Patents by Inventor Peter Ralph

Peter Ralph has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant colony stimulating factor-1
    Patent number: 5470569
    Abstract: A colony stimulating factor. CSF-1, is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein.
    Type: Grant
    Filed: March 14, 1994
    Date of Patent: November 28, 1995
    Assignee: Cetus Oncology Corporation
    Inventors: Ernest S. Kawasaki, Martha B. Ladner, Janelle N. Van Arsdell, Alice M. Wang, Peter Ralph, Mazie Y. Coyne, Mary K. Warren
  • Interleukin-1 antagonist and uses thereof
    Patent number: 5455330
    Abstract: Medicaments that have prophylactic or therapeutic applications for the treatment of disease resulting from the production of cytokines, particularly IL-1, that effectively inhibit the biological activity of the cytokines wherein the medicaments are characterized by being proteinaceous materials lacking a signal sequence for which a cDNA sequence has been identified and sequenced.
    Type: Grant
    Filed: June 30, 1993
    Date of Patent: October 3, 1995
    Assignee: Cetus Oncology Corporation
    Inventors: John S. Haskill, George Martin, Peter Ralph
  • Use of recombinant colony stimulating factor 1
    Patent number: 5422105
    Abstract: A colony stimulating factor, CSF-1, is a lymphokine useful in treating or preventing bacterial, vital or fungal infections, neoplasms, leukopenia, wounds, and in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein.
    Type: Grant
    Filed: March 1, 1994
    Date of Patent: June 6, 1995
    Assignee: Cetus Oncology Corporation
    Inventors: Peter Ralph, Kong T. Chong
  • Uses of recombinant colony stimulating factor-1
    Patent number: 5104650
    Abstract: A colony stimulating factor, CSF-1, is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein.
    Type: Grant
    Filed: September 22, 1987
    Date of Patent: April 14, 1992
    Assignee: Cetus Corporation
    Inventors: Peter Ralph, Mary K. Warren, Kong T. Chong, James J. Devlin, Robert Zimmerman, Ada H. C. Kung
  • DNA encoding for CSF-1 and accompanying recombinant systems
    Patent number: 4847201
    Abstract: A colony stimulating factor, CSF-1, is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein.
    Type: Grant
    Filed: February 9, 1988
    Date of Patent: July 11, 1989
    Assignee: Cetus Corporation
    Inventors: Ernest S. Kaswasaki, Martha B. Ladner, Janelle N. Van Arsdell, Alice M. Wang, Peter Ralph, Mazie Y. Coyne, Mary K. Warren
  • Method for diagnosis of subclassifications of common varied immunodeficiency disease group
    Patent number: 4743540
    Abstract: A method is devised to assay and diagnose common varied immunodeficiency syndrome. This syndrome is subdivided or subset into at least four separate groups of B-cell deficiencies based on a patients peripheral blood B-cell proliferative and/or differentiative response to various stimulatory factors alone or in combination. CVI diagnosis and therapy are aided by this invention.
    Type: Grant
    Filed: September 27, 1983
    Date of Patent: May 10, 1988
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Peter Ralph, Osamu Saiki
  • Purifications of B-cell inducing factor (BIF) and B-cell growth factor (BGF)
    Patent number: 4730036
    Abstract: Highly purified T cell replacing factor (TRF or BIF) essentially free of IL-2 and Interferon activities is obtained in the invention. BIF is useful for treatment of immunoregulatory disorders and/or stimulation of production of immunoglobulins. A method for production of BIF and BGF is described.B cell lines for BIF assays are described as well as an assay for B cell receptor variants and a method for obtaining B cell variants from a variety of source materials.
    Type: Grant
    Filed: January 3, 1984
    Date of Patent: March 8, 1988
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Peter Ralph, Karl Welte