Abstract: A method and an intersection testing module in a ray tracing system for determining whether a ray intersects a three-dimensional axis-aligned box. It is determined whether a first condition is satisfied, wherein the first condition is, or is equivalent to, ? "\[LeftBracketingBar]" C x - C z ? D x D z ? "\[RightBracketingBar]" ? H z ? D x D z + H x . It is determined whether a second condition is satisfied, wherein the second condition is, or is equivalent to, ? "\[LeftBracketingBar]" C y - C z ? D y D z ? "\[RightBracketingBar]" ? H z ? D y D z + H y .

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: The present disclosure features compounds (I) and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: A probe may be inserted into a body cavity to perform diagnostic intervention(s), therapeutic intervention(s), or both. The probe may be inserted through a body aperture that is naturally occurring or man-made, intentionally or by accident. The body aperture may form a seal encircling the probe so that insufflation retention material may be effectively retained in the body cavity so that an operator can perform the intervention(s). However, there may be leakage of the insufflation material. The insufflation retention device is configured to form an effective seal contactingly adjacent the body aperture and to provide a passageway for the introduction of the probe into the body cavity, such that a diagnostic intervention or therapeutic intervention or both may be performed.

Abstract: Methods and decoding units for decoding a compressed data structure to determine a decoded value. The compressed data structure encodes a set of Haar coefficients for a block of pixels, including a plurality of differential coefficients and a sum coefficient. The compressed data structure includes a set of exponent bits representing exponents of the differential coefficients, a set of sign bits representing signs for the differential coefficients, a set of sum bits representing the sum coefficient. The compressed data structure is unpacked to identify the set of exponent bits, the set of sign bits and the set of sum bits. The identified set of exponent bits is used to determine exponents for the differential coefficients. The identified set of sign bits is used to determine signs the differential coefficients. The identified set of sum bits is used to determine the sum coefficient.

Abstract: A method and an intersection testing module in a ray tracing system for performing intersection testing for a ray with respect to a plurality of convex polygons, each of which is defined by an ordered set of vertices. The vertices of the convex polygons are projected onto a pair of axes orthogonal to the ray direction. For each edge of a convex polygon defined by two of the projected vertices, a signed parameter is determined, wherein the sign of the signed parameter is indicative of which side of the edge the ray passes on. If the ray is determined to intersect a point on the edge then the sign of the signed parameter is determined using a module which is configured to: take as inputs, indications which classify each of pi, qi, pj and qj coordinates as negative, zero or positive, and output, for valid combinations of classifications of the pi, qi, pj and qj coordinates, an indication of the sign of the signed parameter.

Abstract: Methods and encoding units for encoding a block of pixels into a compressed data structure. A set of Haar coefficients is determined for the block of pixels, including differential coefficients and a sum coefficient. A set of exponent bits is determined representing exponents for the differential coefficients. A set of sign bits is determined representing signs for the differential coefficients. A set of sum bits is determined representing the sum coefficient. The determined set of exponent bits is packed into a first portion of the compressed data structure; the determined set of sign bits is packed into a second portion of the compressed data structure; and the determined set of sum bits is packed into a third portion of the compressed data structure. The compressed data structure is stored.

Abstract: A method of performing tessellation of a patch in a ray tracing system for rendering an image within a scene. The patch represents a portion of a surface of an object within the scene, and the object is defined in 3D space using a first space-coordinate system. A bounding volume that contains the patch is determined, and determining whether a ray intersects the bounding volume. In response to determining that the ray intersects the bounding volume, and in dependence on tessellation indications associated with the patch, the patch is subdivided one or more times to obtain a plurality of patch sub-units, wherein one or more of the patch sub-units does not represent a primitive. The method includes, subsequent to the subdividing of the patch, determining that at least one of the patch sub-units comprises a primitive, and performing an intersection test between the ray and the primitive for use in rendering the image of the scene.

Abstract: A method of compressing data for representing displacement information in a ray tracing system, wherein the displacement information indicates displacements to be applied to geometry in a scene to be rendered by the ray tracing system. The method includes retrieving a pair of datasets representing the displacement information, wherein a first of the datasets comprises a first array of values, and a second of the datasets comprises a second array of values; retrieving values from a corresponding array position in each of the first and second arrays, wherein the retrieved values form a pair of values representing an upper and lower bound of a magnitude of displacement for the corresponding array position. The method includes identifying which of a plurality of predetermined conditions the pair of values satisfies, and encoding the pair of values as a single value in a compressed dataset, wherein the single value represents the identified predetermined condition.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, eg., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: An apparatus and method for authenticating a user of a vapour generating system include emitting a transmitted signal from a mouthpiece of the system into an oral cavity of the user and detecting a received signal that includes reflections of the transmitted signal from the tongue of the user. The received signal is analysed to derive characteristics of it that include Doppler shifts resulting from the tongue moving towards or away from the receiver. Operation of the system is enabled only if the user moves their tongue in a predetermined pattern, for example by inaudibly speaking a password, so that the derived characteristics match corresponding characteristics of the authorized user that have been stored in a preliminary training step. The predetermined pattern of movement of the tongue is not easy for an unauthorized person to detect or to reproduce. The transmitted signal may be a high frequency acoustic signal.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: The present disclosure features compounds e.g. of formula (I-a) and similar compounds e.g. of formulae (1-g), (1-i), (1-j), (III), (III-a), (III-b) and (IV) disclosed herein and other related compounds, and pharmaceutical compositions thereof. The present disclosure further discloses said compounds and their compositions for use in methods of modulating nucleic acid splicing, as well as said compounds for use in methods of treating e.g.: ·proliferative diseases, such as e.g. cancer, benign neoplasms or angiogenesis, ·neurological diseases or disorders, such as e.g. Huntington's disease, ·autoimmune diseases or disorders, immunodeficiency diseases or disorders, lysosomal storage disease or disorder, cardiovascular diseases or disorders, metabolic diseases or disorders, respiratory diseases or disorders, renal diseases or disorders, or infectious diseases. Exemplary compounds are e.g.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: An embodiment includes a vascular port comprising: first and second portions that are not monolithic with each other; wherein: (a)(i) the first portion includes a first arcuate surface to contour to a first portion of a vessel and the second portion includes a second arcuate surface to contour to a second portion of the vessel; (a)(ii) the first and second portions couple to one another around the vessel when implanted to form a central chamber that houses the vessel; (a)(iii) the first portion includes a port that includes a funnel with a funnel surface that narrows as the funnel surface approaches the central chamber; (a)(iv) the central chamber includes a central longitudinal axis and the funnel includes a central vertical axis that is orthogonal to the longitudinal axis; (a)(v) the second portion includes a hardened, non-compliant surface that intersects the vertical axis.