Patents by Inventor Peter Sieger

Peter Sieger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydrates and polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
    Publication number: 20090298840
    Abstract: Disclosed are hydrates and polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, processes for preparing them and their use as pharmaceutical compositions.
    Type: Application
    Filed: June 4, 2009
    Publication date: December 3, 2009
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Guenter LINZ, Peter SIEGER, Gerd F. KRAEMER, Rolf HERTER, Matthias HOFFMANN, Werner RALL, Rolf SCHMID
  • ENANTIOMERICALLY PURE BETA AGONISTS, PROCESS FOR THE MANUFACTURE THEREOF AND USE THEREOF AS MEDICAMENTS
    Publication number: 20090137578
    Abstract: Enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3, R4, and X? may have the meanings given in the claims and in the specification, processes for preparing them and the use thereof as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.
    Type: Application
    Filed: December 15, 2008
    Publication date: May 28, 2009
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Philipp LUSTENBERGER, Ingo KONETZKI, Peter SIEGER
  • Enantiomeric pure ? agonists, manufacturing and use as a medicament thereof
    Patent number: 7534789
    Abstract: The present invention relates to enantiomerically pure compounds of formula 1 wherein the groups m, n, B, X, R1, m and Ym? may have the meanings given in the claims and specification, methods for preparing them and their use as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: May 19, 2009
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Uwe Ries, Peter Sieger
  • Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions
    Patent number: 7514468
    Abstract: The present invention relates to indolinone derivatives substituted in the 6 position of general formula wherein R1 to R6 and X are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof, which have valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Grant
    Filed: July 22, 2003
    Date of Patent: April 7, 2009
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Armin Heckel, Frank Hilberg, Thorsten Lehmann-Lintz, Guenter Linz, Joerg Kley, Jacobus C. A. Van Meel, Werner Rall, Gerald Juergen Roth, Peter Sieger, Ulrike Tontsch-Grunt
  • Enantiomerically pure beta agonists, process for the manufacture thereof, and use thereof as medicaments
    Patent number: 7491719
    Abstract: Enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3, R4, and X? may have the meanings given in the claims and in the specification, processes for preparing them and the use thereof as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: February 17, 2009
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Philipp Lustenberger, Ingo Konetzki, Peter Sieger
  • Physiologically acceptable salts of 3--1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester
    Publication number: 20090042948
    Abstract: The invention relates to new, physiologically acceptable salts of the active substance ethyl 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazole-5-carbonyl)-pyridin-2-yl-amino]-propionate.
    Type: Application
    Filed: October 8, 2008
    Publication date: February 12, 2009
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Peter Sieger, Norbert Hauel, Rolf Schmid
  • SPECIFIC SALT, ANHYDROUS AND CRYSTALLINE FORM OF A DIHYDROPTERIDIONE DERIVATIVE
    Publication number: 20090030004
    Abstract: The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide, to its crystallisation in the form of an hydrate with water, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.
    Type: Application
    Filed: September 17, 2008
    Publication date: January 29, 2009
    Inventors: Guenter Linz, Peter Sieger, Matthias Grauert, Rolf Schmid
  • Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
    Patent number: 7439358
    Abstract: The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide, to its crystallisation in the form of an hydrate with water, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: October 21, 2008
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Guenter Linz, Peter Sieger, Matthias Grauert, Rolf Schmid
  • BENZOYLGUANIDINE SALT AND HYDRATES THEREOF
    Publication number: 20080241077
    Abstract: 4-[4-(2-pyrrolylcarbonyl)-1-piperazinyl]-3-trifluoromethylbenzoylguanidine hydrochloride and its hydrates, processes for preparing this benzoylguanidine salt and its hydrates, pharmaceutical compositions containing this benzoylguanidine salt and its hydrates, and its use in treating diseases, particularly those in which inhibition of the cellular Na+/H+ exchange is of therapeutic benefit.
    Type: Application
    Filed: June 6, 2008
    Publication date: October 2, 2008
    Inventors: Christian Eickmeier, Peter Sieger, Werner Rall, Volkmar Koerner, Rolf Herter
  • 3-[(2-{[4-(HEXYLOXYCARBONYLAMINOIMINOMETHYL) PHENYLAMINO]METHYL}-1-METHYL-1H-BENZIMIDAZOL-5- CARBONYL)PYRIDIN-2-YLAMINO]PROPIONIC ACID ETHYLESTER METHANSULFONATE AND ITS USE AS A MEDICAMENT
    Publication number: 20080119523
    Abstract: Ethyl 3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl)phenylamino]methyl}-1-methyl-1H-benzimidazole-5-carbonyl)pyridin-2-ylamino]propionate methanesulfonate in the crystalline modifications I and II and as the hemihydrate and the use thereof as a pharmaceutical composition.
    Type: Application
    Filed: January 30, 2008
    Publication date: May 22, 2008
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Rolf Schmid, Peter Sieger, Rainer Sobotta
  • (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1- (pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition
    Publication number: 20080076934
    Abstract: Crystalline forms of the compounds (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole and the monohydrochloride thereof, processes for the preparation thereof and the use thereof as pharmaceutical compositions.
    Type: Application
    Filed: October 2, 2007
    Publication date: March 27, 2008
    Inventors: Guenter Linz, Peter Sieger, Gunnar Schreiner, Werner Rall, Rolf Schmid
  • ENANTIOMERICALLY PURE BETA AGONISTS, MANUFACTURING AND USE THEREOF
    Publication number: 20080070909
    Abstract: The present invention relates to enantiomerically pure compounds of formula 1 wherein the groups R1, R2, R3, m and Ym? may have the meanings given in the claims and specification, processes for preparing them and their use as medicaments, particularly as medicaments for the treatment of respiratory complaints.
    Type: Application
    Filed: August 21, 2007
    Publication date: March 20, 2008
    Inventors: Ingo KONETZKI, Peter Sieger
  • BENZOYLGUANIDINE SALT AND HYDRATES THEREOF
    Publication number: 20080025919
    Abstract: 4-[4-(2-pyrrolylcarbonyl)-1-piperazinyl]-3-trifluoromethylbenzoylguanidine hydrochloride and its hydrates, processes for preparing this benzoylguanidine salt and its hydrates, pharmaceutical compositions containing this benzoylguanidine salt and its hydrates, and its use in treating diseases, particularly those in which inhibition of the cellular Na+/H+ exchange is of therapeutic benefit.
    Type: Application
    Filed: August 21, 2007
    Publication date: January 31, 2008
    Inventors: Christian Eickmeier, Peter Sieger, Werner Rall, Volkmar Koerner, Rolf Herter
  • (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1(pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition
    Patent number: 7294721
    Abstract: Crystalline forms of the compounds (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole and the monohydrochloride thereof, processes for the preparation thereof and the use thereof as pharmaceutical compositions.
    Type: Grant
    Filed: December 13, 2006
    Date of Patent: November 13, 2007
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Guenter Linz, Peter Sieger, Gunnar Schreiner, Werner Rall, Rolf Schmid
  • POLYMORPHS
    Publication number: 20070259900
    Abstract: The invention relates to polymorphous crystal modifications of a DPP-IV inhibitor, the preparation thereof and the use thereof for preparing a medicament.
    Type: Application
    Filed: May 4, 2007
    Publication date: November 8, 2007
    Inventors: Peter SIEGER, Dirk Kemmer, Peter Kohlbauer, Thomas Nicola, Martin Renz
  • Novel Enantiomeric Pure Beta Agonists, Manufacturing and Use as a Medicament Thereof
    Publication number: 20070249595
    Abstract: The present invention relates to enantiomerically pure compounds of formula 1 wherein the groups m, n, B, X, R1, m and Ym- may have the meanings given in the claims and specification, methods for preparing them and their use as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.
    Type: Application
    Filed: March 15, 2007
    Publication date: October 25, 2007
    Inventors: Uwe RIES, Peter SIEGER
  • SPECIFIC SALT, ANHYDROUS AND CRYSTALLINE FORM OF A DIHYDROPTERIDIONE DERIVATIVE
    Publication number: 20070203146
    Abstract: The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide, to its crystallisation in the form of an hydrate with water, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.
    Type: Application
    Filed: January 30, 2007
    Publication date: August 30, 2007
    Inventors: Guenter Linz, Peter Sieger, Matthias Grauert, Rolf Schmid
  • Benzoylguanidlne salt and hydrates thereof
    Publication number: 20070135446
    Abstract: 4-[4-(2-pyrrolylcarbonyl)-1-piperazinyl]-3-trifluoromethylbenzoylguanidine hydrochloride and its hydrates, processes for preparing this benzoylguanidine salt and its hydrates, pharmaceutical compositions containing this benzoylguanidine salt and its hydrates, and its use in treating diseases, particularly those in which inhibition of the cellular Na+/H+exchange is of therapeutic benefit.
    Type: Application
    Filed: January 4, 2007
    Publication date: June 14, 2007
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Christian Elckmeier, Peter Sieger, Werner Rall, Volkmar Koerner, Rolf Herter
  • Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
    Patent number: 7220742
    Abstract: The present invention relates to enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3, R4 and X? may have the meanings given in the claims and in the specification, processes for preparing them and the use thereof as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: May 22, 2007
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Philipp Lustenberger, Ingo Konetzki, Peter Sieger
  • (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1(pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition
    Publication number: 20070099974
    Abstract: Crystalline forms of the compounds (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1 -(carboxymethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole and the monohydrochloride thereof, processes for the preparation thereof and the use thereof as pharmaceutical compositions.
    Type: Application
    Filed: December 13, 2006
    Publication date: May 3, 2007
    Inventors: Guenter Linz, Peter Sieger, Gunnar Schreiner, Werner Rall, Rolf Schmid