Abstract: The present invention relates to compositions containing flame retardant polycarbonate, which are suitable for producing flame-resistant milk-white coloured plates.

Abstract: The present invention relates to a method for the determination of polysorbate in a protein-containing sample. The method of the present invention involves the pretreatment of the sample by alkaline hydrolysis followed by colorimetric determination.

Abstract: The invention relates to flame resistant polycarbonate plates characterised in that the flame-proof properties thereof are maintained even after long exposure to weathering.

Abstract: The present invention provides analytical methods for detecting anti-polymer antibody in an individual. The methods involve contacting a sample from the individual with a water soluble polymer-modified carrier and detecting binding of antibody to the water soluble polymer on the water soluble polymer-modified carrier wherein binding is indicative of the presence of antibody to the water polymer-modified polypeptide. Antibody may be detected to water soluble polymers such as polyethylene glycol, polysialic acid, dextran, hydroxyalkyl starch, or hydroxyethyl starch. When antibody to the water soluble polymer polyethylene glycol is to be detected, the carrier is modified with a non-linear polyethylene glycol derivative.

Abstract: The present invention is related to peptides that can be used to reduce the immune response against FVIII or to induce tolerance to human FVIII in patients with, e.g., hemophilia A. Furthermore, the peptides can be used for immunodiagnostic purposes to detect FVIII-specific CD4+ T cells to monitor patients with hemophilia A during replacement therapy and during immune tolerance induction therapy.

Abstract: A video endoscope comprises an elongate shaft having a longitudinal axis, and a handpiece at the proximal end of the shaft, a distal end of the shaft being provided with a lens and, in the proximal direction from the lens, with an electronic image pickup. The image pickup is connected, via an electrical connection extending along the shaft, to an electrical connector piece arranged on the handpiece. The image pickup and the connector piece can rotate relative to each other about the longitudinal axis of the shaft. The electrical connection comprises at least one flexible, elongate circuit board, which is able to twist about its longitudinal direction and has at least one conductor track.

Abstract: An image pick-up module comprises an electronic image sensor, single-piece circuit board electrically bonded to the image sensor, and at least one cable electrically bonded and leading away from the circuit board. The circuit board has at least three sections, first and second section extending in relation to the other and obliquely or crosswise to the image sensor, and third section arranged between first and second section. The image sensor is arranged on the circuit board opposite the third section. In a method for assembling the image pick-up module, the circuit board has the form of a planar board blank comprising at least three sections folded along flexible connecting sections whereby the at least one cable is bonded to the board, and the board folds whereby a third section is located between first and second section, and the image sensor is bonded to the circuit board opposite the third section.

Abstract: The present invention relates to a method for producing a multi-layer product comprising a) a substrate containing at least one thermoplastic substrate layer and b) at least one protective layer made of a coating composition comprising compounds with at least two functional groups, characterized in that the protective layer(s) are/is applied inline after the production of the substrate containing the substrate layer.

Abstract: The present invention provides novel methods of increasing the survival of a coagulation protein by inhibiting the interaction with a clearance receptor. The invention also provides methods of preparing compositions that inhibit coagulation protein clearance receptors. Conjugated coagulation proteins, including compositions and formulations thereof, are also provided by the present invention.

Abstract: An image pick-up module and method for producing an image pick-up module. An image pick-up module, particularly for installation in an endoscope, the image pick-up module having an electronic image sensor, a first circuit board, a second circuit board and a cable.

Abstract: The present invention relates, in general, to development of non-human transgenic animals expressing a human blood clotting factor, such as Factor VIII, Factor VII, Factor IX and von Willebrand factor. The invention further provides methods of detecting immunogenic events against human blood clotting factor using the transgenic animals described.

Abstract: The present invention provides, among other aspects, storage stabile aqueous formulations of labile proteins at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing a labile therapeutic protein composition at a mildly acidic to neutral pH. Advantageously, the methods and formulations provided herein allow stabile aqueous compositions of labile proteins at mildly acidic to neutral pH useful for parenteral administration.

Abstract: The present invention provides, among other aspects, storage stabile aqueous formulations of immunoglobulins with histidine at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing immunoglobulin compositions by formulating with histidine at a mildly acidic to neutral pH. Advantageously, the methods and formulations provided herein allow stabile aqueous compositions of immunoglobulins at mildly acidic to neutral pH useful for parenteral administration.

Abstract: The present invention relates, in general, to methods for detecting and quantitating plasma-derived protein and recombinant protein in a sample based on the difference in protein glycosylation, when the plasma protein and the recombinant protein are essentially the same protein.

Abstract: The present invention relates, in general, to methods for detecting and quantitating plasma-derived protein and recombinant protein in a sample based on the difference in protein glycosylation, when the plasma protein and the recombinant protein are essentially the same protein.

Abstract: An apparatus (1) for determining surface characteristics of measuring surfaces, comprising at least one first radiation device (2) that emits radiation onto a measuring surface (10), at least one first radiation detection device (4) that receives at least part of the radiation emitted by the at least one radiation device (2) and subsequently scattered from the measuring surface (10) and that outputs at least one measurement signal that is characteristic of the received radiation, and including a second radiation device (12) and a second radiation detection device (14) for carrying out gloss measurements on the measuring surface (10), wherein the second radiation device (12) radiates onto the measuring surface (10) at a specified angle of incidence (a) and the second radiation detection device (14) receives at least part of the radiation emitted by the at least second radiation device (2) and subsequently reflected from the measuring surface (10).

Abstract: A colour measuring unit (1) comprising a radiation device (2) which emits light onto a surface (9) to be examined, wherein the radiation device (2) comprises at least one semiconductor-based light source (6), and a radiation detector device (12) which receives at least a portion of the light scattered by the surface and outputs a signal characteristic of this light, wherein the radiation detector device (12) allows a spectral analysis of the light impinging thereon. According to the invention, the colour measuring unit comprises at least one sensor device (10) which determines at least one electrical parameter of the light source (6), and also a processor device (14) which outputs from this measured parameter at least one value characteristic of the light emitted by the radiation device (2).

Abstract: There is disclosed an endoscopic instrument comprising a shaft having a distal end at which at least one optical sensor is arranged and a proximal end configured for a connection to a supply unit, further comprising a data transmission element which is provided between the at least one optical sensor and the proximal end and which is configured to differentially transmit at least two signals. The data transmission element is embodied as a star quad cable.

Abstract: An image pick-up module, in particular for an endoscope or a miniature camera, has an electronic image sensor, which has a plurality of contact fingers that are arranged in at least one row, and a rigid circuit board to which the contact fingers are electrically contact-connected, the image sensor and the circuit board being arranged approximately parallel to one another, and the contact fingers extending along at least one longitudinal side of the circuit board, which extends approximately transversely to the image sensor, and also a flexible multi-core cable which leads from the circuit board in the direction away from the image sensor and whose cores are likewise electrically contact-connected to the circuit board. The cores are contact-connected at contact-connection points on the circuit board which are closer to the image sensor than that side of the circuit board which is remote from the image sensor.

Abstract: The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.