Abstract: A rotational intravascular ultrasound probe for insertion into a vasculature and a method of manufacturing the same. The rotational intravascular ultrasound probe comprises an elongate catheter having a flexible body and an elongate transducer shaft disposed within the flexible body. The transducer shaft comprises a proximal end portion, a distal end portion, a drive shaft extending from the proximal end portion to the distal end portion, an ultrasonic transducer disposed near the distal end portion for obtaining a circumferential image through rotation, and a transducer housing molded to the drive shaft and the ultrasonic transducer.

Abstract: A computer-implemented method for compressing, an input group of m data values compresses the two least significant bits of each of the data values by mapping the two least significant bits of each of the data values in the input group of m data values collectively onto an m-bit encoding and storing the m-bit encoding, the m-bit encoding being selected from 2m m-bit encodings, the 2m m-bit encodings comprising a first group of encodings comprising (2m?4) m-bit encodings and a second group of encodings comprising four m-bit encodings, wherein if the selected encoding is an encoding from the first group of encodings then the selected encoding represents the two least significant bits for a representative group of m data values in which the second least significant bit of each of the data values is the same as a respective bit of the m-bit encoding, and wherein if the selected encoding is an encoding from the second group of encodings then the selected encoding represents the two least significant bits for a rep

Abstract: A method of performing intersection testing in a ray tracing system, for a ray with respect to a set of two or more primitives. Each primitive is defined by an ordered set of edges, and each edge is defined by a respective pair of vertices. A set of distinct edges is determined for the set of primitives, each distinct edge being part of at least one primitive of the set of primitives and being defined by a different pair of vertices to the other distinct edges in the set, wherein every edge in the ordered sets of edges that define the set of primitives is represented by a distinct edge of the set of distinct edges. For each distinct edge in the set of distinct edges, an edge test is performed to determine which side of the distinct edge the ray passes on. For each primitive in the set of primitives, a result of the edge test is used for each distinct edge that defines that primitive to determine whether or not the ray intersects that primitive.

Abstract: A method of processing a primitive as part of intersection testing in a ray tracing system, the primitive being defined by an ordered set of vertices. Data defining a direction and an origin of a ray to be tested against the primitive, and coordinate data for a set of vertices are received. The coordinate data for the set of vertices is projected into ray space using the ray data, wherein the ray space has two non-parallel axes that are transverse to the direction of the ray, wherein a ray-space frame of reference associated with the axes is centered at a point on the ray such that the ray is represented as that point on the axes in the ray space, and wherein the point is an origin of the ray space. Then, the signs of the coordinate data for the set of vertices are analysed to determine whether a non-intersection condition is fulfilled, wherein fulfilment of the non-intersection condition indicates that the ray does not intersect the primitive.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: Systems and methods for facilitating the provision of goods using automated stores are provided. The automated stores are distributed across a geographical area and are remotely controlled to create an on-line marketplace. Users of the system can access the marketplace using an interactive portal to purchase items. Buyers can create purchase orders for items stocked in the marketplace and collect the items at one or more automated stores. The items are consigned to the buyers in real time at the automated store.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: A school bus stop arm and drive unit therefor are disclosed. The stop arm includes a stop sign and a drive unit for moving the stop sign between a retracted position and a deployed position. In some embodiments the stop sign is illuminated. In some embodiments the drive unit includes a controller.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: Embodiments provided herein relate to methods and compositions for preparing nucleic acid libraries. Some embodiments include preparing libraries from nucleic acids obtained from degraded samples, such as ancient samples and fixed samples.

Abstract: Methods of treating of interstitial lung disease, reducing pulmonary function decline in a subject with interstitial lung disease (ILD), and increasing forced vital capacity (FVC) in a subject suffering from ILD are provided, wherein the methods include administration of treprostinil.

Abstract: A method and an intersection testing module in a ray tracing system for performing intersection testing for a ray with respect to a plurality of convex polygons, each of which is defined by an ordered set of vertices. The vertices of the convex polygons are projected onto a pair of axes orthogonal to the ray direction. For each edge of a convex polygon defined by two of the projected vertices, a signed parameter is determined, wherein the sign of the signed parameter is indicative of which side of the edge the ray passes on. If the ray is determined to intersect a point on the edge then the sign of the signed parameter is determined using a module which is configured to: take as inputs, indications which classify each of pi, qi, pj and qj coordinates as negative, zero or positive, and output, for valid combinations of classifications of the pi, qi, pj and qj coordinates, an indication of the sign of the signed parameter.

Abstract: A method and an intersection testing module in a ray tracing system for determining whether a ray intersects a three-dimensional axis-aligned box. It is determined whether a first condition is satisfied, wherein the first condition is, or is equivalent to, ? "\[LeftBracketingBar]" C x - C z ? D x D z ? "\[RightBracketingBar]" ? H z ? D x D z + H x . It is determined whether a second condition is satisfied, wherein the second condition is, or is equivalent to, ? "\[LeftBracketingBar]" C y - C z ? D y D z ? "\[RightBracketingBar]" ? H z ? D y D z + H y .

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: The present disclosure features compounds (I) and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.