Abstract: Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject.

Abstract: Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject.

Abstract: Anti-SIRP? antibodies, including multi-specific anti-SIRP? antibodies, are provided, as are related compositions and methods. The antibodies of the disclosure bind to SIRP? and can block the interaction of CD47 on one cell with SIRP? on a phagocytic cell. Antibodies that are bispecific for SIRP? and a second antigen are termed Bi-specific Macrophage Enhancing (BiME) antibodies and have emergent properties. The subject anti-SIRP? antibodies find use in various therapeutic methods. Embodiments of the disclosure include isolated antibodies and derivatives and fragments thereof, pharmaceutical formulations comprising one or more of the anti-SIRP? antibodies; and cell lines that produce the antibodies. Also provided are amino acid sequences of exemplary anti-SIRP? antibodies.

Abstract: Methods are provided for enhancing immunization strategies by manipulation, e.g. in vitro manipulation, of phagocytic antigen presenting cells. In the methods of the invention, phagocytic antigen presenting cells (phAPC) are incubated with a particulate antigen in the presence of an anti-CD47 agent in a dose and for a period of time sufficient to allow the phAPC to phagocytose the particulate antigen, which process generates a “loaded” phAPC. The loaded phAPC is contacted with a population of T cells matched for at least one major histocompatibility locus with the phAPC, where the T cells are stimulated after contacting to generate an effector response against an epitope or epitopes present on the particulate antigen.

Abstract: A wind turbine condition monitoring system and method are disclosed where the wind turbines include a tower, a gearbox coupled to the tower, and turbine blades coupled to the gearbox. The monitoring system includes blade sensors coupled to the blades, a hub node coupled to the gearbox and a controller. The controller is in communication with the hub node and blade sensors, and determines blade positions based on blade sensor readings. The blade sensors and hub node can include multi-axis accelerometers. The controller can wirelessly communicate with the blade sensors directly or through the hub node. Using position information, shadowing areas with obstructed communication can be avoided, node separation can be accounted for to reduce power requirements and/or interference from multiple transmitters can be avoided during node communications.

Abstract: Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject.

Abstract: A method of operating a wind turbine includes providing a wind turbine having a plurality of blades. A respective sensor is attached to each of the blades. First measurements of a structural characteristic of each of the blades are repeatedly taken by use of the sensors. A tolerance band is established for the measurements. Signals indicative of the first measurements are wirelessly transmitted only if the first measurements are outside of the tolerance band. The transmitted signals are received at a controller. An actuator signal is sent from the controller to at least one actuator associated with the blades. The sending is in response to the receiving of the transmitted signals. At least one of the blades is actuated dependent upon the actuator signal. The actuating is performed by the at least one actuator. Second measurements of the structural characteristic of each of the blades are repeatedly taken by use of the sensors after the actuating step.

Abstract: A method for state monitoring of a wind energy installation, includes normalizing state data relating to a number of different components of the wind energy installation on the basis of a predetermined data norm. The normalized state data is stored in a database device, and the state data which is stored in the database device is assessed by means of processing device, with the state of the components of the wind energy installation being determined on the basis of the assessment.

Abstract: A wind turbine condition monitoring system and method are disclosed where the wind turbines include a tower, a gearbox coupled to the tower, and turbine blades coupled to the gearbox. The monitoring system includes blade sensors coupled to the blades, a hub node coupled to the gearbox and a controller. The controller is in communication with the hub node and blade sensors, and determines blade positions based on blade sensor readings. The blade sensors and hub node can include multi-axis accelerometers. The controller can wirelessly communicate with the blade sensors directly or through the hub node. Using position information, shadowing areas with obstructed communication can be avoided, node separation can be accounted for to reduce power requirements and/or interference from multiple transmitters can be avoided during node communications.

Abstract: A method of operating a wind turbine includes providing a wind turbine having a plurality of blades. A respective sensor is attached to each of the blades. First measurements of a structural characteristic of each of the blades are repeatedly taken by use of the sensors. A tolerance band is established for the measurements. Signals indicative of the first measurements are wirelessly transmitted only if the first measurements are outside of the tolerance band. The transmitted signals are received at a controller. An actuator signal is sent from the controller to at least one actuator associated with the blades. The sending is in response to the receiving of the transmitted signals. At least one of the blades is actuated dependent upon the actuator signal. The actuating is performed by the at least one actuator. Second measurements of the structural characteristic of each of the blades are repeatedly taken by use of the sensors after the actuating step.

Abstract: In a method for monitoring the load on rotor blades of wind energy installations by measuring acceleration on at least one rotor blade of a wind energy installation and determining load on the rotor blade from the picked-up acceleration signals, dynamic, even uncritical load states can be detected, in differentiated fashion, and combined in a suitable form for evaluation in order to influence, if possible prior to the onset of damage to the rotor blade, the mode of operation of the wind energy installation, in particular the design of the pitch control or angle setting of stall-regulated rotor blades, on the basis both of all of the rotor blades together and of a single rotor blade. Frequency of occurrence of the load values over a certain period of time is determined from amplitudes of the acceleration signal or amplitudes of selected natural oscillations of the frequency spectra are obtained by Fourier transformation.

Abstract: The invention relates to a method and a device for monitoring the state of rotor blades on wind power installations. According to the invention, structure-borne noise is measured by means of at least one displacement sensor arranged on the rotor blade, the output signals of said sensors determine a frequency spectrum in an evaluation unit by means of suitable methods, the frequency spectrum is compared to reference spectra corresponding to defined states of damage and other particular states and stored in the evaluation unit, and the state of the rotor blade is determined therefrom. The aim of the invention is to provide a method and a device which enable existing local inner and outer damage, and other particular damage-causing states of the rotor blades, to be rapidly identified and evaluated, in order to take into account the effect thereof on the operation of the installation in an automatic manner.

Abstract: In a method for monitoring the load on rotor blades of wind energy installations by measuring acceleration on at least one rotor blade of a wind energy installation and determining load on the rotor blade from the picked-up acceleration signals, dynamic, even uncritical load states can be detected, in differentiated fashion, and combined in a suitable form for evaluation in order to influence, if possible prior to the onset of damage to the rotor blade, the mode of operation of the wind energy installation, in particular the design of the pitch control or angle setting of stall-regulated rotor blades, on the basis both of all of the rotor blades together and of a single rotor blade. Frequency of occurrence of the load values over a certain period of time is determined from amplitudes of the acceleration signal or amplitudes of selected natural oscillations of the frequency spectra are obtained by Fourier transformation.

Abstract: The invention relates to a method and a device for monitoring the state of rotor blades on wind power installations. According to the invention, structure-borne noise is measured by means of at least one displacement sensor arranged on the rotor blade, the output signals of said sensors determine a frequency spectrum in an evaluation unit by means of suitable methods, the frequency spectrum is compared to reference spectra corresponding to defined states of damage and other particular states and stored in the evaluation unit, and the state of the rotor blade is determined therefrom. The aim of the invention is to provide a method and a device which enable existing local inner and outer damage, and other particular damage-causing states of the rotor blades, to be rapidly identified and evaluated, in order to take into account the effect thereof on the operation of the installation in an automatic manner.

Abstract: The invention relates to a method and a device for controlling the pitch angles of rotor blades on wind power stations, the pitch angle being controlled to maximize yields and prevent excess loads on the rotor blades. The aim of the invention is to maximize the propulsive power on rotor blades. Said aim is achieved by taking a first measurement of the pressure prevailing on the pressure side (5) and a second measurement of the pressure prevailing on the suction side (6) of a rotor blade (1), determining the difference in pressure between the first and second pressure measurement, and adjusting the pitch angle in accordance with the ratio between the first and second pressure measurement.