Abstract: The present invention relates to the use of (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid of formula (I), prefer-ably in form of one of its salts or solvates or hydrates, preferably (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid in form of monohydrate (I) of formula (I-M-I) or (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)-ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid inform of mono hydrate (II) of formula (I-M-II), in the inhalative treatment of cardiopulmonary and pulmonary disorders, such as pulmonary arterial hypertension (P AH), chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary hypertension (PH) associated with chronic lung disease (PH group 3) such as pulmonary hypertension in chronic obstructive pulmo

Abstract: The invention relates to a protection for a semi-conductor switch against over voltages. A capacitive element is provided on an inlet connection of the semi-conductor switch. The load amount, which flows into said capacitive element, is integrated in order to trigger a protection function when a threshold value is exceeded.

Abstract: A rotor of a gas turbine having two adjacent rotor discs, on each of which moving blades are fastened, an annular rotor component being arranged between the rotor discs and having at its opposite ends circumferential annular grooves, in each of which a circumferential fastening projection on the respective rotor disc engages. When the rotor is stationary a first outer flank of the first annular groove rests under pressure against a first outer flank of the first fastening projection and there is play between a first inner flank of the first annular groove and a first inner flank of the first fastening projection.

Abstract: An apparatus includes a multi-tenant computer system including a processor and a memory operatively coupled to the processor. The apparatus receives a first service request from a first compute device and a second service request from a second compute device. Data values of the first service request are not accessible by the second compute device and data values of the second request are not accessible by the first compute device. The apparatus merges the data values of the first service request and the data values of the second service request and filters the results based on a set of rules not accessible to the second compute device to produce a first filtered result responsive to the second service request. The apparatus also filters the results based on a set of rules not accessible to the first compute device to produce a second filtered result responsive to the first service request.

Abstract: An apparatus includes a multi-tenant computer system including a processor and a memory operatively coupled to the processor. The apparatus receives a first service request from a first compute device and a second service request from a second compute device. Data values of the first service request are not accessible by the second compute device and data values of the second request are not accessible by the first compute device. The apparatus merges the data values of the first service request and the data values of the second service request and filters the results based on a set of rules not accessible to the second compute device to produce a first filtered result responsive to the second service request. The apparatus also filters the results based on a set of rules not accessible to the first compute device to produce a second filtered result responsive to the first service request.

Abstract: In a method for producing a brake disc, a friction surface layer is sprayed onto the base body or onto an intermediate layer applied on the base body by cold gas spraying a particle mixture which consists 25 to 75% by weight of a metal matrix material and 75 to 25% by weight of a carbide material. The metal matrix material consists of an iron-based alloy, nickel-based alloy, titanium or titanium alloy. The carbide material consists of tungsten carbide, titanium carbide, iron carbide, silicon carbide, chromium carbide or niobium carbide.

Abstract: The invention relates to a novel method for scoring sleep stages of a mammal subject, comprising extracting features from polysomnography data using the continuous wavelet transform; grouping the extracted features into clusters that are assigned to different sleep stages; and scoring the sleep stages based on the clusters. The method does not require prior visual knowledge of sleep stages nor supervised training.

Abstract: Disclosed is a cochlear implant (Cl) and a method of generating stimulations for the CI. The Cl may include, at least one optical signal generator configured to generate a plurality of optical signals having a wavelength of at most 1600 nm, and a plurality of light emitters, for delivering the optical signals to different locations along a cochlear nerve. The method may further include optimizing the stimulation energy through selection of stimulation wavelengths and stimulation pulse shapes.

Abstract: In some embodiments, a non-transitory processor-readable medium receives, from a client compute device and at a multi-tenant computer system, a service request that includes an authentication token provided by a third-party compute device and that identifies a single-tenant account (1) of the multi-tenant computer system and (2) associated with the client compute device. The medium sends an information request for first information associated with the service request to the third-party compute device. The medium receives the first information from the third-party compute device in response to the information request. The medium processes the service request based on the first information to produce a service result responsive to the service request. The medium sends the service result to the client compute device.

Abstract: A sleep monitor device for monitoring breathing and other physiological parameters is used to classify, assess, diagnose, and/or treat sleeping disorders (e.g., obstructive sleep apnea and upper airway obstruction, among others). The sleep monitor device can be a wearable device that contains one or more microphones arranged around the subject's neck when worn. Additionally, the wearable device may also include, or otherwise be in communication with, other sensors and/or measurement components, such as optical sources and electrodes. Using the sleep monitor device it is possible to identify upper airway resistances, the site of the obstruction, to monitor tissue resistance, temperature, and oxygen saturation. Early detection of the development of upper airway resistances during sleep can be used to control supportive measures for sleep apnea, such controlling continuous positive airway pressure (“CPAP”) devices or neurological or mechanical stimulators.

Abstract: Disclosed are methods and pharmaceutical compositions for treating and/or preventing hearing loss in a subject in need thereof. The disclosed methods typically utilize and the pharmaceutical compositions typical comprise an effective amount of a polyphenol therapeutic agent such as honokiol.

Abstract: Disclosed is a method of selecting stimulations for a cochlear implant or an auditory implant. The method may include: capturing an acoustical signal; dividing the acoustical signal into a plurality of frequency bands; determining a mean acoustical energy for each frequency band; for each frequency band: comparing the mean acoustical energy with the mean acoustical energy determined for neighboring frequency bands; merging neighboring frequency bands having a difference between the mean acoustical energies that is less than an acoustical energy threshold value; selecting one or more types of stimulation to be applied to one or more locations in a cochlea or along an auditory nerve based on bandwidths of each frequency band. The one or more types of stimulation may be selected from: electrical stimulation, optical stimulation and opto-electrical stimulation, and the one or more locations in cochlea or along the auditory nerve may correspond to specific frequencies of the acoustical signal.

Abstract: In some embodiments, a non-transitory processor-readable medium receives, from a client compute device and at a multi-tenant computer system, a service request that includes an authentication token provided by a third-party compute device and that identifies a single-tenant account (1) of the multi-tenant computer system and (2) associated with the client compute device. The medium sends an information request for first information associated with the service request to the third-party compute device. The medium receives the first information from the third-party compute device in response to the information request. The medium processes the service request based on the first information to produce a service result responsive to the service request. The medium sends the service result to the client compute device.

Abstract: A hydrodynamic installation includes an upper water tank, a lower water tank, a water way system which has a plurality of partial water ways and which connects the upper water tank to the lower water tank. A hydraulic machine is arranged in the water way system, a water protection is arranged in a partial water way, and an electric drive provided for actuating the water protection. The electric drive is constructed in such a manner that it also ensures safe closing of the water protection in the event of a power failure without an emergency power supply being provided to this end.

Abstract: A hydroelectric power plant includes an upper water basin, a lower water basin, a waterway connecting the upper water basin to the lower water basin, a hydraulic machine disposed in the waterway, an inlet valve disposed in a pressure pipeline, and an electric drive for actuating the inlet device. The electric drive is configured in such a way that it ensures reliable closing of the inlet valve even in the event of a power failure, without an emergency power supply being provided therefor.

Abstract: A hydrodynamic installation includes an upper water tank, a lower water tank, a water way system which has a plurality of partial water ways and which connects the upper water tank to the lower water tank. A hydraulic machine is arranged in the water way system, a water protection is arranged in a partial water way, and an electric drive provided for actuating the water protection. The electric drive is constructed in such a manner that it also ensures safe closing of the water protection in the event of a power failure without an emergency power supply being provided to this end.

Abstract: A hydroelectric power plant includes an upper water basin, a lower water basin, a waterway connecting the upper water basin to the lower water basin, a hydraulic machine disposed in the waterway, an inlet valve disposed in a pressure pipeline, and an electric drive for actuating the inlet device. The electric drive is configured in such a way that it ensures reliable closing of the inlet valve even in the event of a power failure, without an emergency power supply being provided therefor.

Abstract: Representative apparatus, method, and system embodiments are disclosed for non-invasive detection an ingested battery or magnet in a human or other animal subject. The various apparatus embodiments include one or more Hall effect sensors, arranged in a hand-held embodiment or arranged along a flexible strip having an adhesive. A calibration may be determined or reference or calibration field measurements may be generated. A flexible strip is arranged, or the hand-held embodiment is moved, over the esophagus of the subject to generate target magnetic field measurements. The presence of an ingested battery or magnet is detected when one or more target magnetic field measurements (or gradient) is or are greater than or equal to a first predetermined threshold, or when a sign reversal occurs for a difference between target and reference measurements. The various apparatus and system embodiments may also include a monitor for signal processing and display of results.

Abstract: A system for neuromodulation device coding for stimulation of a patient includes a neural code library comprising digital representations of neural responses of neural units of at least one normal functioning animal, each digital representation corresponding to one of digital representations of stimulus; a sensory device configured to detect a sensory signal; an analyzer configured to identify one of the digital representations of stimulus in the neural code library in response to receipt of the sensory signal; a processing device configured, for each identified sensory signal, to retrieve the digital representations of neural responses of neural units corresponding to the identified sensory signal from the neural code library, and select one or more neural units of a patient to be stimulated by a neuromodulation device associated with the patient; and a transmitting device configured to stimulate the selected one or more neural units of the patient.

Abstract: A system for neuromodulation device coding for stimulation of a patient includes a neural code library comprising digital representations of neural responses of neural units of at least one normal functioning animal, each digital representation corresponding to one of digital representations of stimulus; a sensory device configured to detect a sensory signal; an analyzer configured to identify one of the digital representations of stimulus in the neural code library in response to receipt of the sensory signal; a processing device configured, for each identified sensory signal, to retrieve the digital representations of neural responses of neural units corresponding to the identified sensory signal from the neural code library, and select one or more neural units of a patient to be stimulated by a neuromodulation device associated with the patient; and a transmitting device configured to stimulate the selected one or more neural units of the patient.