Abstract: Projectile launch apparatus (20) for use in a fluid environment. The apparatus (20) comprises a launch tube (21) having a supercavitating projectile (24) with cavitator (29) received within the launch tube (21). A means for generating expulsion gas (not visible) is arranged to provide expulsion gas to propel the projectile (24) from the launch tube (21), with means for bleeding expulsion gas (31, 32) being provided to bleed a portion of expulsion gas around the projectile (24). This allows expulsion gases to contribute to the formation of the gas cavity around the supercavitating projectile (24) as the projectile (24) is launched from the launch tube (21). Particularly suited to the deployment of supercavitating projectiles underwater, such as in underwater mine disposal applications.

Abstract: A catalyst for the electrochemical conversion of carbon dioxide or carbon monoxide to a C2+ product. The catalyst comprises copper and a metal (M) selected from the group consisting of: yttrium (Y), zinc (Zn), lanthanum (La) and gadolinium (Gd); wherein the molar ratio of Cu:M is from 100:1 to 100:10. The catalyst has particular use in a gas diffusion electrode, a catalyst coated membrane of an electrolyser.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: The present invention relates to novel anti-FLT3 antibodies for specifically targeting extracellular domain of FLT3. The present invention further relates to targeting FLT3 by novel antibody-drug-conjugates (ADCs) based on the novel anti-FLT3 antibodies of the present invention, especially in combination with kinase inhibitors, for use in therapy and/or for use in a method of cancer treatment (e.g., acute myeloid leukemia (AML) with or without internal tandem duplication (ITD) mutations in the FLT3 gene (FLT3-ITD)).

Abstract: 1. Presenting ancestral origin information, comprising: receiving a request to display ancestry data of an individual; obtaining ancestry composition information of the individual, the ancestry composition information including information pertaining to a proportion of the individual's genotype data that is deemed to correspond to a specific ancestry; and presenting the ancestry composition information to be displayed.

Abstract: Siloxane-based coating compositions that may be applied to the surface of a substrate, such as an article of cookware or bakeware, to form a durable non-stick coating with extended easy to clean properties. The coating compositions may include a siloxane resin, an organic oil, and a fluoride component such as particles of calcium fluoride (CaF2), magnesium fluoride (MgF2), strontium fluoride (SrF2), and/or barium fluoride (BaF2).

Abstract: The present disclosure provides computer-implemented methods, systems, and devices for estimating the oxygen saturation levels of the blood of a user. A wearable computing device emits using one or more green light sources, light towards a skin of a user at a green wavelength. The wearable computing device further emits, using one or more red light sources, light towards a skin of a user at a red wavelength. The wearable computing device further emits, using one or more infrared light sources, light towards a skin of a user at an infrared wavelength. The wearable computing device further detects an intensity of green light, red light, and infrared light emitted from the skin of a user. The wearable computing device further determines an estimated oxygen saturation level.

Abstract: A data processing apparatus is provided which controls the use of data in respect of a further operation. The data processing apparatus identifies whether data is trusted or untrusted by identifying whether or not the data was determined by a speculatively executed resolve-pending operation. A permission control unit is also provided to control how the data can be used in respect of a further operation according to a security policy while the speculatively executed operation is still resolve-pending.

Abstract: An example device includes a first register storing a first vector comprised of a set of vector elements; a second register having a set of lanes and configured to store a second vector; and a storage that stores a set of control elements. Each such control element corresponds to a respective one of the vector elements of the set of vector elements in the first register. In addition, each control element of the set of control elements has a first portion that specifies, for the corresponding vector element of the set of vector elements, a lane of the set of lanes of the second register, and a second portion that specifies whether the corresponding vector element of the set of vector elements is to be routed to the lane specified by the first portion. The example device further includes processing circuitry to, based on an instruction that specifies the first register and the second register, generate the second vector based on the set of control elements.

Abstract: Presenting ancestral origin information, comprising: receiving a request to display ancestry data of an individual; obtaining ancestry composition information of the individual, the ancestry composition information including information pertaining to a proportion of the individual's genotype data that is deemed to correspond to a specific ancestry; and presenting the ancestry composition information to be displayed.

Abstract: Disclosed are novel conjugates and methods for the preparation thereof. One of the methods for the preparation of a conjugate comprises a step of: acting a compound of formula (I), with a thiol-containing molecule of formula (II), wherein represents an amino acid, a peptide, a protein, an antibody, a nucleotide, an oligonucleotide, a saccharide, a polysaccharide, a polymer, a small molecule, an optionally substituted C1-C8-alkyl, an optionally substituted phenyl, or an optionally substituted aromatic 5- or 6-membered heterocyclic system; resulting in a compound of formula (III).

Abstract: A method is provided that includes performing, by a processor in response to a vector permutation instruction, permutation of values stored in lanes of a vector to generate a permuted vector, wherein the permutation is responsive to a control storage location storing permute control input for each lane of the permuted vector, wherein the permute control input corresponding to each lane of the permuted vector indicates a value to be stored in the lane of the permuted vector, wherein the permute control input for at least one lane of the permuted vector indicates a value of a selected lane of the vector is to be stored in the at least one lane, and storing the permuted vector in a storage location indicated by an operand of the vector permutation instruction.

Abstract: A method to compare first and second source data in a processor in response to a vector maximum with indexing instruction includes specifying first and second source registers containing first and second source data, a destination register storing compared data, and a predicate register. Each of the registers includes a plurality of lanes. The method includes executing the instruction by, for each lane in the first and second source register, comparing a value in the lane of the first source register to a value in the corresponding lane of the second source register to identify a maximum value, storing the maximum value in a corresponding lane of the destination register, asserting a corresponding lane of the predicate register if the maximum value is from the first source register, and de-asserting the corresponding lane of the predicate register if the maximum value is from the second source register.

Abstract: A projectile for piercing a casing of a mine containing an explosive material. The projectile includes a projectile body having a nose portion and a tail portion and a longitudinal axis, a switch, and electrodes separated such that in use an electrical discharge can flow between them through an explosive material contained within a mine, or to initiate an energetic material provided between the electrodes to detonate an explosive material contained within a mine. Also provided is a method of mine disposal.

Abstract: A method to compare first and second source data in a processor in response to a vector maximum with indexing instruction includes specifying first and second source registers containing first and second source data, a destination register storing compared data, and a predicate register. Each of the registers includes a plurality of lanes. The method includes executing the instruction by, for each lane in the first and second source register, comparing a value in the lane of the first source register to a value in the corresponding lane of the second source register to identify a maximum value, storing the maximum value in a corresponding lane of the destination register, asserting a corresponding lane of the predicate register if the maximum value is from the first source register, and de-asserting the corresponding lane of the predicate register if the maximum value is from the second source register.

Abstract: A fluid cooled mold plate is disclosed. The fluid cooled mold plate has a front side, a rear side, and a perimeter that extends between its front and rear sides. A cooling chamber is formed within the mold plate. The cooling chamber has a front wall, a rear wall, and a perimeter wall that extends between the front and rear walls. An inlet fluid duct extends from a first side of the mold plate perimeter to a first end of the cooling chamber and an outlet fluid duct extends from a second side of the mold plate perimeter to a second end of the cooling chamber. The cooling chamber is occupied by a turbulence generating dispersion mesh that is secured between the front and rear walls the cooling chamber.

Abstract: A vacuum system, including a condenser including a first inlet, a first outlet, and a second outlet, a first ejector connected to a motive fluid source, and a second ejector connected to the motive fluid source and the condenser.

Abstract: Methods and apparatus for manufacturing a microfluidic arrangement are disclosed. In one arrangement, a continuous body of a first liquid is provided in direct contact with a first substrate. A second liquid covers the first liquid. A separation fluid, immiscible with the first liquid, is propelled through at least the first liquid and into contact with the first substrate along all of a selected path on the surface of the first substrate. First liquid that was initially in contact with all of the selected path is displaced away from the selected path. The first liquid is divided to form sub-bodies of first liquid that are separated from each other. For each of one or more of the sub-bodies, a sub-body footprint represents an area of contact between the sub-body and the first substrate, and all of a boundary of the sub-body footprint is in contact with a closed loop of the selected path surrounding the sub-body footprint.

Abstract: Presenting ancestral origin information, comprising: receiving a request to display ancestry data of an individual; obtaining ancestry composition information of the individual, the ancestry composition information including information pertaining to a proportion of the individual's genotype data that is deemed to correspond to a specific ancestry; and presenting the ancestry composition information to be displayed.

Abstract: A fluid cooled mold plate is disclosed. The fluid cooled mold plate has a front side, a rear side, and a perimeter that extends between its front and rear sides. A cooling chamber is formed within the mold plate. The cooling chamber has a front wall, a rear wall, and a perimeter wall that extends between the front and rear walls. An inlet fluid duct extends from a first side of the mold plate perimeter to a first end of the cooling chamber and an outlet fluid duct extends from a second side of the mold plate perimeter to a second end of the cooling chamber. The cooling chamber is occupied by a turbulence generating dispersion mesh that is secured between the front and rear walls the cooling chamber.