or interact with a polynucleotide encoding the RPTP. Also provided are RPTP Ig domain oligomers and Fc fusion polypeptides. Such agents are useful for treating an immunological disorder in a subject according to the methods described herein.Type: ApplicationFiled: October 6, 2008Publication date: May 7, 2009Applicant: VIRAL LOGIC SYSTEMS TECHNOLOGY CORPORATIONInventors: Craig A. Smith, Steven Wiley, Ajamete Kaykas, Jalal Vakili, Peter Probst
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Publication number: 20090035296Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.Type: ApplicationFiled: October 30, 2007Publication date: February 5, 2009Applicant: CORIXA CORPORATIONInventors: Ajay Bhatia, Yasir A. W. Skeiky, Peter Probst
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Publication number: 20090028887Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.Type: ApplicationFiled: October 30, 2007Publication date: January 29, 2009Applicant: CORIXA CORPORATIONInventors: Ajay Bhatia, Yasir A.W. Skeiky, Peter Probst
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Publication number: 20090022755Abstract: The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.Type: ApplicationFiled: March 24, 2006Publication date: January 22, 2009Applicants: GLAXOSMITHKLINE BIOLOGICALS SA, CORIXA CORPORATIONInventors: Brenda Barth, Ajay Bhatia, Mark Alderson, Jean-Francois L. Maisonneuve, Yves Lobet, Florence Bernadette Nozay, Martine Marchand, Pascal Mettens, Yasir A. Skeiky, Peter Probst
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Publication number: 20080317772Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.Type: ApplicationFiled: October 30, 2007Publication date: December 25, 2008Applicant: CORIXA CORPORATIONInventors: Ajay Bhatia, Yasir A.W. Skeiky, Peter Probst
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Patent number: 7462357Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.Type: GrantFiled: June 18, 2004Date of Patent: December 9, 2008Assignee: Corixa CorporationInventors: Ajay Bhatia, Yasir A. W. Skeiky, Peter Probst
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Publication number: 20080299142Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.Type: ApplicationFiled: October 30, 2007Publication date: December 4, 2008Applicant: CORIXA CORPORATIONInventors: Ajay Bhatia, Yasir A.W. Skeiky, Peter Probst
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Publication number: 20080213264Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.Type: ApplicationFiled: October 30, 2007Publication date: September 4, 2008Applicant: CORIXA CORPORATIONInventors: Ajay Bhatia, Yasir A. W. Skeiky, Peter Probst
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Publication number: 20080181918Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.Type: ApplicationFiled: October 30, 2007Publication date: July 31, 2008Applicant: CORIXA CORPORATIONInventors: Ajay Bhatia, Yasir A. W. Skeiky, Peter Probst
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Patent number: 7384638Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.Type: GrantFiled: January 15, 2004Date of Patent: June 10, 2008Assignee: Corixa CorporationInventors: Ajay Bhatia, Peter Probst, Erika Jean Stromberg
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Publication number: 20080131431Abstract: Provide herein are fusion polypeptides that comprise a CD47 extracellular domain or a variant thereof that is fused to a Fc polypeptide. The fusion polypeptides are useful for treating an immunological disease or disorder in a subject according to the methods described herein. The fusion polypeptides are capable of suppressing immunoresponsiveness of an immune cell, inhibiting production of proinflammatory cytokines, including inhibiting immune complex-induced production of cytokines.Type: ApplicationFiled: May 15, 2007Publication date: June 5, 2008Applicant: Viral Logic Systems Technology Corp.Inventors: Craig A. Smith, Steven Wiley, Ajamete Kaykas, Peter Probst
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Publication number: 20070134234Abstract: The poxvirus proteins designated A41L and 130L bind to three receptor-like protein tyrosine phosphatases (RPTP), leukocyte common antigen related protein (LAR), RPTP-?, and RPTP-?, that are present on the cell surface of immune cells. When a host is infected with the poxvirus, binding of A41L to cell surface proteins on the host cells results in suppression of the immune response. The present invention provides agents such as antibodies, and antigen-binding fragments thereof, small molecules, aptamers, small interfering RNAs, and peptide-IgFc fusion polypeptides that interact with one or more of LAR, RPTP-?, and RPTP-? expressed by immune cells or interact with a polynucleotide encoding the RPTP. Also provided are RPTP Ig domain oligomers and Fc fusion polypeptides. Such agents are useful for treating an immunological disorder in a subject according to the methods described herein.Type: ApplicationFiled: September 29, 2006Publication date: June 14, 2007Applicant: Viral Logic Systems Technology Corp.Inventors: Craig Smith, Steven Wiley, Ajamete Kaykas, Jalal Vakili, Peter Probst
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Publication number: 20040234536Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.Type: ApplicationFiled: June 18, 2004Publication date: November 25, 2004Applicant: Corixa CorporationInventors: Ajay Bhatia, Yasir A.W. Skeiky, Peter Probst