Patents by Inventor Peter Sieger

Peter Sieger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

Powdered Medicaments Containing A Tiotropium Salt and Salmeterol Xinafoate

Publication number: 20070031347

Abstract: The invention relates to powdered preparations for inhalation containing a tiotropium salt and salmeterol xinafoate, processes for preparing them and their use in the preparation of a pharmaceutical composition for treating respiratory diseases, particularly for treating COPD (chronic obstructive pulmonary disease) and asthma.

Type: Application

Filed: October 2, 2006

Publication date: February 8, 2007

Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG

Inventors: Mareke Hartig, Michael Trunk, Rainer Soyka, Peter Sieger, Hagen Graebner, Michael Walz
Process for preparing amino crotonyl compounds

Publication number: 20070027170

Abstract: An improved process for preparing 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline and related aminocrotonyl compounds and the preparation of a suitable salt of 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline for use as a pharmaceutically active substance.

Type: Application

Filed: July 14, 2006

Publication date: February 1, 2007

Inventors: Rainer Soyka, Werner Rall, Juergen Schnaubelt, Peter Sieger, Christian Kulinna
8-(3-AMINO-PIPERIDIN-1-YL)-XANTHINES, THEIR PREPARATION, AND THEIR USE AS PHARMACEUTICALS

Publication number: 20070027168

Abstract: The invention relates to 8-[3-amino-piperidin-1-yl]-xanthines and the physiologically acceptable salts thereof, particularly the hydrochlorides thereof.

Type: Application

Filed: July 30, 2006

Publication date: February 1, 2007

Inventors: Waldemar Pfrengle, Peter Sieger
New enantiomerically pure beta agonists, process for the manufacture thereof, and use thereof as medicaments

Publication number: 20070027148

Abstract: Enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3, R4, and X? may have the meanings given in the claims and in the specification, processes for preparing them and the use thereof as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.

Type: Application

Filed: October 4, 2006

Publication date: February 1, 2007

Inventors: Philipp Lustenberger, Ingo Konetzki, Peter Sieger
(R) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1 (pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition

Patent number: 7169934

Abstract: Crystalline forms of the compounds (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole and the monohydrochloride thereof, processes for the preparation thereof and the use thereof as pharmaceutical compositions.

Type: Grant

Filed: June 17, 2003

Date of Patent: January 30, 2007

Assignee: Boehringer Ingelheim International GmbH

Inventors: Guenter Linz, Peter Sieger, Gunnar Schreiner, Werner Rall, Rolf Schmid
Process For Preparing New Tiotropium Salts, New Tiotropium Salts As Such and Pharmaceutical Compositions Thereof

Publication number: 20060287530

Abstract: The invention relates to a process for preparing new tiotropium salts, these new tiotropium salts as such, pharmaceutical formulations containing them and their use for preparing a medicament.

Type: Application

Filed: June 15, 2006

Publication date: December 21, 2006

Applicant: Boehringer Ingelheim International GmbH

Inventors: Mihaela Pop, Stephanie Mulder Houdayer, Peter Sieger, Michael Pieper
Polymorphs of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H- benzimidazole-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester

Publication number: 20060276513

Abstract: Disclosed are polymorphs of the active substance 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazole-5-carbonyl)-pyridin-2 -yl-amino]-propionic acid ethyl ester, the preparation thereof and the use thereof as pharmaceutical compositions.

Type: Application

Filed: May 31, 2006

Publication date: December 7, 2006

Applicant: Boehringer Ingelheim International GmbH

Inventors: Norbert HAUEL, Rolf SCHMID, Peter SIEGER, Rainer SOBOTTA
3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate and the use thereof as a pharmaceutical composition

Publication number: 20060258681

Abstract: The present invention relates to the compound 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate of formula I and the use thereof as a pharmaceutical composition.

Type: Application

Filed: July 28, 2006

Publication date: November 16, 2006

Inventors: Gerald Roth, Guenter Linz, Peter Sieger, Werner Rall, Frank Hilberg, Thomas Bock
Physiologically acceptable salts of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester

Publication number: 20060247278

Abstract: The invention relates to new, physiologically acceptable salts of the active substance ethyl 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazole-5-carbonyl)-pyridin-2-yl-amino]-propionate.

Type: Application

Filed: April 26, 2006

Publication date: November 2, 2006

Applicant: Boehringer Ingelheim International GmbH

Inventors: Peter Sieger, Norbert Hauel, Rolf Schmid
3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate and the use thereof as a pharmaceutical composition

Patent number: 7119093

Abstract: The present invention relates to the compound 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycabonyl-2-indolinone-monoethanesulphonate of formula I and the use thereof as a pharmaceutical composition

Type: Grant

Filed: July 21, 2003

Date of Patent: October 10, 2006

Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG

Inventors: Gerald J. Roth, Guenter Linz, Peter Sieger, Werner Rall, Frank Hilberg, Thomas Bock
Benzoylguanidine salt and hydrates thereof

Publication number: 20060217396

Abstract: 4-[4-(2-pyrrolylcarbonyl)-1-piperazinyl]-3-trifluoromethylbenzoylguanidine hydrochloride and its hydrates, processes for preparing this benzoylguanidine salt and its hydrates, pharmaceutical compositions containing this benzoylguanidine salt and its hydrates, and its use in treating diseases, particularly those in which inhibition of the cellular Na+/H+ exchange is of therapeutic benefit.

Type: Application

Filed: June 1, 2006

Publication date: September 28, 2006

Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG

Inventors: Christian Eickmeier, Peter Sieger, Werner Rall, Volkmar Koerner, Rolf Herter
Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions

Publication number: 20060194813

Abstract: The present invention relates to indolinone derivatives substituted in the 6 position of general formula wherein R1 to R6 and X are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof, which have valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

Type: Application

Filed: July 22, 2003

Publication date: August 31, 2006

Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG

Inventors: Armin Heckel, Frank Hilberg, Thorsten Lehmann-Lintz, Guenter Linz, Joerg Kley, Jacobus Van Meel, Werner Rall, Gerald Roth, Peter Sieger, Ulrike Tontsch-Grunt
Hydrates and polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament

Publication number: 20060035902

Abstract: Disclosed are hydrates and polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, processes for preparing them and their use as pharmaceutical compositions.

Type: Application

Filed: August 4, 2005

Publication date: February 16, 2006

Applicant: Boehringer Ingelheim International GmbH

Inventors: Guenter Linz, Peter Sieger, Gerd Kraemer, Rolf Herter, Matthias Hoffmann, Werner Rall, Rolf Schmid
New enentiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments

Publication number: 20050267106

Abstract: The present invention relates to enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3, R4 and X? may have the meanings given in the claims and in the specification, processes for preparing them and the use thereof as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.

Type: Application

Filed: May 12, 2005

Publication date: December 1, 2005

Applicant: Boehringer Ingelheim International GmbH

Inventors: Philipp Lustenberger, Ingo Konetzki, Peter Sieger
3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl)phenylamino]methyl}-1-methyl-1H-benzimidazol-5-carbonyl)pyridin-2-ylamino]propionic acid ethylester methansulfonate and its use as medicament

Publication number: 20050234104

Abstract: Ethyl 3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl)phenylamino]methyl}-1-methyl-1H-benzimidazole-5-carbonyl)pyridin-2-ylamino]propionate methanesulfonate in the crystalline modifications I and II and as the hemihydrate and the use thereof as a pharmaceutical composition.

Type: Application

Filed: August 13, 2004

Publication date: October 20, 2005

Applicant: Boehringer Ingelheim International GmbH

Inventors: Rolf Schmid, Peter Sieger, Rainer Sobotta
Novel crystalline anhydrate with anticholinergic efficacy

Publication number: 20050143410

Abstract: The invention relates to a new crystalline anhydrate of tiotropium bromide, processes for preparing it and its use for preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.

Type: Application

Filed: October 29, 2004

Publication date: June 30, 2005

Applicant: Boehringer Ingelheim International GmbH

Inventors: Waldemar Pfrengle, Peter Sieger
Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions

Patent number: 6908928

Abstract: Crystalline monohydrate of (1?,2?,4?,5?,7?)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide (tiotropium bromide monohydrate), processes for the preparation thereof, pharmaceutical compositions thereof, and their use.

Type: Grant

Filed: September 24, 2001

Date of Patent: June 21, 2005

Assignee: BI Pharma KG.

Inventors: Rolf Banholzer, Peter Sieger, Christian Kulinna, Michael Trunk, Manfred Graulich, Peter Specht, Helmut Meissner, Andreas Mathes
Process for preparing new tiotropium salts, new tiotropium salts as such and pharmaceutical compositions thereof

Publication number: 20050131007

Abstract: The invention relates to a process for preparing new tiotropium salts, these new tiotropium salts as such, pharmaceutical formulations containing them and their use for preparing a medicament for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.

Type: Application

Filed: October 29, 2004

Publication date: June 16, 2005

Applicant: Boehringer Ingelheim International GmbH

Inventors: Rolf Banholzer, Waldemar Pfrengle, Peter Sieger
Novel tiotropium salts, process for the preparation and pharmaceutical compositions thereof

Publication number: 20050096341

Abstract: The invention relates to new tiotropium salts, processes for preparing them, pharmaceutical formulations containing them and their use for preparing a medicament for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.

Type: Application

Filed: October 29, 2004

Publication date: May 5, 2005

Applicant: Boehringer Ingelheim International GmbH

Inventors: Rolf Banholzer, Waldemar Pfrengle, Peter Sieger
Process for preparing amino crotonyl compounds

Publication number: 20050085495

Abstract: The invention relates to an improved process for preparing 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylam ino)-1 -oxo-2-buten-1 -yl]am ino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline and related aminocrotonyl compounds and the preparation of a suitable salt of 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1 -oxo-2-buten-1 -yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline for use as a pharmaceutically active substance.

Type: Application

Filed: September 15, 2004

Publication date: April 21, 2005

Applicant: Boehringer Ingelheim International GmbH

Inventors: Rainer Soyka, Werner Rall, Juergen Schnaubelt, Peter Sieger, Christian Kulinna

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