Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: Methods of treating of interstitial lung disease, reducing pulmonary function decline in a subject with interstitial lung disease (ILD), and increasing forced vital capacity (FVC) in a subject suffering from ILD are provided, wherein the methods include administration of treprostinil.

Abstract: Methods of treating of interstitial lung disease, reducing pulmonary function decline in a subject with interstitial lung disease (ILD), and increasing forced vital capacity (FVC) in a subject suffering from ILD are provided, wherein the methods include administration of treprostinil.

Abstract: Methods of treating of interstitial lung disease, reducing pulmonary function decline in a subject with interstitial lung disease (ILD), and increasing forced vital capacity (FVC) in a subject suffering from ILD are provided, wherein the methods include administration of treprostinil.

Abstract: The present disclosure features bifunctional oligonucleotides and related compositions that, inter alia, modulate nucleic CA acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: Techniques are disclosed for enforcing application-centric microsegmentation policies in a network using machine learning. A trained machine learning model classifies network communication flows between hosts and applications to generate labeled flows. Based on these classifications, a microsegmentation policy is automatically generated that is independent of underlying network topology and optimized for performance, accuracy, or interpretability. A host in the network receives the microsegmentation policy and applies it locally to flows associated with the host. Enforcement of the policy includes allowing, blocking, quarantining, or redirecting flows according to the labels. The approach enables granular east-west traffic controls, dynamic adaptation to changing flow conditions, and automatic updates based on retrained models. Additional features include hierarchical policy structures, contextual metadata for flow classification, audit logging, and user-facing visualization of microsegments.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: Systems and methods for microsegmentation include receiving network communication information that describes flows between hosts in a network and applications executed on the hosts; generating a network communication model based on the network communication information that labels flows; and providing polices to the hosts based on the network communication model where the policies cause performance a set of actions, locally at a host, on any of the flows based on corresponding labels. The labels are one of healthy and unhealthy. The set of actions include blocking, allowing, and allowing for a period of time before confirmation.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: Furniture for a child is provided. The furniture comprises: a frame; a seat coupled to the frame, wherein the seat is for supporting the child on the furniture; and a toy bar for supporting toys on the furniture, wherein the toy bar is magnetically couplable to the seat and/or frame.

Abstract: A rocker/bouncer for a child A rocker/bouncer for a child is provided. The rocker/bouncer comprises: a base, wherein the base comprises one or more rails on which the rocker/bouncer can rock when the base on placed on a ground surface; a seat for the child, wherein the seat is coupled to the base by a resilient member, e.g. to permit bouncing of the seat relative to the base; and an adjustment member movably coupled to the base, wherein the adjustment member is selectively movable between: a stowed position; a first deployed position, in which the adjustment member protrudes from the one or more rails towards the ground surface by a first distance; and a second deployed position, in which the adjustment member protrudes from the one or more rails towards the ground surface by a second distance different from the first distance.

Abstract: A rotational intravascular ultrasound probe for insertion into a vasculature and a method of manufacturing the same. The rotational intravascular ultrasound probe comprises an elongate catheter having a flexible body and an elongate transducer shaft disposed within the flexible body. The transducer shaft comprises a proximal end portion, a distal end portion, a drive shaft extending from the proximal end portion to the distal end portion, an ultrasonic transducer disposed near the distal end portion for obtaining a circumferential image through rotation, and a transducer housing molded to the drive shaft and the ultrasonic transducer.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.