Patents by Inventor Peter Schwarz
Peter Schwarz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210403504Abstract: The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.Type: ApplicationFiled: September 13, 2021Publication date: December 30, 2021Inventors: Leopold Bruckschwaiger, Sonja Svatos, Julia Nuernberger, Wolfgang Teschner, Harald Butterweck, Hans-Peter Schwarz, Thomas Gundinger, Bernhard Koelbl, Reinhard Grausenburger, Azra Pljevljakovic
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Patent number: 11191837Abstract: The present invention provides long-term stable pharmaceutical formulations of recombinant von-Willebrand Factor (rVWF) and methods for making and administering said formulations.Type: GrantFiled: April 22, 2015Date of Patent: December 7, 2021Assignee: Takeda Pharmaceutical Company LimitedInventors: Peter Matthiessen, Peter Turecek, Hans-Peter Schwarz, Kurt Schnecker
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Patent number: 11136350Abstract: The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.Type: GrantFiled: November 8, 2017Date of Patent: October 5, 2021Assignee: Takeda Pharmaceutical Company LimitedInventors: Leopold Bruckschwaiger, Sonja Svatos, Julia Nuernberger, Wolfgang Teschner, Harald Butterweck, Hans-Peter Schwarz, Thomas Gundinger, Bernhard Koelbl, Reinhard Grausenburger, Azra Pljevljakovic
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Publication number: 20210300997Abstract: The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to a peripheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival.Type: ApplicationFiled: June 14, 2021Publication date: September 30, 2021Inventors: Patrick Küry, Nevena Tzekova, Hans-Peter Hartung, Corinna Hermann, Birgit Maria Reipert, Hans-Peter Schwarz, Hartmut Ehrlich, Sebastian Bunk
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Publication number: 20210238267Abstract: The present invention provides, among other aspects, methods for the treatment of Alzheimer's disease in a subject in need thereof, the method including administration of a therapeutically effective amount of a pooled human immunoglobulin G (IgG) composition to a subject with moderately severe Alzheimer's disease, a subject carrying an ApoE4 allele, or both, where the amount of pooled human IgG is from 300 mg/kg to 800 mg/kg body weight of the subject per two week period, and where the amount is administered in one or more doses during the two week period after initiation of a therapeutic regimen. Also provided, are methods for selecting a treatment regimen for a subject with Alzheimer's disease, including diagnosing the severity of the Alzheimer's disease, determining if the subject carries an APOE4 allele, or both, and assigning a treatment regimen including administration of pooled human immunoglobulin G and/or an anti-beta amyloid monoclonal antibody.Type: ApplicationFiled: April 19, 2021Publication date: August 5, 2021Inventors: David M. Gelmont, Julia Singer, Sandor Fritsch, Hans-Peter Schwarz
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Patent number: 11060966Abstract: The invention relates to a docking station 2 for a surface measuring apparatus 1, more particularly an optical surface measuring apparatus. The docking station has a reference measuring surface 4 which can be brought into a covered state in which it is covered from the environment of the docking station 2 and an uncovered state in which it is not covered from the environment of the docking station 2. When the surface measuring apparatus 1 is in the docking station 2 and the reference measuring surface 4 is in the uncovered state, the surface measuring apparatus 1 can perform a reference measurement of the reference measuring surface 4 and can calibrate the surface measuring apparatus 1 using the reference measurement. In contrast, when the reference measuring surface 4 is in the covered state, it is not exposed to the environment of the docking station 2 and is therefore protected from, for example, dust, light, moisture or mechanical impacts.Type: GrantFiled: June 15, 2018Date of Patent: July 13, 2021Assignee: BYK-GARDNER GMBHInventor: Peter Schwarz
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Publication number: 20210139562Abstract: The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having reduced serine protease and\or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having reduced serine protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing, and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.Type: ApplicationFiled: November 24, 2020Publication date: May 13, 2021Inventors: Wolfgang Teschner, Hans-Peter Schwarz, Ruth Madlener, Sonja Svatos, Azra Pljevljakovic, Alfred Weber
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Patent number: 11006096Abstract: An observation device is provided with an image acquisition unit comprising at least one image sensor, an image display unit, that is arranged for displaying image data that is provided by the image acquisition unit, an image processing unit for image processing procedures, and a control unit comprising a multi-axis input module. The image acquisition unit is configured to provide recorded images having a predefined recording pixel quantity. The image display unit is configured to display display images having a predefined display pixel quantity, wherein the recording pixel quantity is equal to or greater than the display pixel quantity. Image pixels of the display pixel quantity are obtained from the recording pixel quantity. Subsets of the recording pixel quantity are selected to form the display pixel quantity. Image acquisition parameters and display parameters are controlled by the input module.Type: GrantFiled: November 27, 2019Date of Patent: May 11, 2021Assignee: Karl Storz SE & Co. KGInventors: Benedikt Köhler, Andreas Heni, Markus Kupferschmid, Eckhart Baum, Peter Schwarz
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Publication number: 20210054058Abstract: The present invention provides, among other aspects, methods for the manufacture of plasma-derived immunoglobulin G compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-A?, anti-RAGE, and anti-?-synuclein antibodies). Advantageously, the methods provided do not affect the manufacturing processes or capabilities for producing plasma-derived IgG therapeutics. Plasma-derived IgG compositions that are highly enriched for anti-brain disease related protein antibodies (e.g., anti-A?, anti-RAGE, and anti-?-synuclein antibodies), as also provided here. Methods for the treatment of brain diseases and disorders by administration of plasma-derived IgG compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-A?, anti-RAGE, and anti-?-synuclein antibodies), are also provided.Type: ApplicationFiled: June 30, 2020Publication date: February 25, 2021Inventors: Lucia Gnauer, Harald Arno Butterweck, Theresa Bauer, Alfred Weber, Wolfgang Teschner, Hans-Peter Schwarz
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Patent number: 10900979Abstract: The invention generally relates to methods of testing the effectiveness of a von Willebrand factor (VWF) in treating von Willebrand disease (VWD) in a subject comprising measuring VWF cleavage fragments in a blood sample from the subject before and after treatment. In particular, the invention relates to methods of measuring VWF cleavage fragments, wherein an increase in VWF cleavage fragments after the treatment indicates that endogenous a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) in the subject is cleaving the VWF and wherein a decrease or absence of VWF cleavage fragments after the treatment indicates that endogenous ADAMTS13 in the subject is not cleaving the VWF.Type: GrantFiled: January 16, 2019Date of Patent: January 26, 2021Assignees: Baxalta Incorporated, Baxalta GmbHInventors: Katalin Varadi, Hanspeter Rottensteiner, Peter Turecek, Hans-Peter Schwarz, Jutta Schreiner
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Patent number: 10875906Abstract: The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having reduced serine protease and\or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having reduced serine protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing, and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.Type: GrantFiled: January 7, 2019Date of Patent: December 29, 2020Assignees: Baxalta Incorporated, Baxalta GmbHInventors: Wolfgang Teschner, Hans-Peter Schwarz, Ruth Madlener, Sonja Svatos, Azra Pljevljakovic, Alfred Weber
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Publication number: 20200376098Abstract: The present invention relates to formulations of ADAMTS13 with enhanced or desirable properties. As such, the invention provides liquid and lyophilized formulations of ADAMTS13 that are suitable for pharmaceutical administration. Among other aspects, the present invention also provides methods of treating various diseases and conditions related to VWF and/or ADAMTS13 dysfunction in a subject. Also provided herein are kits comprising ADAMTS13 formulations useful for the treatment of various diseases and conditions.Type: ApplicationFiled: July 21, 2020Publication date: December 3, 2020Applicants: BAXALTA INCORPORATED, BAXALTA GMBHInventors: Peter MATTHIESSEN, Peter L. TURECEK, Hans-Peter Schwarz
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Publication number: 20200365032Abstract: An alert system for monitoring at least one incursion into a safe stopping distance of a primary vehicle, the alert system including at least one forward facing sensor mounted relative to the primary vehicle to capture data, at least one image capture device mounted relative to the primary vehicle, at least one alert device associated with the primary vehicle, and a calculation engine to calculate a minimum safe stopping distance for the primary vehicle based on a real time speed of the vehicle and a vehicle weight, and to calculate a separation distance to a third party vehicle to be calculated relative to the primary vehicle based on the data captured by the at least one forward facing sensor, wherein the calculation engine compares the minimum safe stopping distance at any time to the separation distance to the third party vehicle to establish if the third party vehicle is within the minimum safe stopping distance of the primary vehicle, and if the third party vehicle is within the minimum safe stopping diType: ApplicationFiled: February 5, 2019Publication date: November 19, 2020Inventors: Mark Peter SCHWARZ, Julie-Ann Fay Le NOBLE
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Publication number: 20200363625Abstract: An observation instrument has a shaft and an imaging unit, the imaging unit comprising an objective lens system and an electronic image sensor arranged for picking up an image generated by the objective lens system, the imaging unit being pivotably arranged in a distal end section of the shaft, a pivot axis of the imaging unit being transverse to a longitudinal axis of the distal end section of the shaft, wherein the image sensor is arranged substantially parallel to an optical axis of the objective lens system and the imaging unit comprises a deflection element for deflecting light exiting from an image end of the objective lens system to an image pick-up surface of the image sensor. The invention also relates to a video imager arrangement for an observation instrument.Type: ApplicationFiled: May 12, 2020Publication date: November 19, 2020Applicant: KARL STORZ SE & Co KGInventors: Harald Baumann, Peter Schwarz
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Patent number: 10758599Abstract: The present invention relates to formulations of ADAMTS13 with enhanced or desirable properties. As such, the invention provides liquid and lyophilized formulations of ADAMTS13 that are suitable for pharmaceutical administration. Among other aspects, the present invention also provides methods of treating various diseases and conditions related to VWF and/or ADAMTS13 dysfunction in a subject. Also provided herein are kits comprising ADAMTS13 formulations useful for the treatment of various diseases and conditions.Type: GrantFiled: February 14, 2019Date of Patent: September 1, 2020Assignees: Baxalta Incorporated, Baxalta GmbHInventors: Peter Matthiessen, Peter L. Turecek, Hans-Peter Schwarz
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Patent number: 10738107Abstract: The present invention provides, among other aspects, methods for the manufacture of plasma-derived immunoglobulin G compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-A?, anti-RAGE, and anti-?-synuclein antibodies). Advantageously, the methods provided do not affect the manufacturing processes or capabilities for producing plasma-derived IgG therapeutics. Plasma-derived IgG compositions that are highly enriched for anti-brain disease related protein antibodies (e.g., anti-A?, anti-RAGE, and anti-?-synuclein antibodies), as also provided here. Methods for the treatment of brain diseases and disorders by administration of plasma-derived IgG compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-A?, anti-RAGE, and anti-?-synuclein antibodies), are also provided.Type: GrantFiled: December 20, 2016Date of Patent: August 11, 2020Assignees: Baxalta Incorporated, Baxalta GmbHInventors: Lucia Gnauer, Harald Arno Butterweck, Theresa Bauer, Alfred Weber, Wolfgang Teschner, Hans-Peter Schwarz
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Publication number: 20200216518Abstract: The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to a peripheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival.Type: ApplicationFiled: October 18, 2019Publication date: July 9, 2020Inventors: Patrick Küry, Nevena Tzekova, Hans-Peter Hartung, Corinna Hermann, Birgit Maria Reipert, Hans-Peter Schwarz, Hartmut Ehrlich, Sebastian Bunk
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Patent number: 10645372Abstract: An observation device is provided with an image acquisition unit comprising at least one image sensor, an image display unit, that is arranged for displaying image data that is provided by the image acquisition unit, an image processing unit for image processing procedures, and a control unit comprising a multi-axis input module. The image acquisition unit is configured to provide recorded images having a predefined recording pixel quantity. The image display unit is configured to display images having a predefined display pixel quantity, wherein the recording pixel quantity is equal to or greater than the display pixel quantity. Image pixels of the display pixel quantity are obtained from the recording pixel quantity. Subsets of the recording pixel quantity are selected to form the display pixel quantity. Image acquisition parameters and display parameters are controlled by the input module.Type: GrantFiled: December 2, 2016Date of Patent: May 5, 2020Assignee: Karl Storz SE & Co. KGInventors: Benedikt Köhler, Andreas Heni, Markus Kupferschmid, Eckhart Baum, Peter Schwarz
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Publication number: 20200132593Abstract: The invention relates to a docking station 2 for a surface measuring apparatus 1, more particularly an optical surface measuring apparatus. The docking station has a reference measuring surface 4 which can be brought into a covered state in which it is covered from the environment of the docking station 2 and an uncovered state in which it is not covered from the environment of the docking station 2. When the surface measuring apparatus 1 is in the docking station 2 and the reference measuring surface 4 is in the uncovered state, the surface measuring apparatus 1 can perform a reference measurement of the reference measuring surface 4 and can calibrate the surface measuring apparatus 1 using the reference measurement. In contrast, when the reference measuring surface 4 is in the covered state, it is not exposed to the environment of the docking station 2 and is therefore protected from, for example, dust, light, moisture or mechanical impacts.Type: ApplicationFiled: June 15, 2018Publication date: April 30, 2020Inventor: Peter SCHWARZ
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Publication number: 20200099922Abstract: An observation device is provided with an image acquisition unit comprising at least one image sensor, an image display unit, that is arranged for displaying image data that is provided by the image acquisition unit, an image processing unit for image processing procedures, and a control unit comprising a multi-axis input module. The image acquisition unit is configured to provide recorded images having a predefined recording pixel quantity. The image display unit is configured to display display images having a predefined display pixel quantity, wherein the recording pixel quantity is equal to or greater than the display pixel quantity. Image pixels of the display pixel quantity are obtained from the recording pixel quantity. Subsets of the recording pixel quantity are selected to form the display pixel quantity. Image acquisition parameters and display parameters are controlled by the input module.Type: ApplicationFiled: November 27, 2019Publication date: March 26, 2020Inventors: Benedikt Köhler, Andreas Heni, Markus Kupferschmid, Eckhart Baum, Peter Schwarz