Abstract: A device for arrangement in a container of a sorption dryer for a fluid, wherein a cartridge for accommodating a drying agent can be inserted into the container, wherein the device has at least one projection and/or at least one recess on a front side, wherein the projection and/or the recess is arranged eccentrically on the front side.

Abstract: The invention relates to an ejection unit for at least one satellite, in particular a picosatellite, comprising a frame that defines an inner space for receiving the satellite; and a retention device for holding the satellite in the inner space, the retention device being configured such that the satellite is releasable from the retention device.

Abstract: An endoscope or exoscope having a shaft and at least one objective and at least one electronic image recorder for recording an image of an object field, wherein the objective and image recorder are arranged in a distal end region of the endoscope or exoscope, and includes at least one cable, routed within the endoscope or exoscope, for supply of and/or image transmission from the electronic image recorder, wherein the electronic image recorder includes an optical unit, which is rotatable about a first axis of rotation identical or approximately parallel to a direction of view of the scope, and on which the cable is connected and can be wound on a circumferential surface of the optical unit, and wherein the distal end region includes a cavity, in which storage for holding a section of the cable is held.

Abstract: This disclosure relates to a device for irradiating a flowing medium with UV radiation, comprising a flow path for the medium and a gas discharge lamp which has a lamp vessel, arranged coaxially with respect to the flow path and enclosing a plasma chamber for a lamp plasma that emits UV radiation, and an excitation coil for electrodeless inductive excitation of radiation of the lamp plasma. According to a first aspect of this disclosure, a flow conduit body is arranged in the flow path, said flow conduit body being designed to influence, by virtue of its shape and/or its position, the flow of the medium for an even radiation absorption.

Abstract: The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to a peripheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival.

Abstract: The present invention relates to formulations of ADAMTS13 with enhanced or desirable properties. As such, the invention provides liquid and lyophilized formulations of ADAMTS13 that are suitable for pharmaceutical administration. Among other aspects, the present invention also provides methods of treating various diseases and conditions related to VWF and/or ADAMTS13 dysfunction in a subject. Also provided herein are kits comprising ADAMTS13 formulations useful for the treatment of various diseases and conditions.

Abstract: Methods, systems, and computer program products for automatic detection of string and column delimiters in tabular data files are provided herein. A computer-implemented method includes detecting (i) candidate column delimiters in a file containing tabular data and (ii) candidate string delimiters in the file containing tabular data; evaluating the likelihood of validity of each possible candidate column delimiter-candidate string delimiter pairing among the detected candidate column delimiters and the detected candidate string delimiters; and outputting, to at least one user, the candidate column delimiter-candidate string delimiter pairing having the highest likelihood of validity.

Abstract: The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having reduced serine protease and\or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having reduced serine protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing, and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.

Abstract: The present invention provides, among other aspects, methods for the treatment of Alzheimer's disease in a subject in need thereof, the method including administration of a therapeutically effective amount of a pooled human immunoglobulin G (IgG) composition to a subject with moderately severe Alzheimer's disease, a subject carrying an ApoE4 allele, or both, where the amount of pooled human IgG is from 300 mg/kg to 800 mg/kg body weight of the subject per two week period, and where the amount is administered in one or more doses during the two week period after initiation of a therapeutic regimen. Also provided, are methods for selecting a treatment regimen for a subject with Alzheimer's disease, including diagnosing the severity of the Alzheimer's disease, determining if the subject carries an APOE4 allele, or both, and assigning a treatment regimen including administration of pooled human immunoglobulin G and/or an anti-beta amyloid monoclonal antibody.

Abstract: The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma.

Abstract: The present invention relates to compositions containing flame retardant polycarbonate, which are suitable for producing flame-resistant milk-white colored plates. The composition contains polycarbonate, 0.10 to 4.00 weight percent of an acrylate-based scattering additive, 0.50 to 5.00 weight percent of an aromatic-aliphatic polyester, and 0.50 to 8.00 weight percent of a phosphorus-based flame retardant.

Abstract: The present invention relates to formulations of ADAMTS13 with enhanced or desirable properties. As such, the invention provides liquid and lyophilized formulations of ADAMTS13 that are suitable for pharmaceutical administration. Among other aspects, the present invention also provides methods of treating various diseases and conditions related to VWF and/or ADAMTS13 dysfunction in a subject. Also provided herein are kits comprising ADAMTS13 formulations useful for the treatment of various diseases and conditions.

Abstract: The present invention relates to a new and improved method for preparing a highly concentrated immunoglobulin composition from pooled plasma for subcutaneous injection. A composition comprising 20% or more immunoglobulin suitable for subcutaneous use is also described.

Abstract: The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma.

Abstract: The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having reduced serine protease and\or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having reduced serine protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing, and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.

Abstract: The invention relates to a support retainer for filter element with a base body, which extends along a longitudinal axis from an upper end to a lower end and a retainer wall is formed between the upper and the lower end, and wherein the retainer wall is formed perpendicular to the longitudinal axis in a ring-shaped at least in a cross section, and the retainer wall has a plurality of openings and the retainer wall is at least partially manufactured from a plastic, wherein the openings are rhombus-shaped.

Abstract: An apparatus for recording an image of an object field on a body from outside of the body has a shank and an optical unit. The optical unit includes an observation optical unit for recording the image of the object field and is rotatable about an axis of rotation. The observation optical unit has a first stereo channel and a second stereo channel that each has one objective and at least one electronic image recorder. The observation optical unit includes at least one filter that is swivelable into a beam path of the observation optical unit. The at least one filter is swivelable about a swivel axis that is substantially perpendicular to the axis of rotation. At least one filter is swivelable into a beam path of the observation optical unit and into a spatial region arranged laterally with respect to the beam paths of both stereo channels.

Abstract: The present disclosure provides, among other aspects, improved methods for the manufacture of Factor H compositions from plasma precipitation fractions. In some aspects, the methods include an improved process step for extracting Factor H from a plasma precipitate fraction with reduced co-extraction of amidolytic activities. In other aspects, the methods include a heat treatment step for reducing impurities, such as amidolytic enzymes, from a Factor H composition. In yet other aspects, the methods include improved anion exchange, heparin affinity, and/or mixed mode chromatographic enrichment of Factor H. In still other aspects, the improved methods include a combination of the individual improved process steps disclosed herein.

Abstract: Sputter devices comprise a vacuum supply, a gas supply, a substrate holding device, and sputter sources. Each sputter source is held by an individual source support, each of which has an individual reference point allocated on a sputter surface facing the deposition area, and each of which has a source distance to a source reference surface from the individual reference point. The sputter sources are spaced apart from each other, are arranged as a two-dimensional array opposite the deposition area, and extend along the source reference surface. The source reference surface is parallel to the substrate reference surface. At least one of the sputter sources has a source distance deviating from zero.

Abstract: The present invention relates to a new and improved method for preparing a highly concentrated immunoglobulin composition from pooled plasma for subcutaneous injection. A composition comprising 20% or more immunoglobulin suitable for subcutaneous use is also described.