Abstract: The present invention relates to the use of a compound as effective agent for the prevention or treatment of diabetes mellitus in a mammal. Said compounds being selected from the group of phthalide derivatives and exhibit excellent blood glucose lowering effects and thus are effective agents in the prevention or treatment of diabetes mellitus in mammals.

Abstract: A pumping unit having a pump chamber with a rotor mounted in a rotatable manner within the chamber. The pumping chamber is formed by a circumferential wall and two end walls. The circumferential wall is formed on an annular collar of a pump part and has on its inner surface a track on which sealing bodies of a rotor roll. To avoid deformation of the pump part by hydraulic forces or by pressing-in forces, ribs are arranged on the outer surface of the circumferential wall which extend away from the pump chamber. A shoulder is arranged on the side of the end wall which is directed away from the pump chamber. The shoulder is connected by a press fit to the pump housing and has thin walls so that pressing forces do not result in any deformation to the end wall of the pump chamber.

Abstract: A medical system includes a carrier and a multiplicity of electromechanical transducers mounted to the carrier, the transducers being disposable in effective pressure-wave-transmitting contact with a patient. Energization componentry is operatively connected to a first plurality of the transducers for supplying the same with electrical signals of at least one pre-established ultrasonic frequency to produce first pressure waves in the patient. A control unit is operatively connected to the energization componentry and includes an electronic analyzer operatively connected to a second plurality of the transducers for performing electronic 3D volumetric data acquisition and imaging (which includes determining three-dimensional shapes) of internal tissue structures of the patient by analyzing signals generated by the second plurality of the transducers in response to second pressure waves produced at the internal tissue structures in response to the first pressure waves.

Abstract: Devices, systems, methods, and other embodiments associated with a network device for interfacing a host with a network are described. One example network device includes a transmit path, and a receive path. A loopback path connects the transmit path and the receive path. A frame detection logic is configured to monitor network traffic on the transmit path to identify loopback frames. When a loopback frame is detected, a loopback logic routes the identified loopback frame onto the loopback path and then to the receive path. The rerouted loopback frame may then be received by a host or an embedded client from the receive path.

Abstract: For safe storage and simple and safe administration of tablets T by a user, a cartridge 900 is provided that can be inserted into a medicament dispenser 1 for solid medicament portions T and that is designed with a reservoir for receiving the medicament portions T, and a medicament dispenser 1 for this cartridge 900 is also provided. According to the invention, the cartridge 900 comprises a singulation device 910 that is designed to dispense defined medicament portions T and that comprises a movable mechanism 940 for separating a defined medicament portion T from the reservoir and for dispensing it from the medicament dispenser 1, wherein the singulation device 910 is designed to produce an operative connection to an actuating device 14, 220, 224, 226; 15, 210; 230 in the medicament dispenser 1.

Abstract: The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.

Abstract: The invention relates to a shaping tool which is used to shape a workpiece, in particular, a sheet steel component, comprising at least two shaping tool halves. Contoured regions are provided in the region of the shaping tool halves in order to give the workpiece a corresponding contour, at least in sections. Each shaping tool half has a shaping surface shell which is oriented towards the workpiece and a support shaping half. The shaping surface shell is arranged on the support shaping half and comprises a shaping surface, which is oriented towards the workpiece, and a rear side which is oriented away from the workpiece. The support shaping half comprises a contoured area which essentially corresponds to the contour of the workpiece which is to be produced and the contoured area is surrounded by a flange area. Grooves are provided in the contoured area in the region of the rear side of the shaping surface shell.

Abstract: A plant for the heat treatment of solids containing iron oxide includes a fluidized bed reactor. The reactor includes at least one gas supply tube at least partly surrounded by an annular chamber in which a stationary annular fluidized bed is located, and a mixing chamber being located above the upper orifice region of the at least one gas supply tube. The gas flowing through the at least one gas supply tube entrains solids from the stationary annular fluidized bed-into the mixing chamber when passing through the upper orifice region of the at least one gas supply tube.

Abstract: A plant for the heat treatment of solids containing iron oxide. The plant includes a reactor including a fluidized bed reactor. The reactor includes a gas supply system disposed in the reactor, a stationary annular fluidized bed which at least partly surrounds the gas supply system, and a mixing chamber. The gas supply system is configured so that gas flowing through the gas supply system entrains solids from the stationary annular fluidized bed into the mixing chamber.

Abstract: The present invention relates to methods for identifying compounds useful for regulating TNF-alpha levels and/or activity. The invention also relates to methods for decreasing TNF-alpha levels and/or activity. Compounds and compositions according to this invention are useful for treating TNF-mediated diseases. The invention also relates to kits comprising the compounds and compositions herein and a tool for measuring TNF-alpha activity and/or levels.

Abstract: The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.

Abstract: A cupboard installation part with storage compartments is insertable in an upper cupboard and is pivotable from an upper position, moved into the upper cupboard, into a position moved out of the upper cupboard and displaced downward. The cupboard installation part comprises pivot levers aligned parallel, which, on the one hand, are coupled to the cupboard installation part, and, on the other hand, are able to be coupled to the upper cupboard. A supporting element is insertable and mountable in the upper cupboard, on which supporting element a first pivot lever and a second pivot lever are pivotably borne, in each case in a first pivot bearing. The two pivot levers are each pivotably connected to a support part via a second pivot bearing, on which support part the storage compartments are mountable, at least on one side. An easily mountable cupboard installation part is thereby obtained which has a very stable construction and is usable in diverse ways.

Abstract: A method and apparatus for electronic volume data acquisition using ultrasound generates image data in a scanning and imaging process known as coherent aperture combining beamforming (CAC-BF). The CAC-BF technique can be applied in an azimuth dimension and/or an elevation dimension, to form an ultrasound image line, image plane, or image data cube. Several innovations relating to the design and ordering of shots and efficient weighting algorithms that address various performance issues associated with B-mode and other modes such as Doppler, and harmonic imaging are disclosed. The invention has significant advantages over other synthetic aperture imaging techniques and conventional imaging techniques by supporting higher resolution, larger volumes and/or shorter acquisition times than comparative techniques, using similar system hardware complexity.

Abstract: Known pumping devices have a connection lid, a connection cap slipped over the connection lid, a hollow chamber formed between the connection lid and the connection cap, and electrical connections that extend through the connection cap into the hollow chamber. It is disadvantageous that when fuels containing water are being pumped, such as ethanol, corrosion can occur at the electrical connections and at the uninsulated cable segments that are exposed to fuel near the electrical connections, for instance at the electrical coils or flexible cables of the carbon brushes, and in the final analysis this leads to an interruption in the electrical contact and thus to failure of the pumping device. In the electrical device of the invention, corrosion of the electrical connections and of the electrical components adjoining them upstream and downstream is avoided entirely or at least greatly diminished. According to the invention, the electrical connections are each provided in separate chambers of the hollow chamber.

Abstract: The present invention relates to novel classes of compounds of formula I which are caspase and TNF-alpha inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase and TNF-alpha activity and consequently, can be advantageously used as agents against caspase-, interleukin-1-(“IL-1”), apoptosis-, interferon-? inducing factor-(IGIF), interferon-?-(“IFN-?”), or TNF-alpha mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to processes for preparing the compounds of this invention.

Abstract: The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.

Abstract: The present invention relates to a method and a plant for producing low 15 temperature coke, in which granular coal and possibly further solids are heated to a temperature of 700 to 1050° C. in a fluidized-bed reactor (2) by means of an oxygen-containing gas. To improve the utilization of energy it is proposed to introduce a first gas or gas mixture from below through at least one gas supply tube (3) into a mixing chamber region (8) of the reactor (2), the gas supply tube (3) being at least partly surrounded by a stationary annular fluidized bed (6) which is fluidized by supplying fluidizing gas. The gas velocities of the first gas or gas mixture and of the fluidizing gas for the annular fluidized bed (6) are adjusted such that the Particle-Froude-Numbers in the gas supply tube (3) are between 1 and 100, in the annular fluidized bed (6) between 0.02 and 2 and in the 25 mixing chamber (8) between 0.3 and 30.

Abstract: Compositions comprising a catechin as found in green tea, e.g., epigallocatechin gallate, and ligand which activates the peroxisome proliferatoractivated receptor gamma (PPAR-gamma are useful for the treatment and prevention of diabetes mellitus).