Abstract: The present invention relates to a cell-based in vitro screening assay for identifying and selecting therapeutic agents that inhibit amyloid r-induced cytotoxicity.

Abstract: Systems and techniques to generate statistical reports on transactions conducted via an electronic marketplace are based on data extracted from the transaction documents. In general, in one implementation, the technique includes receiving documents sent through an electronic marketplace, and extracting data from the documents. The extracted data may relate to a predetermined statistical category of transactions conducted through the electronic marketplace. The extracted data may be stored for each document, and the stored data may be aggregated according to the predetermined statistical category. In some implementations, a report may be generated that relates to a document flow analysis for documents sent through the marketplace according to the buyer, seller, time period, document type, and/or other parameters.

Abstract: The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.

Abstract: The present invention provides long-term stable pharmaceutical formulations of recombinant von-Willebrand Factor (rVWF) and methods for making and administering said formulations.

Abstract: Described is a pharmaceutical preparation for treating blood coagulation disorders comprising an effective amount of vWF propeptide as well as a method for producing such a preparation.

Abstract: The present invention provides methods for providing a prognosis of treatment of diseases associated with inflammatory disease of the brain, including MS, e.g., relapsing-remitting multiple sclerosis (RRMS), Alzheimer's disease, and Parkinson's disease using molecular markers that are shown to be overexpressed or underexpressed in patients treated with intravenous immunoglobulins (IVIG). Also provided are methods to identify compounds that are useful for the treatment or prevention of MS, e.g., relapsing-remitting multiple sclerosis (RRMS), Alzheimer's disease, and Parkinson's disease.

Abstract: Factor VIII polypeptides having FVIII:C activity that contain modifications in the A3 and/or C1 and/or C2 domains of the sequence of the light chain of Factor VIII, characterized by the binding affinity to low density lipoprotein receptor protein, and methods for producing the same.

Abstract: A computer network architecture for making procurement-related information that has been generated on a transaction level available to data warehousing techniques is described. The network includes a transaction processing layer with at least one accounting component with a general ledger data base for centrally storing information contained in accounted-related data sets, a data warehousing layer and an additional data sourcing layer. A duplicator receives the data sets that will be or have been stored in the general ledger data base and delivers duplicates of those data sets that fulfil a predefined criteria in a procurement context. A source data base stores the duplicated data sets on a data line level. An extractor of the data sourcing layer interfaces with the data warehousing layer and selectively moves data contained in data lines or sets of data lines from the source data base to the data warehousing layer.

Abstract: A colour measuring unit (1) comprising a radiation device (2) which emits light onto a surface (9) to be examined, wherein the radiation device (2) comprises at least one semiconductor-based light source (6), and a radiation detector device (12) which receives at least a portion of the light scattered by the surface and outputs a signal characteristic of this light, wherein the radiation detector device (12) allows a spectral analysis of the light impinging thereon. According to the invention, the colour measuring unit comprises at least one sensor device (10) which determines at least one electrical parameter of the light source (6), and also a processor device (14) which outputs from this measured parameter at least one value characteristic of the light emitted by the radiation device (2).

Abstract: A generalized axiomatic definition of information-theoretic similarity is provided for taxonomies that are structured as directed acyclic graph form which multiple terns may be used to describe an object. The definition is adaptable in the presence of ambiguity, as introduced by an evolving taxonomy or classifiers with imperfect knowledge, and two new similarity measures are introduced based on the definitions. A pragmatic implementation is also provided for similarity measures that arc tightly integrated with an object-relational database and scales to large taxonomies and large datasets.

Abstract: The present invention describes a method for an apparatus for examining surface properties. Properties of effect pigments are to be examined in particular. A surface (9) to be examined is examined at different emission and reception angles and any curvature of the effect pigments is deduced on the basis of these different angles.

Abstract: The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.

Abstract: A device for examining the optical properties of surfaces includes at least one first radiation device which emits radiation to a surface to be examined at a first predetermined spatial angle, at least one first detector device for capturing the radiation emitted to and reflected back from the surface wherein the first detector device, allowing a local resolution of detected radiation, is positioned at least at a second predetermined spatial angle relative to the surface, and at least one further radiation device or second detector device emitting radiation to the surface to be examined at a third predetermined spatial angle or detecting radiation emitted to and reflected back from the surface.

Abstract: An image pick-up module comprises an electronic image sensor, single-piece circuit board electrically bonded to the image sensor, and at least one cable electrically bonded and leading away from the circuit board. The circuit board has at least three sections, first and second section extending in relation to the other and obliquely or crosswise to the image sensor, and third section arranged between first and second section. The image sensor is arranged on the circuit board opposite the third section. In a method for assembling the image pick-up module, the circuit board has the form of a planar board blank comprising at least three sections folded along flexible connecting sections whereby the at least one cable is bonded to the board, and the board folds whereby a third section is located between first and second section, and the image sensor is bonded to the circuit board opposite the third section.

Abstract: An image pick-up module, in particular for an endoscope or a miniature camera, has an electronic image sensor, which has a plurality of contact fingers that are arranged in at least one row, and a rigid circuit board to which the contact fingers are electrically contact-connected, the image sensor and the circuit board being arranged approximately parallel to one another, and the contact fingers extending along at least one longitudinal side of the circuit board, which extends approximately transversely to the image sensor, and also a flexible multi-core cable which leads from the circuit board in the direction away from the image sensor and whose cores are likewise electrically contact-connected to the circuit board. The cores are contact-connected at contact-connection points on the circuit board which are closer to the image sensor than that side of the circuit board which is remote from the image sensor.

Abstract: A computer network architecture for making procurement-related information that has been generated on a transaction level available to data warehousing techniques is described. The network includes a transaction processing layer with at least one accounting component with a general ledger data base for centrally storing information contained in accounted-related data sets, a data warehousing layer and an additional data sourcing layer. A duplicator receives the data sets that will be or have been stored in the general ledger data base and delivers duplicates of those data sets that fulfill a predefined criteria in a procurement context. A source data base stores the duplicated data sets on a data line level. An extractor of the data sourcing layer interfaces with the data warehousing layer and selectively moves data contained in data lines or sets of data lines from the source data base to the data warehousing layer.

Abstract: The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.

Abstract: A method of determining surface properties is provided, in which radiation is irradiated onto a first region of a surface to be examined, then at least some of the radiation irradiated onto the first region and returned by the latter is detected, and a measured value characteristic of this returned radiation is output. In a further step, the radiation is irradiated onto a second region of the surface and once again at least some of the radiation irradiated onto the second region and returned by the latter is detected, and a second measured value characteristic of this radiation is output. Finally, a result value is output which is characteristic of a relationship between the first measured value and the second measured value.

Abstract: A video endoscope comprises a disposable working part. The working part comprises a shaft, at the distal end of which a lens and an image sensor are arranged. The working part furthermore comprises an electrical transmission system for transmitting the image information and at least one light guide for transmitting light from proximal to distal. An operating part is furthermore provided. A proximal end of the working part can be releasably connected to a distal end of the operating part via an interface. Furthermore, a sterile gathered-together hose is arranged on the working part, and the operating part can be enveloped by the hose.

Abstract: A device for the sterile sheathing of a sterilization-sensitive operating part, which can be connected to a medical instrument for surgical intervention, having a handling element, which comprises a bundled sterile hose at a distal end, whereby the handling element further comprises an opening, through which the sterilization-sensitive operating part can be inserted from proximal to distal into the sterile hose such that the sterilization-sensitive operating part can thereby be sheathed with the hose.