Patents by Inventor Peter S. Gagnon

Peter S. Gagnon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10696952
    Abstract: Provided herein are methods for the purification of recombinant adeno-associated virus (rAAV) vectors that can be used for gene transfer and specifically for gene therapy or vaccination. Recombinant AAV vectors of the invention are substantially free of in-process impurities, including production components such as cellular nucleic acids, cellular proteins, helper virus, and media components.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: June 30, 2020
    Assignee: Genzyme Corporation
    Inventors: Paulene Mclean Quigley Sheldon, Peter S. Gagnon, Gina Nichols, Barbara A. Thorne
  • Publication number: 20190010468
    Abstract: Provided herein are methods for the purification of recombinant adeno-associated virus (rAAV) vectors that can be used for gene transfer and specifically for gene therapy or vaccination. Recombinant AAV vectors of the invention are substantially free of in-process impurities, including production components such as cellular nucleic acids, cellular proteins, helper virus, and media components.
    Type: Application
    Filed: June 12, 2018
    Publication date: January 10, 2019
    Inventors: Pauline McLean Quigley SHELDON, Peter S. GAGNON, Gina NICHOLS, Barbara A. THORNE
  • Patent number: 10017746
    Abstract: Provided herein are methods for the purification of recombinant adeno-associated virus (rAAV) vectors that can be used for gene transfer and specifically for gene therapy or vaccination. Recombinant AAV vectors of the invention are substantially free of in-process impurities, including production components such as cellular nucleic acids, cellular proteins, helper virus, and media components.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: July 10, 2018
    Assignee: GENZYME CORPORATION
    Inventors: Pauline McLean Quigley Sheldon, Peter S. Gagnon, Gina Nichols, Barbara A. Thorne
  • Publication number: 20180186831
    Abstract: Methods are disclosed for use of apatite chromatography, particularly without reliance upon phosphate gradients, for purification or separation of at least one intact non-aggregated antibody, or at least one immunoreactive antibody fragment, from an impure preparation. Integration of such methods into multi-step procedures with other fractionation methods are additionally disclosed.
    Type: Application
    Filed: March 2, 2018
    Publication date: July 5, 2018
    Inventor: Peter S. Gagnon
  • Patent number: 9938317
    Abstract: Methods are disclosed for use of apatite chromatography, particularly without reliance upon phosphate gradients, for purification or separation of at least one intact non-aggregated antibody, or at least one immunoreactive antibody fragment, from an impure preparation. Integration of such methods into multi-step procedures with other fractionation methods are additionally disclosed.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: April 10, 2018
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Peter S. Gagnon
  • Patent number: 9442050
    Abstract: Provided are methods and compositions for reducing or eliminating pH excursions in cation and anion exchange chromatography.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: September 13, 2016
    Assignee: BIO-RAD LABORATORIES, INC.
    Inventor: Peter S. Gagnon
  • Publication number: 20150353598
    Abstract: Methods are disclosed for use of apatite chromatography, particularly without reliance upon phosphate gradients, for purification or separation of at least one intact non-aggregated antibody, or at least one immunoreactive antibody fragment, from an impure preparation. Integration of such methods into multi-step procedures with other fractionation methods are additionally disclosed.
    Type: Application
    Filed: August 5, 2015
    Publication date: December 10, 2015
    Inventor: Peter S. Gagnon
  • Patent number: 9193760
    Abstract: The invention provides methods and materials for using apatite chromatography supports to dissociate and remove contaminants that are complexed to biological products. The invention further provides materials and methods for dissociating aggregations of target biological molecules or improperly folded target molecules to improve purification of the target molecule.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: November 24, 2015
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Peter S. Gagnon
  • Patent number: 9127042
    Abstract: Methods are disclosed for use of apatite chromatography, particularly without reliance upon phosphate gradients, for purification or separation of at least one intact non-aggregated antibody, or at least one immunoreactive antibody fragment, from an impure preparation. Integration of such methods into multi-step procedures with other fractionation methods are additionally disclosed.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: September 8, 2015
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Peter S. Gagnon
  • Publication number: 20150024467
    Abstract: Provided herein are methods for the purification of recombinant adeno-associated virus (rAAV) vectors that can be used for gene transfer and specifically for gene therapy or vaccination. Recombinant AAV vectors of the invention are substantially free of in-process impurities, including production components such as cellular nucleic acids, cellular proteins, helper virus, and media components.
    Type: Application
    Filed: December 16, 2011
    Publication date: January 22, 2015
    Applicant: GENZYME CORPORATION
    Inventors: Pauline McLean Quigley Sheldon, Peter S. Gagnon, Gina Nichols, Barbara A. Thorne
  • Patent number: 8911992
    Abstract: Removal of genomic DNA from biological samples using cation exchange is described.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: December 16, 2014
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Peter S. Gagnon
  • Patent number: 8877904
    Abstract: Methods, kits and apparatuses for chromatography purification of antibodies are provided. In some embodiments, antibodies are purified by mixed mode chromatography that does not comprise hydroxyapatite (HT) or fluorapatite (FT). The mixed mode chromatography step is then followed by a HT/FT chromatography step.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: November 4, 2014
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Peter S. Gagnon, Hong Chen, Russ Frost
  • Publication number: 20130267690
    Abstract: Methods, compositions and kits for chromatography purification of antibodies are provided. In some embodiments, antibodies are purified by hydroxyapatite (HT) or fluorapatite (FT) that is treated with a polycationic agent. In some embodiments, the antibodies are treated with a polycationic agent that is also a virucidal agent prior to purification.
    Type: Application
    Filed: September 18, 2012
    Publication date: October 10, 2013
    Applicant: Bio-Rad Laboratories, Inc.
    Inventor: Peter S. Gagnon
  • Publication number: 20130210164
    Abstract: Provided are methods and compositions for reducing or eliminating pH excursions in cation and anion exchange chromatography.
    Type: Application
    Filed: February 8, 2013
    Publication date: August 15, 2013
    Applicant: BIO-RAD LABORATORIES, INC.
    Inventor: Peter S. Gagnon
  • Publication number: 20120276623
    Abstract: Removal of genomic DNA from biological samples using cation exchange is described.
    Type: Application
    Filed: April 28, 2011
    Publication date: November 1, 2012
    Applicant: Bio-Rad Laboratories, Inc.
    Inventor: Peter S. Gagnon
  • Publication number: 20120264915
    Abstract: Methods, kits and apparatuses for chromatography purification of antibodies are provided. In some embodiments, antibodies are purified by mixed mode chromatography that does not comprise hydroxyapatite (HT) or fluorapatite (FT). The mixed mode chromatography step is then followed by a HT/FT chromatography step.
    Type: Application
    Filed: April 30, 2012
    Publication date: October 18, 2012
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: Peter S. Gagnon, Hong Chen, Russ Frost
  • Publication number: 20120252098
    Abstract: The invention provides methods and materials for using apatite chromatography supports to dissociate and remove contaminants that are complexed to biological products. The invention further provides materials and methods for dissociating aggregations of target biological molecules or improperly folded target molecules to improve purification of the target molecule.
    Type: Application
    Filed: September 20, 2011
    Publication date: October 4, 2012
    Applicant: Bio-Rad Laboratories, Inc.
    Inventor: Peter S. Gagnon
  • Patent number: 8188242
    Abstract: Methods, kits and apparatuses for chromatography purification of antibodies are provided. In some embodiments, antibodies are purified by mixed mode chromatography that does not comprise hydroxyapatite (HT) or fluorapatite (FT). The mixed mode chromatography step is then followed by a HT/FT chromatography step.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: May 29, 2012
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Peter S. Gagnon, Hong Chen, Russ Frost
  • Publication number: 20120077961
    Abstract: Methods are disclosed for use of apatite chromatography, particularly without reliance upon phosphate gradients, for purification or separation of at least one intact non-aggregated antibody, or at least one immunoreactive antibody fragment, from an impure preparation. Integration of such methods into multi-step procedures with other fractionation methods are additionally disclosed.
    Type: Application
    Filed: December 2, 2011
    Publication date: March 29, 2012
    Applicant: Bio-Rad Laboratories, Inc.
    Inventor: Peter S. Gagnon
  • Patent number: 8093364
    Abstract: Methods are disclosed for use of apatite chromatography, particularly without reliance upon phosphate gradients, for purification or separation of at least one intact non-aggregated antibody, or at least one immunoreactive antibody fragment, from an impure preparation. Integration of such methods into multi-step procedures with other fractionation methods are additionally disclosed.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: January 10, 2012
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Peter S. Gagnon